P-gp
La P-glicoproteina è una pompa di efflusso dipendente dall'ATP che trasporta una vasta gamma di substrati, inclusi farmaci, tossine e lipidi, fuori dalle cellule. Svolge un ruolo cruciale nella resistenza ai farmaci, in particolare nel cancro, riducendo la concentrazione intracellulare degli agenti chemioterapici. La P-gp è inoltre coinvolta nella barriera ematoencefalica, influenzando l'esposizione del sistema nervoso centrale a vari composti. Presso CymitQuimica, offriamo una gamma di modulatori della P-gp per supportare la tua ricerca sulla resistenza ai farmaci, farmacocinetica e sviluppo terapeutico.
Trovati 54 prodotti di "P-gp"
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Norverapamil hydrochloride
CAS:Norverapamil HCl, a Verapamil metabolite, blocks L-type calcium channels and inhibits P-gp function.Formula:C26H37ClN2O4Purezza:99.47%Colore e forma:SolidPeso molecolare:477.04Verapamil hydrochloride
CAS:Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.Formula:C27H39ClN2O4Purezza:98.7% - 99.98%Colore e forma:White To Off-White PowderPeso molecolare:491.06Zamicastat
CAS:Zamicastat (BIA 5-1058) inhibits DBH, P-gp (IC50=73.8μM), and BCRP (IC50=17.0μM).Formula:C21H21F2N3OSPurezza:99.58%Colore e forma:SolidPeso molecolare:401.47Risperidone
CAS:Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.Formula:C23H27FN4O2Purezza:99.73%Colore e forma:Crystalline SolidPeso molecolare:410.48Glibenclamide
CAS:<p>Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.</p>Formula:C23H28ClN3O5SPurezza:99.05% - 99.75%Colore e forma:SolidPeso molecolare:494.00Trifluoperazine dihydrochloride
CAS:Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Formula:C21H26Cl2F3N3SPurezza:99.57% - 99.96%Colore e forma:Cream Fine PowderPeso molecolare:480.43Piperine
CAS:<p>Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.</p>Formula:C17H19NO3Purezza:98.41% - 98.51%Colore e forma:SolidPeso molecolare:285.34Dofequidar fumarate
CAS:<p>Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through the</p>Formula:C34H35N3O7Purezza:99.93%Colore e forma:SolidPeso molecolare:597.66Encequidar mesylate
CAS:<p>Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.</p>Formula:C39H40N6O10SPurezza:99.84%Colore e forma:SolidPeso molecolare:784.83Atazanavir sulfate
CAS:Atazanavir sulfate, an azapeptide HIV-protease inhibitor, treats HIV/AIDS alongside other anti-HIV drugs.Formula:C38H52N6O7·H2SO4Purezza:99.31% - 99.40%Colore e forma:SolidPeso molecolare:802.93(20S)-Protopanaxadiol
CAS:(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-typeFormula:C30H52O3Purezza:97.07% - 98.91%Colore e forma:SolidPeso molecolare:460.73Atazanavir
CAS:<p>Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.</p>Formula:C38H52N6O7Purezza:98% - 99.95%Colore e forma:Crystalline SolidPeso molecolare:704.86P-gp inhibitor 25
CAS:P-gp Inhibitor 25 (compound 16c) is a P-gp inhibitor that enhances the oral absorption of paclitaxel. It is utilized in cancer research to improve treatment efficacy.Formula:C41H36N4O8Peso molecolare:712.75P-gp inhibitor 14
CAS:Compound 8a, also known as P-gp inhibitor 14, demonstrates high affinity as a P-gp inhibitor and effectively reverses P-gp-mediated multidrug resistance (EC 50 = 48.74 nM). Additionally, this compound exhibits a weak inhibitory effect on CYP3A4 activity [1].Formula:C37H38N2O8Colore e forma:SolidPeso molecolare:638.71Evodine
CAS:<p>1. Evodine has antinociceptive activity.</p>Formula:C18H19NO5Purezza:98%Colore e forma:SolidPeso molecolare:329.35CPI1
CPI1 is an effective and highly specific inhibitor of multidrug resistance protein 1 (MRP1). It exhibits inhibitory activity against MRP1 at the nanomolar level (Ki: 100 nM) and has minimal effect on P-glycoprotein (Pgp). CPI1 competes with LTC4 for binding to the same site on MRP1, inhibiting ATP hydrolysis and substrate transport. It is useful in research related to drug delivery and addressing cancer chemotherapy resistance.Formula:C111H131N23O30SColore e forma:SolidPeso molecolare:2299.43FM04
CAS:FM04 is a potent oral P-gp inhibitor (EC50: 83 nM), disrupting human P-gp NBD2 to enhance cancer treatment.Formula:C26H25NO4Purezza:99.87%Colore e forma:SolidPeso molecolare:415.48P-gb-IN-1
CAS:P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow.Formula:C30H28N2O6Purezza:99.85%Colore e forma:SoildPeso molecolare:512.55Tariquidar methanesulfonate hydrate
CAS:m-PEG8-Ms is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC compounds.Formula:C40H58N4O18S2Purezza:98.13%Colore e forma:SolidPeso molecolare:947.04YS-370
CAS:<p>YS-370 orally blocks P-gp, moderately inhibits CYP3A4, reverses drug resistance, and enhances paclitaxel's anticancer effects.</p>Formula:C37H35BrN4O3Purezza:98.055%Colore e forma:SolidPeso molecolare:663.6Laniquidar TFA
Laniquidar TFA (R101933), a non-competitive P-gp inhibitor, has an IC50 of 0.51 μM; used to study AML and MDS, but with limited bioavailability.Formula:C39H37F3N4O5Purezza:99.85%Colore e forma:SoildPeso molecolare:698.73WS-917
WS-917 is an efficacious and orally active regulator of ABCB1. It enhances the ABCB1 ATPase activity and significantly boosts the antitumor efficacy of combined paclitaxel and anti-PD-1 antibody therapy. WS-917 also promotes the activation of CD8+ T cells.Formula:C16H13N5OS2Peso molecolare:355.44Valspodar
CAS:Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.Formula:C63H111N11O12Purezza:95% - >99.99%Colore e forma:SolidPeso molecolare:1214.62Solamargine
CAS:Solamargine, a steroidal alkaloid from Solanum nigrum, inhibits cancer cell growth and induces apoptosis.Formula:C45H73NO15Purezza:99.17% - 99.96%Colore e forma:SolidPeso molecolare:868.06Ceefourin 1
CAS:<p>Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.</p>Formula:C11H10N4S3Purezza:99.15%Colore e forma:SolidPeso molecolare:294.42Paris saponin VII
CAS:<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Formula:C51H82O21Purezza:99.51% - 99.63%Colore e forma:SolidPeso molecolare:1031.18Polyoxyethylene stearate
CAS:Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.Formula:C20H40O3Purezza:n~9-10Colore e forma:Light Amber SemisolidPeso molecolare:328.29775Isosinensetin
CAS:1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.Formula:C20H20O7Purezza:99.98% - ≥95%Colore e forma:SolidPeso molecolare:372.37Voacamine
CAS:<p>Voacamine: an indole alkaloid, CB1 antagonist, inhibits P-gp, may affect rhythm.</p>Formula:C43H52N4O5Purezza:98.54% - 99.82%Colore e forma:SolidPeso molecolare:704.9Tariquidar
CAS:Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.Formula:C38H38N4O6Purezza:98.07% - 99.45%Colore e forma:SolidPeso molecolare:646.73Selamectin
CAS:Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening inFormula:C43H63NO11Purezza:99.84%Colore e forma:SolidPeso molecolare:769.96Phellamurin
CAS:Phellamurin blocks intestinal P-glycoprotein dose-dependently and it seriously interacts with cyclosporin; coadministration should be avoided.Formula:C26H30O11Purezza:97.91%Colore e forma:SolidPeso molecolare:518.51Sinapine
CAS:<p>Sinapine: an alkaloid with chemo-resistance, antioxidant, and radioprotective properties from cruciferous seeds.</p>Formula:C16H24NO5Purezza:98% - 99.68%Colore e forma:White Or Light-Tan SolidPeso molecolare:310.37Convallatoxin
CAS:Convallatoxin is a natural product.Formula:C29H42O10Purezza:99.27% - 99.53%Colore e forma:Prisms From Methanol + Ether SolidPeso molecolare:550.64Zosuquidar trihydrochloride
CAS:<p>Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.</p>Formula:C32H31F2N3O2·3HClPurezza:99.49% - >99.99%Colore e forma:SolidPeso molecolare:636.99Hypophyllanthin
CAS:<p>Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.</p>Formula:C24H30O7Purezza:98.39%Colore e forma:SolidPeso molecolare:430.49Zosuquidar
CAS:Zosuquidar (RS 33295-198) is a potent P-glycoprotein inhibitor with antitumor activity that inhibits tumor growth.Formula:C32H31F2N3O2Purezza:99.99%Colore e forma:SolidPeso molecolare:527.6HM-30181 mesylate monohydrate
CAS:HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.Formula:C39H42N6O11SPurezza:99.37%Colore e forma:SolidPeso molecolare:802.85Encequidar
CAS:<p>Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.</p>Formula:C38H36N6O7Purezza:99.93%Colore e forma:SolidPeso molecolare:688.73Trifluoperazine
CAS:Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.Formula:C21H24F3N3SPurezza:98.3% - 99.46%Colore e forma:White To Yellowish Crystalline PowderPeso molecolare:407.5γ-Tocotrienol
CAS:γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E.Formula:C28H42O2Purezza:97.27% - 98.13%Colore e forma:SolidPeso molecolare:410.63Sinapine thiocyanate
CAS:Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds.Formula:C16H24NO5·CNSPurezza:99.79% - ≥95%Colore e forma:SolidPeso molecolare:368.45Talinolol
CAS:(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.Formula:C20H33N3O3Purezza:98.8%Colore e forma:SolidPeso molecolare:363.49Elacridar
CAS:<p>Elacridar (GG918) is a potent inhibitor of P-glycoprotein and BCRP.Cost-effective and quality-assured.</p>Formula:C34H33N3O5Purezza:98.12% - >99.99%Colore e forma:SolidPeso molecolare:563.64Chrysosplenetin
CAS:Chrysosplenetin is a metabolic inhibitor of artemisinin.Formula:C19H18O8Purezza:97.43% - 98.4%Colore e forma:SolidPeso molecolare:374.34HTT-D3
CAS:<p>HTT-D3 is a Huntington splicing regulator that induces HTT mRNA degradation, leading to a reduction in HTT protein levels.</p>Formula:C23H25FN6Purezza:99.31%Colore e forma:SolidPeso molecolare:404.48Verapamil
CAS:Verapamil (CP-16533-1), an oral calcium channel blocker, inhibits P-gp and CYP3A4, used for hypertension, arrhythmias, and angina research.Formula:C27H38N2O4Purezza:99.61% - 99.93%Colore e forma:OilPeso molecolare:454.6P-gp inhibitor 1
CAS:<p>P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).</p>Formula:C32H31N5O2Purezza:98.65%Colore e forma:SolidPeso molecolare:517.62P-gp inhibitor 17
CAS:P-gp Inhibitor 17 (compound 2g), a potent inhibitor, directly interacts with the transmembrane domain of P-gp. This compound is useful for studying P-gp-mediated multidrug resistance in tumor cells [1].Formula:C36H49N3O3Colore e forma:SolidPeso molecolare:571.79ONT-093
CAS:ONT-093 (OC-144-093) is an oral P-glycoprotein (P-gp) inhibitor with potential anti-cancer activity, used in the study of myelodysplastic syndromes.Formula:C32H38N4OPurezza:98.86%Colore e forma:SolidPeso molecolare:494.67
