Canale del potassio
I canali del potassio sono un gruppo diversificato di proteine di membrana che facilitano il flusso di ioni potassio (K+) attraverso la membrana cellulare. Questi canali svolgono un ruolo cruciale nel mantenimento del potenziale di membrana a riposo, nella regolazione del volume cellulare e nel controllo dell'eccitabilità dei neuroni e delle cellule muscolari. I canali del potassio sono coinvolti in vari processi fisiologici, tra cui la regolazione del ritmo cardiaco, la secrezione di insulina e il rilascio di neurotrasmettitori. La disfunzione dei canali del potassio è legata a condizioni come aritmie, epilessia e ipertensione. Presso CymitQuimica, offriamo una vasta gamma di modulatori dei canali del potassio per supportare la tua ricerca in elettrofisiologia, salute cardiovascolare e neurobiologia.
Trovati 283 prodotti di "Canale del potassio"
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GW9508
CAS:GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner.
Formula:C22H21NO3Purezza:97.89% - 99.19%Colore e forma:SolidPeso molecolare:347.41JNJ 303
CAS:JNJ 303 is a potent blocker of IKs (IC50 : 64 nM).Formula:C21H29ClN2O4SPurezza:99.28%Colore e forma:SolidPeso molecolare:440.98Ref: TM-T7653
1mg48,00€2mg65,00€5mg89,00€10mg147,00€25mg325,00€50mg472,00€100mg705,00€1mL*10mM (DMSO)92,00€TRAM-34
CAS:TRAM-34 (Triarylmethane-34), an effective and specific inhibitor of the intermediate-conductance Ca2+-activated K+ channel, does not block cytochrome P450.
Formula:C22H17ClN2Purezza:99.01% - 99.91%Colore e forma:SolidPeso molecolare:344.84ML335
CAS:ML335 is a selective activator of TREK-1 and TREK-2.Formula:C15H14Cl2N2O3SPurezza:99.73% - 99.79%Colore e forma:SolidPeso molecolare:373.25Ref: TM-T4224
2mg43,00€5mg63,00€10mg95,00€25mg187,00€50mg283,00€100mg424,00€200mg612,00€1mL*10mM (DMSO)63,00€Loureirin B
CAS:Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.Formula:C18H20O5Purezza:99.33% - 99.86%Colore e forma:SolidPeso molecolare:316.35SKA-31
CAS:SKA-31 (Naphtho[1,2-d]thiazol-2-ylamine) is an activator of KCa3.1 and KCa2 channels (EC50s: 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively).Formula:C11H8N2SPurezza:99.38%Colore e forma:SolidPeso molecolare:200.26Senicapoc
CAS:Senicapoc (ICA-17043) blocks Gardos channel, reduces RBC dehydration, IC50: 11 nM for rubidium flux, 30 nM for dehydration. Used in Sickle Cell therapy.Formula:C20H15F2NOPurezza:95.7% - 99.47%Colore e forma:SolidPeso molecolare:323.34Mitiglinide calcium hydrate
CAS:Mitiglinide calcium hydrate (S-21403 calcium hydrate) is a drug for the treatment of type 2 diabetes.Formula:C38H52CaN2O8Purezza:98.97% - 99.96%Colore e forma:White SolidPeso molecolare:704.91A2793
CAS:A2793 is a dual inhibitor of TWIK-associated acid-sensitive K+ channel 1 (TASK-1)/TRESK, with an IC50 for mTRESK of 6.8 μM.Formula:C13H12ClNO3Purezza:98.54%Colore e forma:SolidPeso molecolare:265.69QO-40
CAS:QO-40 is a KCNQ2/3 potassium channels activator.Formula:C18H11ClF3N3OPurezza:99.57%Colore e forma:SolidPeso molecolare:377.75NS309
CAS:NS309 activates SK/KCa2, IK/KCa3.1 (0.12-1.2 μM EC50, 10-90 nM EC50), and Kv11.1 channels; doesn't affect BK/KCa1.1; modulates neuronal firing.Formula:C8H4Cl2N2O2Purezza:97.55%Colore e forma:SolidPeso molecolare:231.04Ref: TM-T4612
5mg57,00€10mg69,00€25mg119,00€50mg216,00€100mg323,00€200mg470,00€500mg752,00€1mL*10mM (DMSO)63,00€Almitrine mesylate
CAS:Almitrine mesylate targets Ca2+-dependent K+ channels in rat cells, used for chronic lung hypoxemia.Formula:C28H37F2N7O6S2Purezza:99.96%Colore e forma:CoaPeso molecolare:669.76ICA-069673
CAS:ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).Formula:C11H6ClF2N3OPurezza:99.04% - 99.68%Colore e forma:SolidPeso molecolare:269.63BL-1249
CAS:BL-1249 is a selective and potent non-steroidal potassium channel activator with anti-inflammatory activity that activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2).Formula:C17H17N5Purezza:98% - 98.25%Colore e forma:SolidPeso molecolare:291.35Ref: TM-T14666
1mg52,00€5mg111,00€10mg170,00€25mg259,00€50mg354,00€100mg620,00€500mg1.283,00€1mL*10mM (DMSO)155,00€Doxapram
CAS:Doxapram (Dopram) is a respiratory stimulant that inhibits TASK-1, TASK-3, and TASK-1/TASK-3 heterodimer channels.Formula:C24H30N2O2Purezza:99.42%Colore e forma:SolidPeso molecolare:378.51VU590
CAS:VU590 is an inhibitor of extrarenal medullary potassium ROMK.VU590 inhibits Kir7.1 and modulates uterine myometrial contractility and melanocortin signalling.Formula:C24H32N4O7Purezza:98.06%Colore e forma:SolidPeso molecolare:488.53HUP30
CAS:HUP30 is a potent vasodilating agent. HUP30 can stimulate soluble guanylyl cyclase, activate K+ channels, and block extracellular Ca2+ influx.Formula:C14H15N3O3SPurezza:99.96%Colore e forma:SolidPeso molecolare:305.35Ref: TM-TNU0864
5mg38,00€10mg56,00€25mg101,00€50mg164,00€100mg235,00€200mg328,00€1mL*10mM (DMSO)42,00€Eleclazine
CAS:Eleclazine (GS-6615) is a novel and selective voltage-gated sodium channel inhibitor with antiarrhythmic properties that reduces peak sodium current (INaP).Formula:C21H16F3N3O3Purezza:98.67%Colore e forma:SolidPeso molecolare:415.37Dofetilide D4
CAS:Dofetilide D4 (UK 68789 D4), a deuterium-labeled version of Dofetilide, is categorized as a Class III antiarrhythmic medication.Formula:C19H27N3O5S2Purezza:98%Colore e forma:SolidPeso molecolare:445.59Repaglinide D5
CAS:Repaglinide D5 is deuterium labeled Repaglinide. Repaglinide is an insulin secretagogue for treatment type-2 diabetes mellitus.Formula:C27H36N2O4Purezza:98%Colore e forma:SolidPeso molecolare:457.62CPK20
CAS:CPK20 is a potent and selective inhibitor of the KCNT1 channel, useful for epilepsy research.Formula:C23H24F6N2O2SColore e forma:SolidPeso molecolare:506.50Meclofenamic acid
CAS:Meclofenamic acid: non-selective gap-junction blocker, FTO inhibitor, anti-inflammatory.Formula:C14H11Cl2NO2Purezza:99.98%Colore e forma:SolidPeso molecolare:296.15LY 303511
CAS:LY303511, an inactive analogue of LY294002, is a mTOR inhibitor and no inhibition for PI3-K.Formula:C19H18N2O2Purezza:98%Colore e forma:SolidPeso molecolare:306.36AVE-0118
CAS:AVE-0118 is a potassium channel blocker and suppresses persistent atrial fibrillation.Formula:C30H29N3O3Purezza:97.04% - 98.93%Colore e forma:SolidPeso molecolare:479.57Ref: TM-T26689
1mg70,00€5mg132,00€10mg173,00€25mg304,00€50mg449,00€100mg652,00€500mg1.369,00€1mL*10mM (DMSO)159,00€TRAM 39
CAS:TRAM 39 (2-Chloro-α,α-diphenylbenzeneacetonitrile) is a selective blocker of intermediate-conductance Ca2+-activated K+channels.Formula:C20H14ClNPurezza:99.97%Colore e forma:SolidPeso molecolare:303.78Ref: TM-T23471
1mg34,00€2mg47,00€5mg71,00€10mg102,00€25mg200,00€50mg318,00€100mg502,00€500mg1.063,00€GAL-021 sulfate
CAS:GAL-021 sulfate is a BKCa channel blocker that inhibits the analgesic effects of opioids and is used in the study of respiratory control diseases.Formula:C11H24N6O5SPurezza:99.92%Colore e forma:SolidPeso molecolare:352.41ML402
CAS:ML402 (ZINC3671497) is an activator of TREK-1 and TREK-2 with EC50s of 13.7 μM and 5.9 μM.Formula:C14H14ClNO2SPurezza:99.71%Colore e forma:SolidPeso molecolare:295.78Ref: TM-T16109
5mg48,00€10mg75,00€25mg138,00€50mg215,00€100mg318,00€200mg444,00€1mL*10mM (DMSO)49,00€Nifekalant hydrochloride
CAS:Nifekalant hydrochloride is an IKr potassium channel blocker with an IC50 of 10 µM.Formula:C19H28ClN5O5Purezza:99.91%Colore e forma:SolidPeso molecolare:441.91Vernakalant
CAS:Vernakalant (RSD-1235) is a mixed ion channel blocker.Formula:C20H31NO4Purezza:98%Colore e forma:SolidPeso molecolare:349.46Almokalant
CAS:Almokalant: Class III antiarrhythmic, K+ channel blocker, inhibits Ikr current.Formula:C18H28N2O3SPurezza:98%Colore e forma:SolidPeso molecolare:352.49RY796
CAS:RY796 is a selective voltage-gated potassium (KV2) channel inhibitor that inhibits KV2.1 and KV2.2, used in research on neurological disorders.Formula:C21H27N3O2Purezza:98.59%Colore e forma:SolidPeso molecolare:353.46Aprikalim
CAS:Aprikalim opens KATP channels, protects the heart, and at high doses, dilates blood vessels.Formula:C12H16N2OS2Purezza:99.42% - 99.90%Colore e forma:SolidPeso molecolare:268.4CM-TPMF
CAS:CM-TPMF is a highly efficient and potent activator of the K(Ca)2.1 channel, Ser293 in the transmembrane segment 5, neurological disorders.
Formula:C16H17ClN6O2Purezza:99.94%Colore e forma:SolidPeso molecolare:360.8B-TPMF
CAS:B-TPMF is a highly efficient and selective KCa2.1 channel inhibitor with an IC50 of 31 nM, interacting with serine residue at position 293 to inhibit KCa2.1.Formula:C19H24N6O2Purezza:99.82%Colore e forma:SolidPeso molecolare:368.43TWIK-1/TREK-1-IN-2
CAS:TWIK-1/TREK-1-IN-2 (Compound 2g) serves as an inhibitor of both TWIK-1 and TREK-1, targeting the TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50 valuesFormula:C20H29F3N2O2Purezza:98%Colore e forma:SolidPeso molecolare:386.45TWIK-1/TREK-1-IN-1
CAS:Compound 2a, identified as TWIK-1/TREK-1-IN-1, acts as an inhibitor of the TREK-1, a two-pore domain potassium channel (K2p) that forms TREK-1 homodimers andFormula:C21H24F3NO3Purezza:98%Colore e forma:SolidPeso molecolare:395.42ICA
CAS:ICA (N-[4-(2-Pyridinyl)-2-thiazolyl]-2-pyridinamine) is a SK channel inhibitor and exhibits antileishmanial activity (IC50: 2.1 µM).Formula:C13H10N4SPurezza:99.68%Colore e forma:SolidPeso molecolare:254.31Ref: TM-T15546
1mg67,00€5mg123,00€10mg178,00€25mg286,00€50mg396,00€100mg553,00€200mg743,00€1mL*10mM (DMSO)172,00€Amsacrine
CAS:Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.Formula:C21H19N3O3SPurezza:99.2% - 99.34%Colore e forma:Yellow Crystalline Powder SolidPeso molecolare:393.46Vernakalant Hydrochloride
CAS:Vernakalant Hydrochloride (RSD1235 hydrochloride) is a mixed voltage- and frequency-dependent Na+ and atria-preferred K+ channel blocker.Formula:C20H32ClNO4Purezza:99.89%Colore e forma:SolidPeso molecolare:385.93Ref: TM-T17227
1mg74,00€2mg97,00€5mg170,00€10mg274,00€25mg523,00€50mg753,00€100mg1.035,00€1mL*10mM (DMSO)178,00€Pinacidil
CAS:Pinacidil (P 1134) is a guanidine that opens potassium channels and directly dilates peripheral blood vessels in small arteries, lowering blood pressure andFormula:C13H19N5Purezza:99.9%Colore e forma:SolidPeso molecolare:245.32SCH-23390 maleate
CAS:SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective antagonist of dopamine D1-like receptor (1 and D5 receptor with Kis of 0.2 nM and 0.3 nM,Formula:C21H22ClNO5Purezza:98%Colore e forma:SolidPeso molecolare:403.86AVE1231
CAS:AVE1231 is a TASK-1 channel blocker that inhibits TASK-1 and can be used in the study of atrial fibrillation.Formula:C20H27N3O4SPurezza:98.03%Colore e forma:SolidPeso molecolare:405.51HN37
CAS:HN37, KCNQ2 activator (EC50=37 nM). Affordable Excellence: Reliable Quality You Can TrustFormula:C20H21FN2O2Purezza:99.27%Colore e forma:SolidPeso molecolare:340.39UK 78282 hydrochloride
CAS:UK-78282 hydrochloride, a Kv1.3 blocker.UK-78282 hydrochloride inhibits Kv1.3 voltage-gated potassium channels and suppresses human T cell activation.Formula:C29H36ClNO2Purezza:99.89%Colore e forma:SolidPeso molecolare:466.05VU0405601
CAS:VU0405601 is a hERG channel activator that protects against drug-induced cardiac arrhythmias.Formula:C17H13BrN2O2Purezza:99.16%Colore e forma:SolidPeso molecolare:357.2Psora 4
CAS:Psora 4 (5-(4-Phenylbutoxy)psoralen) is a Kv1.3 blocker and a caloric restriction mimetic.Formula:C21H18O4Colore e forma:SolidPeso molecolare:334.37ZTZ240
CAS:ZTZ240 is a KCNQ2 channel activator used in the study of epilepsy.
Formula:C12H8ClFN2OPurezza:99.89%Colore e forma:SolidPeso molecolare:250.66TASK-1-IN-1
CAS:TASK-1-IN-1: Potent, selective TASK-1 blocker (IC50: 148 nM), weaker on TASK-3 (IC50: 1750 nM), anticancer properties.
Formula:C22H20N2O2Purezza:99.57%Colore e forma:SoildPeso molecolare:344.41JNJ-26489112
CAS:JNJ-26489112 is a CNS-active agent and an inhibitor of voltage-gated Na+ channels and N-type Ca2+ channels.Formula:C9H11ClN2O4SPurezza:99.31%Colore e forma:SolidPeso molecolare:278.71KT-362 fumarate
CAS:KT-362 fumarate, a novel antagonist of Ca, K, and Na channels, induces vasodilation and relaxes rabbit arterial strips.
Formula:C26H32N2O7SPurezza:99.75% - 99.98%Colore e forma:SolidPeso molecolare:516.61DMP-543
CAS:DMP-543 (XR-543) is a potassium channel (KV7 channel) blocker that enhances the release of neurotransmitters.Formula:C26H18F2N2OPurezza:99.74%Colore e forma:SolidPeso molecolare:412.43TWIK-1/TREK-1-IN-3
CAS:TWIK-1/TREK-1-IN-3 is a potassium channel TREK-1 inhibitor TWIK-1/TREK-1-IN-3 has antidepressant activity and can be used to study depression.Formula:C19H27F3N2O2Purezza:99.04%Colore e forma:SolidPeso molecolare:372.43ZM 226600
CAS:ZM 226600 is an ATP-sensitive potassium channel opener with an EC50 value of 500 nM. ZM226600 has an inhibitory effect on spontaneous bladder activity.Formula:C16H14F3NO4SPurezza:99.87%Colore e forma:SolidPeso molecolare:373.35Ref: TM-T23563
2mg35,00€5mg50,00€10mg80,00€25mg145,00€50mg226,00€100mg335,00€200mg469,00€1mL*10mM (DMSO)55,00€MK-0448
CAS:MK-0448 is a novel and selective blocker of the Kv1.5 (KCNA5) channel, a key channel involved in cardiac repolarization current I Kur.Formula:C24H21FN4O2SPurezza:99.25% - 99.79%Colore e forma:SolidPeso molecolare:448.51GW 542573X
CAS:GW 542573X is a potent and selective small molecule Ca2+-activated K+ 2 (SK2) channel activator.GW 542573X induces a leftward shift in the Ca2+ response curveFormula:C19H28N2O5Purezza:99.99%Colore e forma:SolidPeso molecolare:364.44XE991
CAS:XE991 is a Kv7 (KCNQ) channel blocker.XE 991 dihydrochloride inhibits Kv7.1 (KCNQ1) and M-current and can be used in the study of neurological disorders.Formula:C26H20N2OPurezza:98.87%Colore e forma:SolidPeso molecolare:376.45SKA-111
CAS:SKA-111 activates KCa3.1 potassium channels, modulates membrane potential in endothelial cells, and dilates rat coronary arteries.Formula:C12H10N2SPurezza:99.9%Colore e forma:SolidPeso molecolare:214.29Ref: TM-T24799
1mg70,00€5mg153,00€10mg250,00€25mg504,00€50mg727,00€100mg1.017,00€500mg2.043,00€1mL*10mM (DMSO)167,00€IKs124
CAS:IKs124 is a KCNE2/KCNQ1 potassium channel blocker, for hKCNE1 and hKCNE3, and can be used to study peptic ulcers.Formula:C18H26N2O3SPurezza:99.53%Colore e forma:SolidPeso molecolare:350.48RL648_81
CAS:RL648_81 is a selective activator of KCNQ2/3 channels (EC50 = 190 nM). RL648_81 can be used in studies about neuronal hyperexcitability neurologic disorders.Formula:C17H17F4N3O2Purezza:99.82%Colore e forma:SolidPeso molecolare:371.33(+)-KCC2 blocker 1
CAS:(+)-KCC2 blocker 1 is a selective blocker of KCC2 (IC50 = 0.4 μM).Formula:C22H25NO5SPurezza:99.88%Colore e forma:SolidPeso molecolare:415.5Ref: TM-T12504
1mg115,00€2mg172,00€5mg255,00€10mg374,00€25mg562,00€50mg787,00€100mg1.074,00€500mg2.147,00€1mL*10mM (DMSO)284,00€PD-118057
CAS:PD-118057, a potent hERG activator, may treat long QT syndrome and heart failure without hERG activity inhibition.Formula:C21H17Cl2NO2Purezza:99.95% - 99.97%Colore e forma:SolidPeso molecolare:386.27Ref: TM-T16444
1mg84,00€2mg107,00€5mg175,00€10mg263,00€25mg464,00€50mg692,00€100mg1.035,00€200mg1.396,00€1mL*10mM (DMSO)192,00€UK 66914
CAS:UK 66914 is a K(+) channel blocker for the study of cardiac arrhythmias.Formula:C18H24N4O3SPurezza:99.75%Colore e forma:SolidPeso molecolare:376.47CyPPA
CAS:CyPPA enhances SK channels, reducing firing rate and extending apamin-sensitive afterhyperpolarization.
Formula:C16H23N5Purezza:99.88%Colore e forma:SolidPeso molecolare:285.39Sigma-1 receptor antagonist 3
CAS:Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor (Ki = 1.14 nM) than σ2 receptor(Ki = 1239 nM).Formula:C19H23ClFN3OPurezza:99.95%Colore e forma:SolidPeso molecolare:363.86DPO-1
CAS:DPO-1 可以高效抑制电压门控钾离子通道Kv1.5，也可以阻断超快速延迟整流钾电流。它能够预防房性心律失常。Formula:C22H29OPPurezza:99.78%Colore e forma:SolidPeso molecolare:340.44Ref: TM-T22745
5mg48,00€10mg74,00€25mg150,00€50mg216,00€100mg313,00€200mg437,00€1mL*10mM (DMSO)52,00€Glibornuride
CAS:Glibornuride is a blocker of ATP-sensitive K+ channel(pKi: 5.75).Formula:C18H26N2O4SPurezza:99.5%Colore e forma:SolidPeso molecolare:366.48Ref: TM-T15385
1mg71,00€5mg152,00€10mg236,00€25mg409,00€50mg580,00€100mg803,00€1mL*10mM (DMSO)167,00€P-1075
CAS:P-1075 activates SUR2-KIR6 channels at 45 nM; may open mitoKATP channels and protect the heart.Formula:C12H17N5Purezza:99.85%Colore e forma:SolidPeso molecolare:231.3Ref: TM-T16420
1mg60,00€5mg126,00€10mg202,00€25mg369,00€50mg560,00€100mg747,00€200mg1.017,00€1mL*10mM (DMSO)96,00€11-deoxy-PGF2a
CAS:11-deoxy-PGF2a is a thromboxane A2 receptor agonist that partially alleviates crowding in Lpar3(−/−) female embryos and induces smooth muscle contractionFormula:C20H34O4Colore e forma:SolidPeso molecolare:338.48Linaprazan
CAS:Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding with an IC50 of 1.0 μM.Formula:C21H26N4O2Purezza:99.54%Colore e forma:SolidPeso molecolare:366.46Ref: TM-T10435
5mg50,00€10mg80,00€25mg145,00€50mg212,00€100mg356,00€1mL*10mM (DMSO)Prezzo su richiestaCLP257
CAS:CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4.
Formula:C14H14FN3O2SPurezza:99.5%Colore e forma:SolidPeso molecolare:307.34Clobutinol hydrochloride
CAS:Clobutinol hydrochloride, an antitussive agent, influences heart rate and blood pressure, and is utilized in cough-related research [1] [2] [3].Formula:C14H23Cl2NOPurezza:98%Colore e forma:SolidPeso molecolare:292.25VU0463271
CAS:VU0463271: KCC2 antagonist, IC50 61 nM, >100x selective over NKCC1, inactive on other GPCRs, channels, transporters.
Formula:C19H18N4OS2Purezza:97.84% - 99.55%Colore e forma:SolidPeso molecolare:382.5MCHR1 antagonist 2
CAS:MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.Formula:C23H21FN2O5Purezza:98.29%Colore e forma:SolidPeso molecolare:424.42Ref: TM-T11966
2mg43,00€5mg66,00€10mg100,00€25mg210,00€50mg334,00€100mg537,00€200mg710,00€1mL*10mM (DMSO)80,00€Kv3 modulator 1
CAS:Kv3 modulator 1 is a voltage-gated potassium channel Kv3 modulator that can be used to study neurologic-level diseases.Formula:C20H20N4O4Purezza:99.41%Colore e forma:SolidPeso molecolare:380.4C 101248
CAS:C 101248 (KCNK13-IN-1) is a selective and potent tandem pore halogen inhibitor of K+ channel 1 (THIK-1) inhibitor and a human and mouse KCNK13 inhibitor.Formula:C15H12N6OPurezza:99.14% - 99.31%Colore e forma:SolidPeso molecolare:292.3Opakalim
CAS:Opakalim is an activator of potassium channels (potassium channel) and exhibits anticonvulsant activity.Formula:C18H22F2N4OColore e forma:SolidPeso molecolare:348.39Kv7.2/Kv7.3 modulator-1
CAS:Kv7.2/Kv7.3 modulator-1 (compound 6a) acts as a modulator for Kv7.2/Kv7.3 channels, with a pEC50 value of 7.96 for opening these channels. Kv7.2/Kv7.3 modulator-1 is applicable in research related to epilepsy, depression, brain injury, and pain.Formula:C20H21F4N3O3Colore e forma:SolidPeso molecolare:427.393Kv7.2/Kv7.3 activator-1
CAS:Kv7.2/Kv7.3 Activator-1 (compound 517) serves as a powerful activator of the Kv7.2/Kv7.3 channels, exhibiting an EC50 value of less than 1 µM. It holds potential for use in neurological disease research.Formula:C19H22F2N4OColore e forma:SolidPeso molecolare:360.40Kv7.2/Kv7.3 agonist 1
CAS:Kv7.2/Kv7.3 agonist 1 (Compound 16) is an orally effective agonist for the KV7.2/7.3 channels (KV7.2/7.3 channel/KCNQ2/3) with an EC50 of 1.03 μM. This compound demonstrates analgesic effects in mouse models of chronic constriction injury (CCI) and Streptozotocin-induced diabetic peripheral neuropathy (DPNP), with ED50 values of 12.02 mg/kg and 9.63 mg/kg, respectively.Formula:C14H14FN3O2Colore e forma:SolidPeso molecolare:275.28Kv3 modulator 5
CAS:Kv3 modulator 5 (Example 5), a Kv3 channel modulator, enhances the Kv3.2 current and may be employed in research of hearing disorders [1].Formula:C20H20N4O4Colore e forma:SolidPeso molecolare:380.4KV1.3-IN-2
CAS:KV1.3-IN-2 (Compound I) selectively inhibits the kv1.3 potassium channel without affecting the hERG channel. It is applicable in research related to immune-associated diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.
Formula:C16H23ClN2O4Colore e forma:SolidPeso molecolare:342.818KCC2 Modulator-2
CAS:KCC2 Modulator-2 (example 53) is a regulator of KCC2 with an EC50 of 0.215 μM. It is used in the research of neurological diseases.Formula:C35H45N5O3Colore e forma:SolidPeso molecolare:583.76cis-KV1.3-IN-1
CAS:cis-KV1.3-IN-1, also known as Compound cis-18, is the cis-isomer of KV1.3-IN-1 and functions as an inhibitor of the KV1.3 channel. In Xenopus laevis oocytes expressing human hKV1.3, cis-KV1.3-IN-1 (10 μM) achieves an inhibition rate of 25.53% against KV1.3.Formula:C23H30N2O4SColore e forma:SolidPeso molecolare:430.56
