ERK
ERK è una proteina chiave nella via di segnalazione MAPK (Mitogen-Activated Protein Kinase), coinvolta nella trasmissione dei segnali dai recettori di superficie cellulare al DNA nel nucleo della cellula. ERK svolge un ruolo cruciale nella regolazione di vari processi cellulari, tra cui la proliferazione, la differenziazione e la sopravvivenza. La disregolazione della segnalazione ERK è associata allo sviluppo del cancro e di altre malattie, rendendola un importante bersaglio per l'intervento terapeutico. Presso CymitQuimica, offriamo una selezione di inibitori e modulatori di ERK di alta qualità per supportare la tua ricerca sulla segnalazione cellulare, oncologia e sviluppo terapeutico.
Trovati 216 prodotti per "ERK".
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Yoda 1
CAS:Yoda 1 is an agonist of the Piezo1 channel that agonizes human- and mouse-derived Piezo1. Yoda 1 is also an inhibitor of GlyT2. Cost-effective, quality assurance.Formula:C13H8Cl2N4S2Purezza:98% - 99.98%Colore e forma:SolidPeso molecolare:355.27Ref: TM-T7506
1mg44,00€2mg57,00€1mL*10mM (DMSO)88,00€5mg90,00€10mg109,00€25mg219,00€50mg424,00€100mg620,00€500mg1.314,00€ERK5-IN-2
CAS:ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.Formula:C17H11BrFN3O2Purezza:99.01%Colore e forma:SolidPeso molecolare:388.19Ref: TM-T5535
1mg46,00€5mg90,00€1mL*10mM (DMSO)101,00€10mg160,00€25mg268,00€50mg401,00€100mg580,00€200mg798,00€Asperulosidic acid
CAS:Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines.Formula:C18H24O12Purezza:99.47%Colore e forma:SolidPeso molecolare:432.38Ref: TM-TN1410
1mg120,00€2mg170,00€5mg260,00€1mL*10mM (DMSO)286,00€10mg432,00€25mg708,00€50mg964,00€100mg1.288,00€CAFESTOL
CAS:Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.Formula:C20H28O3Purezza:97.06% - 99.08%Colore e forma:Yellow SolidPeso molecolare:316.43Sulforaphene
CAS:Sulforaphene, from radish seeds, aids cancer cell apoptosis and inhibits migration; has an ED50 for velvetleaf at ~2x10^-4 M.Formula:C6H9NOS2Purezza:97.55% - 99.67%Colore e forma:Slightly Yellowish LiquidPeso molecolare:175.27Ref: TM-TL0016
1mg34,00€2mg46,00€1mL*10mM (DMSO)65,00€5mg66,00€10mg92,00€25mg167,00€50mg241,00€100mg359,00€200mg525,00€Acalabrutinib
CAS:Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity.Formula:C26H23N7O2Purezza:98.94% - 99.64%Colore e forma:White SolidPeso molecolare:465.51Ref: TM-T3626
5mg44,00€1mL*10mM (DMSO)48,00€10mg57,00€25mg78,00€50mg90,00€100mg144,00€200mg215,00€500mg355,00€XMD8-92
CAS:XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).Formula:C26H30N6O3Purezza:98.21%Colore e forma:SolidPeso molecolare:474.55Triptonide
CAS:Triptonide treats autoimmune diseases, has antileukemic/tumor effects, is anti-inflammatory, and boosts IL-37.Formula:C20H22O6Purezza:99.11% - 99.64%Colore e forma:Pink SolidPeso molecolare:358.39Ref: TM-T5S1058
1mg52,00€2mg74,00€5mg108,00€1mL*10mM (DMSO)133,00€10mg158,00€25mg268,00€50mg409,00€100mg595,00€200mg833,00€Peramivir Trihydrate
CAS:Peramivir Trihydrate (RWJ-270201) is a neuraminidase inhibitor (IC50: 0.09 nM) which prevents normal processing of virus particles such that virus particles areFormula:C15H28N4O4·3H2OPurezza:99.52% - 99.87%Colore e forma:SolidPeso molecolare:382.45Ulixertinib
CAS:Ulixertinib (VRT752271) (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.Formula:C21H22Cl2N4O2Purezza:99.31% - 99.95%Colore e forma:SolidPeso molecolare:433.33N-tert-butyl-α-Phenylnitrone
CAS:N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.Formula:C11H15NOPurezza:99.46% - 99.84%Colore e forma:SolidPeso molecolare:177.24(E/Z)-BIX 02189
CAS:(E/Z)-BIX 02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.Formula:C27H28N4O2Purezza:98% - 99.89%Colore e forma:SolidPeso molecolare:440.54Ref: TM-T2416
1mg38,00€5mg82,00€1mL*10mM (DMSO)92,00€10mg116,00€25mg210,00€50mg358,00€100mg550,00€200mg780,00€Pluripotin
CAS:Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) andFormula:C27H25F3N8O2Purezza:98.77% - 99.57%Colore e forma:White SolidPeso molecolare:550.53Ref: TM-T6948
1mg34,00€2mg48,00€5mg63,00€1mL*10mM (DMSO)74,00€10mg88,00€25mg140,00€50mg207,00€100mg333,00€Tenuifoliside A
CAS:Tenuifoliside A has anti-apoptotic , neuroprotective activity.Formula:C31H38O17Purezza:98.99% - 99.91%Colore e forma:White SolidPeso molecolare:682.62BAY885
CAS:BAY885 is a new ERK5 inhibitor.Formula:C25H28F3N7O2Purezza:99.83%Colore e forma:SolidPeso molecolare:515.53Ref: TM-T10479
50mgPrezzo su richiesta1mg49,00€5mg144,00€1mL*10mM (DMSO)165,00€10mg221,00€25mg401,00€Mogrol
CAS:Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling.Formula:C30H52O4Purezza:99.85% - 99.95%Colore e forma:Yellow SolidPeso molecolare:476.73Temuterkib
CAS:LY3214996 (Temuterkib) is a potent oral ERK1/2 inhibitor with potential cancer-fighting properties.Formula:C22H27N7O2SPurezza:99.57% - >99.99%Colore e forma:SolidPeso molecolare:453.56Ref: TM-T4091
1mg57,00€2mg74,00€5mg98,00€1mL*10mM (DMSO)105,00€10mg158,00€25mg330,00€50mg497,00€100mg710,00€GPR34 receptor antagonist 2
CAS:GPR34 receptor antagonist 2 (Tyrosine, N-[(2E)-3-(4'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-2-propen-1-yl]-O-(phenylmethyl)-) is an anti-inflammatory agent.Formula:C31H26ClNO4Purezza:97.26%Colore e forma:SolidPeso molecolare:512Ref: TM-T8848
1mg110,00€5mg259,00€1mL*10mM (DMSO)288,00€10mg425,00€25mg700,00€50mg982,00€100mg1.314,00€500mg2.637,00€ERK5-IN-1
CAS:ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).Formula:C25H29N7O2Purezza:97.70%Colore e forma:SolidPeso molecolare:459.54Tauroursodeoxycholate
CAS:Tauroursodeoxycholate (UR 906), a hydrophilic bile acid, low in humans, may treat PBC, insulin resistance, and ALS.Formula:C26H45NO6SPurezza:98.77% - 99.93%Colore e forma:White SolidPeso molecolare:499.7Loureirin B
CAS:Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.Formula:C18H20O5Purezza:99.33% - 99.86%Colore e forma:White SolidPeso molecolare:316.35UNC569
CAS:UNC569 selectively inhibits kidney URAT1, regulating uric acid excretion and aiding gout patient's uric balance.Formula:C22H29FN6Purezza:98.91% - 99.67%Colore e forma:SolidPeso molecolare:396.5DEL-22379
CAS:DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ～0.5 μM.Formula:C26H28N4O3Purezza:99.3% - 99.53%Colore e forma:SolidPeso molecolare:444.532,5-Dihydroxyacetophenone
CAS:2,5-Dihydroxyacetophenone has anti-anxiety, neuroprotective, anti-inflammatory properties, and modulates cell signaling and melanogenesis.Formula:C8H8O3Purezza:99.75%Colore e forma:SolidPeso molecolare:152.15Butein
CAS:Butein is a cAMP-specific PDE inhibitor, protein tyrosine kinase inhibitor, and SIRT1 activator.Cost-effective and quality-assured.Formula:C15H12O5Purezza:98.76% - >99.99%Colore e forma:Yellow SolidPeso molecolare:272.25Ref: TM-T6427
1mg40,00€2mg52,00€1mL*10mM (DMSO)82,00€5mg84,00€10mg101,00€25mg202,00€50mg326,00€100mg520,00€Pachymic acid
CAS:Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways.Formula:C33H52O5Purezza:99.43% - >99.99%Colore e forma:White PowderPeso molecolare:528.76β-Neoendorphin acetate(77739-21-0 free base)
CAS:beta-Neoendorphin acetate is an agonist of κ-opioid receptorFormula:C56H81N13O14Purezza:99.91%Colore e forma:SolidPeso molecolare:1160.34GRK5-IN-2
CAS:GRK5-IN-2, a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor.Formula:C20H20N4O4Purezza:99.92%Colore e forma:SolidPeso molecolare:380.4Ref: TM-T9609
2mg34,00€5mg52,00€1mL*10mM (DMSO)52,00€10mg75,00€25mg138,00€50mg215,00€100mg318,00€200mg444,00€6-OAU
CAS:6-OAU is a GPR84 agonist, activates it in HEK293 cells with a 105 nM EC50.Formula:C12H21N3O2Purezza:99.01% - 99.77%Colore e forma:White SolidPeso molecolare:239.31Ref: TM-T2036
1mg152,00€2mg203,00€1mL*10mM (DMSO)285,00€5mg313,00€10mg447,00€25mg713,00€50mg1.018,00€100mg1.369,00€Nitidine chloride
CAS:1.Formula:C21H18ClNO4Purezza:96.59% - 99.55%Colore e forma:SolidPeso molecolare:383.82XMD17-109
CAS:XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).Formula:C36H46N8O3Purezza:98.75% - 99.7%Colore e forma:White SolidPeso molecolare:638.8Ref: TM-T1842
1mg39,00€2mg50,00€5mg82,00€1mL*10mM (DMSO)104,00€10mg137,00€25mg210,00€50mg339,00€100mg510,00€DCLK1-IN-1
CAS:DCLK1-IN-1 is a selective, in vivo compatible chemical probe of the kinase domain of doublecortin-like kinase 1 (DCLK1).Cost-effective and quality-assured.Formula:C26H28F3N7O2Purezza:98.77% - 99.28%Colore e forma:Yellow SolidPeso molecolare:527.54AG126
CAS:AG126 (Tyrphostin AG126) selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42). AG-126 weakly inhibits epidermal GFRK and platelet-derived GFRK.Formula:C10H5N3O3Purezza:97.35%Colore e forma:SolidPeso molecolare:215.16ASP2453
CAS:ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C.Formula:C40H48F3N7O4Purezza:99.71%Colore e forma:SolidPeso molecolare:747.85Epieriocalyxin A
CAS:Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.Formula:C20H24O5Purezza:97.00%Colore e forma:SolidPeso molecolare:344.4Avatrombopag maleate
CAS:Avatrombopag (AKR-501/E5501) is an oral TPO receptor agonist for thrombocytopenia treatment, approved in 2018.Formula:C33H38Cl2N6O7S2Colore e forma:SolidPeso molecolare:765.72DMU-212
CAS:DMU-212, a Resveratrol derivative, has antimitotic, antiproliferative, antioxidant properties; induces apoptosis via ERK1/2.Formula:C18H20O4Purezza:99.86%Colore e forma:SolidPeso molecolare:300.35Ref: TM-T36674
2mg34,00€5mg50,00€1mL*10mM (DMSO)56,00€10mg84,00€25mg152,00€50mg259,00€100mg385,00€500mg873,00€SUN11602
CAS:SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.Formula:C26H37N5O2Purezza:98.06%Colore e forma:SolidPeso molecolare:451.6RU-301
CAS:RU-301 is a novel pan-tam inhibitorFormula:C21H19F3N4O4SPurezza:98.87%Colore e forma:SolidPeso molecolare:480.46Ref: TM-T7425
1mg98,00€5mg222,00€1mL*10mM (DMSO)241,00€10mg344,00€25mg587,00€50mg803,00€100mg1.063,00€ERK-IN-3
CAS:ERK-IN-3 (ASN007 free base) is a potent and orally active inhibitor of ERK.Formula:C22H25ClFN7O2Purezza:99.76% - 99.81%Colore e forma:White SolidPeso molecolare:473.93Milnacipran
CAS:Milnacipran, an SNRI with 85% bioavailability, treats fibromyalgia and is well absorbed orally.Formula:C15H22N2OColore e forma:SolidPeso molecolare:246.35Methylnissolin
CAS:Methylnissolin (3-Hydroxy-9,10-dimethoxyptercarpan) is derived from Astragalus and has antibacterial and anti-cancer effects.Formula:C17H16O5Purezza:99.68% - 99.98%Colore e forma:SolidPeso molecolare:300.31SHP099
CAS:SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cellsFormula:C16H19Cl2N5Purezza:98.73% - 99.4%Colore e forma:SolidPeso molecolare:352.26Ref: TM-T3564
1mg34,00€2mg49,00€1mL*10mM (DMSO)57,00€5mg74,00€10mg94,00€25mg165,00€50mg213,00€100mg388,00€EF24
CAS:EF24 treatment boosts caspase 3/9 activity, hinders MEK1/ERK phosphorylation, and exhibits strong anti-tumor effects in OSCC by deactivating MAPK/ERK.Formula:C19H15F2NOPurezza:99.71%Colore e forma:SolidPeso molecolare:311.33Ref: TM-T27242
1mg38,00€5mg80,00€1mL*10mM (DMSO)88,00€10mg126,00€25mg222,00€50mg334,00€100mg505,00€500mg1.071,00€1g1.431,00€Deltonin
CAS:Deltonin inhibits ERK1/2 & AKT; toxic to HepG2 (IC50: 7.66μM), C26 (IC50: 1.22μM), MDA-MB-231 cells (IC50: 1.58μM).Formula:C45H72O17Purezza:98.77% - 99.79%Colore e forma:SolidPeso molecolare:885.04trans-Zeatin
CAS:trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrientFormula:C10H13N5OPurezza:97.13% - 98.96%Colore e forma:White SolidPeso molecolare:219.24Ref: TM-TMS2181
1mL*10mM (DMSO)33,00€10mg37,00€25mg52,00€50mg66,00€100mg96,00€200mg128,00€500mg205,00€Ravoxertinib
CAS:Ravoxertinib (GDC-0994) is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM).Formula:C21H18ClFN6O2Purezza:98% - 99.87%Colore e forma:SolidPeso molecolare:440.86Ref: TM-T6511
1mg38,00€2mg49,00€5mg80,00€1mL*10mM (DMSO)88,00€10mg90,00€25mg164,00€50mg268,00€100mg399,00€Bohemine
CAS:Bohemine is a cyclin-dependent kinase inhibitor.Formula:C18H24N6OPurezza:99.09% - 99.53%Colore e forma:SolidPeso molecolare:340.42Prosaptide TX14(A) acetate
Prosaptide TX14(A) acetate is a potent GPR37L1 and GPR37 agonist. Prosaptide Tx14(A) TFA increases both ERK1 and ERK2 phosphorylation in Schwann cells.Formula:C71H114N16O28Purezza:95.29%Colore e forma:SolidPeso molecolare:1639.76Tauroursodeoxycholate sodium
CAS:Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.Formula:C26H44NNaO6SPurezza:97.90%Colore e forma:SolidPeso molecolare:521.69
