p38 MAPK
Le p38 MAPK sono un sottogruppo di MAPK che rispondono ai segnali di stress e sono coinvolte nella regolazione dell'infiammazione, della differenziazione cellulare, dell'apoptosi e dell'autofagia. La segnalazione delle p38 MAPK è cruciale nelle risposte immunitarie ed è implicata in varie malattie, tra cui condizioni infiammatorie croniche, cancro e disturbi neurodegenerativi. Presso CymitQuimica, offriamo una gamma completa di inibitori e modulatori delle p38 MAPK per supportare la tua ricerca sull'infiammazione, la risposta allo stress e lo sviluppo terapeutico.
Trovati 129 prodotti per "p38 MAPK".
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OVA-E1 peptide TFA
CAS:OVA-E1 peptide TFA activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.Formula:C49H77F3N10O16Purezza:98%Colore e forma:SolidPeso molecolare:1119.1884MAP3K5-IN-1
CAS:Compound 7, also known as 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine, serves as an inhibitor of protein kinases, displaying IC50 values of 0.092 μM for PKC-α, 0.26 μM for ROCK, and 0.77 μM for ASK1. Additionally, this compound exhibits significant cytotoxicity towards PC-3 cancer cells, with an IC50 of 0.16 μM [1].Formula:C28H24N4O4Colore e forma:SolidPeso molecolare:480.51Klotho-derived peptide 1 hydrochloride
Klotho-derived peptide 1 (KP1 human) hydrochloride inhibits the interaction between TGF-β and TGF-β receptor 2, suppressing the activation of TGF-β-induced Smad2/3 and mitogen-activated protein kinase (MAPK). Additionally, it exhibits antifibrotic and renal protective effects in mouse models.Colore e forma:Odour SolidCyclotraxin B
CAS:TrkB receptor antagonist; inhibits BDNF-TrkB signaling (IC50 = 0.30 nM); alters receptor shape; may reduce anxiety in mice.Formula:C48H73N13O17S3Purezza:98%Colore e forma:SolidPeso molecolare:1200.36NR-11c
NR-11c is a selective and potent p38α PROTAC degrader. It effectively degrades p38α in various tumor cells. When administered to mice via intraperitoneal or tail vein injection, NR-11c primarily acts in the liver. It is used for cancer research.Formula:C59H71BrF2N10O8SColore e forma:SolidPeso molecolare:1198.22Talmapimod hydrochloride
CAS:Talmapimod hydrochloride: selective p38α inhibitor, 9 nM IC50, 10x less effective on p38β, >2000-fold selective vs 20+ kinases.Formula:C27H31Cl2FN4O3Purezza:98%Colore e forma:SolidPeso molecolare:549.46R1487 Hydrochloride
CAS:R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38α.Formula:C19H19ClF2N4O3Purezza:99.35% - 99.42%Colore e forma:Yellow SolidPeso molecolare:424.829Urolithin A
CAS:Applications Urolithin A is a major metabolite of ellagitannin and exhibits anti-inflammatory and antioxidant properties.
References Ishimoto, H., et. al.: Bioorg. Med. Chem. Lett., 21, 5901 (2011);Formula:C13H8O4Colore e forma:NeatPeso molecolare:228.2CAL-101
CAS:Prodotto controllatoApplications CAL-101 is a PI3K/mTOR pathway inhibitor used in the treatment of myeloid leukemia through sensitizing the cells to combatting drugs. Potent PI3K-p110-delta inhibitor.
References Airiau, K. et al.: Cell. Death. Dis., 4, e827 (2013); Kulesz-Martin, M. et al Canc. Biol. Ther., 14m 95 (2013);Formula:C22H18FN7OColore e forma:NeatPeso molecolare:415.4SB-203580
CAS:Prodotto controllatoStability -200C
Applications A pyridinyl imidazole which acts as a specific inhibitor of p38 MAP kinase. Does not inhibit the MAP kinase homologs JNK and p42 MAP kinase.
References Kawasaki, H., et al.: J. Biol. Chem., 272, 18518 (1997), Ward, S.G., et al.: Biochem. Soc. Trans., 245, 304S (1997), Clerk, A., et al.: FEBS Lett., 426, 93 (1998),Formula:C21H16FN3OSColore e forma:NeatPeso molecolare:377.43Wortmannin
CAS:Prodotto controllatoApplications Wortmannin is a phosphatidylinositol 3 kinase (PI3K) inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Liberman R., et. al.: J. Biol. Chem., 289, 1355 (2014)Formula:C23H24O8Colore e forma:NeatPeso molecolare:428.43Sertaconazole
CAS:Sertaconazole is a broad-spectrum antifungal.Formula:C20H15Cl3N2OSPurezza:99.48%Colore e forma:White SolidPeso molecolare:437.77UM-164
CAS:UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.Formula:C30H31F3N8O3SPurezza:98.72% - 99.52%Colore e forma:SolidPeso molecolare:640.679Sertaconazole nitrate
CAS:Sertaconazole nitrate, a broad-spectrum topical antifungal, treats skin and mucosal infections.Formula:C20H16Cl3N3O4SPurezza:98.66% - 99.65%Colore e forma:SolidPeso molecolare:500.783Pexmetinib
CAS:Pexmetinib (ARRY-614) is an orally bioavailable dual p38 MAPK/Tie-2 inhibitor.Cost-effective and quality-assured.Formula:C31H33FN6O3Purezza:99.07% - 99.66%Colore e forma:SolidPeso molecolare:556.6305BMS-582949 hydrochloride
CAS:The BMS-582949 hydrochloride (BMS-582949 HCl) is a highly specific p38α MAPK inhibitor (IC50: 13 nM).Formula:C22H27ClN6O2Purezza:97.57% - 98.75%Colore e forma:White SolidPeso molecolare:442.942Gypenoside L
CAS:Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.Formula:C42H72O14Purezza:99.42% - 99.65%Colore e forma:SolidPeso molecolare:801.0127Cornuside
CAS:Cornuside boosts immunity, reduces inflammation, protects heart and liver, and guards against brain injury by modulating stress responses.Formula:C24H30O14Purezza:99.86% - >99.99%Colore e forma:SolidPeso molecolare:542.4866
