Canale del sodio
I canali del sodio sono proteine di membrana essenziali che permettono il passaggio degli ioni sodio (Na+) attraverso la membrana cellulare, generando e propagando segnali elettrici nei neuroni, nelle cellule muscolari e in altri tessuti eccitabili. Questi canali sono vitali per l'inizio e la conduzione dei potenziali d'azione, rendendoli cruciali in processi come la trasmissione degli impulsi nervosi, la contrazione muscolare e la funzione cardiaca. La disregolazione dei canali del sodio può portare a disturbi neurologici, aritmie e condizioni di dolore cronico. Presso CymitQuimica, offriamo una varietà di modulatori dei canali del sodio per supportare la tua ricerca in neurobiologia, cardiologia e gestione del dolore.
Trovati 217 prodotti di "Canale del sodio"
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Riluzole
CAS:<p>Riluzole (RP-54274) is an anticonvulsant, glutamate antagonist, and prolongs ALS patient survival.</p>Formula:C8H5F3N2OSPurezza:99.71% - 99.88%Colore e forma:PowderPeso molecolare:234.2Benzocaine N-Glucoside (a/b mixture)
CAS:Prodotto controllato<p>Stability Hygroscopic<br>Applications The N-Glucoside of Benzocaine (B202970) with anesthetic activity. A potential sun-screening agent.<br>References Rybczynska, B. et al.: Parfum. Kosm., 48, 125 (1967); Nikolin, A. et al.: Glas. Hemi. Tehnol. Bosne Herceg., 16, 93 (1968);<br></p>Formula:C15H21NO7Colore e forma:NeatPeso molecolare:327.3310,11-Dihydro-10-hydroxy Carbamazepine-d4
CAS:10,11-Dihydro-10-hydroxy Carbamazepine-d4 is a deuterated compound of 10,11-Dihydro-10-hydroxy Carbamazepine. 10,11-Dihydro-10-hydroxy Carbamazepine has a CAS number of 29331-92-8. Licarbazepine is the pharmacologically active metabolite of oxcarbazepine, a drug indicated for the treatment of partial seizures and bipolar disorders.Formula:C15H10D4N2O2Colore e forma:SolidPeso molecolare:258.31Propafenone-d5 HCl
CAS:Propafenone-d5 HCl is a deuterated compound of Propafenone HCl. Propafenone HCl has a CAS number of 34183-22-7. Propafenone HCl is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial and ventricular arrhythmias.Formula:C21H23D5ClNO3Peso molecolare:382.94Deacetamide Acetonitrile-pentisomide
CAS:Prodotto controllato<p>Applications Deacetamide Acetonitrile-pentisomide is an intermediate in the synthesis of Pentisomide (P275600). Pentisomide is a sodium channel blocker; derivative of disopyramide. Antiarrhythmic (class I).<br>References Kuhlkamp, V., et al.: Int. J. Cardiol., 36, 69 (1992); Yuan, S., et al.: Cardiovasc. Drug Rev., 11, 74 (1993)<br></p>Formula:C19H31N3Colore e forma:NeatPeso molecolare:301.47N-(Chloroacetyl)-2,5-dimethylaniline
CAS:Prodotto controllato<p>Applications N-(Chloroacetyl)-2,5-dimethylaniline is an intermediate in the synthesis of impurities of Lidocaine (L397800), an anesthetic local agent and antiarrythmic class IB agent.<br>References Groningsson, K., et al.: Anal. Profiles Drug Subs., 14, 207 (1985), Davies, P.S., et al.: Drugs, 64, 937 (2004),<br></p>Formula:C10H12ClNOColore e forma:NeatPeso molecolare:197.663-(2-Chloropropionyl)amino-4-methyl-2-methoxycarbonylthiophene
CAS:Prodotto controllato<p>Applications 3-(2-Chloropropionyl)amino-4-methyl-2-methoxycarbonylthiophene is an intermediate in the synthesis of Articaine-d7 Hydrochloride which is the labelled form of Articaine Hydrochloride (A777905). Articaine Hydrochloride is the Hydrochloride Salt of Articaine (A777900). Articaine is an amide based short-acting local anesthetic use for regional anaesthesia in day-case settings such arthroscopy, hand, food surgery and in dentistry.<br>References Malamed, S.F., et al.: J. Am. Dent. Assoc., 132, 177 (2001); Luan, F., et al.: Bioorg. Med. Chem., 21, 1870 (2013)<br></p>Formula:C10H12ClNO3SColore e forma:NeatPeso molecolare:261.73Methocarbamol D5
CAS:Methocarbamol is a central muscle relaxant. Methocarbamol D5 is deuterium labeled Methocarbamol.Formula:C11H15NO5Purezza:98%Colore e forma:SolidPeso molecolare:246.27Propafenone D7 hydrochloride
CAS:Propafenone D7 hydrochloride is the deuterium labeled Propafenone, and is a classic anti-arrhythmic medication.Formula:C21H28ClNO3Purezza:98%Colore e forma:SolidPeso molecolare:384.95Nav1.8-IN-14
CAS:Nav1.8-IN-14 (compound 20) is an effective selective inhibitor of Nav1.8. It is utilized in the research of pain-associated diseases.Formula:C18H17F5N4O3SColore e forma:SolidPeso molecolare:464.411,2,4-Oxadiazol-3-amine
CAS:Prodotto controllato<p>Applications 1,2,4-oxadiazol-3-amine (cas# 39512-64-6) is a useful research chemical.<br></p>Formula:C2H3N3OColore e forma:NeatPeso molecolare:85.063-Deoxyyunaconitine
CAS:Prodotto controllato<p>Applications 3-Deoxyyunaconitine is a metabolite of Aconitine (A189875), a neurotoxin that binds, activates tetrodotoxin-sensitive Na+ channels and prolongs the opening of the sodium-ion channel by suppressing conformational changes.<br>References Derbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010), Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010),<br></p>Formula:C35H49NO10Colore e forma:NeatPeso molecolare:643.766-(Propylamino)-2-hydroxy-N-(2,6-dimethylphenyl)hexanamide
Prodotto controllato<p>Applications 6-(Propylamino)-2-hydroxy-N-(2,6-dimethylphenyl)-hexanamide is a derivative of Bupivacaine (B689560), a sodium channel blocker, local anesthetic.<br>References Wilson, T.D., et al.: Anal. Profiles Drug Subs., 19, 59 (1990), McClellan, K.J., et al.: Drugs, 56, 355 (1998),<br></p>Formula:C17H28N2O2Colore e forma:NeatPeso molecolare:292.416Clopamide
CAS:Clopamide (Brinaldix) is a piperidine and sulfamoylbenzamide-based diuretic with thiazide-like diuretic activity.Formula:C14H20ClN3O3SPurezza:99.71%Colore e forma:White To Yellowish Crystalline PowderPeso molecolare:345.84Halofuginone
CAS:Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.Formula:C16H17BrClN3O3Purezza:99.53%Colore e forma:Off-White SolidPeso molecolare:414.68Ref: TM-T6856
1mg37,00€5mg87,00€10mg123,00€25mg240,00€50mg363,00€100mg547,00€500mg1.198,00€1mL*10mM (DMSO)Prezzo su richiestaHalofuginone hydrobromide
CAS:Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.Formula:C16H17BrClN3O3·HBrPurezza:97.01% - 99.73%Colore e forma:SolidPeso molecolare:495.59Ref: TM-T3524
1mg37,00€2mg52,00€5mg79,00€10mg112,00€25mg219,00€50mg328,00€100mg495,00€500mg947,00€1mL*10mM (DMSO)88,00€GX-585
CAS:GX-585 is a novel potent inhibitor of NaV1.7 and highly selective against NaV1.5, having limited selectivity against NaV1.1 and NaV1.2.Formula:C24H25Cl2FN4O3SPurezza:99.02% - 99.03%Colore e forma:SolidPeso molecolare:539.45GDC-0276
CAS:GDC-0276 is an orally active, selective, and potent NaV1.7 inhibitor that can be used for the study of pain-related diseases.Formula:C24H31FN2O4SPurezza:99.77%Colore e forma:SolidPeso molecolare:462.58Relutrigine
CAS:Relutrigine, Oral sodium current inhibitor, suppresses sustained INa (SCN8A mutations), reduces neuronal excitability, for anticonvulsant therapy.Formula:C15H11F6N5O2Purezza:99.68%Colore e forma:SolidPeso molecolare:407.27Ref: TM-T69652
1mg260,00€5mg650,00€10mg1.009,00€25mg1.504,00€50mg1.963,00€100mg2.520,00€1mL*10mM (DMSO)583,00€Nav1.1 activator 1
CAS:Nav1.1 activator 1, Selective Nav1.1 agonist, BBB permeable, increases current decay time, for central nervous system disorder research.Formula:C24H23F3N4OPurezza:98%Colore e forma:SolidPeso molecolare:440.46(5R)-BW-4030W92
CAS:(5R)-BW-4030W92 is the R-type of BW-4030W92, the active enantiomer.Formula:C11H9Cl2FN4Purezza:98.27%Colore e forma:SolidPeso molecolare:287.12GX-936
CAS:GX-936, Selective Nav1.7 inhibitor, binds activated VSD4 to oppose inactivation, for pain perception research.Formula:C24H20F3N7O3S2Purezza:98%Colore e forma:SolidPeso molecolare:575.59NHE3-IN-2
CAS:NHE3-IN-2 is an inhibitor of NHE3 (Na+/H+ exchanger-3), applicable for treating hypertension, thrombosis, and ischaemic diseases.Formula:C15H12ClN5Colore e forma:SolidPeso molecolare:297.74PF 05089771 tosylate
CAS:PF-05089771 inhibits Nav1.7 channels (IC50: 11-33 nM), selective over Nav1.1-1.6/1.8, Ca+, K+ channels, TRPV1; 1000x affinity for half-inactivated state.Formula:C18H12Cl2FN5O3S2·C7H8O3SPurezza:98.55%Colore e forma:SolidPeso molecolare:672.56Phenamil
CAS:Phenamil is an inhibitor of epithelial sodium channels, activates the osteomorphin protein pathway to promote bone repair and induces significant fat formation.Formula:C12H12ClN7OPurezza:99.07%Colore e forma:SolidPeso molecolare:305.72GNE-0439
CAS:GNE-0439 is a Nav1.7-selective inhibitor (IC50 0.34 μM), also targeting Nav1.5 and mutant N1742K channels, valuable for ion channel research.Formula:C21H31NO3Purezza:99.60%Colore e forma:SolidPeso molecolare:345.48Ref: TM-T11437
1mg154,00€5mg371,00€10mg620,00€25mg1.305,00€50mg1.783,00€100mg2.250,00€1mL*10mM (DMSO)409,00€Sodium Channel inhibitor 2
CAS:Sodium Channel inhibitor 2 is a blocker of sodium channel.Formula:C26H25Cl2N3OPurezza:98%Colore e forma:SolidPeso molecolare:466.4DPI 201-106
CAS:DPI 201-106: cardioselective h1 Na channel inhibitor, enhances heart contraction, blocks potassium and calcium currents.Formula:C29H30N4O2Purezza:99.94%Colore e forma:SolidPeso molecolare:466.57Nav1.7 inhibitor
CAS:Nav1.7 inhibitor is a Nav1.7 inhibitor for research in the field of pain and anesthesia.Formula:C15H11Cl3FNO4SPurezza:97.52%Colore e forma:SolidPeso molecolare:426.68Ref: TM-T12184
1mg42,00€2mg55,00€5mg89,00€10mg135,00€25mg264,00€50mg423,00€100mg677,00€1mL*10mM (DMSO)87,00€E 0747
CAS:<p>E 0747 is an antiarrhythmic agent of class 1C type. E-0747 suppresses arrhythmia by inhibiting the Na channels of cardiac cells.</p>Formula:C21H28ClN3O4Purezza:95.17%Colore e forma:SolidPeso molecolare:421.92GX-674
CAS:GX-674 is a highly potent and selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC50 value of 0.1 nM measured at -40 mV for the study ofFormula:C21H13ClF2N6O3S2Purezza:98.60%Colore e forma:SolidPeso molecolare:534.95Silperisone HCl
CAS:Silperisone HCl is a muscle relaxant and vasodilator, treating myoclonus, hypertonia, dystonia, and myospasm by blocking Na+ and Ca2+ channels.Formula:C15H25ClFNSiPurezza:99.97%Colore e forma:SolidPeso molecolare:301.9TC-N 1752
CAS:TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities.Formula:C25H27F3N6O3Purezza:99.71%Colore e forma:SolidPeso molecolare:516.52Ref: TM-T23439
1mg35,00€5mg80,00€10mg117,00€25mg259,00€50mg383,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)88,00€Nisoxetine hydrochloride
CAS:Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitorFormula:C17H21NO2·HClPurezza:99.21%Colore e forma:White SolidPeso molecolare:307.82KR-32568
CAS:KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM).Formula:C13H12FN3O2Purezza:99.91%Colore e forma:SolidPeso molecolare:261.25Elpetrigine
CAS:Elpetrigine (GW273293) is a potential sodium channel blocker with antiepileptic activity that can be used to study epilepsy.Formula:C10H7Cl3N4Purezza:99.04% - 99.43%Colore e forma:SolidPeso molecolare:289.55NaV1.2/1.6 channel blocker-1
CAS:NaV1.2/1.6 channel blocker-1 is a NaV1.2/1.6 channel blocker that inhibits rNaV1.6 and can be used to study generalised epilepsy and movement disorders.Formula:C14H14N2OSPurezza:99.54%Colore e forma:SolidPeso molecolare:258.34NHE3-IN-1
CAS:<p>NHE3-IN-1 是钠/质子交换剂 3 (NHE-3) 的抑制剂。</p>Formula:C12H10ClN3SPurezza:99.93%Colore e forma:SolidPeso molecolare:263.75Ralitoline
CAS:Ralitoline (Ralitolinum) is an anticonvulsant with anticancer activity and sodium channel blocking activity.Formula:C13H13ClN2O2SPurezza:98.45%Colore e forma:SolidPeso molecolare:296.77(Rac)-AMG8379
CAS:<p>(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379 which is an orally active and selective sulfonamide NaV1.7 antagonist.</p>Formula:C25H16ClF2N3O5SPurezza:99.6%Colore e forma:SolidPeso molecolare:543.93Ref: TM-T12655
1mg185,00€2mg279,00€5mg425,00€10mg625,00€25mg938,00€50mg1.311,00€100mg1.795,00€500mg3.591,00€Sodium Channel inhibitor 4
CAS:Sodium Channel Inhibitor 4 is a compound that functions as a sodium channel inhibitor [1].Formula:C19H18ClN3O4S2Purezza:98%Colore e forma:SolidPeso molecolare:451.95PF 04531083
CAS:PF 04531083 is a selective blocker of the NaV1.8 channel. PF 04531083 can be used for neuropathic and inflammatory pain studies.Formula:C17H16ClN5O2Purezza:99.85%Colore e forma:SolidPeso molecolare:357.79GDC-0310
CAS:GDC-0310 is a selective, orally available Nav1.7 inhibitor with an IC50 of 0.6 nM for human Nav1.7, suitable for pain research.Formula:C25H29Cl2FN2O4SPurezza:99.877%Colore e forma:SolidPeso molecolare:543.48Aneratrigine
CAS:Aneratrigine is a blocker of the sodium channel protein type 9 subunit alpha, utilized in research on neuropathic pain diseases [1].Formula:C19H20ClF2N5O2S2Purezza:98%Colore e forma:SolidPeso molecolare:487.97SLC13A5-IN-1
CAS:SLC13A5-IN-1 is a selective inhibitor of sodium-citrate co-transporter (SLC13A5),completely blocks the uptake of 14C-citrate(IC50 : 0.022 μM in HepG2 cells).Formula:C19H19Cl3N2O3SPurezza:99.67%Colore e forma:SolidPeso molecolare:461.79Ref: TM-T12931
1mg48,00€5mg92,00€10mg152,00€25mg268,00€50mg447,00€100mg623,00€200mg883,00€500mg1.305,00€1mL*10mM (DMSO)114,00€Co 102862
CAS:Co 102862 is a voltage-gated sodium channel blocker. Co 102862 can be used for anticonvulsant studies.Formula:C14H12FN3O2Purezza:99.82%Colore e forma:SolidPeso molecolare:273.266-Iodoamiloride
CAS:6-Iodoamiloride is a potent inhibitor of acid-sensing ion channel 1 (ASIC1), exhibiting an IC50 value of 88 nM.Formula:C6H8IN7OPurezza:98%Colore e forma:SolidPeso molecolare:321.08Aneratrigine hydrochloride
CAS:Aneratrigine hydrochloride is a Nav 1.9 blocker that may be used to prevent or treat sodium channel blocker-related disorders.Formula:C19H21Cl2F2N5O2S2Purezza:98.37% - 99.16%Colore e forma:SolidPeso molecolare:524.43VGSCs-IN-1
CAS:VGSCs-IN-1, a VGSC inhibitor and Riluzole analog, exhibits good blocking activity on Nav1.4 and can be used to study cellular excitability disorders.Formula:C12H12F3N3OSPurezza:99.88%Colore e forma:SolidPeso molecolare:303.3Funapide
CAS:Funapide (TV 45070) is a potent Nav1.7 inhibitor, potentially treating inflammation and various pains.Formula:C22H14F3NO5Purezza:99.91%Colore e forma:SolidPeso molecolare:429.35Ref: TM-T15358
1mg127,00€5mg305,00€10mg464,00€25mg747,00€50mg1.008,00€100mg1.359,00€1mL*10mM (DMSO)335,00€
