OAT
I trasportatori di anioni organici sono una famiglia di proteine di membrana che mediano l'assorbimento e l'escrezione di vari anioni organici endogeni ed esogeni, inclusi farmaci, tossine e sottoprodotti metabolici. Gli OAT sono principalmente espressi nei reni e nel fegato, dove svolgono un ruolo cruciale nella detossificazione e nell'eliminazione dei farmaci. La disfunzione degli OAT può portare a tossicità da farmaci e disturbi renali. Presso CymitQuimica, offriamo una varietà di modulatori degli OAT per supportare la tua ricerca in farmacologia, tossicologia e funzione renale.
Trovati 31 prodotti di "OAT"
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URAT1&XO inhibitor 2
CAS:Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 μM forFormula:C14H12BrNO3Purezza:98%Colore e forma:SolidPeso molecolare:322.15URAT1 inhibitor 1
CAS:URAT1 inhibitor 1 (1g) is an inhibitor of uric acid transporter 1 (URAT1) (IC50: 32 nM), has the potential to treat hyperuricemia associated with gout.Formula:C19H15Br2N5O2S2Purezza:98%Colore e forma:SolidPeso molecolare:569.29URAT1 inhibitor 6
CAS:URAT1 inhibitor 6 (Compound 1h), with an IC50 of 35 nM for hURAT1, demonstrates 200-fold and 8-fold greater potency compared to Lesinurad and Benzbromarone,Formula:C9H7BrN3NaO2S2Colore e forma:SolidPeso molecolare:356.2URAT1 inhibitor 8
CAS:URAT1 Inhibitor 8 (example 247) serves as a highly potent inhibitor of URAT1, demonstrating an IC50 value of 0.001 μM.Formula:C19H13ClFN3O4SColore e forma:SolidPeso molecolare:433.84Lingdolinurad
CAS:Lingdolinurad is a uric acid transporter protein inhibitor targeting hURAT1 for the study of hyperuricemia or gout.Formula:C17H12BrN3O2Purezza:96.26%Colore e forma:SolidPeso molecolare:370.2TRPV1 antagonist 10
CAS:TRPV1 antagonist 10 is a potent, orally active TRPV1 antagonist with an IC50 of 33.06 nM and serves as a moderate to weak inhibitor of URAT1 (IC50 = 22.51 μM) and GLUT9 (inhibition of 60.25% at 50 μM). It exhibits analgesic and urate-lowering properties and is applicable for research in hyperuricemia and inflammatory pain.Formula:C16H14N2O5Colore e forma:SolidPeso molecolare:314.293KPH2f
CAS:KPH2f: dual URAT1/GLUT9 inhibitor, orally active, IC50: 0.24μM (URAT1), 9.37μM (GLUT9), minimal OAT1/ABCG2 impact.Formula:C24H16N3NaO2SColore e forma:SolidPeso molecolare:433.46hURAT1 inhibitor 2
CAS:hURAT1 inhibitor 2 (Compound 5) is an inhibitor of hURAT1 (uric acid transporter 1, SLC22A12) with an IC50 of 18 nM. It also exhibits some inhibitory activity against OATP1B1, with an IC50 of 0.73 μM. hURAT1 inhibitor 2 can be used in research related to hyperuricemia, gout, and other diseases associated with abnormal uric acid metabolism.Formula:C17H11Br2FO3Colore e forma:SolidPeso molecolare:442.074URAT1 inhibitor 3
URAT1 inhibitor 3: potent oral URAT1 blocker, IC50=0.8 nM, for gout/hyperuricemia study.Formula:C14H8Cl2N2O2Colore e forma:SolidPeso molecolare:307.13URAT1 inhibitor 2
URAT1 inhibitor 2: oral URAT1/CYP blocker, IC50 of 1.36μM (URAT1), 16.97μM (CYP1A2), 5.22μM (CYP2C9); potential gout treatment.Formula:C21H18BrN3O2SColore e forma:SolidPeso molecolare:456.36URAT1-IN-14
CAS:URAT1-IN-14 is a potent and orally active inhibitor of uric acid transporter 1 (URAT1). It demonstrates an IC50 value of 0.72 μM for inhibiting human URAT1 in HEK293 cells and exhibits low cytotoxicity in Hep-G2 cells. URAT1-IN-14 reduces uric acid levels in a hyperuricemia mouse model and is applicable in research on hyperuricemia and gout.Formula:C19H19NO3SColore e forma:SolidPeso molecolare:341.42
