MEK
MEK è una chinasi a doppia specificità che svolge un ruolo centrale nella via di segnalazione MAPK/ERK attivando ERK attraverso la fosforilazione. La segnalazione MEK è cruciale per la regolazione della crescita, sopravvivenza e differenziazione cellulare. Un'attività anomala di MEK è stata implicata in vari tipi di cancro e disturbi dello sviluppo, rendendola un importante bersaglio terapeutico. Presso CymitQuimica, offriamo una varietà di inibitori e modulatori di MEK per supportare la tua ricerca in oncologia, segnalazione cellulare e sviluppo terapeutico.
Trovati 74 prodotti per "MEK".
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Lidocaine Hydrochloride hydrate
CAS:Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Formula:C14H22N2O·HCl·H2OPurezza:99.95%Colore e forma:SolidPeso molecolare:288.82Lidocaine hydrochloride
CAS:Lidocaine HCl: local anesthetic, antiarrhythmic, stronger & longer-lasting than procaine but shorter than bupivacaine/prilocaine.Formula:C14H23ClN2OPurezza:99.83% - 99.92%Colore e forma:SolidPeso molecolare:270.798Lidocaine
CAS:Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.Formula:C14H22N2OPurezza:99.88% - >99.99%Colore e forma:White SolidPeso molecolare:234.34PD 198306
CAS:PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.Formula:C18H16F3IN2O2Purezza:99.66%Colore e forma:SolidPeso molecolare:476.23Ref: TM-T21980
1mg60,00€5mg131,00€1mL*10mM (DMSO)152,00€10mg178,00€25mg314,00€50mg447,00€100mg622,00€500mg1.224,00€MAPK Inhibitor Library
A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;Colore e forma:Odour SolidRef: TM-L1400
1mgPrezzo su richiesta10μL*10mM (DMSO)Prezzo su richiesta20μL*10mM (DMSO)Prezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaCobimetinib (R-enantiomer)
CAS:Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.Formula:C21H21F3IN3O2Purezza:98%Colore e forma:SolidPeso molecolare:531.318MEK1/2-IN-3
MEK1/2-IN-3 (Compound M15) is an inhibitor of MEK1, with an IC50 value of 10.29 nM. It effectively suppresses tumor cell proliferation and migration, induces apoptosis, and exhibits good liver microsomal stability. MEK1/2-IN-3 is applicable in the study of solid tumors.Formula:C28H23F3IN3O4Colore e forma:SolidPeso molecolare:649.4NST-628
CAS:NST-628 is a pan-RAF-MEK molecular glue that prevents RAF from phosphorylating and activating MEK. NST-628 inhibits the RAF-MEK signaling complex.Formula:C22H18F2N4O5SPurezza:98.62% - 98.86%Colore e forma:White SolidPeso molecolare:488.46DS03090629
DS03090629, an orally active MEK inhibitor, functions by competitively inhibiting MEK activity in the presence of ATP. This compound demonstrates strong binding affinity to both MEK and phosphorylated MEK, with dissociation constants (Kd) of 0.11 and 0.15 nM, respectively. It has shown efficacy in suppressing the proliferation of melanoma cell lines that overexpress BRAF mutations, achieving IC50 values of 74.3 and 97.8 nM for BRAF V600E and MEK1 F53L transfected A375 cells, respectively. DS03090629 is thus considered promising for anti-melanoma therapies.Formula:C25H26ClN5O2Colore e forma:SolidPeso molecolare:463.96MS432
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.Formula:C50H65F3IN7O6SPurezza:98%Colore e forma:SolidPeso molecolare:1076.06U0124
CAS:Inactive analog of U0126(MEK-1/2 inhibitor), used as a negative controlFormula:C8H10N4S2Purezza:98%Colore e forma:SolidPeso molecolare:226.32MEK4 inhibitor-1
CAS:MEK4 inhibitor-1 targets MEK4 enzyme in pancreatic cancer, IC50=61 nM.Formula:C13H10FN3O2SColore e forma:SolidPeso molecolare:291.3FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.Colore e forma:LiquidRef: TM-L1610
1mgPrezzo su richiesta10μL*10mM (DMSO)Prezzo su richiesta20μL*10mM (DMSO)Prezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaMidkine Protein, Human, Recombinant (His & Avi), Biotinylated
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed asColore e forma:Lyophilized PowderPeso molecolare:16.46 kDa (predicted) same as Tris-Bis PAGE result.Ref: TM-TMPK-00024
5µg94,00€10µg138,00€20µg220,00€50µg434,00€100µg732,00€200µg1.324,00€500µg2.925,00€Anti-Midkine Antibody (5T766)
Anti-Midkine Antibody (5T766) is an antibody targeting Midkine. Anti-Midkine Antibody (5T766) can be used in ELISA, IHC.Colore e forma:Odour LiquidMidkine Protein, Mouse, Recombinant (His)
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed asPurezza:> 95% as determined by Bis-Tris PAGE - > 95% as determined by Bis-Tris PAGE > 95% as determined by HPLCColore e forma:Transparent SolutionPeso molecolare:14.03 kDa (predicted). The protein migrates to 17-20 kDa based on Tris-Bis PAGE result.Midkine Protein, Human, Recombinant (His & Avi)
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed asPurezza:> 95% as determined by Bis-Tris PAGE - > 95% as determined by Bis-Tris PAGEColore e forma:White Lyophilized PowderPeso molecolare:16.46 kDa (predicted) same as Tris-Bis PAGE result.Trametinib
CAS:Trametinib (GSK1120212), an ATP-noncompetitive MEK 1/2 inhibitor (IC50: 0.7/0.9 nM), weakly inhibits >180 kinases.Formula:C26H23FIN5O4Purezza:98% - 99.96%Colore e forma:SolidPeso molecolare:615.39CI-1040
CAS:CI-1040 (PD 184352) (PD184352) is an ATP non-competitive MEK1/2 inhibitor (IC50: 17 nM).Formula:C17H14ClF2IN2O2Purezza:99.64%Colore e forma:Off-White To Pale Beige SolidPeso molecolare:478.66zapnometinib
CAS:Zapnometinib (ATR-002) is a MEK inhibitor.Formula:C13H7ClF2INO2Purezza:99.67%Colore e forma:SolidPeso molecolare:409.55Ro 5126766
CAS:RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.Formula:C21H18FN5O5SPurezza:98.3% - 98.81%Colore e forma:White SolidPeso molecolare:471.46Ref: TM-T6971
1mg54,00€2mg78,00€5mg109,00€1mL*10mM (DMSO)112,00€10mg169,00€25mg311,00€50mg500,00€100mg718,00€anemarsaponin B
CAS:Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activityFormula:C45H74O18Purezza:99.06% - 99.11%Colore e forma:SolidPeso molecolare:903.06BIX02189
CAS:BIX 02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).Formula:C27H28N4O2Purezza:97.84%Colore e forma:SolidPeso molecolare:440.54Ref: TM-T21295
2mg33,00€5mg52,00€1mL*10mM (DMSO)55,00€10mg71,00€25mg119,00€50mg198,00€100mg296,00€200mg427,00€PD98059
CAS:PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.Formula:C16H13NO3Purezza:98.63% - >99.99%Colore e forma:Green SolidPeso molecolare:267.28Ref: TM-T2623
5mg38,00€10mg50,00€1mL*10mM (DMSO)55,00€25mg78,00€50mg101,00€100mg168,00€200mg250,00€500mg421,00€Pimasertib
CAS:Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.Formula:C15H15FIN3O3Purezza:98.25% - 99.57%Colore e forma:SolidPeso molecolare:431.2Ref: TM-T6131
2mg34,00€5mg50,00€1mL*10mM (DMSO)52,00€10mg58,00€25mg96,00€50mg140,00€100mg207,00€200mg270,00€Refametinib
CAS:Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).Formula:C19H20F3IN2O5SPurezza:99.85% - >99.99%Colore e forma:SolidPeso molecolare:572.34Ref: TM-T6636
2mg43,00€5mg63,00€1mL*10mM (DMSO)79,00€10mg93,00€25mg147,00€50mg222,00€100mg326,00€200mg485,00€RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formula:C29H35N7O4Purezza:98% - 99.91%Colore e forma:SolidPeso molecolare:545.63Selumetinib
CAS:Selumetinib (AZD6244) is a selectivity and non-ATP-competitive MEK1/2 inhibitor. Selumetinib has antitumor activity. Cost-effective and quality-assured.Formula:C17H15BrClFN4O3Purezza:98.1% - 99.90%Colore e forma:White SolidPeso molecolare:457.68TAK-733
CAS:TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.Formula:C17H15F2IN4O4Purezza:98.31% - 99.2%Colore e forma:SolidPeso molecolare:504.23APS-2-79
CAS:APS-2-79: KSR-dependent MEK inhibitor, blocks ATP biotin at KSR2, IC50 of 120 nM, disrupts Ras-MAPK signaling.Formula:C23H21N3O3Colore e forma:SolidPeso molecolare:387.43Trametinib (DMSO solvate)
CAS:Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 :2 nM)Formula:C28H29FIN5O5SPurezza:99.71% - 99.92%Colore e forma:SolidPeso molecolare:693.53Binimetinib
CAS:Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity. Cost-effective and quality-assured.Formula:C17H15BrF2N4O3Purezza:98.03% - >99.99%Colore e forma:SolidPeso molecolare:441.23GW 284543 hydrochloride
CAS:GW 284543 hydrochloride is a selective inhibitor of MEK5 .Formula:C23H21ClN2O3Purezza:99.73%Colore e forma:SolidPeso molecolare:408.87Mirdametinib
CAS:Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity.Formula:C16H14F3IN2O4Purezza:99.11% - 99.63%Colore e forma:White SolidPeso molecolare:482.19Ref: TM-T6189
5mg49,00€1mL*10mM (DMSO)52,00€10mg71,00€25mg120,00€50mg172,00€100mg259,00€200mg385,00€500mg627,00€1g850,00€GDC-0623
CAS:GDC-0623 (RG 7421) is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.Formula:C16H14FIN4O3Purezza:98.95% - 99.02%Colore e forma:SolidPeso molecolare:456.21Ref: TM-T6843
1mg50,00€2mg70,00€5mg113,00€1mL*10mM (DMSO)113,00€10mg177,00€25mg265,00€50mg349,00€100mg580,00€AZD8330
CAS:AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.Formula:C16H17FIN3O4Purezza:98.72% - 99.91%Colore e forma:SolidPeso molecolare:461.23Aurothiomalate sodium
CAS:Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.Formula:C4H3AuNa2O4SPurezza:99.19%Colore e forma:SolidPeso molecolare:390.07Ref: TM-T20168
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiesta200mgPrezzo su richiestaPimasertib HCl
CAS:Pimasertib HCl, an oral MEK1/2 inhibitor, may thwart tumor growth by blocking RAS/RAF/MEK/ERK signaling.Formula:C15H16ClFIN3O3Colore e forma:SolidPeso molecolare:467.66SL327
CAS:SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.Formula:C16H12F3N3SPurezza:97.98% - >99.99%Colore e forma:SolidPeso molecolare:335.35PD184161
CAS:PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].Formula:C17H13BrClF2IN2O2Purezza:99.40%Colore e forma:SolidPeso molecolare:557.56Ref: TM-T21635
1mg35,00€2mg49,00€5mg74,00€10mg119,00€25mg259,00€50mg430,00€100mg620,00€200mg888,00€500mg1.333,00€BI-847325
CAS:BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.Formula:C29H28N4O2Purezza:97.13% - 97.54%Colore e forma:Yellow SolidPeso molecolare:464.56U0126-EtOH
CAS:U0126-etoh (U0126 Ethanol) is a non-ATP competitive inhibitor of MEK1 (IC50=72 nM) and MEK2 (IC50=58 nM) with selectivity, inhibit autophagy. Low-Cost!Formula:C18H16N6S2·C2H6OPurezza:99.72% - 99.88%Colore e forma:SolidPeso molecolare:426.6trans-Zeatin
CAS:trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrientFormula:C10H13N5OPurezza:97.13% - 98.96%Colore e forma:White SolidPeso molecolare:219.24Ref: TM-TMS2181
1mL*10mM (DMSO)33,00€10mg37,00€25mg52,00€50mg66,00€100mg96,00€200mg128,00€500mg205,00€Cobimetinib
CAS:Cobimetinib (GDC-0973) is a MEK1 inhibitor with selective and oral activity. Cobimetinib exhibits antitumor activity. Cost-effective and quality-assured.Formula:C21H21F3IN3O2Purezza:98% - 99.96%Colore e forma:White SolidPeso molecolare:531.31Ref: TM-T3623
500mgPrezzo su richiesta1mg38,00€2mg49,00€5mg80,00€10mg90,00€1mL*10mM (DMSO)94,00€25mg170,00€50mg261,00€100mg429,00€U0126
CAS:U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively.Formula:C18H16N6S2Purezza:99.61%Colore e forma:White SolidPeso molecolare:380.49APS-2-79 hydrochloride
CAS:APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization.Formula:C23H21N3O3·HClPurezza:98.64% - 99.55%Colore e forma:SolidPeso molecolare:423.89Isorhamnetin
CAS:Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin.Formula:C16H12O7Purezza:99.20% - >99.99%Colore e forma:Yellow SolidPeso molecolare:316.26Ref: TM-T2836
1mg38,00€2mg49,00€5mg78,00€1mL*10mM (DMSO)81,00€10mg113,00€25mg222,00€50mg371,00€100mg532,00€PD318088
CAS:PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-Formula:C16H13BrF3IN2O4Purezza:99.60%Colore e forma:White SolidPeso molecolare:561.09RO4987655
CAS:RO4987655 (RG7167) is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for MEK1/MEK2).Formula:C20H19F3IN3O5Purezza:98.21%Colore e forma:White SolidPeso molecolare:565.28GW284543
CAS:GW284543 (UNC10225170) is a selective inhibitor of MEK5 .Formula:C23H20N2O3Purezza:99.75%Colore e forma:SolidPeso molecolare:372.42
