P-gp
La P-glicoproteina è una pompa di efflusso dipendente dall'ATP che trasporta una vasta gamma di substrati, inclusi farmaci, tossine e lipidi, fuori dalle cellule. Svolge un ruolo cruciale nella resistenza ai farmaci, in particolare nel cancro, riducendo la concentrazione intracellulare degli agenti chemioterapici. La P-gp è inoltre coinvolta nella barriera ematoencefalica, influenzando l'esposizione del sistema nervoso centrale a vari composti. Presso CymitQuimica, offriamo una gamma di modulatori della P-gp per supportare la tua ricerca sulla resistenza ai farmaci, farmacocinetica e sviluppo terapeutico.
Trovati 54 prodotti di "P-gp"
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Laniquidar TFA
Laniquidar TFA (R101933), a non-competitive P-gp inhibitor, has an IC50 of 0.51 μM; used to study AML and MDS, but with limited bioavailability.Formula:C39H37F3N4O5Purezza:99.85%Colore e forma:SoildPeso molecolare:698.73WS-917
WS-917 is an efficacious and orally active regulator of ABCB1. It enhances the ABCB1 ATPase activity and significantly boosts the antitumor efficacy of combined paclitaxel and anti-PD-1 antibody therapy. WS-917 also promotes the activation of CD8+ T cells.Formula:C16H13N5OS2Peso molecolare:355.44Valspodar
CAS:Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.Formula:C63H111N11O12Purezza:95% - >99.99%Colore e forma:SolidPeso molecolare:1214.62Solamargine
CAS:Solamargine, a steroidal alkaloid from Solanum nigrum, inhibits cancer cell growth and induces apoptosis.Formula:C45H73NO15Purezza:99.17% - 99.96%Colore e forma:SolidPeso molecolare:868.06Ceefourin 1
CAS:<p>Ceefourin 1 is a highly selective multidrug resistance protein 4 (MRP4) inhibitor.</p>Formula:C11H10N4S3Purezza:99.15%Colore e forma:SolidPeso molecolare:294.42Paris saponin VII
CAS:<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Formula:C51H82O21Purezza:99.51% - 99.63%Colore e forma:SolidPeso molecolare:1031.18Polyoxyethylene stearate
CAS:Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.Formula:C20H40O3Purezza:n~9-10Colore e forma:Light Amber SemisolidPeso molecolare:328.29775Isosinensetin
CAS:1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.Formula:C20H20O7Purezza:99.98% - ≥95%Colore e forma:SolidPeso molecolare:372.37Voacamine
CAS:<p>Voacamine: an indole alkaloid, CB1 antagonist, inhibits P-gp, may affect rhythm.</p>Formula:C43H52N4O5Purezza:98.54% - 99.82%Colore e forma:SolidPeso molecolare:704.9Tariquidar
CAS:Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.Formula:C38H38N4O6Purezza:98.07% - 99.45%Colore e forma:SolidPeso molecolare:646.73Selamectin
CAS:Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening inFormula:C43H63NO11Purezza:99.84%Colore e forma:SolidPeso molecolare:769.96Phellamurin
CAS:Phellamurin blocks intestinal P-glycoprotein dose-dependently and it seriously interacts with cyclosporin; coadministration should be avoided.Formula:C26H30O11Purezza:97.91%Colore e forma:SolidPeso molecolare:518.51Sinapine
CAS:Sinapine: an alkaloid with chemo-resistance, antioxidant, and radioprotective properties from cruciferous seeds.Formula:C16H24NO5Purezza:98% - 99.68%Colore e forma:White Or Light-Tan SolidPeso molecolare:310.37Convallatoxin
CAS:Convallatoxin is a natural product.Formula:C29H42O10Purezza:99.27% - 99.53%Colore e forma:Prisms From Methanol + Ether SolidPeso molecolare:550.64Zosuquidar trihydrochloride
CAS:Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.Formula:C32H31F2N3O2·3HClPurezza:99.49% - >99.99%Colore e forma:SolidPeso molecolare:636.99Hypophyllanthin
CAS:<p>Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.</p>Formula:C24H30O7Purezza:98.39%Colore e forma:SolidPeso molecolare:430.49Zosuquidar
CAS:Zosuquidar (RS 33295-198) is a potent P-glycoprotein inhibitor with antitumor activity that inhibits tumor growth.Formula:C32H31F2N3O2Purezza:99.99%Colore e forma:SolidPeso molecolare:527.6HM-30181 mesylate monohydrate
CAS:HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.Formula:C39H42N6O11SPurezza:99.37%Colore e forma:SolidPeso molecolare:802.85Encequidar
CAS:<p>Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.</p>Formula:C38H36N6O7Purezza:99.93%Colore e forma:SolidPeso molecolare:688.73Trifluoperazine
CAS:Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.Formula:C21H24F3N3SPurezza:98.3% - 99.46%Colore e forma:White To Yellowish Crystalline PowderPeso molecolare:407.5
