MAPK
Le MAPK sono una famiglia di chinasi proteiche coinvolte in una varietà di processi cellulari, tra cui crescita, proliferazione, differenziazione e risposte allo stress. La via di segnalazione MAPK è composta da diversi livelli, tra cui ERK, JNK e p38 MAPK, ciascuno con ruoli distinti nella funzione cellulare. La disregolazione della segnalazione MAPK è collegata al cancro, alle malattie infiammatorie e ai disturbi metabolici. Presso CymitQuimica, offriamo una vasta gamma di inibitori e attivatori delle MAPK per supportare la tua ricerca in biologia cellulare, trasduzione del segnale e meccanismi delle malattie.
Trovati 893 prodotti per "MAPK". Vengono mostrati i primi 500.
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p38 MAP Kinase Inhibitor IV
CAS:p38 MAPK inhibitor IV blocks p38α/β/γ/δ with IC50s 0.13-8.63 μM and stops TNF-α/IL-1β at 22/44 nM in human cells.Formula:C12H4Cl6O4SColore e forma:SolidPeso molecolare:456.94ARS-2102
CAS:ARS-2102 is a potent covalent KRAS G12C inhibitor for use in cancer research .Formula:C28H31ClF2N6O2Colore e forma:SolidPeso molecolare:557.03ERK5-IN-4
CAS:ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.Formula:C16H11Cl2FN4O2Colore e forma:SolidPeso molecolare:381.19KRAS inhibitor-15
CAS:KRAS inhibitor-15 blocks KRAS G12C and p-ERK in cancer cells; potent against pancreatic and lung cancers. IC50: 0.954 μM (KRAS), 2.03/>33.3 μM (p-ERK).Formula:C20H17Cl2FN4OSColore e forma:SolidPeso molecolare:451.34KRAS inhibitor-10
CAS:KRAS inhibitor-10: potent, selective KRAS protein blocker; effective in various cancers; oral; tetrahydroisoquinoline class.Formula:C30H37N3O5Colore e forma:SolidPeso molecolare:519.63ERK5-IN-3
CAS:ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).Formula:C24H23Cl2FN4O2Colore e forma:SolidPeso molecolare:489.37SR-3737
CAS:SR-3737 is potent both JNK3 and p38 inhibitor.Formula:C29H25FN4O4Purezza:98%Colore e forma:SolidPeso molecolare:512.53KRAS G12C inhibitor 45
CAS:KRAS G12C inhibitor 45 is a potent KRAS G12C inhibitor .Formula:C32H33F2N5O5SColore e forma:SolidPeso molecolare:637.7JNK3 inhibitor-4
CAS:JNK3 inhibitor-4: potent, selective JNK3 blocker (IC50=1.0nM), neuroprotective, BBB-permeable.Formula:C28H27N7OColore e forma:SolidPeso molecolare:477.56HPK1-IN-17
CAS:HPK1-IN-17 selectively inhibits HPK1, a MAP4Ks family kinase from blood progenitor cells; useful against HPK1-related diseases like cancer.Formula:C26H28N6OColore e forma:SolidPeso molecolare:440.54(R)-CE3F4
CAS:(R)-CE3F4 is a selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1)(IC50 of 4.2 μM),Formula:C11H10Br2FNOColore e forma:SolidPeso molecolare:351.01PHT-7.3
CAS:PHT-7.3 is a selective connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain inhibitorFormula:C24H23N3O3SPurezza:98%Colore e forma:SolidPeso molecolare:433.52KRAS inhibitor-17
CAS:KRAS inhibitor-17 blocks G12C mutation (IC50: 3.37μM) and p-ERK in MIA PaCA-2 (IC50: 9.25μM). Could target pancreatic, colorectal, lung cancers.Formula:C21H18Cl2FN3O2SColore e forma:SolidPeso molecolare:466.36BRAF V600E/CRAF-IN-2
CAS:Potent BRAFV600E/CRAF inhibitor, IC50: 0.888/0.229 μM, induces G0/G1 arrest and apoptosis in HCT-116 cells, potential for cancer research.Formula:C30H30F3N5O2Colore e forma:SolidPeso molecolare:549.59JNK-1-IN-1
CAS:JNK-1-IN-1 is an inhibitor specifically targeting JNK-1, also exhibiting inhibition of MKK7 with an IC50 value of 7.8μM.Formula:C24H22N6SColore e forma:SolidPeso molecolare:426.54BAY-846
CAS:BAY-846: allosteric MEK inhibitor, long-lasting, highly bioavailable, low brain entry, effective in K-Ras A549 model.Formula:C19H13F4IN4O4SColore e forma:SolidPeso molecolare:596.29CK1-IN-2
CAS:CK1-IN-2 (compound Nr.4) is a potent CK1 inhibitor p38a, and is used in DUX4 overexpression-associated diseases, such as muscular dystrophy.Formula:C17H12FN3O2Purezza:99.31%Colore e forma:SolidPeso molecolare:309.296-T-GDP
CAS:6-T-GDP (6-Thioguanosine 5'-diphosphate) is a metabolite of thiopurine. It inhibits the activity of Rac1, thereby reducing the transcription of inflammatory factors and the expression of cell adhesion molecules, which ultimately suppresses leukocyte migration and the occurrence of tissue inflammation.Formula:C10H15N5O10P2SColore e forma:SolidPeso molecolare:459.27B-Raf IN 7
CAS:"B-Raf IN 7 inhibits B-Raf (IC50: 110.23 nM); fights colon, breast, liver, cervical, prostate cancers (IC50: 7.50-12.83 μM)."Formula:C15H16N6O3Colore e forma:SolidPeso molecolare:328.33BRAF inhibitor
CAS:BRAF inhibitor is an inhibitor of B-Raf.Formula:C22H18F2N4O3SPurezza:98.2% - 98.41%Colore e forma:SolidPeso molecolare:456.47Ref: TM-T10599
1mg44,00€5mg87,00€1mL*10mM (DMSO)99,00€10mg137,00€25mg236,00€50mg371,00€100mg530,00€200mg770,00€
