PDE
Le fosfodiesterasi (PDEs) sono enzimi che idrolizzano i nucleotidi ciclici, come cAMP e cGMP, nelle loro forme inattive, svolgendo un ruolo chiave nella regolazione delle vie di segnalazione intracellulare. Gli inibitori delle PDE sono utilizzati nel trattamento di varie condizioni, tra cui malattie cardiovascolari, disfunzione erettile e disturbi respiratori, grazie alla loro capacità di modulare i livelli di nucleotidi ciclici. Presso CymitQuimica, offriamo una gamma di inibitori delle PDE per supportare la tua ricerca nella segnalazione cellulare, farmacologia e sviluppo terapeutico.
Trovati 203 prodotti per "PDE".
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Carbodenafil
CAS:Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).Formula:C24H32N6O3Purezza:98.96% - 99.89%Colore e forma:White SolidPeso molecolare:452.5493N-Methylbenzamide
CAS:N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.Formula:C8H9NOPurezza:99.83%Colore e forma:Physical Description Off-White Crystalline Solid (Ntp 1992)Peso molecolare:135.1632Roflumilast
CAS:Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potentialFormula:C17H14Cl2F2N2O3Purezza:99.76% - 99.86%Colore e forma:SolidPeso molecolare:403.21Enpp-1-IN-14
CAS:Enpp-1-IN-14: potent ENPP1 inhibitor, IC50 = 32.38 nM, exhibits anti-tumor properties.Formula:C15H22ClN5O4SPurezza:99.83%Colore e forma:SoildPeso molecolare:403.884Pumafentrine
CAS:Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.Formula:C29H39N3O3Purezza:99.85%Colore e forma:White SolidPeso molecolare:477.64Amrinone
CAS:Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.Formula:C10H9N3OPurezza:98.88% - 99.45%Colore e forma:SolidPeso molecolare:187.198Zatolmilast
CAS:Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).Formula:C21H15ClF3NO2Purezza:98.20%Colore e forma:SolidPeso molecolare:405.798Trapidil
CAS:Trapidil (Avantrin) is a coronary vasodilator agent.Formula:C10H15N5Purezza:99.42%Colore e forma:White SolidPeso molecolare:205.2596Zomepirac sodium salt
CAS:Zomepirac sodium salt (McN-2783-21-98) is a prostaglandin synthetase inhibitor.Formula:C15H13ClNNaO3Purezza:98.65% - ≥95%Colore e forma:Yellow SolidPeso molecolare:313.71ATX inhibitor 1
CAS:ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).Formula:C21H23Cl2N2O6PPurezza:99.52%Colore e forma:White SolidPeso molecolare:501.3ITI-214
CAS:ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members, exhibits potent PDE1 inhibitory activity.Formula:C29H29FN7O5PPurezza:98.21% - 98.81%Colore e forma:SolidPeso molecolare:605.56EMD57439
CAS:EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).Formula:C22H23N3O4SPurezza:99.35% - 99.57%Colore e forma:White SolidPeso molecolare:425.5Pimobendan
CAS:Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).Formula:C19H18N4O2Purezza:99.91%Colore e forma:White SolidPeso molecolare:334.37MR-L2
CAS:MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).Formula:C19H16Cl3FN4OPurezza:98.09% - 98.94%Colore e forma:SolidPeso molecolare:441.714Milrinone
CAS:Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.Formula:C12H9N3OPurezza:99.22% - 99.92%Colore e forma:SolidPeso molecolare:211.22NSP-805
CAS:NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.Formula:C17H19N3O2Purezza:99.85%Colore e forma:Yellow SolidPeso molecolare:297.3517Theodrenaline hydrochloride
CAS:Theodrenaline hydrochloride is an inhibitor targeting SARS-CoV-2 for the study of hypotension induced by spinal anesthesia.Formula:C17H22ClN5O5Purezza:97.05% - 98.18%Colore e forma:SolidPeso molecolare:411.84Phyllodulcin
CAS:Phyllodulcin, an orally active sweetener discovered in Hydrangea macrophylla var. thunbergii, functions as a non-selective phosphodiesterase inhibitor that mitigates allergic reactions by suppressing the activation of lymphocytes. Additionally, it combats obesity through the regulation of leptin levels, genes associated with fat browning, and the hypothalamic BDNF-TrkB signaling pathway.Formula:C16H14O5Peso molecolare:286.2794PDE3/4-IN-2
CAS:PDE3/4-IN-2 is a potent dual PDE3/PDE4 inhibitor with IC50 values of 0.13 nM for PDE3A and 50 nM for PDE4B1. It is used to investigate PDE-related diseases such as asthma, COPD, sepsis, and nephritis. the dual-target activity of PDE3/4-IN-2 provides a mechanistic basis for dissecting cAMP regulation and inflammatory signaling pathways.Formula:C28H33N5O4Purezza:99.99%Peso molecolare:503.59PDE4-IN-21
PDE4-IN-21 (Compound L19) is an effective PDE4 inhibitor with an IC50 of 0.48 μM. It demonstrates substantial inhibitory activity and notable metabolic stability in rat liver microsomes.Formula:C15H10Cl2N6SColore e forma:SolidPeso molecolare:377.25
