MEK
MEK è una chinasi a doppia specificità che svolge un ruolo centrale nella via di segnalazione MAPK/ERK attivando ERK attraverso la fosforilazione. La segnalazione MEK è cruciale per la regolazione della crescita, sopravvivenza e differenziazione cellulare. Un'attività anomala di MEK è stata implicata in vari tipi di cancro e disturbi dello sviluppo, rendendola un importante bersaglio terapeutico. Presso CymitQuimica, offriamo una varietà di inibitori e modulatori di MEK per supportare la tua ricerca in oncologia, segnalazione cellulare e sviluppo terapeutico.
Trovati 75 prodotti per "MEK".
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RO4927350
CAS:RO4927350 is a potent, selective MEK1/2 inhibitor, blocking MAPK pathway in vitro/vivo and showing notable antitumor effects.Formula:C27H28N4O6SColore e forma:SolidPeso molecolare:536.6Cobimetinib racemate
CAS:Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activatedFormula:C21H21F3IN3O2Purezza:98.00% - 99.71%Colore e forma:SolidPeso molecolare:531.31MS934
CAS:MS934, a novel VHL-recruiting MEK 1/2 degrader, exhibits potent anti-proliferative effects on HT-29 cell growth, achieving a GI50 of 0.023 μM.Formula:C52H69F3IN7O6SPurezza:98%Colore e forma:SolidPeso molecolare:1104.11MEK-IN-6 hydrate
CAS:MEK-IN-6 hydrate (compound 69), a MEK inhibitor, exhibits an IC50 value of 2 nM in A375 cells [1].Formula:C18H22FN3O5SPurezza:98%Colore e forma:SolidPeso molecolare:411.45Nedometinib
CAS:Nedometinib (NFX-179) is a MEK1 inhibitor with anticancer and antitumor activities, which can be used to study malignant tumors.Formula:C17H16FIN4O3Purezza:99.18%Colore e forma:SolidPeso molecolare:470.24GSK1790627
CAS:GSK1790627, the N-deacetylated metabolite of Trametinib, represents an orally active MEK inhibitor that promotes autophagy and triggers apoptosis [1].Formula:C24H21FIN5O3Colore e forma:SolidPeso molecolare:573.36BAY-846
CAS:BAY-846: allosteric MEK inhibitor, long-lasting, highly bioavailable, low brain entry, effective in K-Ras A549 model.Formula:C19H13F4IN4O4SColore e forma:SolidPeso molecolare:596.29EBI-1051
CAS:EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).Formula:C18H15F2IN2O5Purezza:98%Colore e forma:SolidPeso molecolare:504.22MEK4 inhibitor-2
CAS:MEK4 Inhibitor-2, a novel MEK4 inhibitor, demonstrates efficacy against pancreatic adenocarcinoma, exhibiting an IC50 value of 83 nM.Formula:C20H15FN4O3SColore e forma:SolidPeso molecolare:410.42G-479
CAS:G-479, a potent MEK inhibitor and improved analogue of GDC-0623, has distributed polarity enhancing bioactivity.Formula:C16H15FIN5O4Colore e forma:SolidPeso molecolare:487.22Luvometinib
CAS:Luvometinib is an inhibitor of the mitogen-activated protein kinase (MEK) with antitumor activity.Formula:C26H22F2IN5O4SColore e forma:SolidPeso molecolare:665.45Refametinib R enantiomer
CAS:Refametinib R enantiomer (RDEA119 R enantiomer) is an MEK inhibitor with an EC50 of 2.0-15 nM.Refametinib (R enantiomer) has anticancer activity and can be usedFormula:C19H20F3IN2O5SPurezza:99.86%Colore e forma:Yellow SolidPeso molecolare:572.34Atebimetinib
CAS:Atebimetinib, Oral MEK inhibitor, suppresses MAPK signaling, for combination therapy in metastatic pancreatic cancer and NSCLC.Formula:C23H27FN4O6SPurezza:99.40%Colore e forma:White SolidPeso molecolare:506.55Ref: TM-T206215
1mg69,00€5mg147,00€1mL*10mM (DMSO)166,00€10mg224,00€25mg358,00€50mg512,00€100mg707,00€MEK1/2-IN-2
MEK1/2-IN-2 is a potent, ATP-competitive MEK1/2 inhibitor that exhibits equal inhibitory effects on wild-type MEK1/2 and a group of MEK1/2 mutant cells.Formula:C28H22ClFN6OColore e forma:SolidPeso molecolare:512.97DS03090629
DS03090629, an orally active MEK inhibitor, functions by competitively inhibiting MEK activity in the presence of ATP. This compound demonstrates strong binding affinity to both MEK and phosphorylated MEK, with dissociation constants (Kd) of 0.11 and 0.15 nM, respectively. It has shown efficacy in suppressing the proliferation of melanoma cell lines that overexpress BRAF mutations, achieving IC50 values of 74.3 and 97.8 nM for BRAF V600E and MEK1 F53L transfected A375 cells, respectively. DS03090629 is thus considered promising for anti-melanoma therapies.Formula:C25H26ClN5O2Purezza:>99.99%Colore e forma:SolidPeso molecolare:463.96
