MEK
MEK è una chinasi a doppia specificità che svolge un ruolo centrale nella via di segnalazione MAPK/ERK attivando ERK attraverso la fosforilazione. La segnalazione MEK è cruciale per la regolazione della crescita, sopravvivenza e differenziazione cellulare. Un'attività anomala di MEK è stata implicata in vari tipi di cancro e disturbi dello sviluppo, rendendola un importante bersaglio terapeutico. Presso CymitQuimica, offriamo una varietà di inibitori e modulatori di MEK per supportare la tua ricerca in oncologia, segnalazione cellulare e sviluppo terapeutico.
Trovati 75 prodotti di "MEK"
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Lidocaine
CAS:Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.Formula:C14H22N2OPurezza:99.95% - >99.99%Colore e forma:Needles From Benzene Or Alcohol SolidPeso molecolare:234.34Lidocaine Hydrochloride hydrate
CAS:Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Formula:C14H22N2O·HCl·H2OPurezza:99.95%Colore e forma:SolidPeso molecolare:288.82Lidocaine hydrochloride
CAS:<p>Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.</p>Formula:C14H23ClN2OPurezza:99.81% - 99.92%Colore e forma:White Crystal PowderPeso molecolare:270.798FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Colore e forma:LiquidMEK/PI3K-IN-2
CAS:MEK/PI3K-IN-2 is a potent dual inhibitor (MEK1 IC50: 352 nM, PI3Kα: 107 nM, PI3Kδ: 137 nM) that reduces pAKT, pERK1/2, and hinders tumor cell growth.Formula:C38H41F5IN9O7Colore e forma:SolidPeso molecolare:957.68NST-628
CAS:NST-628 is a pan-RAF-MEK molecular glue that prevents RAF from phosphorylating and activating MEK. NST-628 inhibits the RAF-MEK signaling complex.Formula:C22H18F2N4O5SPurezza:98.62%Colore e forma:SolidPeso molecolare:488.46U0124
CAS:Inactive analog of U0126(MEK-1/2 inhibitor), used as a negative controlFormula:C8H10N4S2Purezza:98%Colore e forma:SolidPeso molecolare:226.32Debromohymenialdisine
CAS:Debromohymenialdisine is a natural product for research related to life sciences. The catalog number is T35596 and the CAS number is 75593-17-8.Formula:C11H11N5O2Colore e forma:SolidPeso molecolare:245.242Cobimetinib (R-enantiomer)
CAS:Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.Formula:C21H21F3IN3O2Purezza:98%Colore e forma:SolidPeso molecolare:531.318MEK1/2-IN-3
MEK1/2-IN-3 (Compound M15) is an inhibitor of MEK1, with an IC50 value of 10.29 nM. It effectively suppresses tumor cell proliferation and migration, induces apoptosis, and exhibits good liver microsomal stability. MEK1/2-IN-3 is applicable in the study of solid tumors.Formula:C28H23F3IN3O4Colore e forma:SolidPeso molecolare:649.4BAY-6035
CAS:BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more than 100-fold selectivity over other histone methyltransferases.Formula:C22H28N4O3Purezza:99.97%Colore e forma:SolidPeso molecolare:396.48MEK/PI3K-IN-1
CAS:MEK/PI3K-IN-1 (6r) is a dual MEK/PI3K inhibitor; IC50: 124 nM (MEK1), 130 nM (PI3Kα), 236 nM (PI3Kδ). It reduces pAKT, pERK1/2, and hinders tumor growth.Formula:C36H37F5IN9O6Colore e forma:SolidPeso molecolare:913.63MAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Colore e forma:Odour SolidRef: TM-L1400
1mgPrezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaMEK4 inhibitor-1
CAS:MEK4 inhibitor-1 targets MEK4 enzyme in pancreatic cancer, IC50=61 nM.Formula:C13H10FN3O2SColore e forma:SolidPeso molecolare:291.3DS03090629
DS03090629, an orally active MEK inhibitor, functions by competitively inhibiting MEK activity in the presence of ATP. This compound demonstrates strong binding affinity to both MEK and phosphorylated MEK, with dissociation constants (Kd) of 0.11 and 0.15 nM, respectively. It has shown efficacy in suppressing the proliferation of melanoma cell lines that overexpress BRAF mutations, achieving IC50 values of 74.3 and 97.8 nM for BRAF V600E and MEK1 F53L transfected A375 cells, respectively. DS03090629 is thus considered promising for anti-melanoma therapies.Formula:C25H26ClN5O2Colore e forma:SolidPeso molecolare:463.96PD 198306
CAS:PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.Formula:C18H16F3IN2O2Purezza:99.66%Colore e forma:SolidPeso molecolare:476.23Ref: TM-T21980
1mg64,00€5mg138,00€10mg188,00€25mg330,00€50mg472,00€100mg655,00€500mg1.293,00€1mL*10mM (DMSO)160,00€Midkine Protein, Mouse, Recombinant (His)
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed asPurezza:> 95% as determined by Bis-Tris PAGE > 95% as determined by HPLC - > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLCColore e forma:Lyophilized PowderPeso molecolare:14.03 kDa (predicted). The protein migrates to 17-20 kDa based on Tris-Bis PAGE result.Anti-Midkine Antibody (5T766)
Anti-Midkine Antibody (5T766) is an antibody targeting Midkine. Anti-Midkine Antibody (5T766) can be used in ELISA, IHC.Colore e forma:Odour LiquidMidkine Protein, Human, Recombinant (His & Avi)
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed asColore e forma:Lyophilized PowderPeso molecolare:16.46 kDa (predicted) same as Tris-Bis PAGE result.Midkine Protein, Human, Recombinant (His & Avi), Biotinylated
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed asColore e forma:Lyophilized PowderPeso molecolare:16.46 kDa (predicted) same as Tris-Bis PAGE result.Ref: TM-TMPK-00024
5µg97,00€10µg157,00€20µg252,00€50µg497,00€100µg823,00€200µg1.488,00€500µg3.185,00€Trametinib
CAS:Trametinib (GSK1120212), an ATP-noncompetitive MEK 1/2 inhibitor (IC50: 0.7/0.9 nM), weakly inhibits >180 kinases.Formula:C26H23FIN5O4Purezza:98% - 99.96%Colore e forma:SolidPeso molecolare:615.39zapnometinib
CAS:Zapnometinib (ATR-002) is a MEK inhibitor.Formula:C13H7ClF2INO2Purezza:99.67%Colore e forma:SolidPeso molecolare:409.55Ro 5126766
CAS:RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.Formula:C21H18FN5O5SPurezza:98.3% - 98.81%Colore e forma:SolidPeso molecolare:471.46Ref: TM-T6971
1mg57,00€2mg82,00€5mg115,00€10mg172,00€25mg329,00€50mg527,00€100mg758,00€1mL*10mM (DMSO)118,00€anemarsaponin B
CAS:Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activityFormula:C45H74O18Purezza:99.06% - 99.11%Colore e forma:SolidPeso molecolare:903.06BIX02189
CAS:BIX 02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).Formula:C27H28N4O2Purezza:97.84%Colore e forma:SolidPeso molecolare:440.54Ref: TM-T21295
2mg34,00€5mg50,00€10mg74,00€25mg126,00€50mg210,00€100mg313,00€200mg452,00€1mL*10mM (DMSO)58,00€PD98059
CAS:PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.Formula:C16H13NO3Purezza:98.63% - >99.99%Colore e forma:Yellow SolidPeso molecolare:267.28Ref: TM-T2623
5mg40,00€10mg52,00€25mg82,00€50mg106,00€100mg177,00€200mg264,00€500mg444,00€1mL*10mM (DMSO)58,00€Pimasertib
CAS:Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.Formula:C15H15FIN3O3Purezza:98.25% - 99.57%Colore e forma:SolidPeso molecolare:431.2Ref: TM-T6131
2mg37,00€5mg49,00€10mg62,00€25mg92,00€50mg147,00€100mg220,00€200mg285,00€1mL*10mM (DMSO)55,00€Refametinib
CAS:Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).Formula:C19H20F3IN2O5SPurezza:99.85% - >99.99%Colore e forma:SolidPeso molecolare:572.34Ref: TM-T6636
2mg46,00€5mg66,00€10mg87,00€25mg156,00€50mg235,00€100mg344,00€200mg512,00€1mL*10mM (DMSO)84,00€RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formula:C29H35N7O4Purezza:98% - 99.91%Colore e forma:SolidPeso molecolare:545.63Selumetinib
CAS:Selumetinib (AZD6244) is a selectivity and non-ATP-competitive MEK1/2 inhibitor. Selumetinib has antitumor activity. Cost-effective and quality-assured.Formula:C17H15BrClFN4O3Purezza:98.1% - 99.90%Colore e forma:White Or Pale White SolidPeso molecolare:457.68TAK-733
CAS:TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.Formula:C17H15F2IN4O4Purezza:98.31% - 99.53%Colore e forma:SolidPeso molecolare:504.23APS-2-79
CAS:APS-2-79: KSR-dependent MEK inhibitor, blocks ATP biotin at KSR2, IC50 of 120 nM, disrupts Ras-MAPK signaling.Formula:C23H21N3O3Colore e forma:SolidPeso molecolare:387.43Trametinib (DMSO solvate)
CAS:Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 :2 nM)Formula:C28H29FIN5O5SPurezza:99.71% - 99.92%Colore e forma:SolidPeso molecolare:693.53Binimetinib
CAS:Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity. Cost-effective and quality-assured.Formula:C17H15BrF2N4O3Purezza:98.03% - >99.99%Colore e forma:SolidPeso molecolare:441.23GW 284543 hydrochloride
CAS:GW 284543 hydrochloride is a selective inhibitor of MEK5 .Formula:C23H21ClN2O3Purezza:99.73%Colore e forma:SolidPeso molecolare:408.87Mirdametinib
CAS:Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity.Formula:C16H14F3IN2O4Purezza:99.11% - 99.63%Colore e forma:White PowderPeso molecolare:482.19Ref: TM-T6189
1g898,00€5mg51,00€10mg74,00€25mg127,00€50mg175,00€100mg273,00€200mg406,00€500mg662,00€1mL*10mM (DMSO)55,00€GDC-0623
CAS:GDC-0623 (RG 7421) is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.Formula:C16H14FIN4O3Purezza:98.95% - 99.02%Colore e forma:SolidPeso molecolare:456.21Ref: TM-T6843
1mg52,00€2mg73,00€5mg119,00€10mg187,00€25mg280,00€50mg369,00€100mg612,00€1mL*10mM (DMSO)119,00€AZD8330
CAS:AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.Formula:C16H17FIN3O4Purezza:98.72%Colore e forma:SolidPeso molecolare:461.23Aurothiomalate sodium
CAS:<p>Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.</p>Formula:C4H3AuNa2O4SPurezza:99.66%Colore e forma:SoildPeso molecolare:390.07Pimasertib HCl
CAS:Pimasertib HCl, an oral MEK1/2 inhibitor, may thwart tumor growth by blocking RAS/RAF/MEK/ERK signaling.Formula:C15H16ClFIN3O3Colore e forma:SolidPeso molecolare:467.66SL327
CAS:SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.Formula:C16H12F3N3SPurezza:97.98% - >99.99%Colore e forma:SolidPeso molecolare:335.35PD184161
CAS:PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].Formula:C17H13BrClF2IN2O2Purezza:99.40%Colore e forma:SolidPeso molecolare:557.56Ref: TM-T21635
1mg38,00€2mg52,00€5mg79,00€10mg126,00€25mg273,00€50mg454,00€100mg653,00€200mg938,00€500mg1.406,00€BI-847325
CAS:BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.Formula:C29H28N4O2Purezza:97.13% - 97.54%Colore e forma:SolidPeso molecolare:464.56U0126-EtOH
CAS:U0126-etoh (U0126 Ethanol) is a non-ATP competitive inhibitor of MEK1 (IC50=72 nM) and MEK2 (IC50=58 nM) with selectivity, inhibit autophagy. Low-Cost!Formula:C18H16N6S2·C2H6OPurezza:99.72% - 99.88%Colore e forma:SolidPeso molecolare:426.6trans-Zeatin
CAS:trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrientFormula:C10H13N5OPurezza:97.13% - 98.96%Colore e forma:White To Light Yellow Crystal PowderPeso molecolare:219.24Ref: TM-TMS2181
10mg39,00€25mg55,00€50mg70,00€100mg92,00€200mg135,00€500mg216,00€1mL*10mM (DMSO)34,00€Cobimetinib
CAS:Cobimetinib (GDC-0973) is a MEK1 inhibitor with selective and oral activity. Cobimetinib exhibits antitumor activity. Cost-effective and quality-assured.Formula:C21H21F3IN3O2Purezza:98% - 99.61%Colore e forma:SolidPeso molecolare:531.31Ref: TM-T3623
1mg40,00€2mg51,00€5mg85,00€10mg96,00€25mg173,00€50mg276,00€100mg454,00€500mgPrezzo su richiesta1mL*10mM (DMSO)88,00€U0126
CAS:U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively.Formula:C18H16N6S2Purezza:99.61%Colore e forma:White SolidPeso molecolare:380.49APS-2-79 hydrochloride
CAS:APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization.Formula:C23H21N3O3·HClPurezza:98.64% - 99.55%Colore e forma:SolidPeso molecolare:423.89Ref: TM-T6760
1mg44,00€2mg55,00€5mg71,00€10mg106,00€25mg250,00€50mg401,00€100mg563,00€500mg1.225,00€1mL*10mM (DMSO)71,00€Isorhamnetin
CAS:<p>Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin.</p>Formula:C16H12O7Purezza:99.20% - >99.99%Colore e forma:SolidPeso molecolare:316.26PD318088
CAS:PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-Formula:C16H13BrF3IN2O4Purezza:99.81%Colore e forma:SolidPeso molecolare:561.09CI-1040
CAS:CI-1040 (PD 184352) (PD184352) is an ATP non-competitive MEK1/2 inhibitor (IC50: 17 nM).Formula:C17H14ClF2IN2O2Purezza:99.64%Colore e forma:Off-White To Pale Beige SolidPeso molecolare:478.66RO4987655
CAS:RO4987655 (RG7167) is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for MEK1/MEK2).Formula:C20H19F3IN3O5Purezza:98.21%Colore e forma:SolidPeso molecolare:565.28GW284543
CAS:GW284543 (UNC10225170) is a selective inhibitor of MEK5 .Formula:C23H20N2O3Purezza:99.75%Colore e forma:SolidPeso molecolare:372.42Trametiglue
CAS:Trametiglue, a potent Trametinib derivative, selectively targets KSR-MEK and RAF-MEK through unique binding.Formula:C25H24FIN6O5SColore e forma:SolidPeso molecolare:666.46PD 334581
CAS:MEK1 inhibitorFormula:C20H19F3IN5O2Purezza:98%Colore e forma:SolidPeso molecolare:545.3JTP-70902
CAS:JTP-70902 is a protein kinase inhibitor with antineoplastic activity.Formula:C24H21BrFN5O5SColore e forma:SolidPeso molecolare:590.42(R)-PD 0325901CL
CAS:(R)-PD 0325901CL, a PD 0325901CL isomer, is a MEK inhibitor used in cancer research, effective against cancer cells in vitro and in vivo.Formula:C16H14ClF2IN2O4Colore e forma:SolidPeso molecolare:498.65MEK-IN-1
CAS:MEK-IN-1 is a MEK inhibitor.Formula:C24H20N4O4Purezza:98%Colore e forma:SolidPeso molecolare:428.44MEK inhibitor
CAS:MEK inhibitor is a MEK receptor and cell cycle protein/CDK complex inhibitor with antitumor activity that can be used to study tumor cell proliferation.Formula:C26H26N4O2Purezza:97.48%Colore e forma:SolidPeso molecolare:426.51MEK-IN-4
CAS:MEK-IN-4 is a MEK inhibitor that can be used to study inflammatory diseases and cancer.Formula:C21H18N4OSPurezza:98.35% - 99.16%Colore e forma:SolidPeso molecolare:374.46(2Z,3Z)-U0126
CAS:U0126 selectively inhibits MEK1/2, blocks MAPK/ERK signaling, and suppresses Ki-ras-induced cell growth, with IC50s of 72 nM and 58 nM for MEK1/2.Formula:C18H16N6S2Colore e forma:SolidPeso molecolare:380.49Avutometinib potassium
CAS:Avutometinib potassium, a MEKi, blocks Delta and Omicron infection in airway cells, potentially lessening disease severity.Formula:C21H17FKN5O5SColore e forma:SolidPeso molecolare:509.55BAY-846
CAS:BAY-846: allosteric MEK inhibitor, long-lasting, highly bioavailable, low brain entry, effective in K-Ras A549 model.Formula:C19H13F4IN4O4SColore e forma:SolidPeso molecolare:596.29MS934
CAS:<p>MS934, a novel VHL-recruiting MEK 1/2 degrader, exhibits potent anti-proliferative effects on HT-29 cell growth, achieving a GI50 of 0.023 μM.</p>Formula:C52H69F3IN7O6SPurezza:98%Colore e forma:SolidPeso molecolare:1104.11RO4927350
CAS:RO4927350 is a potent, selective MEK1/2 inhibitor, blocking MAPK pathway in vitro/vivo and showing notable antitumor effects.Formula:C27H28N4O6SColore e forma:SolidPeso molecolare:536.6MEK-IN-6 hydrate
CAS:MEK-IN-6 hydrate (compound 69), a MEK inhibitor, exhibits an IC50 value of 2 nM in A375 cells [1].Formula:C18H22FN3O5SPurezza:98%Colore e forma:SolidPeso molecolare:411.45GSK1790627
CAS:GSK1790627, the N-deacetylated metabolite of Trametinib, represents an orally active MEK inhibitor that promotes autophagy and triggers apoptosis [1].Formula:C24H21FIN5O3Colore e forma:SolidPeso molecolare:573.36Cobimetinib racemate
CAS:Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activatedFormula:C21H21F3IN3O2Purezza:98.00% - 99.71%Colore e forma:SolidPeso molecolare:531.31Nedometinib
CAS:<p>Nedometinib (NFX-179) is a MEK1 inhibitor with anticancer and antitumor activities, which can be used to study malignant tumors.</p>Formula:C17H16FIN4O3Purezza:99.18%Colore e forma:SolidPeso molecolare:470.24MEK1/2-IN-2
MEK1/2-IN-2 is a potent, ATP-competitive MEK1/2 inhibitor that exhibits equal inhibitory effects on wild-type MEK1/2 and a group of MEK1/2 mutant cells.Formula:C28H22ClFN6OColore e forma:SolidPeso molecolare:512.97EBI-1051
CAS:EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).Formula:C18H15F2IN2O5Purezza:98%Colore e forma:SolidPeso molecolare:504.22Luvometinib
CAS:Luvometinib is an inhibitor of the mitogen-activated protein kinase (MEK) with antitumor activity.Formula:C26H22F2IN5O4SColore e forma:SolidPeso molecolare:665.45MEK4 inhibitor-2
CAS:MEK4 Inhibitor-2, a novel MEK4 inhibitor, demonstrates efficacy against pancreatic adenocarcinoma, exhibiting an IC50 value of 83 nM.Formula:C20H15FN4O3SColore e forma:SolidPeso molecolare:410.42Refametinib R enantiomer
CAS:<p>Refametinib R enantiomer (RDEA119 R enantiomer) is an MEK inhibitor with an EC50 of 2.0-15 nM.Refametinib (R enantiomer) has anticancer activity and can be used</p>Formula:C19H20F3IN2O5SPurezza:99.86%Colore e forma:SolidPeso molecolare:572.34G-479
CAS:G-479, a potent MEK inhibitor and improved analogue of GDC-0623, has distributed polarity enhancing bioactivity.Formula:C16H15FIN5O4Colore e forma:SolidPeso molecolare:487.22
