Canale del sodio
I canali del sodio sono proteine di membrana essenziali che permettono il passaggio degli ioni sodio (Na+) attraverso la membrana cellulare, generando e propagando segnali elettrici nei neuroni, nelle cellule muscolari e in altri tessuti eccitabili. Questi canali sono vitali per l'inizio e la conduzione dei potenziali d'azione, rendendoli cruciali in processi come la trasmissione degli impulsi nervosi, la contrazione muscolare e la funzione cardiaca. La disregolazione dei canali del sodio può portare a disturbi neurologici, aritmie e condizioni di dolore cronico. Presso CymitQuimica, offriamo una varietà di modulatori dei canali del sodio per supportare la tua ricerca in neurobiologia, cardiologia e gestione del dolore.
Trovati 209 prodotti di "Canale del sodio"
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Nav1.8-IN-1
CAS:<p>Nav1.8-IN-1 (CHEMBL1270208) is an inhibitor of human NaV1.8</p>Formula:C20H15ClF3N3O2Purezza:97.59%Colore e forma:SolidPeso molecolare:421.8QX-222 chloride
CAS:QX-222 chloride (Lidocaine N-Methyl Hydrochloride) is a sodium channel blocker.Formula:C13H21ClN2OPurezza:97.37%Colore e forma:SolidPeso molecolare:256.77Carbamazepine
CAS:Carbamazepine: a tricyclic with anticonvulsant and analgesic effects, treats trigeminal neuralgia.Formula:C15H12N2OPurezza:99.78% - 99.79%Colore e forma:SolidPeso molecolare:236.27λ-Cyhalothrin
CAS:λ-Cyhalothrin (Icon) is a type II synthetic pyrethroid insecticide featuring a high-efficiency, broad-spectrum formula with an α-cyano group.Formula:C23H19ClF3NO3Purezza:99.76%Colore e forma:SolidPeso molecolare:449.85Rimeporide
CAS:Rimeporide (EMD-87580) (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.Formula:C11H15N3O5S2Purezza:97.66%Colore e forma:SolidPeso molecolare:333.38Ref: TM-T5319
1mg48,00€2mg65,00€5mg96,00€10mg170,00€25mg378,00€50mg552,00€100mg787,00€1mL*10mM (DMSO)114,00€Flecainide hydrochloride
CAS:Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias.Formula:C17H21ClF6N2O3Purezza:97.79%Colore e forma:SolidPeso molecolare:450.81Raxatrigine
CAS:Raxatrigine (CNV 1014802) has been investigated for the treatment of Bipolar Disorder and Bipolar Depression.Formula:C18H19FN2O2Purezza:98% - 99.43%Colore e forma:SolidPeso molecolare:314.35N-Me-aminopyrimidinone9
CAS:N-Me-aminopyrimidinone9 is a sodium channel antagonistFormula:C16H21N3OSPurezza:99.21%Colore e forma:SolidPeso molecolare:303.42Ref: TM-T8444
1mg62,00€5mg123,00€10mg180,00€25mg298,00€50mg419,00€100mg567,00€200mg752,00€1mL*10mM (DMSO)123,00€Levobupivacaine
CAS:Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide.Formula:C18H28N2OPurezza:99.72%Colore e forma:SolidPeso molecolare:288.43Ref: TM-T1787
5mg48,00€10mg63,00€25mg93,00€50mg136,00€100mg188,00€200mg283,00€500mg487,00€1mL*10mM (DMSO)49,00€Propafenone hydrochloride
CAS:<p>Propafenone hydrochloride (Arythmol8) is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial.</p>Formula:C21H27NO3·HClPurezza:99.67%Colore e forma:White SolidPeso molecolare:377.9Benzocaine xHCl(94-09-7(free base))
Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel(IC50 of 0.8 mM tested with a potential of +30 mV).Formula:C9H11NO2·xHClPurezza:99.37%Colore e forma:SolidPeso molecolare:N/AVX-150
CAS:VX-150 is a highly selective NaV1.8 inhibitor relative to the other sodium channel subtypes (>400-fold).Formula:C21H17F4N2O7PPurezza:97.58%Colore e forma:SolidPeso molecolare:516.34Ref: TM-T9683
1mg66,00€5mg144,00€10mg235,00€25mg472,00€50mg755,00€100mg1.206,00€1mL*10mM (DMSO)164,00€PF-01247324
CAS:PF-01247324 is a selective and orally bioavailable Nav1.8 channel blocker (IC50: 196 nM).Formula:C13H10Cl3N3OPurezza:99.22%Colore e forma:SolidPeso molecolare:330.6PF 05089771
CAS:PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV.Formula:C18H12Cl2FN5O3S2Purezza:99.03% - 99.42%Colore e forma:SolidPeso molecolare:500.35Ref: TM-T7502L
1mg67,00€5mg145,00€10mg187,00€25mg309,00€50mgPrezzo su richiesta1mL*10mM (DMSO)164,00€PF-05186462
CAS:PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.Formula:C19H10ClF4N5O3S2Purezza:99.10% - 99.37%Colore e forma:SolidPeso molecolare:531.89Ralfinamide mesylate
CAS:Ralfinamide mesylate (FCE-26742A (mesylate)) is an orally available Na+ channel blocker.Formula:C18H23FN2O5SPurezza:99.83%Colore e forma:SolidPeso molecolare:398.45Ref: TM-T7547
1mg55,00€5mg118,00€10mg180,00€25mg296,00€50mg393,00€100mg553,00€200mg743,00€1mL*10mM (DMSO)180,00€Ajmaline
CAS:Ajmaline, a class Ia anti-arrhythmic, diagnoses Brugada syndrome and treats tachycardia; inhibits cardiac Kv1.5/Kv4.3 channels.Formula:C20H26N2O2Purezza:99.67% - 99.87%Colore e forma:SolidPeso molecolare:326.43ICA-121431
CAS:ICA-121431: a potent Nav1.7 inhibitor (IC50=19 nM for rat), minimal effect on human Nav1.5/Nav1.7.Formula:C23H19N3O3S2Purezza:98.06%Colore e forma:SolidPeso molecolare:449.55(+)-Kavain
CAS:(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.Formula:C14H14O3Purezza:97% - ≥95%Colore e forma:White Fine PowderPeso molecolare:230.26Benzamil
CAS:Benzamil blocks ENaC, inhibiting sodium transport (IC50=4 nM) and binds with Kd=5 nM to bovine kidney membranes.Formula:C13H14ClN7OPurezza:99.79%Colore e forma:SolidPeso molecolare:319.7520(S)-Ginsenoside Rg3
CAS:20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.Formula:C42H72O13Purezza:98.11% - 99.93%Colore e forma:SolidPeso molecolare:785.01Dronedarone
CAS:Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.Formula:C31H44N2O5SPurezza:98.85% - 99.99%Colore e forma:SolidPeso molecolare:556.76Evenamide
CAS:Evenamide (NW-3509) is a sodium channel blocker. Which shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness.Formula:C16H26N2O2Purezza:96.74% - 99.15%Colore e forma:SolidPeso molecolare:278.39Ref: TM-T15260
1mg42,00€5mg88,00€10mg127,00€25mg250,00€50mg399,00€100mg645,00€200mg898,00€1mL*10mM (DMSO)87,00€Metaflumizone
CAS:Metaflumizone (BAS-320I) is a sodium channel blocker insecticide.Formula:C24H16F6N4O2Purezza:98.73%Colore e forma:SolidPeso molecolare:506.40Cyfluthrin
CAS:Cyfluthrin binds to voltage-sensitive sodium channel such as Nav 1.8 sodium channel and modify their gating kinetics, thereby disrupting nerve function of pestsFormula:C22H18Cl2FNO3Purezza:99.76%Colore e forma:SolidPeso molecolare:434.29A-803467
CAS:A-803467 is a selective NaV1.8 channel blocker.Formula:C19H16ClNO4Purezza:96.94% - 98%Colore e forma:SolidPeso molecolare:357.79Metergoline
CAS:Metergoline (Methergoline) is a dopamine agonist and serotonin antagonist.Formula:C25H29N3O2Purezza:99.83% - 99.97%Colore e forma:SolidPeso molecolare:403.52Tenapanor
CAS:Tenapanor (RDX 5791), an NHE3 inhibitor, regulates sodium in the gut and kidney with a strong preclinical safety record and minimal side effects.Formula:C50H66Cl4N8O10S2Purezza:99.49% - 99.85%Colore e forma:SolidPeso molecolare:1145.05Dimethyl lithospermate B
CAS:Dimethyl lithospermate B (dmLSB) is a selective Na+ channel agonist.Formula:C38H34O16Purezza:97.18% - 99.62%Colore e forma:SolidPeso molecolare:746.67Ref: TM-T8299
1mg144,00€2mg213,00€5mg376,00€10mg550,00€25mg867,00€50mg1.159,00€100mg1.568,00€200mg2.118,00€1mL*10mM (DMSO)530,00€Eslicarbazepine Acetate
CAS:Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use as an adjunctive therapy for partial-onset seizures.Formula:C17H16N2O3Purezza:99.58% - >99.99%Colore e forma:White To Off-White SolidPeso molecolare:296.32Ref: TM-T3285
5mg38,00€10mg50,00€25mg92,00€50mg124,00€100mg170,00€200mg268,00€500mg393,00€1mL*10mM (DMSO)55,00€Nicainoprol
CAS:Nicainoprol (RU-42924) is a fast-sodium-channel blocking drug. Nicainoprol is a potent antiarrhythmic agent.Formula:C21H27N3O3Purezza:99.54%Colore e forma:SolidPeso molecolare:369.46Ref: TM-T4539
1mg140,00€5mg344,00€10mg512,00€25mg812,00€50mg1.093,00€100mg1.473,00€1mL*10mM (DMSO)350,00€Sodium ionophore III
CAS:Sodium ionophore III (ETH2120) is a Na+ ionophore suitable for the test of sodium activity in plasma, serum, and blood.Formula:C34H52N2O4Purezza:99.51% - 99.78%Colore e forma:SolidPeso molecolare:552.79BI 01383298
CAS:BI 01383298 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5).Formula:C19H19Cl2FN2O3SPurezza:99.71%Colore e forma:SolidPeso molecolare:445.34GS967
CAS:<p>GS967 is a potent, and selective inhibitor of cardiac late sodium current (late INa ).</p>Formula:C14H7F6N3OPurezza:98% - >99.99%Colore e forma:SolidPeso molecolare:347.22Ref: TM-T2049
2mg35,00€5mg52,00€10mg79,00€25mg159,00€50mg284,00€100mg495,00€200mg718,00€500mg1.111,00€Pilsicainide HCl
CAS:Pilsicainide HCl (SUN 1165) is a pure sodium channel blockerFormula:C17H25ClN2OPurezza:99.01% - 99.80%Colore e forma:SolidPeso molecolare:308.85AZ194
CAS:CRMP2-Ubc9-NaV1.7 inhibitor 194, is a CRMP2-Ubc9-NaV1.7 inhibitor.Formula:C34H31F2N3O3Purezza:99.61%Colore e forma:SolidPeso molecolare:567.62Ref: TM-T9461
1mg81,00€5mg170,00€10mg274,00€25mg512,00€50mg740,00€100mg1.035,00€500mg2.072,00€1mL*10mM (DMSO)188,00€RY785
CAS:RY785 is a potent and selective inhibitor of voltage-gated potassium channel such as KV2.2 (IC50 = 50 nM). RY785 may be used in pain relief studies.Formula:C21H20N4O2SPurezza:99.78%Colore e forma:SolidPeso molecolare:392.47Ref: TM-T12786
1mg51,00€5mg144,00€10mg235,00€25mg399,00€50mg560,00€100mg787,00€200mg1.093,00€1mL*10mM (DMSO)125,00€6-Benzoylheteratisine
CAS:6-Benzoylheteratisine (Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth) is a Aconitum alkaloid.Formula:C29H37NO6Purezza:99.87%Colore e forma:SolidPeso molecolare:495.61Benzonatate
CAS:Benzonatate is an antagonist of sodium channel protein.Formula:C30H53NO11Purezza:99.92%Colore e forma:Colorless To Faintly Yellow Oil LiquidPeso molecolare:603.74PF-06869206
CAS:PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM).Formula:C15H14ClF3N4O2Purezza:99.79% - 99.88%Colore e forma:SolidPeso molecolare:374.75Ref: TM-TQ0011
5mg39,00€10mg64,00€25mg125,00€50mg210,00€100mgPrezzo su richiesta1mL*10mM (DMSO)35,00€Levobupivacaine hydrochloride
CAS:Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a reversible neuronal sodium channel inhibitor, used as a long-acting local anesthetic.Formula:C18H28N2O·HClPurezza:99.74%Colore e forma:White Crystalline PowderPeso molecolare:324.893-Deoxyaconitine
CAS:3- Deoxyaconitine is a derivative of Aconitine (A189875), which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thusFormula:C34H47NO10Purezza:98.31%Colore e forma:SolidPeso molecolare:629.74Ralfinamide
CAS:Ralfinamide (Priralfinamide) is an orally available Na-channel blocker for the treatment of neuropathic pain and other pain conditions.Formula:C17H19FN2O2Purezza:99.41%Colore e forma:SolidPeso molecolare:302.34Riluzole
CAS:<p>Riluzole (RP-54274) is an anticonvulsant, glutamate antagonist, and prolongs ALS patient survival.</p>Formula:C8H5F3N2OSPurezza:99.71% - 99.88%Colore e forma:PowderPeso molecolare:234.2Benzocaine N-Glucoside (a/b mixture)
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications The N-Glucoside of Benzocaine (B202970) with anesthetic activity. A potential sun-screening agent.<br>References Rybczynska, B. et al.: Parfum. Kosm., 48, 125 (1967); Nikolin, A. et al.: Glas. Hemi. Tehnol. Bosne Herceg., 16, 93 (1968);<br></p>Formula:C15H21NO7Colore e forma:NeatPeso molecolare:327.33Propoxycaine hydrochloride
CAS:Propoxycaine hydrochloride is an ester local anesthetic that inhibits voltage-gated sodium channels, modulates nerve impulses, and induces loss of sensation.Formula:C16H27ClN2O3Purezza:97.25%Colore e forma:SolidPeso molecolare:330.85N-Formylguanidine
CAS:Prodotto controllatoFormula:C2H5N3OColore e forma:Off-WhitePeso molecolare:87.08110,11-Dihydro-10-hydroxy Carbamazepine-d4
CAS:10,11-Dihydro-10-hydroxy Carbamazepine-d4 is a deuterated compound of 10,11-Dihydro-10-hydroxy Carbamazepine. 10,11-Dihydro-10-hydroxy Carbamazepine has a CAS number of 29331-92-8. Licarbazepine is the pharmacologically active metabolite of oxcarbazepine, a drug indicated for the treatment of partial seizures and bipolar disorders.Formula:C15H10D4N2O2Peso molecolare:258.31Propafenone-d5 HCl
CAS:Propafenone-d5 HCl is a deuterated compound of Propafenone HCl. Propafenone HCl has a CAS number of 34183-22-7. Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.Formula:C21H23D5ClNO3Peso molecolare:382.94N-(Chloroacetyl)-2,5-dimethylaniline
CAS:Prodotto controllato<p>Applications N-(Chloroacetyl)-2,5-dimethylaniline is an intermediate in the synthesis of impurities of Lidocaine (L397800), an anesthetic local agent and antiarrythmic class IB agent.<br>References Groningsson, K., et al.: Anal. Profiles Drug Subs., 14, 207 (1985), Davies, P.S., et al.: Drugs, 64, 937 (2004),<br></p>Formula:C10H12ClNOColore e forma:NeatPeso molecolare:197.66Deacetamide Acetonitrile-pentisomide
CAS:Prodotto controllato<p>Applications Deacetamide Acetonitrile-pentisomide is an intermediate in the synthesis of Pentisomide (P275600). Pentisomide is a sodium channel blocker; derivative of disopyramide. Antiarrhythmic (class I).<br>References Kuhlkamp, V., et al.: Int. J. Cardiol., 36, 69 (1992); Yuan, S., et al.: Cardiovasc. Drug Rev., 11, 74 (1993)<br></p>Formula:C19H31N3Colore e forma:NeatPeso molecolare:301.473-(2-Chloropropionyl)amino-4-methyl-2-methoxycarbonylthiophene
CAS:Prodotto controllato<p>Applications 3-(2-Chloropropionyl)amino-4-methyl-2-methoxycarbonylthiophene is an intermediate in the synthesis of Articaine-d7 Hydrochloride which is the labelled form of Articaine Hydrochloride (A777905). Articaine Hydrochloride is the Hydrochloride Salt of Articaine (A777900). Articaine is an amide based short-acting local anesthetic use for regional anaesthesia in day-case settings such arthroscopy, hand, food surgery and in dentistry.<br>References Malamed, S.F., et al.: J. Am. Dent. Assoc., 132, 177 (2001); Luan, F., et al.: Bioorg. Med. Chem., 21, 1870 (2013)<br></p>Formula:C10H12ClNO3SColore e forma:NeatPeso molecolare:261.73Propafenone D7 hydrochloride
CAS:Propafenone D7 hydrochloride is the deuterium labeled Propafenone, and is a classic anti-arrhythmic medication.Formula:C21H28ClNO3Purezza:98%Colore e forma:SolidPeso molecolare:384.95Methocarbamol D5
CAS:Methocarbamol is a central muscle relaxant. Methocarbamol D5 is deuterium labeled Methocarbamol.Formula:C11H15NO5Purezza:98%Colore e forma:SolidPeso molecolare:246.27Nav1.8-IN-14
CAS:Nav1.8-IN-14 (compound 20) is an effective selective inhibitor of Nav1.8. It is utilized in the research of pain-associated diseases.Formula:C18H17F5N4O3SPeso molecolare:464.416-(Propylamino)-2-hydroxy-N-(2,6-dimethylphenyl)hexanamide
Prodotto controllato<p>Applications 6-(Propylamino)-2-hydroxy-N-(2,6-dimethylphenyl)-hexanamide is a derivative of Bupivacaine (B689560), a sodium channel blocker, local anesthetic.<br>References Wilson, T.D., et al.: Anal. Profiles Drug Subs., 19, 59 (1990), McClellan, K.J., et al.: Drugs, 56, 355 (1998),<br></p>Formula:C17H28N2O2Colore e forma:NeatPeso molecolare:292.4163-Deoxyyunaconitine
CAS:Prodotto controllato<p>Applications 3-Deoxyyunaconitine is a metabolite of Aconitine (A189875), a neurotoxin that binds, activates tetrodotoxin-sensitive Na+ channels and prolongs the opening of the sodium-ion channel by suppressing conformational changes.<br>References Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010), Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010),<br></p>Formula:C35H49NO10Colore e forma:NeatPeso molecolare:643.761,2,4-Oxadiazol-3-amine
CAS:Prodotto controllato<p>Applications 1,2,4-oxadiazol-3-amine (cas# 39512-64-6) is a useful research chemical.<br></p>Formula:C2H3N3OColore e forma:NeatPeso molecolare:85.06Halofuginone
CAS:Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.Formula:C16H17BrClN3O3Purezza:99.53%Colore e forma:Off-White SolidPeso molecolare:414.68Ref: TM-T6856
1mg37,00€5mg87,00€10mg123,00€25mg240,00€50mg363,00€100mg547,00€500mg1.198,00€1mL*10mM (DMSO)Prezzo su richiestaClopamide
CAS:Clopamide (Brinaldix) is a piperidine and sulfamoylbenzamide-based diuretic with thiazide-like diuretic activity.Formula:C14H20ClN3O3SPurezza:99.71%Colore e forma:White To Yellowish Crystalline PowderPeso molecolare:345.84GX-674
CAS:GX-674 is a highly potent and selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC50 value of 0.1 nM measured at -40 mV for the study ofFormula:C21H13ClF2N6O3S2Purezza:98.60%Colore e forma:SolidPeso molecolare:534.95(5R)-BW-4030W92
CAS:(5R)-BW-4030W92 is the R-type of BW-4030W92, the active enantiomer.Formula:C11H9Cl2FN4Purezza:98.27%Colore e forma:SolidPeso molecolare:287.12NHE3-IN-2
CAS:NHE3-IN-2 is an inhibitor of NHE3 (Na+/H+ exchanger-3), applicable for treating hypertension, thrombosis, and ischaemic diseases.Formula:C15H12ClN5Colore e forma:SolidPeso molecolare:297.74PF 05089771 tosylate
CAS:PF-05089771 inhibits Nav1.7 channels (IC50: 11-33 nM), selective over Nav1.1-1.6/1.8, Ca+, K+ channels, TRPV1; 1000x affinity for half-inactivated state.Formula:C18H12Cl2FN5O3S2·C7H8O3SPurezza:98.55%Colore e forma:SolidPeso molecolare:672.56GNE-0439
CAS:GNE-0439 is a Nav1.7-selective inhibitor (IC50 0.34 μM), also targeting Nav1.5 and mutant N1742K channels, valuable for ion channel research.Formula:C21H31NO3Purezza:99.60%Colore e forma:SolidPeso molecolare:345.48Ref: TM-T11437
1mg162,00€5mg393,00€10mg655,00€25mg1.378,00€50mg1.882,00€100mg2.375,00€1mL*10mM (DMSO)432,00€Sodium Channel inhibitor 2
CAS:Sodium Channel inhibitor 2 is a blocker of sodium channel.Formula:C26H25Cl2N3OPurezza:98%Colore e forma:SolidPeso molecolare:466.4E 0747
CAS:<p>E 0747 is an antiarrhythmic agent of class 1C type. E-0747 suppresses arrhythmia by inhibiting the Na channels of cardiac cells.</p>Formula:C21H28ClN3O4Purezza:95.17%Colore e forma:SolidPeso molecolare:421.92Halofuginone hydrobromide
CAS:Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.Formula:C16H17BrClN3O3·HBrPurezza:97.01% - 99.73%Colore e forma:SolidPeso molecolare:495.59Ref: TM-T3524
1mg37,00€2mg52,00€5mg79,00€10mg112,00€25mg219,00€50mg328,00€100mg495,00€500mg947,00€1mL*10mM (DMSO)88,00€GX-585
CAS:GX-585 is a novel potent inhibitor of NaV1.7 and highly selective against NaV1.5, having limited selectivity against NaV1.1 and NaV1.2.Formula:C24H25Cl2FN4O3SPurezza:99.02% - 99.03%Colore e forma:SolidPeso molecolare:539.45GDC-0276
CAS:GDC-0276 is an orally active, selective, and potent NaV1.7 inhibitor that can be used for the study of pain-related diseases.Formula:C24H31FN2O4SPurezza:99.77%Colore e forma:SolidPeso molecolare:462.58Nav1.7 inhibitor
CAS:Nav1.7 inhibitor is a Nav1.7 inhibitor for research in the field of pain and anesthesia.Formula:C15H11Cl3FNO4SPurezza:97.52%Colore e forma:SolidPeso molecolare:426.68Ref: TM-T12184
1mg44,00€2mg58,00€5mg94,00€10mg142,00€25mg279,00€50mg445,00€100mg715,00€1mL*10mM (DMSO)93,00€DPI 201-106
CAS:<p>DPI 201-106: cardioselective h1 Na channel inhibitor, enhances heart contraction, blocks potassium and calcium currents.</p>Formula:C29H30N4O2Purezza:99.94%Colore e forma:SolidPeso molecolare:466.57Phenamil
CAS:Phenamil is an inhibitor of epithelial sodium channels, activates the osteomorphin protein pathway to promote bone repair and induces significant fat formation.Formula:C12H12ClN7OPurezza:99.07%Colore e forma:SolidPeso molecolare:305.72TC-N 1752
CAS:TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities.Formula:C25H27F3N6O3Purezza:99.71%Colore e forma:SolidPeso molecolare:516.52Ref: TM-T23439
1mg35,00€5mg80,00€10mg117,00€25mg259,00€50mg383,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)88,00€Ralitoline
CAS:<p>Ralitoline (Ralitolinum) is an anticonvulsant with anticancer activity and sodium channel blocking activity.</p>Formula:C13H13ClN2O2SPurezza:98.45%Colore e forma:SolidPeso molecolare:296.77NaV1.2/1.6 channel blocker-1
CAS:NaV1.2/1.6 channel blocker-1 is a NaV1.2/1.6 channel blocker that inhibits rNaV1.6 and can be used to study generalised epilepsy and movement disorders.Formula:C14H14N2OSPurezza:99.54%Colore e forma:SolidPeso molecolare:258.34Elpetrigine
CAS:Elpetrigine (GW273293) is a potential sodium channel blocker with antiepileptic activity that can be used to study epilepsy.Formula:C10H7Cl3N4Purezza:99.04% - 99.43%Colore e forma:SolidPeso molecolare:289.55Silperisone HCl
CAS:Silperisone HCl is a muscle relaxant and vasodilator, treating myoclonus, hypertonia, dystonia, and myospasm by blocking Na+ and Ca2+ channels.Formula:C15H25ClFNSiPurezza:99.97%Colore e forma:SolidPeso molecolare:301.9Nisoxetine hydrochloride
CAS:Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitorFormula:C17H21NO2·HClPurezza:99.21%Colore e forma:White SolidPeso molecolare:307.82KR-32568
CAS:KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM).Formula:C13H12FN3O2Purezza:99.91%Colore e forma:SolidPeso molecolare:261.25Ref: TM-T36569
1mg46,00€5mg42,00€10mg58,00€25mg106,00€50mg160,00€100mg235,00€200mg743,00€1mL*10mM (DMSO)48,00€NHE3-IN-1
CAS:<p>NHE3-IN-1 是钠/质子交换剂 3 (NHE-3) 的抑制剂。</p>Formula:C12H10ClN3SPurezza:99.93%Colore e forma:SolidPeso molecolare:263.756-Iodoamiloride
CAS:6-Iodoamiloride is a potent inhibitor of acid-sensing ion channel 1 (ASIC1), exhibiting an IC50 value of 88 nM.Formula:C6H8IN7OPurezza:98%Colore e forma:SolidPeso molecolare:321.08(Rac)-AMG8379
CAS:<p>(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379 which is an orally active and selective sulfonamide NaV1.7 antagonist.</p>Formula:C25H16ClF2N3O5SPurezza:99.6%Colore e forma:SolidPeso molecolare:543.93Ref: TM-T12655
1mg185,00€2mg279,00€5mg425,00€10mg625,00€25mg938,00€50mg1.311,00€100mg1.795,00€500mg3.591,00€SLC13A5-IN-1
CAS:SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5),completely blocks the uptake of 14C-citrate(IC50 : 0.022 μM in HepG2 cells).Formula:C19H19Cl3N2O3SPurezza:99.67%Colore e forma:SolidPeso molecolare:461.79Ref: TM-T12931
1mg50,00€5mg97,00€10mg160,00€25mg283,00€50mg472,00€100mg658,00€200mg933,00€500mg1.378,00€1mL*10mM (DMSO)120,00€Sodium Channel inhibitor 4
CAS:Sodium Channel Inhibitor 4 is a compound that functions as a sodium channel inhibitor [1].Formula:C19H18ClN3O4S2Purezza:98%Colore e forma:SolidPeso molecolare:451.95Co 102862
CAS:Co 102862 is a voltage-gated sodium channel blocker. Co 102862 can be used for anticonvulsant studies.Formula:C14H12FN3O2Purezza:99.82%Colore e forma:SolidPeso molecolare:273.26GDC-0310
CAS:GDC-0310 is a selective, orally available Nav1.7 inhibitor with an IC50 of 0.6 nM for human Nav1.7, suitable for pain research.Formula:C25H29Cl2FN2O4SPurezza:99.877%Colore e forma:SolidPeso molecolare:543.48PF 04531083
CAS:PF 04531083 is a selective blocker of the NaV1.8 channel. PF 04531083 can be used for neuropathic and inflammatory pain studies.Formula:C17H16ClN5O2Purezza:99.85%Colore e forma:SolidPeso molecolare:357.79Aneratrigine
CAS:Aneratrigine is a blocker of the sodium channel protein type 9 subunit alpha, utilized in research on neuropathic pain diseases [1].Formula:C19H20ClF2N5O2S2Purezza:98%Colore e forma:SolidPeso molecolare:487.97VGSCs-IN-1
CAS:VGSCs-IN-1, a VGSC inhibitor and Riluzole analog, exhibits good blocking activity on Nav1.4 and can be used to study cellular excitability disorders.Formula:C12H12F3N3OSPurezza:99.88%Colore e forma:SolidPeso molecolare:303.3Funapide
CAS:Funapide (TV 45070) is a potent Nav1.7 inhibitor, potentially treating inflammation and various pains.Formula:C22H14F3NO5Purezza:99.91%Colore e forma:SolidPeso molecolare:429.35Ref: TM-T15358
1mg127,00€5mg305,00€10mg464,00€25mg747,00€50mg1.008,00€100mg1.359,00€1mL*10mM (DMSO)335,00€Aneratrigine hydrochloride
CAS:Aneratrigine hydrochloride is a Nav 1.9 blocker that may be used to prevent or treat sodium channel blocker-related disorders.Formula:C19H21Cl2F2N5O2S2Purezza:98.37% - 99.16%Colore e forma:SolidPeso molecolare:524.43ErSO-TFPy
CAS:ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.Formula:C19H13F7N2O2Colore e forma:SolidPeso molecolare:434.307PF-05661014
CAS:PF-05661014, a demethylated analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing the inactivated state through interaction with the D4 VSD. This compound is utilized in research focused on sodium channel modulation.Formula:C17H16N4O3S2Colore e forma:SolidPeso molecolare:388.46Olorigliflozin
CAS:Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.Formula:C23H27ClO7Colore e forma:SolidPeso molecolare:450.909Nav1.7 blocker 1
CAS:Nav1.7 blocker 1 (example 41), an effective Na+ channel (Na v) blocker, exhibits a potent IC50 value of 0.037 μM. This compound is utilized in pain research, encompassing neuropathic, postoperative, and inflammatory pain among others [1].Formula:C22H21FN4O4Peso molecolare:424.42N-Depropylpropafenone
CAS:N-Depropylpropafenone, an active metabolite of Propafenone, is produced through the metabolism by the CYP450 enzyme system (primarily CYP2D6). It functions by blocking sodium ion channels, thereby delaying the depolarization process in myocardial cells and exhibiting antiarrhythmic properties.Formula:C18H21NO3Colore e forma:SolidPeso molecolare:299.36Olisutrigine bromide
CAS:Olisutrigine bromide is a sodium channel blocker used as an analgesic.Formula:C25H35BrN2Colore e forma:SolidPeso molecolare:443.463Nav1.8-IN-5
CAS:Nav1.8-IN-5 (Example 1), a voltage-gated sodium channel Nav1.8 inhibitor, is applicable in the research of Nav1.8-mediated diseases including pain, pain-related disorders, and cardiovascular diseases (such as atrial fibrillation) [1].Formula:C23H15F4N3O2Peso molecolare:441.38Lubeluzole dihydrochloride
CAS:Lubeluzole (dihydrochloride) acts as a neuroprotective agent by blocking neuronal voltage-gated sodium channels and also affects cardiac sodium channels, exhibiting both tonic and blocking effects. This compound is considered promising in the research of antiarrhythmic agents.Formula:C22H27Cl2F2N3O2SColore e forma:SolidPeso molecolare:506.44
