OAT
I trasportatori di anioni organici sono una famiglia di proteine di membrana che mediano l'assorbimento e l'escrezione di vari anioni organici endogeni ed esogeni, inclusi farmaci, tossine e sottoprodotti metabolici. Gli OAT sono principalmente espressi nei reni e nel fegato, dove svolgono un ruolo cruciale nella detossificazione e nell'eliminazione dei farmaci. La disfunzione degli OAT può portare a tossicità da farmaci e disturbi renali. Presso CymitQuimica, offriamo una varietà di modulatori degli OAT per supportare la tua ricerca in farmacologia, tossicologia e funzione renale.
Trovati 31 prodotti di "OAT"
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URAT1 inhibitor 7
CAS:URAT1 inhibitor 7, a uric acid transporter protein URAT1 inhibitor.URAT1 inhibitor 7 inhibits CYP2C9 and can be used in the study of hyperuricemia and gout.Formula:C19H10ClFN4O3SPurezza:97.14%Colore e forma:SoildPeso molecolare:428.824'-hydroxy Trazodone
CAS:<p>4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone.1It is an inhibitor of organic anion transporter 3 (OAT3; Ki= 16.9 μM) and is</p>Formula:C19H22ClN5O2Colore e forma:SolidPeso molecolare:387.87Epaminurad HCl
CAS:Epaminurad HCl is a URAT1 inhibitor with partial inhibition of OAT1 and OAT3 (organic anion transporters).Epaminurad HCl is a pro-uric acid excretory agent used for the prevention and treatment of gout and hyperuricemia.Formula:C14H11Br2ClN2O3Purezza:99.01% - 99.42%Colore e forma:SoildPeso molecolare:450.51hURAT1 inhibitor 1
Compound 27b, also known as hURAT1 inhibitor 1, is an isomarine-derived, orally active inhibitor that targets both hURAT1 and GLUT9 with IC50 values of 0.16 μM and 4.47 μM, respectively. This compound exhibits significant anti-hyperuricemia effects and has demonstrated potent uric acid-lowering activity in a hyperuricemia mouse model at a dose of 10 mg/kg. Importantly, Compound 27b displays no notable in vitro cytotoxicity or in vivo hepatotoxicity, and possesses favorable pharmacokinetic (PK) characteristics.Formula:C24H19BrO4Peso molecolare:451.31URAT1 inhibitor 10
URAT1 inhibitor10 (Compound 23a) is a URAT1 inhibitor with an IC50 of 0.052 μM. It exhibits oral efficacy and low cytotoxicity. The compound demonstrates high selectivity for OAT1, with an IC50 of 9.17 μM.URAT1 inhibitor 11
CAS:URAT1 inhibitor11 (Compound 7) is a potent URAT1 inhibitor, exhibiting an IC50 of 0.18 μM. It effectively reduces uric acid levels in zebrafish with hyperuricemia induced by Potassium oxonate and Xanthinesodium salt.Formula:C20H16F4N2O2Colore e forma:SolidPeso molecolare:392.35Euphol acetate
CAS:Euphol acetate, a triterpene from Euphorbia broteri, inhibits liver transport proteins OATP1B1/3.Formula:C32H52O2Colore e forma:SolidPeso molecolare:468.75URAT1/GLUT9-IN-1
URAT1/GLUT9-IN-1 (compound 29) effectively inhibits urate transporter 1 (URAT1) with an IC50 value of 2.01 μM and glucose transporter 9 (GLUT9) with an IC50 of 18.21 μM. This compound exhibits favorable pharmacokinetic properties and oral bioavailability, making it useful for research in gout and hyperuricemia.Ruzinurad
CAS:Ruzinurad (WO2020088641, compound I) is a potent URAT1 inhibitor, exhibiting high selectivity.Formula:C14H12BrNO2SColore e forma:SolidPeso molecolare:338.22Lesinurad sodium
CAS:Lesinurad sodium (RDEA594 sodium) is a selective inhibitor of uric acid reabsorption and is used in the study of cardiovascular diseases.Formula:C17H13BrN3NaO2SPurezza:99.97%Colore e forma:SolidPeso molecolare:426.26Verinurad
CAS:Verinurad (RDEA3170) (RDEA3170) is an organic anion transporter URAT1 (SLC22A12) inhibitor for the treatment of gout and hyperuricemia.Formula:C20H16N2O2SPurezza:97.36% - 99.22%Colore e forma:SolidPeso molecolare:348.42Cabotegravir
CAS:Cabotegravir (S/GSK1265744) (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor and inhibits the HIV-1 integrase catalyzed strand transfer reaction (Formula:C19H17F2N3O5Purezza:98.55% - 99.92%Colore e forma:SolidPeso molecolare:405.35Lesinurad
CAS:Lesinurad (RDEA594), a selective uric acid reabsorption inhibitor, is used to treat gout without causing liver damage.Formula:C17H14BrN3O2SPurezza:99.83% - 99.86%Colore e forma:SolidPeso molecolare:404.28Epaminurad
CAS:<p>Epaminurad (UR-1102) is an oral URAT1 inhibitor for gout research with a Ki of 0.057 μM, modestly affects OAT1/3.</p>Formula:C14H10Br2N2O3Colore e forma:SolidPeso molecolare:414.05Dotinurad
CAS:Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) is a potent agent of uricosuric (IC50: 3.6 μM for uric acid).Formula:C14H9Cl2NO4SPurezza:97.43% - 98.04%Colore e forma:SolidPeso molecolare:358.2XOR/URAT1-IN-1
CAS:Compound II15, known as XOR/URAT1-IN-1, serves as a dual inhibitor targeting xanthine oxidoreductase (XOR) and uric acid transporter 1 (URAT1), exhibiting IC50 values of 6 nM and 12.9 μM, respectively. This compound effectively reduces uric acid levels in a mouse model of acute hyperuricemia induced by potassium oxonate and hypoxanthine.Formula:C18H13ClN2O3Peso molecolare:340.76JTT-552
CAS:<p>JTT-552, a uric acid transporter 1 (URAT1) inhibitor, is used potentially for the treatment of hyperuricemia.</p>Formula:C15H12ClNO3Purezza:98%Colore e forma:SolidPeso molecolare:289.71URAT1 inhibitor 4
CAS:URAT1 inhibitor 4 is a potent, orally active Lesinurad derivative with a 7.56 μM IC50, showing greater in vivo efficacy.Formula:C27H20BrN3O4S3Colore e forma:SolidPeso molecolare:626.56Xininurad
CAS:Xininurad (XNW3009) is a urate transporter (URAT) inhibitor.Formula:C15H10Br2FN3O2Colore e forma:SolidPeso molecolare:443.07Puliginurad
CAS:Puliginurad (YL-90148) is a urate transporter protein inhibitor that inhibits the reabsorption of uric acid.Puliginurad is used in the treatment of gout.Formula:C19H16N2O2SPurezza:99.96% - 99.96%Colore e forma:SolidPeso molecolare:336.41URAT1&XO inhibitor 2
CAS:Compound BDEO (URAT1&XO inhibitor 2) serves as a dual-action inhibitor targeting both xanthine oxidase (XO) and URAT1, demonstrating an IC50 value of 3.3 μM forFormula:C14H12BrNO3Purezza:98%Colore e forma:SolidPeso molecolare:322.15URAT1 inhibitor 1
CAS:URAT1 inhibitor 1 (1g) is an inhibitor of uric acid transporter 1 (URAT1) (IC50: 32 nM), has the potential to treat hyperuricemia associated with gout.Formula:C19H15Br2N5O2S2Purezza:98%Colore e forma:SolidPeso molecolare:569.29URAT1 inhibitor 6
CAS:URAT1 inhibitor 6 (Compound 1h), with an IC50 of 35 nM for hURAT1, demonstrates 200-fold and 8-fold greater potency compared to Lesinurad and Benzbromarone,Formula:C9H7BrN3NaO2S2Colore e forma:SolidPeso molecolare:356.2URAT1 inhibitor 8
CAS:URAT1 Inhibitor 8 (example 247) serves as a highly potent inhibitor of URAT1, demonstrating an IC50 value of 0.001 μM.Formula:C19H13ClFN3O4SColore e forma:SolidPeso molecolare:433.84Lingdolinurad
CAS:Lingdolinurad is a uric acid transporter protein inhibitor targeting hURAT1 for the study of hyperuricemia or gout.Formula:C17H12BrN3O2Purezza:96.26%Colore e forma:SolidPeso molecolare:370.2TRPV1 antagonist 10
CAS:TRPV1 antagonist 10 is a potent, orally active TRPV1 antagonist with an IC50 of 33.06 nM and serves as a moderate to weak inhibitor of URAT1 (IC50 = 22.51 μM) and GLUT9 (inhibition of 60.25% at 50 μM). It exhibits analgesic and urate-lowering properties and is applicable for research in hyperuricemia and inflammatory pain.Formula:C16H14N2O5Colore e forma:SolidPeso molecolare:314.293KPH2f
CAS:KPH2f: dual URAT1/GLUT9 inhibitor, orally active, IC50: 0.24μM (URAT1), 9.37μM (GLUT9), minimal OAT1/ABCG2 impact.Formula:C24H16N3NaO2SColore e forma:SolidPeso molecolare:433.46hURAT1 inhibitor 2
CAS:hURAT1 inhibitor 2 (Compound 5) is an inhibitor of hURAT1 (uric acid transporter 1, SLC22A12) with an IC50 of 18 nM. It also exhibits some inhibitory activity against OATP1B1, with an IC50 of 0.73 μM. hURAT1 inhibitor 2 can be used in research related to hyperuricemia, gout, and other diseases associated with abnormal uric acid metabolism.Formula:C17H11Br2FO3Colore e forma:SolidPeso molecolare:442.074URAT1 inhibitor 3
URAT1 inhibitor 3: potent oral URAT1 blocker, IC50=0.8 nM, for gout/hyperuricemia study.Formula:C14H8Cl2N2O2Colore e forma:SolidPeso molecolare:307.13URAT1 inhibitor 2
URAT1 inhibitor 2: oral URAT1/CYP blocker, IC50 of 1.36μM (URAT1), 16.97μM (CYP1A2), 5.22μM (CYP2C9); potential gout treatment.Formula:C21H18BrN3O2SColore e forma:SolidPeso molecolare:456.36URAT1-IN-14
CAS:URAT1-IN-14 is a potent and orally active inhibitor of uric acid transporter 1 (URAT1). It demonstrates an IC50 value of 0.72 μM for inhibiting human URAT1 in HEK293 cells and exhibits low cytotoxicity in Hep-G2 cells. URAT1-IN-14 reduces uric acid levels in a hyperuricemia mouse model and is applicable in research on hyperuricemia and gout.Formula:C19H19NO3SColore e forma:SolidPeso molecolare:341.42
