P-gp
La P-glicoproteina è una pompa di efflusso dipendente dall'ATP che trasporta una vasta gamma di substrati, inclusi farmaci, tossine e lipidi, fuori dalle cellule. Svolge un ruolo cruciale nella resistenza ai farmaci, in particolare nel cancro, riducendo la concentrazione intracellulare degli agenti chemioterapici. La P-gp è inoltre coinvolta nella barriera ematoencefalica, influenzando l'esposizione del sistema nervoso centrale a vari composti. Presso CymitQuimica, offriamo una gamma di modulatori della P-gp per supportare la tua ricerca sulla resistenza ai farmaci, farmacocinetica e sviluppo terapeutico.
Trovati 54 prodotti di "P-gp"
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γ-Tocotrienol
CAS:γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E.Formula:C28H42O2Purezza:97.27% - 98.13%Colore e forma:SolidPeso molecolare:410.63Sinapine thiocyanate
CAS:Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds.Formula:C16H24NO5·CNSPurezza:99.79% - ≥95%Colore e forma:SolidPeso molecolare:368.45Talinolol
CAS:(±)-Talinolol is a selective β1 adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity.Formula:C20H33N3O3Purezza:98.8%Colore e forma:SolidPeso molecolare:363.49Elacridar
CAS:<p>Elacridar (GG918) is a potent inhibitor of P-glycoprotein and BCRP.Cost-effective and quality-assured.</p>Formula:C34H33N3O5Purezza:98.12% - >99.99%Colore e forma:SolidPeso molecolare:563.64Chrysosplenetin
CAS:Chrysosplenetin is a metabolic inhibitor of artemisinin.Formula:C19H18O8Purezza:97.43% - 98.4%Colore e forma:SolidPeso molecolare:374.34HTT-D3
CAS:<p>HTT-D3 is a Huntington splicing regulator that induces HTT mRNA degradation, leading to a reduction in HTT protein levels.</p>Formula:C23H25FN6Purezza:99.31%Colore e forma:SolidPeso molecolare:404.48Verapamil
CAS:Verapamil (CP-16533-1), an oral calcium channel blocker, inhibits P-gp and CYP3A4, used for hypertension, arrhythmias, and angina research.Formula:C27H38N2O4Purezza:99.61% - 99.93%Colore e forma:OilPeso molecolare:454.6P-gp inhibitor 1
CAS:<p>P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).</p>Formula:C32H31N5O2Purezza:98.65%Colore e forma:SolidPeso molecolare:517.62P-gp inhibitor 17
CAS:P-gp Inhibitor 17 (compound 2g), a potent inhibitor, directly interacts with the transmembrane domain of P-gp. This compound is useful for studying P-gp-mediated multidrug resistance in tumor cells [1].Formula:C36H49N3O3Colore e forma:SolidPeso molecolare:571.79ONT-093
CAS:ONT-093 (OC-144-093) is an oral P-glycoprotein (P-gp) inhibitor with potential anti-cancer activity, used in the study of myelodysplastic syndromes.Formula:C32H38N4OPurezza:98.86%Colore e forma:SolidPeso molecolare:494.67coniferyl ferulate
CAS:<p>Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis.</p>Formula:C20H20O6Purezza:99.39%Colore e forma:SolidPeso molecolare:356.37PGP-4008
CAS:PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.Formula:C26H23N3OPurezza:97.41% - 97.99%Colore e forma:SolidPeso molecolare:393.488-Prenylchrysin
CAS:<p>8-Prenylchrysin is a C8-isopentenyl flavonoid compound. It acts as an inhibitor of P-glycoprotein (P-gp) and can be utilized in cancer research.</p>Formula:C20H18O4Colore e forma:SolidPeso molecolare:322.354NSC73306
CAS:NSC73306 is a thiosemicarbazone known for its role as a cell-permeable agent, exhibiting increased toxicity towards cells expressing p-glycoprotein.Formula:C16H14N4O2SColore e forma:SolidPeso molecolare:326.373
