MEK
MEK è una chinasi a doppia specificità che svolge un ruolo centrale nella via di segnalazione MAPK/ERK attivando ERK attraverso la fosforilazione. La segnalazione MEK è cruciale per la regolazione della crescita, sopravvivenza e differenziazione cellulare. Un'attività anomala di MEK è stata implicata in vari tipi di cancro e disturbi dello sviluppo, rendendola un importante bersaglio terapeutico. Presso CymitQuimica, offriamo una varietà di inibitori e modulatori di MEK per supportare la tua ricerca in oncologia, segnalazione cellulare e sviluppo terapeutico.
Trovati 75 prodotti per "MEK".
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Ro 5126766
CAS:RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.Formula:C21H18FN5O5SPurezza:98.3% - 98.81%Colore e forma:White SolidPeso molecolare:471.46Ref: TM-T6971
1mg54,00€2mg78,00€5mg109,00€1mL*10mM (DMSO)112,00€10mg169,00€25mg311,00€50mg500,00€100mg718,00€anemarsaponin B
CAS:Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activityFormula:C45H74O18Purezza:99.06% - 99.11%Colore e forma:SolidPeso molecolare:903.06BIX02189
CAS:BIX 02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).Formula:C27H28N4O2Purezza:97.84%Colore e forma:SolidPeso molecolare:440.54Ref: TM-T21295
2mg33,00€5mg52,00€1mL*10mM (DMSO)55,00€10mg71,00€25mg119,00€50mg198,00€100mg296,00€200mg427,00€PD98059
CAS:PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.Formula:C16H13NO3Purezza:98.63% - >99.99%Colore e forma:Green SolidPeso molecolare:267.28Ref: TM-T2623
5mg38,00€1mL*10mM (DMSO)39,00€10mg50,00€25mg78,00€50mg101,00€100mg168,00€200mg250,00€500mg421,00€Pimasertib
CAS:Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.Formula:C15H15FIN3O3Purezza:98.25% - 99.57%Colore e forma:SolidPeso molecolare:431.2Ref: TM-T6131
2mg34,00€5mg50,00€1mL*10mM (DMSO)52,00€10mg58,00€25mg96,00€50mg140,00€100mg207,00€200mg270,00€Refametinib
CAS:Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).Formula:C19H20F3IN2O5SPurezza:99.85% - >99.99%Colore e forma:SolidPeso molecolare:572.34Ref: TM-T6636
2mg43,00€5mg63,00€1mL*10mM (DMSO)79,00€10mg93,00€25mg147,00€50mg222,00€100mg326,00€200mg485,00€RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formula:C29H35N7O4Purezza:95.67% - 99.91%Colore e forma:SolidPeso molecolare:545.63Selumetinib
CAS:Selumetinib (AZD6244) is a selectivity and non-ATP-competitive MEK1/2 inhibitor. Selumetinib has antitumor activity. Cost-effective and quality-assured.Formula:C17H15BrClFN4O3Purezza:98.73% - 99.90%Colore e forma:White SolidPeso molecolare:457.68TAK-733
CAS:TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.Formula:C17H15F2IN4O4Purezza:98.31% - 99.2%Colore e forma:White SolidPeso molecolare:504.23APS-2-79
CAS:APS-2-79: KSR-dependent MEK inhibitor, blocks ATP biotin at KSR2, IC50 of 120 nM, disrupts Ras-MAPK signaling.Formula:C23H21N3O3Colore e forma:SolidPeso molecolare:387.43Trametinib (DMSO solvate)
CAS:Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 :2 nM)Formula:C28H29FIN5O5SPurezza:99.71% - 99.92%Colore e forma:SolidPeso molecolare:693.53Binimetinib
CAS:Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity. Cost-effective and quality-assured.Formula:C17H15BrF2N4O3Purezza:98.03% - >99.99%Colore e forma:SolidPeso molecolare:441.23GW 284543 hydrochloride
CAS:GW 284543 hydrochloride is a selective inhibitor of MEK5 .Formula:C23H21ClN2O3Purezza:99.73%Colore e forma:SolidPeso molecolare:408.87Mirdametinib
CAS:Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity.Formula:C16H14F3IN2O4Purezza:99.11% - 99.81%Colore e forma:White SolidPeso molecolare:482.19Ref: TM-T6189
5mg49,00€1mL*10mM (DMSO)52,00€10mg71,00€25mg120,00€50mg172,00€100mg259,00€200mg385,00€500mg627,00€1g850,00€GDC-0623
CAS:GDC-0623 (RG 7421) is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.Formula:C16H14FIN4O3Purezza:98.95% - 99.02%Colore e forma:SolidPeso molecolare:456.21Ref: TM-T6843
1mg50,00€2mg70,00€5mg113,00€1mL*10mM (DMSO)113,00€10mg177,00€25mg265,00€50mg349,00€100mg580,00€AZD8330
CAS:AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.Formula:C16H17FIN3O4Purezza:98.72% - 99.91%Colore e forma:SolidPeso molecolare:461.23Aurothiomalate sodium
CAS:Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.Formula:C4H3AuNa2O4SPurezza:99.66%Colore e forma:SolidPeso molecolare:390.07Ref: TM-T20168
5mgPrezzo su richiesta10mgPrezzo su richiesta25mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiesta200mgPrezzo su richiestaPimasertib HCl
CAS:Pimasertib HCl, an oral MEK1/2 inhibitor, may thwart tumor growth by blocking RAS/RAF/MEK/ERK signaling.Formula:C15H16ClFIN3O3Colore e forma:SolidPeso molecolare:467.66SL327
CAS:SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.Formula:C16H12F3N3SPurezza:97.98% - >99.99%Colore e forma:SolidPeso molecolare:335.35PD184161
CAS:PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].Formula:C17H13BrClF2IN2O2Purezza:99.40%Colore e forma:SolidPeso molecolare:557.56Ref: TM-T21635
1mg35,00€2mg49,00€5mg74,00€10mg119,00€25mg259,00€50mg430,00€100mg620,00€200mg888,00€500mg1.333,00€
