OAT
I trasportatori di anioni organici sono una famiglia di proteine di membrana che mediano l'assorbimento e l'escrezione di vari anioni organici endogeni ed esogeni, inclusi farmaci, tossine e sottoprodotti metabolici. Gli OAT sono principalmente espressi nei reni e nel fegato, dove svolgono un ruolo cruciale nella detossificazione e nell'eliminazione dei farmaci. La disfunzione degli OAT può portare a tossicità da farmaci e disturbi renali. Presso CymitQuimica, offriamo una varietà di modulatori degli OAT per supportare la tua ricerca in farmacologia, tossicologia e funzione renale.
Trovati 33 prodotti per "OAT".
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URAT1 inhibitor 7
CAS:URAT1 inhibitor 7, a uric acid transporter protein URAT1 inhibitor.URAT1 inhibitor 7 inhibits CYP2C9 and can be used in the study of hyperuricemia and gout.Formula:C19H10ClFN4O3SPurezza:97.14%Colore e forma:SolidPeso molecolare:428.82URAT1 inhibitor 10
URAT1 inhibitor10 (Compound 23a) is a URAT1 inhibitor with an IC50 of 0.052 μM. It exhibits oral efficacy and low cytotoxicity. The compound demonstrates high selectivity for OAT1, with an IC50 of 9.17 μM.Colore e forma:Odour SolidhURAT1 inhibitor 1
Compound 27b, also known as hURAT1 inhibitor 1, is an isomarine-derived, orally active inhibitor that targets both hURAT1 and GLUT9 with IC50 values of 0.16 μM and 4.47 μM, respectively. This compound exhibits significant anti-hyperuricemia effects and has demonstrated potent uric acid-lowering activity in a hyperuricemia mouse model at a dose of 10 mg/kg. Importantly, Compound 27b displays no notable in vitro cytotoxicity or in vivo hepatotoxicity, and possesses favorable pharmacokinetic (PK) characteristics.Formula:C24H19BrO4Colore e forma:SolidPeso molecolare:451.31URAT1 inhibitor 11
CAS:URAT1 inhibitor11 (Compound 7) is a potent URAT1 inhibitor, exhibiting an IC50 of 0.18 μM. It effectively reduces uric acid levels in zebrafish with hyperuricemia induced by Potassium oxonate and Xanthinesodium salt.Formula:C20H16F4N2O2Colore e forma:SolidPeso molecolare:392.354'-hydroxy Trazodone
CAS:4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone.1It is an inhibitor of organic anion transporter 3 (OAT3; Ki= 16.9 μM) and isFormula:C19H22ClN5O2Colore e forma:SolidPeso molecolare:387.87URAT1-IN-15
URAT1-IN-15 (Compound 9) is an orally active, selective URAT1 inhibitor with an IC50 value of 69.81 nM. It inhibits CYP2C9 with an IC50 of 8.39 μM. URAT1-IN-15 displays uricosuric activity, making it suitable for hyperuricemia research.Epaminurad HCl
CAS:Epaminurad HCl is a URAT1 inhibitor with partial inhibition of OAT1 and OAT3 (organic anion transporters).Epaminurad HCl is a pro-uric acid excretory agent used for the prevention and treatment of gout and hyperuricemia.Formula:C14H11Br2ClN2O3Purezza:99.01% - 99.98%Colore e forma:Yellow SolidPeso molecolare:450.51URAT1/GLUT9-IN-1
URAT1/GLUT9-IN-1 (compound 29) effectively inhibits urate transporter 1 (URAT1) with an IC50 value of 2.01 μM and glucose transporter 9 (GLUT9) with an IC50 of 18.21 μM. This compound exhibits favorable pharmacokinetic properties and oral bioavailability, making it useful for research in gout and hyperuricemia.HYJ-2
HYJ-2 is a URAT1 inhibitor and uric acid-lowering agent. It inhibits URAT1-mediated uric acid transport by interacting with key residues within the URAT1 binding pocket. HYJ-2 effectively reduces serum uric acid levels in hyperuricemic mice without causing liver or kidney damage. It exhibits low cytotoxicity toward hepatocytes and renal cells and does not significantly induce hepatocyte apoptosis or mitochondrial dysfunction. HYJ-2 is useful for research related to hyperuricemia and gout.Ruzinurad
CAS:Ruzinurad (WO2020088641, compound I) is a potent URAT1 inhibitor, exhibiting high selectivity.Formula:C14H12BrNO2SPurezza:99.34%Colore e forma:SolidPeso molecolare:338.22Lesinurad sodium
CAS:Lesinurad sodium (RDEA594 sodium) is a selective inhibitor of uric acid reabsorption and is used in the study of cardiovascular diseases.Formula:C17H13BrN3NaO2SPurezza:99.97%Colore e forma:SolidPeso molecolare:426.263Epaminurad
CAS:Epaminurad (UR-1102) is an oral URAT1 inhibitor for gout research with a Ki of 0.057 μM, modestly affects OAT1/3.Formula:C14H10Br2N2O3Colore e forma:SolidPeso molecolare:414.049Dotinurad
CAS:Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) is a potent agent of uricosuric (IC50: 3.6 μM for uric acid).Formula:C14H9Cl2NO4SPurezza:97.43% - 98.04%Colore e forma:SolidPeso molecolare:358.197Cabotegravir
CAS:Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (Formula:C19H17F2N3O5Purezza:98.55% - 99.92%Colore e forma:Red SolidPeso molecolare:405.35Lesinurad
CAS:Lesinurad (RDEA594), a selective uric acid reabsorption inhibitor, is used to treat gout without causing liver damage.Formula:C17H14BrN3O2SPurezza:99.83% - 99.86%Colore e forma:SolidPeso molecolare:404.281Verinurad
CAS:Verinurad (RDEA3170) (RDEA3170) is an organic anion transporter URAT1 (SLC22A12) inhibitor for the treatment of gout and hyperuricemia.Formula:C20H16N2O2SPurezza:97.36% - 99.22%Colore e forma:SolidPeso molecolare:348.418XOR/URAT1-IN-1
CAS:Compound II15, known as XOR/URAT1-IN-1, serves as a dual inhibitor targeting xanthine oxidoreductase (XOR) and uric acid transporter 1 (URAT1), exhibiting IC50 values of 6 nM and 12.9 μM, respectively. This compound effectively reduces uric acid levels in a mouse model of acute hyperuricemia induced by potassium oxonate and hypoxanthine.Formula:C18H13ClN2O3Colore e forma:SolidPeso molecolare:340.76URAT1 inhibitor 4
CAS:URAT1 inhibitor 4 is a potent, orally active Lesinurad derivative with a 7.56 μM IC50, showing greater in vivo efficacy.Formula:C27H20BrN3O4S3Colore e forma:SolidPeso molecolare:626.56Xininurad
CAS:Xininurad (XNW3009) is a urate transporter (URAT) inhibitor.Formula:C15H10Br2FN3O2Colore e forma:SolidPeso molecolare:443.065JTT-552
CAS:JTT-552, a uric acid transporter 1 (URAT1) inhibitor, is used potentially for the treatment of hyperuricemia.Formula:C15H12ClNO3Purezza:98%Colore e forma:SolidPeso molecolare:289.71
