Canale del sodio
I canali del sodio sono proteine di membrana essenziali che permettono il passaggio degli ioni sodio (Na+) attraverso la membrana cellulare, generando e propagando segnali elettrici nei neuroni, nelle cellule muscolari e in altri tessuti eccitabili. Questi canali sono vitali per l'inizio e la conduzione dei potenziali d'azione, rendendoli cruciali in processi come la trasmissione degli impulsi nervosi, la contrazione muscolare e la funzione cardiaca. La disregolazione dei canali del sodio può portare a disturbi neurologici, aritmie e condizioni di dolore cronico. Presso CymitQuimica, offriamo una varietà di modulatori dei canali del sodio per supportare la tua ricerca in neurobiologia, cardiologia e gestione del dolore.
Trovati 367 prodotti per "Canale del sodio".
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ASIC1a antagonist-1
CAS:ASIC1a antagonist-1 (Compound 5b) is an orthosteric non-competitive antagonist of the acid-sensing ion channel 1a (ASIC1a) with an IC50 of 27 nM at pH 6.7. It alters the pH dependency of ASIC1a activation and suppresses its maximum response. Additionally, ASIC1a antagonist-1 completely inhibits the induction of long-term potentiation (LTP) in the CA3-CA1 pathway. This compound is useful for research into brain diseases and pathologies.Formula:C23H29Cl3N4O2Peso molecolare:499.86Nav1.7 blocker 1
CAS:Nav1.7 blocker 1 (example 41), an effective Na+ channel (Na v) blocker, exhibits a potent IC50 value of 0.037 μM. This compound is utilized in pain research, encompassing neuropathic, postoperative, and inflammatory pain among others [1].Formula:C22H21FN4O4Colore e forma:SolidPeso molecolare:424.42Quinacainol dihydrochloride
CAS:Quinacainol dihydrochloride (PK 10139 dihydrochloride) is the bis(2 hydrochloride) salt form of Quinacainol. It acts as an inhibitor of the sodium current, with an EC50 of 95 µM. This compound displays antiarrhythmic activity by modulating the electrophysiological properties of the heart.Formula:C21H32Cl2N2OColore e forma:SolidPeso molecolare:399.398Zilvetrigine
CAS:Zilvetrigine is a sodium channel (sodium channel) blocker. It can be used as an analgesic.Formula:C20H20ClN3O2Colore e forma:SolidPeso molecolare:369.845Olorigliflozin
CAS:Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.Formula:C23H27ClO7Colore e forma:SolidPeso molecolare:450.909ErSO-TFPy
CAS:ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.Formula:C19H13F7N2O2Colore e forma:SolidPeso molecolare:434.307Olisutrigine bromide
CAS:Olisutrigine bromide is a sodium channel blocker used as an analgesic.Formula:C25H35BrN2Colore e forma:SolidPeso molecolare:443.463Nav1.5-IN-1
CAS:Nav1.5-IN-1 is a selective Nav1.5 inhibitor with an IC50 of 1.38 μM, demonstrating specificity towards other Nav subtypes. It reduces the cardiac conduction velocity in isolated rat hearts and is applicable in arrhythmia research.Formula:C36H36ClN3O4SPeso molecolare:642.21Nav1.8-IN-19
CAS:Nav1.8-IN-19 (Compound 122) is a potent inhibitor of Nav1.8.Formula:C21H20F3N5O3SPeso molecolare:479.48Nav1.8-IN-20
CAS:Nav1.8-IN-20 (Compound I) is an orally active inhibitor of the voltage-gated sodium channel Nav1.8, with an IC50 value of 14 nM. It effectively blocks the generation and propagation of action potentials in peripheral nociceptive neurons, providing analgesic effects. Nav1.8-IN-20 shows potential for research in several pain types, including acute, chronic, inflammatory, and neuropathic pain.Formula:C18H10Cl2F3N3O4Peso molecolare:460.19Lubeluzole dihydrochloride
CAS:Lubeluzole (dihydrochloride) acts as a neuroprotective agent by blocking neuronal voltage-gated sodium channels and also affects cardiac sodium channels, exhibiting both tonic and blocking effects. This compound is considered promising in the research of antiarrhythmic agents.Formula:C22H27Cl2F2N3O2SColore e forma:SolidPeso molecolare:506.44PF-05661014
CAS:PF-05661014, a demethylated analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing the inactivated state through interaction with the D4 VSD. This compound is utilized in research focused on sodium channel modulation.Formula:C17H16N4O3S2Colore e forma:SolidPeso molecolare:388.46Gonyautoxin III
CAS:Gonyautoxin III (GTX-III) is a paralytic shellfish toxin. It inhibits voltage-gated sodium channels at the axonal level, with an IC50 value of 14.9 nM, thereby disrupting the conduction of nerve impulses. Gonyautoxin III also exhibits cytotoxic activity against mouse neuroblastoma cells and is applicable in research on cancer and neurological diseases.Formula:C10H17N7O8SPeso molecolare:395.35Nav1.7-IN-22
CAS:Nav1.7-IN-22 (P58 13-2) is a selective inhibitor of the voltage-gated sodium channel Nav1.7. By blocking the activity of the Nav1.7 channel, Nav1.7-IN-22 suppresses the generation and transmission of abnormal electrical signals in sensory neurons. This compound is applicable for research related to pain.Formula:C20H18FN5O4S2Peso molecolare:475.52Suzetrigine
CAS:Suzetrigine (VX-548) is an oral NaV1.8 inhibitor with analgesic properties for acute pain research.Formula:C21H20F5N3O4Purezza:98.08% - 99.97%Colore e forma:White SolidPeso molecolare:473.39Ref: TM-T69552
300gPrezzo su richiesta1mg55,00€5mg108,00€1mL*10mM (DMSO)112,00€10mg161,00€25mg253,00€50mg434,00€100mg707,00€200mg973,00€µ-Conotoxin-CnIIIC acetate
µ-Conotoxin-CnIIIC acetate is a NaV1.4 sodium channel antagonist, a conotoxin peptide consisting of 22 amino acids, used for muscle relaxation and pain relief.Formula:C92H139N35O28S6·xC2H4O2Purezza:99.94%Colore e forma:SolidPeso molecolare:2375.70 (free base)Ref: TM-T78108
Prodotto fuori produzioneµ-Conotoxin GIIIB
CAS:μ-Conotoxin GIIIB, a 22-residue polypeptide derived from the venom of the piscivorous cone snail Conus geographus, serves as an inhibitor of the Na V 1.4Formula:C101H175N39O30S7Purezza:98%Colore e forma:SolidPeso molecolare:2640.17µ-Conotoxin BuIIIA
μ-Conotoxin BuIIIA (Mu-Conotoxin BuIIIA), a toxin derived from Cone snail venom, functions as a voltage-gated sodium channel (VGSC) blocker.Formula:C106H172N44O31S6Purezza:98%Colore e forma:SolidPeso molecolare:2751.17µ-Conotoxin SIIIA
CAS:μ-Conotoxin SIIIA, a tetrodotoxin (TTX)-resistant sodium channel blocker, is a toxic peptide derived from Conus snail venom.Formula:C83H123N33O27S6Purezza:98%Colore e forma:SolidPeso molecolare:2207.46µ-Conotoxin BuIIIB
CAS:μ-Conotoxin BuIIIB (Mu-Conotoxin BuIIIB), a selective blocker of mammalian neuronal voltage-gated sodium channels (VGSC), is derived from Cone snail venom andFormula:C106H172N46O30S6Purezza:98%Colore e forma:SolidPeso molecolare:2763.18
