ATPasi

FR-167356 inhibits a3 isoform H⁺-ATPase (IC50: 170-370 nM), targeting osteoclasts, kidneys, macrophages; reduces B16-F10 bone metastasis.

BMS-199264 hydrochloride is selective inhibitor of mitochondrial F1F0 ATP hydrolase,inhibit decline of ATP and myocardial necrosis during myocardial ischemia.

Ro 18-5364 is a potent inhibitor of the gastric (H+ + K+)-ATPase with an apparent Ki of 0.1 μM at pH 6.

Suloctidil HCl is a peripheral vascular dilator.

YHV98-4 is a selective Hv1 channel (Hv1 channel) inhibitor that can cross the blood-brain barrier. It specifically inhibits the Hv1 channel with a half-maximal inhibitory concentration of 1 µM without affecting other ion channels. YHV98-4 decreases the spread of p-tau, enhances ATP production, and promotes microglial mitophagy. By inhibiting the Hv1 channel and reducing ROS production, it alleviates inflammatory pain. Additionally, YHV98-4 enhances the transfer of mitochondria (mitochondria) from microglia to neurons, aiding in the delivery of functional mitochondria, thereby repairing neuronal damage and improving cognitive function. It mitigates inflammation and is applicable in Alzheimer’s disease research.

Hsp90-IN-38 (compound 20m) is an inhibitor of HSP90 (heat shock protein). It demonstrates a strong binding affinity to HSP90 with a Kd of 87 nM. The compound inhibits ATPase activity with an IC50 of 0.13 μM. Hsp90-IN-38 also shows inhibitory effects on HCT116, MCF-7, SKBr3, K562, and A549 cells with IC50 values of 0.187, 0.072, 0.105, 0.403, and 0.031 μM, respectively.

Istaroxime is an effective inhibitor of Na+, K+-ATPase (IC50: 0.11 μM).

Antimalarial agent 7 is a potent and effective inhibitor of PfATP4. Antimalarial agent 7 has potential for the study of the human plasmodium falciparum.

ATP synthase inhibitor 2 is an inhibitor of Pseudomonas aeruginosa ATP synthase (IC₅₀ = 10 μg/mL).

4-PSQ is an orally active neuroprotective agent. It exhibits both antioxidant and anti-inflammatory properties. 4-PSQ improves cognitive impairment and abnormal depression and anxiety-like emotions in mice by regulating Na⁺, K⁺-ATPase activity, NFκB signaling pathway, and p21 expression. This compound can be used for research in neurological disorders.

ASI-222 is an aminoglycoside cardiotonic compound. It functions by inhibiting sodium-potassium ATPase (Na+/K+ ATPase) and exhibits positive inotropic effects. ASI-222 can be utilized in cardiovascular disease research.