Raf
Le chinasi Raf sono componenti chiave della via di segnalazione MAPK/ERK, svolgendo un ruolo critico nella trasmissione dei segnali dalla membrana cellulare al nucleo. L'attivazione di Raf porta alla fosforilazione di MEK, che successivamente attiva ERK, influenzando la divisione, la differenziazione e la sopravvivenza cellulare. Le mutazioni in Raf, in particolare in B-Raf, sono associate a vari tipi di cancro, rendendo Raf un bersaglio cruciale nella terapia del cancro. Presso CymitQuimica, offriamo una varietà di inibitori e modulatori di Raf per supportare la tua ricerca in oncologia, trasduzione del segnale e sviluppo terapeutico.
Trovati 82 prodotti di "Raf"
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Anti-Phospho-RAF1 (Ser259) Antibody (5X237)
<p>Anti-Phospho-RAF1 (Ser259) Antibody (5X237) is an antibody targeting Phospho-RAF1 (Ser259). Anti-Phospho-RAF1 (Ser259) Antibody (5X237) can be used in ELISA, WB, IHC, IF.</p>Colore e forma:Odour LiquidRAS GTPase inhibitor 1
CAS:RAS GTPase inhibitor 1 is a RAS GTPase inhibitor with potential antitumor activity.Formula:C27H28ClF4N5O2Purezza:98.43%Colore e forma:SolidPeso molecolare:565.99Regorafenib
CAS:Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orallyFormula:C21H15ClF4N4O3Purezza:98% - 99.95%Colore e forma:SolidPeso molecolare:482.82PLX8394
CAS:<p>Plixorafenib (PLX8394) is an orally active inhibitor of the serine/threonine protein kinase B-Raf (BRAF) protein.Cost-effective and quality-assured.</p>Formula:C25H21F3N6O3SPurezza:98.75% - >99.99%Colore e forma:SolidPeso molecolare:542.53L-779450
CAS:L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.Formula:C20H14ClN3OPurezza:≥95%Colore e forma:SolidPeso molecolare:347.8Takeda-6d
CAS:Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.Formula:C27H19ClFN5O3SPurezza:98.27%Colore e forma:SolidPeso molecolare:547.99GW 5074
CAS:GW 5074 (Raf1 Kinase Inhibitor I)(IC50=9 nM) is an effective and specific c-Raf inhibitor.Formula:C15H8Br2INO2Purezza:99.32%Colore e forma:SolidPeso molecolare:520.94PLX-4720
CAS:PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.Formula:C17H14ClF2N3O3SPurezza:97.78% - 99.83%Colore e forma:SolidPeso molecolare:413.83AZ304
CAS:<p>AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).</p>Formula:C27H25N5O2Purezza:99.82%Colore e forma:SolidPeso molecolare:451.52Encorafenib
CAS:Encorafenib (LGX818) is an orally available mutated BRaf V600E inhibitor(IC50=0.3 nM) with potential antineoplastic activity.Formula:C22H27ClFN7O4SPurezza:99.51% - 99.83%Colore e forma:SolidPeso molecolare:540.01Raf inhibitor 2
CAS:Raf inhibitor 2 (CID 25014542) is novel inhibitor of Raf kinases.Formula:C15H8Br2ClNO2Purezza:98.53%Colore e forma:SolidPeso molecolare:429.49Kobe2602
CAS:Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities.Formula:C14H9F4N5O4SPurezza:98.36% - 99.39%Colore e forma:SolidPeso molecolare:419.31Regorafenib monohydrate
CAS:<p>Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine</p>Formula:C21H17ClF4N4O4Purezza:99.69%Colore e forma:SolidPeso molecolare:500.83ZM 336372
CAS:ZM 336372 is a potent and selective c-Raf inhibitor.Formula:C23H23N3O3Purezza:97.24% - 97.51%Colore e forma:SolidPeso molecolare:389.45Plx-4032
CAS:Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.Formula:C23H18ClF2N3O3SPurezza:98.53% - 99.36%Colore e forma:SolidPeso molecolare:489.92SB-590885
CAS:SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay).Formula:C27H27N5O2Purezza:95.42% - 99.06%Colore e forma:SolidPeso molecolare:453.54AD80
CAS:AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.Formula:C22H19F4N7OPurezza:99.49% - 99.75%Colore e forma:SolidPeso molecolare:473.43K-Ras(G12C) inhibitor 9
CAS:K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).Formula:C16H21ClIN3O4SPurezza:97.33% - 97.45%Colore e forma:SolidPeso molecolare:513.78BI-882370
CAS:BI-882370 is a specific RAF kinase inhibitor.Formula:C28H33F2N7O2SPurezza:97.33% - 99.07%Colore e forma:SolidPeso molecolare:569.67RAF265
CAS:RAF265 (CHIR-265) inhibits C-Raf/B-Raf/V600E (IC50: 3-60 nM), blocks VEGFR2 (EC50: 30 nM), in Phase 2 trials.Formula:C24H16F6N6OPurezza:99.56%Colore e forma:SolidPeso molecolare:518.41
