MAPK

Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.

Trovati 894 prodotti di "MAPK"

Purezza (%)

100

prodotti per pagina.

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(R)-STU104
CAS:
- 2767124-77-4
(R)-STU104 is a TAK1-MKK3 protein-protein interaction (PPI) inhibitor. (R)-STU104 is a candidate compound for the treatment of ulcerative colitis.
Formula:C₁₈H₁₈O₄
Purezza:98.91% - 99.42%
Colore e forma:Solid
Peso molecolare:298.33
Ref: TM-T60657
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REDX05358
CAS:
- 1884226-20-3
REDX05358: Selective pan RAF inhibitor for BRAF/RAS mutant tumors with high affinity, safety, and low paradoxical activation.
Formula:C₂₆H₂₁ClN₄O₃
Colore e forma:Solid
Peso molecolare:472.92
Ref: TM-T28510
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KRAS inhibitor-3
CAS:
- 900897-56-5
KRAS inhibitor-3 targets WT/oncogenic KRAS; high affinity (KD: 0.28-0.74 μM); disrupts KRAS-Raf interaction.
Formula:C₂₅H₂₇N₅O
Colore e forma:Solid
Peso molecolare:413.51
Ref: TM-T72659
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CK1-IN-2
CAS:
- 1383376-92-8
CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor p38a, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.
Formula:C₁₇H₁₂FN₃O₂
Purezza:99.31%
Colore e forma:Solid
Peso molecolare:309.29
Ref: TM-T79145
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BAY-846
CAS:
- 1836185-18-2
BAY-846: allosteric MEK inhibitor, long-lasting, highly bioavailable, low brain entry, effective in K-Ras A549 model.
Formula:C₁₉H₁₃F₄IN₄O₄S
Colore e forma:Solid
Peso molecolare:596.29
Ref: TM-T70133
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Spiclomazine HCl
CAS:
- 27007-85-8
Spiclomazine HCl induced apoptosis in pancreatic cancer cells, which was generally related to cell viability, migration, and invasion.
Formula:C₂₂H₂₅Cl₂N₃OS₂
Colore e forma:Solid
Peso molecolare:482.49
Ref: TM-T34695
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PF-04880594
CAS:
- 1111636-35-1
PF-04880594 is a potent and selective RAF inhibitor which inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 exhibits antitumor activity [1].
Formula:C₁₉H₁₆F₂N₈
Colore e forma:Solid
Peso molecolare:394.38
Ref: TM-T21602
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KRAS G12C inhibitor 48
KRAS G12C inhibitor 48: potent with IC50 639.91 nM; hampers H358, H23, A549 cell growth with IC50s of 0.796, 6.33, 16.14 µM, respectively.
Formula:C₃₆H₃₉ClN₈O₂
Colore e forma:Solid
Peso molecolare:651.2
Ref: TM-T72348
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KRAS G12C inhibitor 31
CAS:
- 2752352-86-4
KRAS G12C inhibitor 31 is an inhibitor of KRAS G12C that can be used to study cancer.
Formula:C₂₅H₂₂ClFN₆O₃
Colore e forma:Solid
Peso molecolare:508.93
Ref: TM-T63502
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Nek2-IN-6
CAS:
- 2410376-96-2
Nek2-IN-6 inhibitor .
Formula:C₃₃H₃₃F₃N₆O₄S
Colore e forma:Solid
Peso molecolare:666.71
Ref: TM-T73287
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L-167307
CAS:
- 188352-45-6
L-167307 is a p38 kinase inhibitor.
Formula:C₂₂H₁₇FN₂OS
Purezza:98%
Colore e forma:Solid
Peso molecolare:376.45
Ref: TM-T24368
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KRAS4b-IN-D14
CAS:
- 924249-06-9
KRAS4b-IN-D14 inhibits oncogenic KRAS4b, shrinks tumors, and induces cancer cell apoptosis.
Formula:C₂₄H₂₄ClN₅O₄
Colore e forma:Solid
Peso molecolare:481.93
Ref: TM-T71717
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HPK1-IN-15
CAS:
- 2201098-03-3
HPK1-IN-15 selectively inhibits HPK1, a MAP4K family kinase, potentially aiding in cancer treatment.
Formula:C₂₄H₂₁ClF₃N₅
Colore e forma:Solid
Peso molecolare:471.91
Ref: TM-T63046
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KRAS G12D inhibitor 13
CAS:
- 2648552-62-7
KRAS G12D inhibitor 13 targets KRAS G12D-mediated cancers with potency (WO2021108683A1, cmpd 142).
Formula:C₃₁H₃₃F₂N₇O₃
Colore e forma:Solid
Peso molecolare:589.64
Ref: TM-T64178
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KRAS G12C inhibitor 42
CAS:
- 2454488-02-7
KRAS G12C inhibitor 42 targets KRAS G12C for potential cancer therapy. (Patent WO2020146613A1, compound 10)
Formula:C₃₃H₃₄FN₇O₂
Colore e forma:Solid
Peso molecolare:579.67
Ref: TM-T64095
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p38-α MAPK-IN-4
CAS:
- 2396754-57-5
p38-α MAPK-IN-4 (Compound 69) is a selective inhibitor of p38α MAPK, demonstrating potent inhibition with an IC50 of 1.5 μM.
Formula:C₁₇H₁₃BrN₂O
Colore e forma:Solid
Peso molecolare:341.2
Ref: TM-T61091
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LCRF-0004
CAS:
- 1229611-73-7
LCRF-0004 inhibits RON kinase, key in KRAS-driven pancreatic cancer, reducing cell migration and enhancing chemo sensitivity.
Formula:C₂₈H₁₈F₄N₆O₂S
Colore e forma:Solid
Peso molecolare:578.54
Ref: TM-T71177
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KRAS G12C inhibitor 39
CAS:
- 2326522-16-9
KRAS G12C inhibitor 39 effectively targets KRAS G12C, a key protein in cancer research.
Formula:C₃₇H₄₃N₉O₂
Colore e forma:Solid
Peso molecolare:645.8
Ref: TM-T72342
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CBS-3595
CAS:
- 908380-97-2
CBS-3595: potent p38α MAPK/PDE-4 dual inhibitor, strong anti-inflammatory, low toxicity.
Formula:C₁₈H₁₇FN₄O₂S
Purezza:98%
Colore e forma:Solid
Peso molecolare:372.42
Ref: TM-T26964
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GP17
CAS:
- 1415050-57-5
GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.
Formula:C₂₆H₂₁F₃N₄O
Colore e forma:Solid
Peso molecolare:462.47
Ref: TM-T24098

MAPK

Trovati 894 prodotti di "MAPK"

(R)-STU104

Ref: TM-T60657

REDX05358

Ref: TM-T28510

KRAS inhibitor-3

Ref: TM-T72659

CK1-IN-2

Ref: TM-T79145

BAY-846

Ref: TM-T70133

Spiclomazine HCl

Ref: TM-T34695

PF-04880594

Ref: TM-T21602

KRAS G12C inhibitor 48

Ref: TM-T72348

KRAS G12C inhibitor 31

Ref: TM-T63502

Nek2-IN-6

Ref: TM-T73287

L-167307

Ref: TM-T24368

KRAS4b-IN-D14

Ref: TM-T71717

HPK1-IN-15

Ref: TM-T63046

KRAS G12D inhibitor 13

Ref: TM-T64178

KRAS G12C inhibitor 42

Ref: TM-T64095

p38-α MAPK-IN-4

Ref: TM-T61091

LCRF-0004

Ref: TM-T71177

KRAS G12C inhibitor 39

Ref: TM-T72342

CBS-3595

Ref: TM-T26964

GP17

Ref: TM-T24098