Raf
Le chinasi Raf sono componenti chiave della via di segnalazione MAPK/ERK, svolgendo un ruolo critico nella trasmissione dei segnali dalla membrana cellulare al nucleo. L'attivazione di Raf porta alla fosforilazione di MEK, che successivamente attiva ERK, influenzando la divisione, la differenziazione e la sopravvivenza cellulare. Le mutazioni in Raf, in particolare in B-Raf, sono associate a vari tipi di cancro, rendendo Raf un bersaglio cruciale nella terapia del cancro. Presso CymitQuimica, offriamo una varietà di inibitori e modulatori di Raf per supportare la tua ricerca in oncologia, trasduzione del segnale e sviluppo terapeutico.
Trovati 81 prodotti per "Raf".
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BI-882370
CAS:BI-882370 is a specific RAF kinase inhibitor.Formula:C28H33F2N7O2SPurezza:97.33% - 99.07%Colore e forma:SolidPeso molecolare:569.67K-Ras(G12C) inhibitor 9
CAS:K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).Formula:C16H21ClIN3O4SPurezza:97.33% - 97.45%Colore e forma:SolidPeso molecolare:513.78Ref: TM-T6556
1mg34,00€5mg78,00€10mg108,00€1mL*10mM (DMSO)108,00€25mg215,00€50mg311,00€100mg425,00€200mg597,00€SB-590885
CAS:SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay).Formula:C27H27N5O2Purezza:95.42% - 99.06%Colore e forma:SolidPeso molecolare:453.54Plx-4032
CAS:Plx-4032 (Vemurafenib) is a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma.Formula:C23H18ClF2N3O3SPurezza:98.53% - 99.94%Colore e forma:SolidPeso molecolare:489.92Regorafenib
CAS:Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orallyFormula:C21H15ClF4N4O3Purezza:98% - 99.95%Colore e forma:SolidPeso molecolare:482.82Ref: TM-T1792
5mg34,00€1mL*10mM (DMSO)35,00€10mg49,00€25mg75,00€50mg90,00€100mg137,00€200mg175,00€500mg294,00€L-779450
CAS:L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.Formula:C20H14ClN3OPurezza:98.48%Colore e forma:SolidPeso molecolare:347.8PLX-4720
CAS:PLX-4720 is a potent and selective B-Raf (V600E) inhibitor designed to block the ATP-binding site of oncogenic B-Raf.Cost-effective and quality-assured.Formula:C17H14ClF2N3O3SPurezza:97.78% - 99.96%Colore e forma:White SolidPeso molecolare:413.83CCT196969
CAS:CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.Formula:C27H24FN7O3Purezza:98.93% - 99.65%Colore e forma:SolidPeso molecolare:513.52Belvarafenib
CAS:Belvarafenib (HM95573) is a potent pan-RAF inhibitor with antitumor activity and inhibits B-RAF, B-RAFv600E, and C-RAF.Cost-effective and quality-assured.Formula:C23H16ClFN6OSPurezza:98% - 99.65%Colore e forma:Yellow SolidPeso molecolare:478.93I-49 free base
I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novelFormula:C23H26ClF3N4O2Purezza:99.64% - 99.88%Colore e forma:Yellow SolidPeso molecolare:482.92B-Raf IN 1
CAS:B-Raf IN 1 is a B-Raf (IC50: 24 nM) and c-Raf (IC50: 25 nM) inhibitor.Formula:C29H24F3N5OPurezza:97.22% - 99.27%Colore e forma:SolidPeso molecolare:515.53Ref: TM-T1845
1mg87,00€2mg113,00€5mg177,00€1mL*10mM (DMSO)210,00€10mg313,00€25mg530,00€50mg757,00€100mg1.044,00€Vemurafenib
CAS:Vemurafenib (RG7204) is a B-RAF inhibitor that inhibits RAFV600E and c-RAF-1 (IC50=31/48 nM) selectively and potently.Formula:C23H18ClF2N3O3SPurezza:98% - 99.65%Colore e forma:SolidPeso molecolare:489.92LY3009120
CAS:LY3009120 (DP-4978) is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. Phase 1.Formula:C23H29FN6OPurezza:96.96% - ≥95%Colore e forma:Yellow SolidPeso molecolare:424.51PROTAC BRAF-V600E degrader-1
CAS:PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.Formula:C48H54F2N10O10SPurezza:99.43%Colore e forma:SolidPeso molecolare:1001.07KRPEP-2D acetate
KRPEP-2D acetate: inhibitor targeting K-Ras(G12D) mutant, a crucial cancer-related protein.Formula:C110H186N44O27S2Purezza:99.34%Colore e forma:SolidPeso molecolare:2621.06Dabrafenib Mesylate
CAS:Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).Formula:C24H24F3N5O5S3Purezza:99.45% - 99.82%Colore e forma:SolidPeso molecolare:615.67Doramapimod
CAS:Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.Formula:C31H37N5O3Purezza:97.14% - 98.80%Colore e forma:SolidPeso molecolare:527.66Ref: TM-T6277
5mg34,00€1mL*10mM (DMSO)42,00€10mg52,00€25mg74,00€50mg96,00€100mg120,00€200mg213,00€500mg359,00€1g532,00€TAK-580
CAS:TAK-580 (MLN2480) is an oral, selective pan-Raf kinase inhibitor in Clinicalal trials.Formula:C17H12Cl2F3N7O2SPurezza:99.60% - 99.77%Colore e forma:White SolidPeso molecolare:506.29Regorafenib Hydrochloride
CAS:Regorafenib HCl (BAY73-4506) is an oral inhibitor targeting angiogenic, stromal, and cancer kinases with strong antitumor effects.Formula:C21H16Cl2F4N4O3Purezza:99.56%Colore e forma:SolidPeso molecolare:519.28AZ 628
CAS:AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.Formula:C27H25N5O2Purezza:99.50%Colore e forma:SolidPeso molecolare:451.52
