MAPK

Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.

Trovati 894 prodotti di "MAPK"

Purezza (%)

100

prodotti per pagina.

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SR-3306
CAS:
- 1128096-91-2
SR-3306 is a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor with IC50 values of 67 nM, 283 nM, 159 nM.Cost-effective and quality-assured.
Formula:C₂₈H₂₆N₈O
Purezza:99.38% - 99.71%
Colore e forma:Solid
Peso molecolare:490.56
Ref: TM-T16927
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JNK-1-IN-1
CAS:
- 1262406-02-9
JNK-1-IN-1 is an inhibitor specifically targeting JNK-1, also exhibiting inhibition of MKK7 with an IC50 value of 7.8μM.
Formula:C₂₄H₂₂N₆S
Colore e forma:Solid
Peso molecolare:426.54
Ref: TM-T73109
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GNE-1858
CAS:
- 2680616-96-8
GNE-1858 inhibits HPK1; IC50: 1.9 nM for wild-type, 1.9 nM (HPK1-TSEE), 4.5 nM (HPK1-SA).
Formula:C₂₁H₂₆F₂N₈
Purezza:99.36%
Colore e forma:Solid
Peso molecolare:428.48
Ref: TM-T11438
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ADTL-EI1712
CAS:
- 2414916-45-1
ADTL-EI1712: ERK1/2/5 inhibitor (ERK1 IC50=40.43nM, ERK5=64.5nM), blocks HL-60/MKN74 cell growth, not HeLa; effective in MKN74 mouse model.
Formula:C₂₂H₁₈Cl₂N₄O₂S₂
Colore e forma:Solid
Peso molecolare:505.44
Ref: TM-T38377
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Angiogenesis inhibitor BT2
CAS:
- 922029-50-3
BT2 inhibits angiogenesis, vascular permeability by targeting ERK, FosB, VCAM-1, and related genes, affecting MEK1 and suppressing retinal markers.
Formula:C₁₈H₁₈N₂O₄
Colore e forma:Solid
Peso molecolare:326.35
Ref: TM-T71722
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MEK-IN-4
CAS:
- 297744-42-4
MEK-IN-4 is a MEK inhibitor that can be used to study inflammatory diseases and cancer.
Formula:C₂₁H₁₈N₄OS
Purezza:98.35% - 99.16%
Colore e forma:Solid
Peso molecolare:374.46
Ref: TM-T28012
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JX 401
CAS:
- 349087-34-9
JX 401 is a p38α inhibitor.
Formula:C₂₁H₂₅NO₂S
Purezza:98%
Colore e forma:Solid
Peso molecolare:355.49
Ref: TM-T22885
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SB 204900
CAS:
- 173220-67-2
SB 204900 inhibit the release of histamine and TNF-α from RBL-2H3 cells.
Formula:C₁₈H₁₇NO₂
Colore e forma:Solid
Peso molecolare:279.33
Ref: TM-T28671
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HPK1-IN-29
CAS:
- 2699604-50-5
"HPK1-IN-29 suppresses HPK1, boosting anti-tumor immunity; potential for immune disease research."
Formula:C₂₆H₁₈F₃N₅O₂
Colore e forma:Solid
Peso molecolare:489.45
Ref: TM-T63270
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DDO3711
CAS:
- 2673364-10-6
"DDO3711, a PHORC, links an ASK1 inhibitor to a PP5 activator, inhibiting ASK1 (IC50=164.1 nM), dephosphorylating p-ASK1, and showing anti-cancer potential."
Formula:C₄₂H₄₁N₉O₆
Colore e forma:Solid
Peso molecolare:767.83
Ref: TM-T73460
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KRAS G12C inhibitor 29
CAS:
- 847337-63-7
KRAS G12C inhibitor 29 is an inhibitor of KRAS G12C and can be used to study cancer.
Formula:C₂₃H₂₁ClFN₅O₂
Colore e forma:Solid
Peso molecolare:453.9
Ref: TM-T62785
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8-CPT-2Me-cAMP, sodium salt
CAS:
- 634207-53-7
8-CPT-2Me-cAMP sodium activates Epac GEFS, targets Rap1/2, has 2.2 μM EC50 for Epac1, doesn't activate PKA, and prompts Ca2+ release in β-cells.
Formula:C₁₇H₁₆ClN₅NaO₆PS
Colore e forma:Solid
Peso molecolare:507.82
Ref: TM-T22014
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SCH-53870
CAS:
- 188480-50-4
SCH-53870 inhibits p21-hRas nucleotide exchange in vitro.
Formula:C₁₈H₁₈N₂O₄S
Colore e forma:Solid
Peso molecolare:358.41
Ref: TM-T28733
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KRAS inhibitor-16
CAS:
- 2230873-67-1
KRAS inhibitor-16 blocks KRAS G12C and p-ERK in cancer cells; potential for pancreatic, colorectal, lung cancer treatment. IC50: 0.457 μM.
Formula:C₂₀H₁₆Cl₂FN₃O₂S
Colore e forma:Solid
Peso molecolare:452.33
Ref: TM-T62752
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SOS1-IN-12
CAS:
- 2654741-56-5
SOS1-IN-12 is a potent inhibitor of SOS1, acting on SOS1 (Ki: 0.11 nM) and on pERK (IC50: 47 nM).
Formula:C₂₃H₂₆F₃N₅
Colore e forma:Solid
Peso molecolare:429.48
Ref: TM-T62371
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BMS-214662 hydrochloride
CAS:
- 195981-08-9
BMS-214662: a farnesyltransferase inhibitor, nonsedating benzodiazepine, blocks Ras-related tumorigenesis.
Formula:C₂₅H₂₄ClN₅O₂S₂
Colore e forma:Solid
Peso molecolare:526.07
Ref: TM-T68227
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MTBT
CAS:
- 1110905-26-4
MTBT is the proliferation of cancer cells inhibitor. It induces cell cycle arrest and activates p38 MAPK.
Formula:C₁₄H₁₁NO₂S₂
Colore e forma:Solid
Peso molecolare:289.37
Ref: TM-T24505
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ARS-2102
CAS:
- 2098509-21-6
ARS-2102 is a potent covalent KRAS G12C inhibitor for use in cancer research .
Formula:C₂₈H₃₁ClF₂N₆O₂
Colore e forma:Solid
Peso molecolare:557.03
Ref: TM-T73396
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ERK5-IN-4
CAS:
- 1888305-17-6
ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.
Formula:C₁₆H₁₁Cl₂FN₄O₂
Colore e forma:Solid
Peso molecolare:381.19
Ref: TM-T61628
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KRAS inhibitor-15
CAS:
- 2230873-75-1
KRAS inhibitor-15 blocks KRAS G12C and p-ERK in cancer cells; potent against pancreatic and lung cancers. IC50: 0.954 μM (KRAS), 2.03/>33.3 μM (p-ERK).
Formula:C₂₀H₁₇Cl₂FN₄OS
Colore e forma:Solid
Peso molecolare:451.34
Ref: TM-T62737

MAPK

Trovati 894 prodotti di "MAPK"

SR-3306

Ref: TM-T16927

JNK-1-IN-1

Ref: TM-T73109

GNE-1858

Ref: TM-T11438

ADTL-EI1712

Ref: TM-T38377

Angiogenesis inhibitor BT2

Ref: TM-T71722

MEK-IN-4

Ref: TM-T28012

JX 401

Ref: TM-T22885

SB 204900

Ref: TM-T28671

HPK1-IN-29

Ref: TM-T63270

DDO3711

Ref: TM-T73460

KRAS G12C inhibitor 29

Ref: TM-T62785

8-CPT-2Me-cAMP, sodium salt

Ref: TM-T22014

SCH-53870

Ref: TM-T28733

KRAS inhibitor-16

Ref: TM-T62752

SOS1-IN-12

Ref: TM-T62371

BMS-214662 hydrochloride

Ref: TM-T68227

MTBT

Ref: TM-T24505

ARS-2102

Ref: TM-T73396

ERK5-IN-4

Ref: TM-T61628

KRAS inhibitor-15

Ref: TM-T62737