p38 MAPK
Le p38 MAPK sono un sottogruppo di MAPK che rispondono ai segnali di stress e sono coinvolte nella regolazione dell'infiammazione, della differenziazione cellulare, dell'apoptosi e dell'autofagia. La segnalazione delle p38 MAPK è cruciale nelle risposte immunitarie ed è implicata in varie malattie, tra cui condizioni infiammatorie croniche, cancro e disturbi neurodegenerativi. Presso CymitQuimica, offriamo una gamma completa di inibitori e modulatori delle p38 MAPK per supportare la tua ricerca sull'infiammazione, la risposta allo stress e lo sviluppo terapeutico.
Trovati 115 prodotti per "p38 MAPK".
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p38α inhibitor 5
CAS:The compound p38α inhibitor5 (compound 1) is a PROTAC-type ligand that targets p38 and is utilized in the synthesis of NR-11c.Formula:C26H23BrF2N2O3Colore e forma:SolidPeso molecolare:529.37NR 7h
Potent p38α/β degrader, DC50 < 50 nM; spares p38γ/δ, JNK1/2, ERK1/2. Inhibits MK2 in cancer cells & BMDM. Mimics p38α knockout, active in vivo.Colore e forma:Solidp38 MAP Kinase Inhibitor Ⅵ
CAS:p38 MAP Kinase Inhibitor Ⅵ is a potent p38 MAP Kinase inhibitor with anti-inflammatory activity.Formula:C16H13FN2OS2Purezza:98.53%Colore e forma:Yellow SolidPeso molecolare:332.42Klotho-derived peptide 1 hydrochloride
Klotho-derived peptide 1 (KP1 human) hydrochloride inhibits the interaction between TGF-β and TGF-β receptor 2, suppressing the activation of TGF-β-induced Smad2/3 and mitogen-activated protein kinase (MAPK). Additionally, it exhibits antifibrotic and renal protective effects in mouse models.Colore e forma:Odour SolidDB-10
DB-10 serves as a precursor to 3-nbutylphthalide (NBP). It is absorbed by cells in a temperature and energy-dependent manner through the pyrilamine cation transporter. DB-10 enhances cell survival and rapidly converts into an active form in vivo, increasing accumulation within the brain. This compound is applicable in ischemic stroke research.Colore e forma:Odour SolidNR-11c
NR-11c is a selective and potent p38α PROTAC degrader. It effectively degrades p38α in various tumor cells. When administered to mice via intraperitoneal or tail vein injection, NR-11c primarily acts in the liver. It is used for cancer research.Formula:C59H71BrF2N10O8SColore e forma:SolidPeso molecolare:1198.22OVA-E1 peptide TFA
CAS:OVA-E1 peptide TFA activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.Formula:C49H77F3N10O16Purezza:98%Colore e forma:SolidPeso molecolare:1119.19R1487 Hydrochloride
CAS:R1487 Hydrochloride (R1487 (Hydrochloride)) is an orally bioavailable and highly selective inhibitors of p38α.Formula:C19H19ClF2N4O3Purezza:99.35% - 99.42%Colore e forma:Yellow SolidPeso molecolare:424.83Adezmapimod
CAS:Adezmapimod (SB 203580) is a p38 MAPK inhibitor (IC50=0.3-0.5 μM) that is selective and ATP-competitive.Formula:C21H16FN3OSPurezza:99.42% - 99.93%Colore e forma:SolidPeso molecolare:377.43ASK1-IN-1
CAS:ASK1-IN-1 inhibits apoptosis kinase 1, crucial in cell stress responses, with 21 nM IC50.Formula:C19H19N9O2Purezza:99.92%Colore e forma:White SolidPeso molecolare:405.41Pexmetinib
CAS:Pexmetinib (ARRY-614) is an orally bioavailable dual p38 MAPK/Tie-2 inhibitor.Cost-effective and quality-assured.Formula:C31H33FN6O3Purezza:99.07% - 99.66%Colore e forma:SolidPeso molecolare:556.63BMS-582949 hydrochloride
CAS:The BMS-582949 hydrochloride (BMS-582949 HCl) is a highly specific p38α MAPK inhibitor (IC50: 13 nM).Formula:C22H27ClN6O2Purezza:97.57% - 98.75%Colore e forma:White SolidPeso molecolare:442.95Ref: TM-T3462
1mg34,00€5mg67,00€1mL*10mM (DMSO)73,00€10mg96,00€25mg161,00€50mg250,00€100mg371,00€200mg523,00€Andrograpanin
CAS:Andrograpanin (19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE) is a bioactive compound from Andrographis paniculata.Formula:C20H30O3Purezza:99.03% - 99.45%Colore e forma:SolidPeso molecolare:318.45UM-164
CAS:UM-164 (DAS-DFGO-II), a highly potent c-Src inhibitor with a dissociation constant (Kd) of 2.7 nM, also effectively inhibits p38α and p38β.Formula:C30H31F3N8O3SPurezza:98.72% - 99.52%Colore e forma:SolidPeso molecolare:640.68FERULIC ACID METHYL ESTER
CAS:FERULIC ACID METHYL ESTER (Methyl ferulate) is a hydroxycinnamic acid that is abundant in plants. FERULIC ACID METHYL ESTER has antioxidant activities.Formula:C11H12O4Purezza:99.66% - 99.95%Colore e forma:SolidPeso molecolare:208.21Sertaconazole nitrate
CAS:Sertaconazole nitrate, a broad-spectrum topical antifungal, treats skin and mucosal infections.Formula:C20H15Cl3N2OS·HNO3Purezza:98.66% - 99.65%Colore e forma:SolidPeso molecolare:500.78Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.Formula:C51H82O21Purezza:99.57% - 99.63%Colore e forma:SolidPeso molecolare:1031.18R1487
CAS:R1487 is an orally bioavailable and highly selective p38α mitogen-activated protein kinase inhibitor.Formula:C19H18F2N4O3Purezza:99.77%Colore e forma:SolidPeso molecolare:388.37SR-318
CAS:SR-318 inhibits TNF-α (IC50=283 nM), selectively targets p38 MAPK: IC50 of 5nM (p38α), 32nM (p38β), 6.11μM (p38α/β).Formula:C27H33N5O2Purezza:99.74%Colore e forma:SolidPeso molecolare:459.58Ref: TM-T12997
2mg35,00€5mg55,00€1mL*10mM (DMSO)55,00€10mg92,00€25mg166,00€50mg259,00€100mg371,00€200mg533,00€Cornuside
CAS:Cornuside boosts immunity, reduces inflammation, protects heart and liver, and guards against brain injury by modulating stress responses.Formula:C24H30O14Purezza:99.86% - >99.99%Colore e forma:SolidPeso molecolare:542.49
