p38 MAPK
Le p38 MAPK sono un sottogruppo di MAPK che rispondono ai segnali di stress e sono coinvolte nella regolazione dell'infiammazione, della differenziazione cellulare, dell'apoptosi e dell'autofagia. La segnalazione delle p38 MAPK è cruciale nelle risposte immunitarie ed è implicata in varie malattie, tra cui condizioni infiammatorie croniche, cancro e disturbi neurodegenerativi. Presso CymitQuimica, offriamo una gamma completa di inibitori e modulatori delle p38 MAPK per supportare la tua ricerca sull'infiammazione, la risposta allo stress e lo sviluppo terapeutico.
Trovati 117 prodotti di "p38 MAPK"
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p38α inhibitor 5
CAS:<p>The compound p38α inhibitor5 (compound 1) is a PROTAC-type ligand that targets p38 and is utilized in the synthesis of NR-11c.</p>Formula:C26H23BrF2N2O3Colore e forma:SolidPeso molecolare:529.37Z16078526
CAS:<p>Z16078526 promotes Ucp1, p38 MAPK, lipolysis, thermogenic genes, and mitochondrial activity in mouse brown adipocytes.</p>Formula:C18H17N3O4SPurezza:98.93%Colore e forma:SolidPeso molecolare:371.41p38α inhibitor 3
CAS:<p>p38α inhibitor 3 is a inhibitor of the mitogen-activated protein kinase p38α that can block the effectiveness of myoblast differentiation.</p>Formula:C19H20FNOPurezza:99.94%Colore e forma:SoildPeso molecolare:297.37p38 MAP Kinase Inhibitor Ⅵ
CAS:p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.Formula:C16H13FN2OS2Purezza:98.53%Colore e forma:SolidPeso molecolare:332.42PDE4-IN-26
<p>PDE4-IN-26 (Compound A5) is an orally active, highly selective inhibitor of PDE4. It exhibits anti-inflammatory properties by inhibiting p38 MAPK phosphorylation. In mouse models of acute lung injury and chronic obstructive pulmonary disease, PDE4-IN-26 reduces lung inflammation, damage, and fibrosis, while promoting sputum secretion and alleviating cough. It is useful for researching lung injury-related diseases.</p>Formula:C22H18F2N4O3SColore e forma:SolidPeso molecolare:456.47WYE-687
CAS:<p>WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).</p>Formula:C28H32N8O3Purezza:99.93%Colore e forma:SolidPeso molecolare:528.61R1487 Hydrochloride
CAS:<p>R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38α.</p>Formula:C19H19ClF2N4O3Purezza:99.42%Colore e forma:SolidPeso molecolare:424.83Adezmapimod
CAS:<p>Adezmapimod (SB 203580) is a p38 MAPK inhibitor (IC50=0.3-0.5 μM) that is selective and ATP-competitive.</p>Formula:C21H16FN3OSPurezza:99.42% - 99.93%Colore e forma:White SolidPeso molecolare:377.43Talmapimod
CAS:<p>Talmapimod (SCIO-469): Oral ATP-competitive p38α inhibitor, IC50 = 9 nM (p38α), 90 nM (p38β), >2000-fold selectivity over 20 kinases.</p>Formula:C27H30ClFN4O3Purezza:98% - 99.9%Colore e forma:SolidPeso molecolare:513SB 202190
CAS:<p>SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 (IC50=50/100 nM) selectively and cell-permeably.</p>Formula:C20H14FN3OPurezza:98% - 99.84%Colore e forma:Pale YellowPeso molecolare:331.34BMS582949
CAS:<p>BMS-582949 inhibits p38 MAPK with 13 nM IC50, blocking kinase activity and activation.</p>Formula:C22H26N6O2Purezza:98.11%Colore e forma:SolidPeso molecolare:406.48Andrograpanin
CAS:<p>Andrograpanin (19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE) is a bioactive compound from Andrographis paniculata.</p>Formula:C20H30O3Purezza:99.03% - 99.457%Colore e forma:SolidPeso molecolare:318.45UM-164
CAS:<p>UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.</p>Formula:C30H31F3N8O3SPurezza:98.72% - 99.52%Colore e forma:SolidPeso molecolare:640.68ASK1-IN-1
CAS:<p>ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.</p>Formula:C19H19N9O2Purezza:99.92%Colore e forma:SolidPeso molecolare:405.41Cornuside
CAS:<p>Cornuside boosts immunity, reduces inflammation, protects heart and liver, and guards against brain injury by modulating stress responses.</p>Formula:C24H30O14Purezza:99.86% - >99.99%Colore e forma:SolidPeso molecolare:542.49Rotundic acid
CAS:<p>Rotundic acid fights various cancers: HepG2, A375, NCI-H446, MCF-7, and HT-29.</p>Formula:C30H48O5Purezza:96.91% - 99.97%Colore e forma:SolidPeso molecolare:488.7FERULIC ACID METHYL ESTER
CAS:<p>FERULIC ACID METHYL ESTER (Methyl ferulate) is a hydroxycinnamic acid that is abundant in plants. FERULIC ACID METHYL ESTER has antioxidant activities.</p>Formula:C11H12O4Purezza:99.66% - 99.95%Colore e forma:SolidPeso molecolare:208.21Gypenoside L
CAS:<p>Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.</p>Formula:C42H72O14Purezza:99.42% - 99.65%Colore e forma:SolidPeso molecolare:801.01Pexmetinib
CAS:<p>Pexmetinib (ARRY-614) is an orally bioavailable dual p38 MAPK/Tie-2 inhibitor.Cost-effective and quality-assured.</p>Formula:C31H33FN6O3Purezza:99.07% - 99.66%Colore e forma:SolidPeso molecolare:556.63SB 239063
CAS:<p>SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.</p>Formula:C20H21FN4O2Purezza:99.42% - 99.81%Colore e forma:SolidPeso molecolare:368.4
