MAPK
Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.
Trovati 901 prodotti per "MAPK". Vengono mostrati i primi 500.
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MRTX0902
CAS:MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM.Formula:C22H24N6OPurezza:99.69%Colore e forma:SolidPeso molecolare:388.47ARS-1630
CAS:ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.Formula:C21H17ClF2N4O2Purezza:97.78%Colore e forma:SolidPeso molecolare:430.84Ref: TM-T10376
1mg38,00€5mg86,00€1mL*10mM (DMSO)88,00€10mg112,00€25mg216,00€50mg310,00€100mg408,00€200mg580,00€PD 198306
CAS:PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.Formula:C18H16F3IN2O2Purezza:99.66%Colore e forma:SolidPeso molecolare:476.23Ref: TM-T21980
1mg64,00€5mg138,00€1mL*10mM (DMSO)160,00€10mg188,00€25mg330,00€50mg472,00€100mg655,00€500mg1.293,00€LUT014
CAS:LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.Formula:C27H19F3N8OPurezza:99.03%Colore e forma:SolidPeso molecolare:528.49TINK-IN-1
CAS:TINK-IN-1 is a selective and potent TNIK inhibitor (IC50: 8 nM).TINK-IN-1 inhibits colorectal cancer cell viability and can be used to study mental retardation.Formula:C24H24N4O3Purezza:99.8%Colore e forma:SolidPeso molecolare:416.47Ref: TM-T77660
1mg39,00€2mg50,00€5mg82,00€10mg120,00€25mg236,00€50mg353,00€100mg517,00€500mg1.099,00€CC-90003
CAS:CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.Formula:C22H21F3N6O2Purezza:99.42%Colore e forma:SolidPeso molecolare:458.44INH154
CAS:INH154 is a potent Nek2 and Hec1 binding (INH) inhibitor with IC50s of 120 nM in MB468 cells and 200 nM in Hela cells for INH.Formula:C22H24N4OSPurezza:99.95%Colore e forma:SolidPeso molecolare:392.52Ref: TM-T11657
2mg34,00€5mg54,00€1mL*10mM (DMSO)59,00€10mg82,00€25mg136,00€50mg203,00€100mg299,00€200mg416,00€Tanzisertib
CAS:Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.Formula:C21H23F3N6O2Purezza:98.66% - 99.28%Colore e forma:SolidPeso molecolare:448.44ERK5-IN-5
CAS:ERK5-IN-5 is extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity anticonvulsant activity inhibits A549 cell proliferation.Formula:C19H16ClN3OPurezza:99.89%Colore e forma:SolidPeso molecolare:337.8Ref: TM-T77734
1mg81,00€2mg105,00€5mg170,00€10mg264,00€25mg532,00€50mg868,00€100mg1.378,00€500mg2.673,00€JNK-IN-13
CAS:JNK-IN-13 is a JNK inhibitor that inhibits JNK3 and JNK2 and can be used in the study of diabetes, inflammation, and neurological disorders.Formula:C13H7ClN4SPurezza:98.74%Colore e forma:SolidPeso molecolare:286.74SU3327
CAS:SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).Formula:C5H3N5O2S3Purezza:98.39%Colore e forma:SolidPeso molecolare:261.3HI-TOPK-032
CAS:HI-TOPK-032 is an effective and specific inhibitor of TOPK.Formula:C20H11N5OSPurezza:98.52%Colore e forma:SolidPeso molecolare:369.4ETC-206
CAS:ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM).Formula:C25H20N4O2Purezza:99.72% - 99.79%Colore e forma:SolidPeso molecolare:408.45Ref: TM-T15250
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg92,00€25mg140,00€50mg215,00€100mg318,00€500mg692,00€BAY 2965501
CAS:BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor that induces pERK activation.BAY 2965501 can be used in the study of cancer.Formula:C20H19FN4O3SPurezza:99.89%Colore e forma:SolidPeso molecolare:414.45(R)-BI-2852
CAS:(R)-5-hydroxy isoindolin-1-one is an RAS protein inhibitor with antiproliferative and antitumor properties.Formula:C31H28N6O2Purezza:97.80%Colore e forma:SoildPeso molecolare:516.59BI-3406
CAS:BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Formula:C23H25F3N4O3Purezza:99.2% - 99.66%Colore e forma:SolidPeso molecolare:462.46Ref: TM-T12979
1mg70,00€5mg152,00€1mL*10mM (DMSO)166,00€10mg236,00€25mg439,00€50mg628,00€100mg872,00€500mg1.738,00€BAS 00489700
CAS:BAS 00489700 is a N-UTR interaction inhibitor. BAS 00489700 inhibits virus replication in cell culture.Formula:C19H16N2O4Purezza:99.78%Colore e forma:SolidPeso molecolare:336.34Ref: TM-T67854
1mg85,00€5mg170,00€1mL*10mM (DMSO)170,00€10mg250,00€25mg371,00€50mg522,00€100mg712,00€200mg954,00€ACBI3
CAS:ACBI3 is a selective pan-KRAS degrader with anticancer activity that degrades oncogenic KRAS. ACBI3 inhibits the growth of most cancer cell lines driven by KRAS mutations.Formula:C50H62N14O6S2Purezza:99.24% - 99.41%Colore e forma:White SolidPeso molecolare:1019.25Azelnidipine
CAS:Azelnidipine (UR-12592) is a dihydropyridine used as calcium channel blocker.Formula:C33H34N4O6Purezza:99.78%Colore e forma:White SolidPeso molecolare:582.65Ref: TM-T0121
2mg34,00€5mg49,00€1mL*10mM (DMSO)59,00€10mg64,00€25mg103,00€50mg167,00€100mg260,00€200mg385,00€AX-15836
CAS:AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).Formula:C32H40N8O5SPurezza:98.96%Colore e forma:SolidPeso molecolare:648.78Ref: TM-T14360
1mg54,00€2mg77,00€5mg114,00€1mL*10mM (DMSO)164,00€10mg167,00€25mg281,00€50mg401,00€100mg567,00€500mg1.161,00€B-Raf IN 2
CAS:B-Raf IN 2, compound Ia, is a highly effective and specific inhibitor of BRAF. It exhibits significant potential for cancer research.Formula:C20H17F2N5O4SPurezza:98.86%Colore e forma:SolidPeso molecolare:461.44Xl-281
CAS:XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.Formula:C24H19ClN4O4Purezza:95.77% - 98.83%Colore e forma:White SolidPeso molecolare:462.89ERK5-IN-6
CAS:ERK5-IN-6 is an ERK5 kinase inhibitor with antiproliferative, anticonvulsant, and antitumor activity for the study of central nervous system related diseases.Formula:C23H21N3Purezza:99.87%Colore e forma:SolidPeso molecolare:339.43Ro-3201195
CAS:Ro-3201195 is a novel orally available p38 MAPK inhibitor with high selectivity.Formula:C19H18FN3O4Purezza:99.84%Colore e forma:SolidPeso molecolare:371.36Ref: TM-T68134
1mg122,00€5mg289,00€1mL*10mM (DMSO)311,00€10mg432,00€25mg707,00€50mg973,00€100mg1.333,00€500mg2.665,00€MK2-IN-3 hydrate
CAS:MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)Formula:C21H18N4O2Purezza:99.58%Colore e forma:SolidPeso molecolare:358.39Ref: TM-T12058
1mg34,00€5mg60,00€1mL*10mM (DMSO)73,00€10mg87,00€25mg172,00€50mg250,00€100mg350,00€200mg480,00€Cephradine
CAS:Cephradine (Anspor) is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.Formula:C16H19N3O4SPurezza:99.63%Colore e forma:White Crystalline Powder; Polymorphic SolidPeso molecolare:349.40Divarasib
CAS:Divarasib (GDC-6036), an investigational KRAS G12C inhibitor for solid tumors, has an IC50 of <0.01 μM.Formula:C29H32ClF4N7O2Purezza:99.23% - 99.83%Colore e forma:SolidPeso molecolare:622.06Ref: TM-T9972
1mg220,00€5mg522,00€1mL*10mM (DMSO)707,00€10mg737,00€25mg1.161,00€50mg1.603,00€100mg2.133,00€(R)-Ketorolac
CAS:(R)-Ketorolac ((+)-Ketorolac) is the R-enantiomer of Ketorolac, with potent analgesic activity.Formula:C15H13NO3Purezza:99.55%Colore e forma:White SolidPeso molecolare:255.27Ref: TM-T12624
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg113,00€25mg222,00€50mg313,00€100mg437,00€PF-3644022
CAS:PF-3644022 is a selective MK2 inhibitor, effective against TNFα (IC50: 5.2 nM, Ki: 3 nM), with anti-inflammatory properties. Also blocks MK3 and PRAK.Formula:C21H18N4OSPurezza:98.13%Colore e forma:SolidPeso molecolare:374.46Ref: TM-T16501
1mg34,00€5mg105,00€1mL*10mM (DMSO)177,00€10mg192,00€25mg394,00€50mg587,00€100mg788,00€500mg1.575,00€MAP4K4-IN-3
CAS:MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.Formula:C15H12ClN5Purezza:98.07%Colore e forma:White SolidPeso molecolare:297.74Ref: TM-T11942
5mg44,00€1mL*10mM (DMSO)48,00€10mg74,00€25mg144,00€50mg222,00€100mg354,00€200mg523,00€500mg797,00€KRAS G12C inhibitor 19
CAS:KRAS G12C inhibitor 19 is a potent KRAS G12C inhibitor that shows anti-tumor activity in cellular assays, and the family inhibits tumor growth.Formula:C25H19ClF2N4O3SPurezza:97.46%Colore e forma:SolidPeso molecolare:528.96MRTX-1257
CAS:MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.Formula:C33H39N7O2Purezza:96.76% - 97.3%Colore e forma:SolidPeso molecolare:565.71Ref: TM-T16143
1mg60,00€2mg85,00€5mg124,00€1mL*10mM (DMSO)166,00€10mg195,00€25mg351,00€50mg512,00€100mg743,00€200mg982,00€K-Ras G12C-IN-4
CAS:K-Ras G12C-IN-4 是一种 KRAS G12C 共价抑制剂。Formula:C31H33ClN4O4Purezza:99.41%Colore e forma:White SolidPeso molecolare:561.07Ref: TM-T11738
1mg71,00€5mg161,00€1mL*10mM (DMSO)192,00€10mg236,00€25mg403,00€50mg532,00€100mg783,00€200mg1.054,00€Setidegrasib
CAS:KRAS G12D inhibitor 17, a quinazoline-linked prolinamide, degrades mutant KRAS protein; a PROTAC.Formula:C60H65FN12O7SColore e forma:SolidPeso molecolare:1117.3FAM49B (190-198) mouse
CAS:FAM49B (190-198) mouse represents a peptide fragment of the mitochondria-localized protein FAM49B, which is instrumental in regulating mitochondrial fission, function, and integrity, in addition to influencing tumor progression. Beyond its role in mitochondrial dynamics, FAM49B serves as a negative regulator of T cell activation by inhibiting GTPase Rac activity and affecting cytoskeleton reorganization.Formula:C49H71N9O14SColore e forma:SolidPeso molecolare:1042.2Tagarafdeg
CAS:Tagarafdeg (CFT1946) is a PROTAC degradator targeting mutant BRAF, capable of degrading BRAF V600E, G469A, G466V mutations, anti proliferation.Formula:C45H49F2N11O9SPurezza:>99.99% - ＞99.99%Colore e forma:SolidPeso molecolare:958LYMTAC-2
LYMTAC-2 is a lysosome-targeting chimera (LYMTAC) developed to degrade membrane-associated proteins through lysosomal membrane proteins (LMP) such as RNF152, LAPTM4a, and LAPTM5. It forms a ternary complex with target proteins like KRASG12D, facilitating their relocation to lysosomes and resulting in ubiquitin-dependent degradation. This compound has potential for studying membrane protein regulation and devising strategies to counter resistance in KRAS-driven signaling pathways.Colore e forma:SolidPeso molecolare:1248.44ERK1/2 inhibitor 10
ERK1/2 inhibitor 10 (Compound 36c) is a potent inhibitor of ERK1 and ERK2, with IC50 values of 0.11 nM and 0.08 nM, respectively. It effectively hinders the phosphorylation of downstream substrates p90RSK and c-Myc. Additionally, ERK1/2 inhibitor 10 induces apoptosis and incomplete autophagy-related cell death. This compound demonstrates significant antitumor efficacy in models of triple-negative breast cancer and colorectal cancer harboring BRAF and RAS mutations.Formula:C23H20ClN5O2SPeso molecolare:465.10262R18
CAS:14.3.3 protein antagonist, blocks binding to Raf-1/Bad/ASK1/exoenzyme S, competitive, no phosphorylation needed, KD ~80 nM.Formula:C101H157N27O29S3Purezza:98%Colore e forma:SolidPeso molecolare:2309.69ASP6918
ASP6918 is a potent, orally active KRAS G12C inhibitor with an IC50 of 0.028 µM. It inhibits cell growth and demonstrates antitumor activity.Formula:C36H43N7O3Peso molecolare:621.34274SHP2-IN-38
SHP2-IN-38 is an innovative green fluorescent inhibitor targeting SHP2, exhibiting IC50 values as follows: 2.89 μM (SHP2), 8.73 μM (SHP1), 11.08 μM (PTP1B), and 33.07 μM (TCPTP). It impedes the SHP2-mediated ERK signaling pathway and inhibits MV4-11 cell proliferation in vitro with an IC50 of 7.90 μM. The excitation wavelength of SHP2-IN-38 is 360 nm, with a maximum emission wavelength of 550 nm in DMSO and 540 nm in DMF. Additionally, it demonstrates green fluorescent imaging in HeLa cells and zebrafish.Colore e forma:Odour SolidHPK1-IN-4
CAS:HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.Formula:C23H26N6O3Purezza:97.06%Colore e forma:Yellow SolidPeso molecolare:434.49Ref: TM-T40350
1mg123,00€5mg295,00€1mL*10mM (DMSO)326,00€10mg447,00€25mg782,00€50mg1.071,00€100mg1.468,00€Antimicrobial agent-21
CAS:Antimicrobial agent-21 is a potent mitogen activated protein kinase inhibitor with antibacterial, anti-inflammatory and antitumor activity for the treatment ofFormula:C18H13N3OSPurezza:99.82%Colore e forma:SolidPeso molecolare:319.38Ref: TM-T67942
1mg54,00€5mg116,00€10mg172,00€1mL*10mM (DMSO)180,00€25mg278,00€50mg371,00€100mg510,00€200mg687,00€KRAS-IN-43
KRAS-IN-43 (Compound 9) is a broad-spectrum KRAS inhibitor with IC50 values of 0.15 μM for KRASG12V, 0.14 μM for KRASG12C, and 0.47 μM for wild-type KRAS. It disrupts the interaction between KRAS and cRAF and suppresses ERK phosphorylation. KRAS-IN-43 shows potential for research in KRAS mutation-associated cancers, including pancreatic, colorectal, and lung cancers.Colore e forma:Odour SolidPROTAC MEK1 Degrader-1
CAS:PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2Formula:C53H66FIN8O11S2Purezza:98%Colore e forma:SolidPeso molecolare:1201.17RTIL 13
CAS:RTIL 13 inhibits dynamin GTPase (IC50: 2.3 μM), targets its lipid binding domain, and suppresses endocytosis (IC50: 9.3 & 7.1 μM).Formula:C30H55BrN2O3Colore e forma:SolidPeso molecolare:571.685Z16078526
CAS:Z16078526 promotes Ucp1, p38 MAPK, lipolysis, thermogenic genes, and mitochondrial activity in mouse brown adipocytes.Formula:C18H17N3O4SPurezza:99.18%Colore e forma:SolidPeso molecolare:371.41MS432
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.Formula:C50H65F3IN7O6SPurezza:98%Colore e forma:SolidPeso molecolare:1076.06MAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Colore e forma:Odour SolidRef: TM-L1400
1mgPrezzo su richiesta10μL*10mM (DMSO)Prezzo su richiesta20μL*10mM (DMSO)Prezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaMAP4K4-IN-6
MAP4K4-IN-6 (Compound 15f) is a MAP4K4 inhibitor with an IC50 of 80 nM. It reduces the phosphorylation of c-Jun and exhibits neuroprotective effects. Additionally, MAP4K4-IN-6 enhances the vitality of motor neurons and can be utilized in the study of amyotrophic lateral sclerosis (ALS).Colore e forma:Odour Solid
