ERK
ERK è una proteina chiave nella via di segnalazione MAPK (Mitogen-Activated Protein Kinase), coinvolta nella trasmissione dei segnali dai recettori di superficie cellulare al DNA nel nucleo della cellula. ERK svolge un ruolo cruciale nella regolazione di vari processi cellulari, tra cui la proliferazione, la differenziazione e la sopravvivenza. La disregolazione della segnalazione ERK è associata allo sviluppo del cancro e di altre malattie, rendendola un importante bersaglio per l'intervento terapeutico. Presso CymitQuimica, offriamo una selezione di inibitori e modulatori di ERK di alta qualità per supportare la tua ricerca sulla segnalazione cellulare, oncologia e sviluppo terapeutico.
Trovati 205 prodotti di "ERK"
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Pluripotin
CAS:Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) andFormula:C27H25F3N8O2Purezza:98.77% - 98.82%Colore e forma:SolidPeso molecolare:550.53Tenuifoliside A
CAS:Tenuifoliside A has anti-apoptotic , neuroprotective activity.Formula:C31H38O17Purezza:98.99% - 99.91%Colore e forma:SolidPeso molecolare:682.62BAY885
CAS:BAY885 is a new ERK5 inhibitor.Formula:C25H28F3N7O2Purezza:99.83%Colore e forma:SolidPeso molecolare:515.53Mogrol
CAS:Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.Formula:C30H52O4Purezza:99.85% - 99.90%Colore e forma:SolidPeso molecolare:476.73Temuterkib
CAS:<p>LY3214996 (Temuterkib) is a potent oral ERK1/2 inhibitor with potential cancer-fighting properties.</p>Formula:C22H27N7O2SPurezza:99.57% - >99.99%Colore e forma:SolidPeso molecolare:453.56ERK5-IN-1
CAS:ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).Formula:C25H29N7O2Purezza:97.70%Colore e forma:SolidPeso molecolare:459.54Tauroursodeoxycholate
CAS:Tauroursodeoxycholate (UR 906), a hydrophilic bile acid, low in humans, may treat PBC, insulin resistance, and ALS.Formula:C26H45NO6SPurezza:98.77% - 99.93%Colore e forma:White SolidPeso molecolare:499.7Loureirin B
CAS:Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.Formula:C18H20O5Purezza:99.33% - 99.86%Colore e forma:SolidPeso molecolare:316.35UNC569
CAS:UNC569 selectively inhibits kidney URAT1, regulating uric acid excretion and aiding gout patient's uric balance.Formula:C22H29FN6Purezza:98.91% - 99.67%Colore e forma:SolidPeso molecolare:396.5DEL-22379
CAS:DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ～0.5 μM.Formula:C26H28N4O3Purezza:99.3% - 99.53%Colore e forma:SolidPeso molecolare:444.532,5-Dihydroxyacetophenone
CAS:2,5-Dihydroxyacetophenone has anti-anxiety, neuroprotective, anti-inflammatory properties, and modulates cell signaling and melanogenesis.Formula:C8H8O3Purezza:99.75%Colore e forma:Yellow PowderPeso molecolare:152.15Butein
CAS:Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.Formula:C15H12O5Purezza:98.76% - >99.99%Colore e forma:SolidPeso molecolare:272.25Pachymic acid
CAS:Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways.Formula:C33H52O5Purezza:99.43% - >99.99%Colore e forma:White PowderPeso molecolare:528.76β-Neoendorphin acetate(77739-21-0 free base)
CAS:<p>beta-Neoendorphin acetate is an agonist of κ-opioid receptor</p>Formula:C56H81N13O14Purezza:99.91%Colore e forma:SolidPeso molecolare:1160.34GRK5-IN-2
CAS:GRK5-IN-2, a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor.Formula:C20H20N4O4Purezza:99.92%Colore e forma:SolidPeso molecolare:380.46-OAU
CAS:6-OAU is a GPR84 agonist, activates it in HEK293 cells with a 105 nM EC50.Formula:C12H21N3O2Purezza:98.14% - 99.01%Colore e forma:SolidPeso molecolare:239.31Nitidine chloride
CAS:1.Formula:C21H18ClNO4Purezza:96.59% - 99.55%Colore e forma:SolidPeso molecolare:383.82XMD17-109
CAS:<p>XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).</p>Formula:C36H46N8O3Purezza:98.75% - 99.7%Colore e forma:SolidPeso molecolare:638.8DCLK1-IN-1
CAS:<p>DCLK1-IN-1 is a selective, in vivo compatible chemical probe of the kinase domain of doublecortin-like kinase 1 (DCLK1).Cost-effective and quality-assured.</p>Formula:C26H28F3N7O2Purezza:98.55% - 99.28%Colore e forma:SolidPeso molecolare:527.54AG126
CAS:AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42). AG-126 weakly inhibits epidermal GFRK and platelet-derived GFRK.Formula:C10H5N3O3Purezza:97.35%Colore e forma:SolidPeso molecolare:215.16ASP2453
CAS:ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.Formula:C40H48F3N7O4Purezza:99.71%Colore e forma:SolidPeso molecolare:747.85Epieriocalyxin A
CAS:Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.Formula:C20H24O5Purezza:97.00%Colore e forma:SolidPeso molecolare:344.4Avatrombopag maleate
CAS:Avatrombopag (AKR-501/E5501) is an oral TPO receptor agonist for thrombocytopenia treatment, approved in 2018.Formula:C33H38Cl2N6O7S2Colore e forma:SolidPeso molecolare:765.72DMU-212
CAS:<p>DMU-212, a Resveratrol derivative, has antimitotic, antiproliferative, antioxidant properties; induces apoptosis via ERK1/2.</p>Formula:C18H20O4Purezza:99.86%Colore e forma:SolidPeso molecolare:300.35SUN11602
CAS:SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.Formula:C26H37N5O2Purezza:99.36%Colore e forma:SolidPeso molecolare:451.6RU-301
CAS:RU-301 is a novel pan-tam inhibitorFormula:C21H19F3N4O4SPurezza:98.87%Colore e forma:SolidPeso molecolare:480.46ERK-IN-3
CAS:<p>ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.</p>Formula:C22H25ClFN7O2Purezza:99.55% - 99.76%Colore e forma:SolidPeso molecolare:473.93Methylnissolin
CAS:<p>Methylnissolin (3-Hydroxy-9,10-dimethoxyptercarpan) is derived from Astragalus and has antibacterial and anti-cancer effects.</p>Formula:C17H16O5Purezza:99.68% - 99.98%Colore e forma:SolidPeso molecolare:300.31EF24
CAS:EF24 treatment boosts caspase 3/9 activity, hinders MEK1/ERK phosphorylation, and exhibits strong anti-tumor effects in OSCC by deactivating MAPK/ERK.Formula:C19H15F2NOPurezza:99.71%Colore e forma:SolidPeso molecolare:311.33Deltonin
CAS:Deltonin inhibits ERK1/2 & AKT; toxic to HepG2 (IC50: 7.66μM), C26 (IC50: 1.22μM), MDA-MB-231 cells (IC50: 1.58μM).Formula:C45H72O17Purezza:98.77% - 99.79%Colore e forma:SolidPeso molecolare:885.04trans-Zeatin
CAS:trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrientFormula:C10H13N5OPurezza:97.13% - 98.96%Colore e forma:White To Light Yellow Crystal PowderPeso molecolare:219.24Ravoxertinib
CAS:<p>Ravoxertinib (GDC-0994) is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM).</p>Formula:C21H18ClFN6O2Purezza:98% - 99.87%Colore e forma:SolidPeso molecolare:440.86Bohemine
CAS:Bohemine is a cyclin-dependent kinase inhibitor.Formula:C18H24N6OPurezza:99.09% - 99.53%Colore e forma:SolidPeso molecolare:340.42Prosaptide TX14(A) acetate
<p>Prosaptide TX14(A) acetate is a potent GPR37L1 and GPR37 agonist. Prosaptide Tx14(A) TFA increases both ERK1 and ERK2 phosphorylation in Schwann cells.</p>Formula:C71H114N16O28Purezza:95.29%Colore e forma:SolidPeso molecolare:1639.76Tauroursodeoxycholate sodium
CAS:Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.Formula:C26H44NNaO6SPurezza:97.90%Colore e forma:SolidPeso molecolare:521.69FR 180204
CAS:<p>FR 180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2.</p>Formula:C18H13N7Purezza:98% - 99.74%Colore e forma:SolidPeso molecolare:327.34MRTX1133
CAS:<p>View and buy MRTX1133 from TargetMol.MRTX1133 is a potent, selective, and noncovalent inhibitor of KRAS G12D.</p>Formula:C33H31F3N6O2Purezza:97.39% - 99.6%Colore e forma:SolidPeso molecolare:600.63KO-947
CAS:<p>KO-947 is a potent and specific inhibitor of ERK1/2 kinases.</p>Formula:C21H17N5OPurezza:97.84%Colore e forma:SolidPeso molecolare:355.39AZD8330
CAS:AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.Formula:C16H17FIN3O4Purezza:98.72%Colore e forma:SolidPeso molecolare:461.23(E/Z)-BIX02188
CAS:BIX02188 inhibits MEK5 (IC50: 4.3 nM) and ERK5 (810 nM) but not MEK1/2, JNK2, or ERK2.Formula:C25H24N4O2Purezza:97.39% - 98.38%Colore e forma:SolidPeso molecolare:412.48Tizaterkib
CAS:Tizaterkib (AZD-0364) is a potent and selective ERK2 inhibitor.Formula:C24H24F2N8O2Purezza:99.6% - 99.63%Colore e forma:SolidPeso molecolare:494.5ERK-IN-4
CAS:<p>ERK-IN-4 is a cell-permeable ERK inhibitor with potential antiproliferative effects for the study of diseases caused by immune dysfunction.</p>Formula:C14H17ClN2O3SPurezza:98.92% - 99.84%Colore e forma:SolidPeso molecolare:328.814Ulixertinib hydrochloride
CAS:Ulixertinib hydrochloride (Ulixertinib HCl) is an ERK1/2 inhibitor with anticancer and antitumor activity that inhibits the NB cell cycle and promotes apoptosisFormula:C21H23Cl3N4O2Purezza:99.85%Colore e forma:SolidPeso molecolare:469.79ADTL-EI1712
CAS:ADTL-EI1712: ERK1/2/5 inhibitor (ERK1 IC50=40.43nM, ERK5=64.5nM), blocks HL-60/MKN74 cell growth, not HeLa; effective in MKN74 mouse model.Formula:C22H18Cl2N4O2S2Colore e forma:SolidPeso molecolare:505.44Dihydrolipoic acid
CAS:<p>Dihydrolipoic acid (USAF XR-12), a dithiol carboxylic acid, is a potent antioxidant active against various reactive oxygen species at 0.01-0.5 mM.</p>Formula:C8H16O2S2Purezza:97.51%Colore e forma:Yellow To Orange LiquidPeso molecolare:208.34Angiogenesis inhibitor BT2
CAS:BT2 inhibits angiogenesis, vascular permeability by targeting ERK, FosB, VCAM-1, and related genes, affecting MEK1 and suppressing retinal markers.Formula:C18H18N2O4Colore e forma:SolidPeso molecolare:326.35mSIRK
CAS:mSIRK (G-Protein βγ Binding Peptide) is an ERK1 and ERK2 dual activator that promotes alpha-subunit dissociation.Formula:C93H150N20O25Purezza:99.26%Colore e forma:SolidPeso molecolare:1948.312,5-Dihydroxybiphenyl
CAS:<p>2,5-Dihydroxybiphenyl: a small molecule that induces trichothiodystrophy A protein dimerization, modulating TFIIH activity.</p>Formula:C12H10O2Purezza:99.66%Colore e forma:White To Grey-Brownish PowderPeso molecolare:186.21ERK1/2 inhibitor 1
CAS:<p>ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.</p>Formula:C29H32ClN5O4Purezza:98.81%Colore e forma:SolidPeso molecolare:550.05UC-857993
CAS:UC-857993 is a selective SOS1-Ras inhibitor with a Kd of 14.7 μM that inhibits ERK, Ras, and reduces MEF growth.Formula:C25H22ClNO2Colore e forma:SolidPeso molecolare:403.9GABAB receptor antagonist 1
CAS:(E)-GABAB receptor antagonist 1 decreases GABA-induced IP3 (inositol trisphosphate) production with IC50 of 37.9 μM.GABAB receptor antagonist 1 is a selectiveFormula:C18H24O4Purezza:98%Colore e forma:SolidPeso molecolare:304.38ERK5-IN-3
CAS:ERK5-IN-3 inhibits ERK5 strongly (IC50: 6 nM) and hampers Hela cell growth (IC50: 31 nM).Formula:C24H23Cl2FN4O2Colore e forma:SolidPeso molecolare:489.37CAY10561
CAS:CAY10561: potent, selective ERK2 inhibitor (Ki=2nM); blocks cell proliferation; IC50 in COLO 205 cells: 0.54μM.Formula:C22H17Cl2FN4O2Colore e forma:SolidPeso molecolare:459.3BNC-1
CAS:BNC-1 reduces amyloid in mice, enhances synapses by activating Elk-1.Formula:C16H14N2O3Purezza:98%Colore e forma:SolidPeso molecolare:282.29PERK-IN-3
CAS:PERK-IN-3 is a potent inhibitor of PERK(IC50 of 7.4 nM).Formula:C22H16F2N4O2Purezza:98%Colore e forma:SolidPeso molecolare:406.38Migoprotafib
CAS:Migoprotafib (GDC-1971) is a potent and highly selective SHP2 (Src Homology-2 Domain-Containing Phosphatase 2) inhibitor for advanced solid tumours.Formula:C25H26N8OPurezza:98.31%Colore e forma:SolidPeso molecolare:454.53D-87503
CAS:D-87503 is a dual extracellular signaling-related kinase (ERK)/PI3K inhibitor.Formula:C17H15N5OSColore e forma:SolidPeso molecolare:337.4GP17
CAS:GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease that acts by targeting the ATP-binding pocket of IRE1α.Formula:C26H21F3N4OColore e forma:SolidPeso molecolare:462.47PB1
CAS:PB1, a stable borane-protected TCEP analogue, effectively reduces disulfides intracellularly and aids retinal cell survival post-axotomy.Formula:C14H22BO4PColore e forma:SolidPeso molecolare:296.11ERK5-IN-4
CAS:ERK5-IN-4 (34b) is a potent, specific ERK5 inhibitor; IC50: 77 nM full-length, 300 nM ΔTAD in HEK293 cells.Formula:C16H11Cl2FN4O2Colore e forma:SolidPeso molecolare:381.19Cuspin-1
CAS:Cuspin-1, a small molecule, increases SMN levels by 50% in SMA by boosting ERK phosphorylation and Ras-Raf-MEK signaling.Formula:C13H10BrNOColore e forma:SolidPeso molecolare:276.13Tinlorafenib
CAS:Tinlorafenib (PF-07284890), a BRAFV600E/K inhibitor, is oral & CNS-permeable, used for BRAF-linked CNS tumors. IC50: 4.25/2.7 nM.Formula:C19H19ClF2N4O3SColore e forma:SolidPeso molecolare:456.89RLX-33
CAS:<p>RLX-33 blocks RXFP3 and relaxin 3 effects, controls food intake in rats, and may help study metabolic syndrome.</p>Formula:C24H19ClN4O4Purezza:99.89%Colore e forma:SolidPeso molecolare:462.89ZINC12409120
CAS:ZINC12409120 (R-4584) is a selective ERK inhibitor.ZINC12409120 inhibits ERK with an IC50 of 5.0 μM.ZINC12409120 inhibits ERK activity by interfering with FGF23Formula:C20H16N4O2Purezza:99.71% - 99.95%Colore e forma:SolidPeso molecolare:344.37(E)-GABAB receptor antagonist 1
CAS:(E)-GABAB antagonist 1 inhibits GABA IP3 production, with an IC50 of 37.9 μM and acts as a selective negative modulator.Formula:C18H24O4Purezza:98.09%Colore e forma:SolidPeso molecolare:304.38NMDAR/TRPM4-IN-2
CAS:Potent NMDAR/TRPM4-IN-2 blocks NMDAR/TRPM4, protects brain and retinal neurons, and prevents mitochondrial dysfunction with an IC50 of 2.1 μM.Formula:C11H19BrCl2N2Purezza:99.75%Colore e forma:SolidPeso molecolare:330.092SKI2496
CAS:SKI2496: potent, oral GnRH receptor antagonist, hGnRHR IC50=0.46nM, 84% LH inhibition at 12h, 76% at 24h, selective for humans over monkeys/rats.Formula:C35H36F7N5O5Colore e forma:SolidPeso molecolare:739.68KRAS G12C inhibitor 61
CAS:KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM.Formula:C31H33ClFN7O2Purezza:98%Colore e forma:SolidPeso molecolare:590.09ERK1/2 inhibitor 8
CAS:ERK1/2 inhibitor 8 is a potent inhibitor of ERK that acts on ERK2 (IC50: 0.48 nM).Formula:C23H20ClN7O2SColore e forma:SolidPeso molecolare:493.97Firazorexton hydrate
CAS:Firazorexton hydrate (TAK-994) is a brain-penetrant and orally active agonist of the orexin type 2 receptor (OX2R) with a potent EC50 of 19 nM.Formula:C22H25F3N2O4SH2OColore e forma:SolidPeso molecolare:497.53(R)-VX-11e
CAS:(R)-VX-11e is an isomer of VX-11e, a potent and selective ERK2 inhibitor with potential to inhibit tumor growth.Formula:C24H20Cl2FN5O2Purezza:98.73%Colore e forma:SolidPeso molecolare:500.35Inflachromene
CAS:Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene is used in the study of epilepsy.Formula:C21H19N3O4Purezza:97.36% - 99.88%Colore e forma:SolidPeso molecolare:377.39CXJ-2
CAS:CXJ-2, a cyclic peptide, binds EDPs, inhibits PI3K/ERK, and reduces hepatic cell growth/migration, offering antifibrotic effects.Formula:C55H87N15O22Purezza:98%Colore e forma:SolidPeso molecolare:1310.37DL-threo dihydrosphingosine
CAS:DL-threo dihydrosphingosine blocks ERK, inhibits smooth muscle proliferation, and works against growth factor/G-protein ERK activation.Formula:C18H39NO2Colore e forma:SolidPeso molecolare:301.51K145 hydrochloride
CAS:<p>K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM.</p>Formula:C18H25ClN2O3SPurezza:99.8%Colore e forma:SolidPeso molecolare:384.92Laxiflorin B
CAS:Laxiflorin B, a novel selective inhibitor of ERK 1/2 derived from herbal sources, exhibits antitumor activity [1].Formula:C20H24O5Purezza:98%Colore e forma:SolidPeso molecolare:344.4ERK-IN-2 free base
CAS:ERK-IN-2 free base inhibits ERK2 (IC50: 1.8 nM); potential off-target effects at >10 μM.Formula:C16H17N5O2Colore e forma:SolidPeso molecolare:311.34ERK1/2 inhibitor 5
CAS:ERK1/2 inhibitor 5: potent against ERK1/2, may combat cancer and inflammation.Formula:C28H32ClFN6O5Colore e forma:SolidPeso molecolare:587.04ERK1/2 inhibitor 9
CAS:ERK1/2 Inhibitor 9 (Probe 1), a covalent antagonist of ERK1/2, exhibits sub-micromolar efficacy in cellular assays (A375 GI50=0.47 μM) and facilitates theFormula:C31H32ClN7O3Purezza:98%Colore e forma:SolidPeso molecolare:586.08ERK1/2 inhibitor 7
CAS:ERK1/2 inhibitor 7 is a potent inhibitor of ERK, acting on ERK2 (IC50: 0.94 nM).Formula:C23H22FN7OSColore e forma:SolidPeso molecolare:463.53EVT801
CAS:EVT801 is a highly selective and low-toxic VEGFR-3 inhibitor that inhibits VEGF-C-induced tumor lymphoid and angiogenesis and reduces CCL4, CCL5 and MDSC.Formula:C19H21N5O3Purezza:97.4%Colore e forma:SolidPeso molecolare:367.4I-287
CAS:I-287 is a selective, orally active PAR2 inhibitor that functions as a negative allosteric modulator of Gαq and Gα12/13 activity and their downstream effectors.Formula:C30H30ClFN4O4Colore e forma:SolidPeso molecolare:565.04ERK Inhibitor II (Negative control)
CAS:ERK Inhibitor II, a control, blocks ERK and insulin receptor activation, aiding diabetes research.Formula:C18H12N6OColore e forma:SolidPeso molecolare:328.33MRS2693 trisodium
CAS:MRS2693 trisodium, a selective P2Y6 agonist with an EC50 of 0.015 μM, demonstrates cytoprotective effects in a mouse hindlimb skeletal muscle ischemia-reperfusion injury model by reducing NF-kappaB activation and stimulating the ERK1/2 pathway [1] [2].Formula:C9H10IN2Na3O12P2Colore e forma:SolidPeso molecolare:596MEK-IN-6
CAS:MEK-IN-6 (Example 69), a potent MEK inhibitor, effectively inhibits ERK1/2 (Thr202/Tyr204) phosphorylation in A375 cells, with an IC50 of 2 nM, making itFormula:C18H20FN3O4SPurezza:98%Colore e forma:SolidPeso molecolare:393.43MK-8353
CAS:MK-8353 (SCH900353) is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)Formula:C37H41N9O3SPurezza:96.15% - 97.19%Colore e forma:SolidPeso molecolare:691.84AL 8810
CAS:AL-8810 is an 11β-fluoro analog of PGF 2α with selective antagonist effects at the PGF 2α receptor (FP receptor) [1].Formula:C24H31FO4Colore e forma:SolidPeso molecolare:402.5MAP855
CAS:MAP855: potent, selective, oral MEK1/2 inhibitor; IC50=3 nM, pERKEC50=5 nM; effective on wild-type/mutant MEK1/2.Formula:C28H23ClF2N6O3Colore e forma:SolidPeso molecolare:564.97SHR2415
SHR2415: Potent, selective ERK1/2 inhibitor, oral; ERK1 IC50: 2.8 nM, ERK2 IC50: 5.9 nM; effective in Colo205 (IC50: 44.6 nM), for cancer research.Formula:C23H22ClN7O2Colore e forma:SolidPeso molecolare:463.92(rel)-AR234960
CAS:(rel)-AR234960 is an active relative configuration of AR234960. AR234960 is a non-peptide agonist of MAS.Formula:C27H30FN5O5SColore e forma:SolidPeso molecolare:555.63DOR agonist 2
CAS:Compound 3 (DOR agonist 2) acts as a Delta Opioid Receptor agonist. It inhibits the expression of TNF-α, obstructs NF-κB transportation to the nucleus, and activates the G protein-mediated ERK1/2 pathway. This compound is useful for research into neurodegenerative diseases.Formula:C29H26N2O3Colore e forma:SolidPeso molecolare:450.53SOS1 activator 2
CAS:<p>SOS1 activator 2 (Compound 65) is a benzothiazole derivative and an activator of SOS1. It demonstrates a high binding affinity for SOS1, with a Kd of 9 nM. By modulating the Ras-ERK signaling pathway, SOS1 activator 2 is suitable for tumor research.</p>Formula:C26H28ClFN6Colore e forma:SolidPeso molecolare:478.992KU004
CAS:<p>KU004, a potent dual EGFR/HER2 inhibitor, exhibits anticancer properties. It inhibits the proliferation of human breast cancer SKBR3 cells by inducing G1 phase arrest. KU004 blocks the activation of HER2, EGFR, and the downstream Akt and Erk pathways, primarily inducing apoptosis (Apoptosis) through the extrinsic pathway. Additionally, KU004 is a novel quinazoline derivative.</p>Formula:C29H27ClFN4O2PColore e forma:SolidPeso molecolare:548.98ERK-IN-2
CAS:ERK-IN-2, an ERK2 inhibitor, exhibits an IC50 value of 1.8 nM. At doses greater than 10 μM, it may induce off-target toxicity and/or activity [1].Formula:C16H18ClN5O2Purezza:98%Colore e forma:SolidPeso molecolare:347.80ATX inhibitor 26
CAS:ATX inhibitor 26 is an Autotaxin (ATX) inhibitor with an IC50 of 57 nM in human plasma. It effectively inhibits cell migration and collagen gel contraction. Additionally, ATX inhibitor 26 demonstrates significant antifibrotic activity, reducing collagen deposition in a Bleomycin (BLM)-induced pulmonary fibrosis model.Formula:C18H19Cl2N7O3Colore e forma:SolidPeso molecolare:452.30Hypothemycin
CAS:Hypothemycin, a fungal polyketide, inhibits multiple kinases (VEGFR, MEK, FLT-3, PDGFR, ERK) with Kis ranging from 10 nM to 2.4 μM.Formula:C19H22O8Purezza:98%Colore e forma:SolidPeso molecolare:378.37ERK1/2 inhibitor 6
CAS:ERK1/2 inhibitor 6 - potent cancer/inflammation treatment from WO2021063335A1.Formula:C27H29ClFN7O5Colore e forma:SolidPeso molecolare:586.01ERK2 IN-1
CAS:<p>ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.</p>Formula:C36H34FN7O2SPurezza:98%Colore e forma:SolidPeso molecolare:647.76KRAS inhibitor-27
CAS:<p>KRAS inhibitor-27 (Compound 15h) is a KRAS inhibitor that effectively targets KRAS G12D/G12V mutated cells (AsPC-1 and SW620) and wild-type KRAS cells (HT-29), with IC50 values of 378 nM, 0.6 nM, and 3230 nM, respectively. It reduces ERK phosphorylation, with IC50 values of 0.6 nM and 1 nM in AsPC-1 and SW620 cells, respectively, and decreases DUSP4 expression, thereby inhibiting the MAPK signaling pathway.</p>Formula:C31H28ClF3N6O3SColore e forma:SolidPeso molecolare:657.106KRASG12C IN-15
CAS:KRASG12C IN-15 (Compound 21) is an orally active KRASG12C inhibitor that effectively blocks SOS1-mediated GDP/GTP exchange with an IC50 of 19 nM. It inhibits ERK phosphorylation with an IC50 of 0.051 μM and reduces the viability of KRASG12C mutant MIA PaCa-2 cells with an IC50 of 0.023 μM. Additionally, KRASG12C IN-15 demonstrates antitumor activity in a MIA PaCa-2 xenograft mouse model.Formula:C31H32FN3O2Colore e forma:SolidPeso molecolare:497.603
