PDE
Le fosfodiesterasi (PDEs) sono enzimi che idrolizzano i nucleotidi ciclici, come cAMP e cGMP, nelle loro forme inattive, svolgendo un ruolo chiave nella regolazione delle vie di segnalazione intracellulare. Gli inibitori delle PDE sono utilizzati nel trattamento di varie condizioni, tra cui malattie cardiovascolari, disfunzione erettile e disturbi respiratori, grazie alla loro capacità di modulare i livelli di nucleotidi ciclici. Presso CymitQuimica, offriamo una gamma di inibitori delle PDE per supportare la tua ricerca nella segnalazione cellulare, farmacologia e sviluppo terapeutico.
Trovati 165 prodotti di "PDE"
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Amrinone
CAS:<p>Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.</p>Formula:C10H9N3OPurezza:98.88% - 99.45%Colore e forma:SolidPeso molecolare:187.2MR-L2
CAS:MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).Formula:C19H16Cl3FN4OPurezza:98.09% - 98.94%Colore e forma:SolidPeso molecolare:441.71Carbodenafil
CAS:<p>Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).</p>Formula:C24H32N6O3Purezza:98.96% - 99.89%Colore e forma:SolidPeso molecolare:452.55ITI-214
CAS:ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members, exhibits potent PDE1 inhibitory activity.Formula:C29H29FN7O5PPurezza:98.21%Colore e forma:SolidPeso molecolare:605.56Cilostazol
CAS:<p>Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.</p>Formula:C20H27N5O2Purezza:99.58% - 99.90%Colore e forma:Off-White SolidPeso molecolare:369.46EMD57439
CAS:EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).Formula:C22H23N3O4SPurezza:99.35% - 99.57%Colore e forma:SolidPeso molecolare:425.5Roflumilast
CAS:Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potentialFormula:C17H14Cl2F2N2O3Purezza:99.76% - 99.86%Colore e forma:SolidPeso molecolare:403.21Zatolmilast
CAS:Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).Formula:C21H15ClF3NO2Purezza:98.20%Colore e forma:SolidPeso molecolare:405.8N-Methylbenzamide
CAS:<p>N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.</p>Formula:C8H9NOPurezza:99.83%Colore e forma:Physical Description Off-White Crystalline Solid (Ntp 1992)Peso molecolare:135.16NSP-805
CAS:NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.Formula:C17H19N3O2Purezza:99.85%Colore e forma:SolidPeso molecolare:297.35Pumafentrine
CAS:<p>Pumafentrine（BY 343） is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.</p>Formula:C29H39N3O3Purezza:>99.99%Colore e forma:SolidPeso molecolare:477.64ATX inhibitor 1
CAS:ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).Formula:C21H23Cl2N2O6PPurezza:99.52%Colore e forma:SolidPeso molecolare:501.3Pimobendan
CAS:<p>Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).</p>Formula:C19H18N4O2Purezza:99.91%Colore e forma:SolidPeso molecolare:334.37Milrinone
CAS:Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.Formula:C12H9N3OPurezza:99.22% - 99.92%Colore e forma:SolidPeso molecolare:211.22Trapidil
CAS:Trapidil (Avantrin) is a coronary vasodilator agent.Formula:C10H15N5Purezza:99.42%Colore e forma:SolidPeso molecolare:205.26OPC18750 HCl
CAS:OPC18750 HCl is a phosphodiesterase inhibitor with positive inotropic effects that can be used to study asthma, cancer, diabetes, and psychiatric disorders.Formula:C20H23ClN2O4Purezza:98.92%Colore e forma:SoildPeso molecolare:390.86FCPR03
CAS:FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively.Formula:C15H19F2NO3Purezza:99.94%Colore e forma:SolidPeso molecolare:299.31BC 11-38
CAS:<p>BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).</p>Formula:C15H16N2OS2Purezza:98.95% - 99.28%Colore e forma:SolidPeso molecolare:304.43PDE10A-IN-5
<p>PDE10A-IN-5 (Compound A30) is an orally active inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 value of 3.5 nM. By inhibiting PDE10A, it activates the cyclic adenosine monophosphate (cAMP)-related signaling pathway, exhibiting activity against pulmonary vascular remodeling. This compound is applicable to research in the field of pulmonary arterial hypertension.</p>Colore e forma:Odour SolidDazonone
CAS:<p>Dazonone (Imidazo[2,1-b]quinazolin-2(3H)-one, 6-chloro-1,5-dihydro-3-methyl-) is a specific PDE III inhibitors.</p>Formula:C11H10ClN3OPurezza:99.54% - 99.73%Colore e forma:SolidPeso molecolare:235.67PDE5-IN-9
CAS:<p>WAY-639921 treats cardiovascular and respiratory conditions by inhibiting PDE1c.</p>Formula:C18H14N4SPurezza:99.98%Colore e forma:SolidPeso molecolare:318.4PDE4B-IN-4
PDE4B-IN-4 is an inhibitor of PDE4B (IC50: 2.82 nM) and TNF-α (IC50: 7.20 nM). It demonstrates anti-inflammatory properties by reducing neutrophilia in a mouse model of lipopolysaccharide (LPS)-induced sepsis.Formula:C26H27N5O5Colore e forma:SolidPeso molecolare:489.52Enpp-1-IN-27
Enpp-1-IN-27 is a selective ENPP1 inhibitor with an IC50 of 14.68 nM, exhibiting approximately 410-fold selectivity over ENPP2 and roughly 10-fold selectivity over ENPP3. This compound stabilizes cGAMP levels and activates the STING pathway, leading to cytokine release and an enhanced innate immune response. In addition, Enpp-1-IN-27 activates ISRE and boosts cGAMP-mediated immune responses, demonstrating significant antitumor effects in 4T1 and CT26 syngeneic mouse models. It is applicable to breast cancer and colon cancer research.Colore e forma:Odour SolidOglemilast
CAS:Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo.Formula:C20H13Cl2F2N3O5SPurezza:99.82%Colore e forma:SolidPeso molecolare:516.3Arofylline
CAS:Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies.Formula:C14H13ClN4O2Purezza:98.19%Colore e forma:SolidPeso molecolare:304.73BAY 2666605
CAS:<p>BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.</p>Formula:C17H12F4N2O2Purezza:99.81%Colore e forma:SolidPeso molecolare:352.28ONO-8430506
CAS:ONO-8430506 is an orally available, potent autotaxin (ATX)/ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX activity in mouse plasma.Formula:C27H28FN3O3Purezza:98.34%Colore e forma:SolidPeso molecolare:461.53BI 1015550
CAS:Nerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM.Cost-effective and quality-assured.Formula:C20H25ClN6O2SPurezza:98.06% - 99.96%Colore e forma:SoildPeso molecolare:448.97cis-Tadalafil
CAS:<p>Tadalafil: a carboline-based PDE5 inhibitor, treats erectile dysfunction, prostatic hyperplasia, and pulmonary hypertension.</p>Formula:C22H19N3O4Purezza:99.89%Colore e forma:SolidPeso molecolare:389.4UK 227786
CAS:<p>UK 227786 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.</p>Formula:C22H22Cl2N4O4Purezza:99.9%Colore e forma:SoildPeso molecolare:477.34(1R,2R)-MK-8189
CAS:(1R,2R)-MK-8189 is an isomer of MK-8189, a potent and selective pyrimidine PDE10A inhibitor.Formula:C19H22N6OSPurezza:>99.99% - >99.99%Colore e forma:SoildPeso molecolare:382.48Theodrenaline hydrochloride
CAS:<p>Theodrenaline hydrochloride is an inhibitor targeting SARS-CoV-2 for the study of hypotension induced by spinal anesthesia.</p>Formula:C17H22ClN5O5Purezza:98% - 98.18%Colore e forma:SoildPeso molecolare:411.84Enpp-1-IN-14
CAS:<p>Enpp-1-IN-14: potent ENPP1 inhibitor, IC50 = 32.38 nM, exhibits anti-tumor properties.</p>Formula:C15H22ClN5O4SPurezza:99.83%Colore e forma:SoildPeso molecolare:403.88Acetildenafil
CAS:Acetildenafil is an analog of the phosphodiesterase inhibitor sildenafil.Formula:C25H34N6O3Colore e forma:Off-White To Pale Yelow SolidPeso molecolare:466.58Autotaxin modulator 1
CAS:Autotaxin modulator 1 is a new modulator of Autotaxin.Formula:C28H31F6NO3Purezza:99.46%Colore e forma:SolidPeso molecolare:543.54Bay 60-7550
CAS:Bay 60-7550 is a PDE2 inhibitor that exerts positive inotropic effects in the rat heart by increasing PKA-mediated phosphorylation.Formula:C27H32N4O4Purezza:98.14%Colore e forma:SolidPeso molecolare:476.57BAY 73-6691 racemate
CAS:BAY 73-6691 racemate (Rac-BAY 73-6691) is a phosphodiesterase 9A (PDE9A) inhibitor, useful for studying Parkinson’s disease.Formula:C15H12ClF3N4OColore e forma:SolidPeso molecolare:356.73Anti-ALDH7A1 Antibody-FITC (5P692)
Anti-ALDH7A1 Antibody-FITC (5P692) is a FITC-conjugated Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody-FITC (5P692) can be used in FCM.Colore e forma:Odour LiquidALDH7A1 Protein, Human, Recombinant (His)
ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family.Colore e forma:Lyophilized PowderPeso molecolare:56 kDa (predicted); 56 kDa (reducing conditions)Anti-ALDH7A1 Antibody (6G475)
Anti-ALDH7A1 Antibody (6G475) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (6G475) can be used in IHC-P.Colore e forma:Odour LiquidDNMDP
CAS:DNMDP is a potent and selective PDE3A inhibitor with anticancer activity. It binds to PDE3A, promoting its interaction with Schlafen 12 (SLFN12).Formula:C15H20N4O3Colore e forma:SolidPeso molecolare:304.34ENPP1 Inhibitor C
CAS:ML-354 (VU0099704) is an antagonist with and PAR4 for the study of cardiovascular diseases.Formula:C15H18N6Purezza:99.28%Colore e forma:SolidPeso molecolare:282.34PF-05085727
CAS:PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11.Formula:C20H18F3N7Purezza:98%Colore e forma:SolidPeso molecolare:413.4Anti-ALDH7A1 Antibody (1G435)
Anti-ALDH7A1 Antibody (1G435) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (1G435) can be used in ELISA.Colore e forma:Odour LiquidAnti-ALDH7A1 Antibody (5P692)
Anti-ALDH7A1 Antibody (5P692) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (5P692) can be used in FCM,ICC/IF.Colore e forma:Odour LiquidN-Ethyl tadalafil
CAS:N-Ethyl tadalafil (NEthyl tadalafil) is a PDE inhibitor used in the study of cardiovascular disease.Formula:C23H21N3O4Purezza:99.58%Colore e forma:SolidPeso molecolare:403.43BI-2545
CAS:BI-2545 is a potent and selective autotaxin (ATX) inhibitor with IC50 values of 2.2 nM and 3.4 nM for human and rat ATX, reduces plasma LPA levels.Formula:C23H19F6N5O3Colore e forma:SolidPeso molecolare:527.42PF-05180999
CAS:α-2,3-sialyltransferase-IN-1 (Lith-O-Asp analog) is an α-2,3-sialyltransferase inhibitor with anticancer activity.Formula:C19H17F3N8Purezza:99.43% - 99.82%Colore e forma:SolidPeso molecolare:414.39Anti-ALDH7A1 Antibody (3P955)
Anti-ALDH7A1 Antibody (3P955) is a Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (3P955) can be used in WB,ELISA,IP.Colore e forma:Odour LiquidRS-25344
CAS:RS-25344: a strong PDE4 blocker, curbs eosinophil movement, boosts sperm motility in vitro.Formula:C19H13N5O4Purezza:98.98%Colore e forma:SolidPeso molecolare:375.34PF-8380
CAS:PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood).Formula:C22H21Cl2N3O5Purezza:98.70% - 99.25%Colore e forma:SolidPeso molecolare:478.33PQ-10
CAS:<p>PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.</p>Formula:C22H21N5O3Purezza:99.86%Colore e forma:SolidPeso molecolare:403.43Roflumilast N-oxide
CAS:Roflumilast N-oxide is an inhibitor of PDE type 4.Formula:C17H14Cl2F2N2O4Purezza:98.19% - 99.69%Colore e forma:SolidPeso molecolare:419.21Balipodect
CAS:Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.Formula:C23H17FN6O2Purezza:98% - 99.79%Colore e forma:SolidPeso molecolare:428.42Irsogladine
CAS:<p>Irsogladine (Dicloguamine) is an anti-ulcer agent that promotes gap junction intercellular communication via M1 muscarinic acetylcholine receptor binding.</p>Formula:C9H7Cl2N5Purezza:99.74% - 99.91%Colore e forma:White Or Colorless Crystal Or Crystalline Powder Odorless Slightly BitterPeso molecolare:256.09THPP-1
CAS:THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).Formula:C23H21ClN6O3Purezza:99.46%Colore e forma:SolidPeso molecolare:464.9K-Ras-PDEδ-IN-1
CAS:<p>K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).</p>Formula:C25H26FN5O2Purezza:99.48%Colore e forma:SolidPeso molecolare:447.5Cilomilast
CAS:Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.Formula:C20H25NO4Purezza:97.37% - 99.52%Colore e forma:White SolidPeso molecolare:343.42ICI 63197
CAS:ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.Formula:C9H13N5OPurezza:99.70%Colore e forma:White SolidPeso molecolare:207.23IBMX
CAS:<p>IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μM</p>Formula:C10H14N4O2Purezza:98% - >99.99%Colore e forma:Off-WhitePeso molecolare:222.242,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide
CAS:2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide is a PDE inhibitor.Formula:C9H9Cl2F2NO3SPurezza:98.60%Colore e forma:SolidPeso molecolare:320.14Olprinone
CAS:Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuateFormula:C14H10N4OPurezza:99.68%Colore e forma:SolidPeso molecolare:250.26HA130
CAS:<p>HA130 is a selective ATX (autotaxin) inhibitor.</p>Formula:C24H19BFNO5SPurezza:98.26% - ≥95%Colore e forma:SolidPeso molecolare:463.29Ro 20-1724
CAS:Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1Formula:C15H22N2O3Purezza:98.82% - 99.79%Colore e forma:SolidPeso molecolare:278.35Mardepodect
CAS:<p>Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE.</p>Formula:C25H20N4OPurezza:99.81% - 99.94%Colore e forma:SolidPeso molecolare:392.45BW-A 78U
CAS:BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.Formula:C13H12FN5Purezza:99.45%Colore e forma:SolidPeso molecolare:257.27MBCQ
CAS:MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.Formula:C16H12ClN3O2Purezza:99.45%Colore e forma:SolidPeso molecolare:313.74HA 155
CAS:HA 155 (Autotaxin Inhibitor IV) is a boronic acid-based compound, inhibiting ATX with IC50 of 5.7 nM by selectively binding to its catalytic threonine.Formula:C24H19BFNO5SPurezza:99.88%Colore e forma:SolidPeso molecolare:463.29Ibudilast
CAS:Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.Formula:C14H18N2OPurezza:99.83% - >99.99%Colore e forma:White SolidPeso molecolare:230.31ML-030
CAS:ML-030 is a potent PDE4 inhibitor, selective for subtypes (A1, B1, B2, C1, D2) with IC50 ranging from 6.7 to 452 nM.Formula:C20H20N4O4SPurezza:97.93%Colore e forma:SolidPeso molecolare:412.46SEP-0372814
CAS:SEP-0372814 is a potent inhibitor of PDE10.Formula:C21H19N7Purezza:99.29%Colore e forma:SolidPeso molecolare:369.42YM976
CAS:YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)Formula:C17H16ClN3OPurezza:99.84%Colore e forma:SolidPeso molecolare:313.78Cilostamide
CAS:<p>Cilostamide (OPC3689) is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)</p>Formula:C20H26N2O3Purezza:98.87%Colore e forma:White To Off-White SolidPeso molecolare:342.43D159687
CAS:D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant benefit.Formula:C21H19ClN2O2Purezza:97.57%Colore e forma:SolidPeso molecolare:366.84RS-25344 hydrochloride
CAS:RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitorFormula:C19H14ClN5O4Purezza:99.25%Colore e forma:SolidPeso molecolare:411.8BRL-50481
CAS:<p>BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.</p>Formula:C9H12N2O4SPurezza:99.66%Colore e forma:SolidPeso molecolare:244.27Piclamilast
CAS:Piclamilast (RP 73401) is a PDE4 inhibitor.Formula:C18H18Cl2N2O3Purezza:98.28% - 99.57%Colore e forma:SolidPeso molecolare:381.25Ensifentrine
CAS:Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), thatFormula:C26H31N5O4Purezza:99.76% - 99.94%Colore e forma:SolidPeso molecolare:477.56Z-HA155
CAS:<p>Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.</p>Formula:C24H19BFNO5SPurezza:99.18%Colore e forma:SolidPeso molecolare:463.29Crisaborole
CAS:Crisaborole (AN-2728) is a Phosphodiesterase 4 Inhibitor.Formula:C14H10BNO3Purezza:99.70%Colore e forma:SolidPeso molecolare:251.05Udenafil
CAS:Udenafil is an inhibitor of PDE5 .Formula:C25H36N6O4SPurezza:99.90%Colore e forma:Off-White SolidPeso molecolare:516.66GSK256066
CAS:<p>GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold</p>Formula:C27H26N4O5SPurezza:99.60% - 99.66%Colore e forma:SolidPeso molecolare:518.58Nortadalafil
CAS:Nortadalafil, a demethylated form of Tadalafil, is a PDE5 inhibitor used to treat ED and pulmonary arterial hypertension as Adcirca.Formula:C21H17N3O4Purezza:99.42%Colore e forma:SolidPeso molecolare:375.38Homo Sildenafil
CAS:Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.Formula:C23H32N6O4SPurezza:99.88%Colore e forma:White SolidPeso molecolare:488.6GEBR-7b
CAS:<p>GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) is a phosphodiesterase-4 (PDE4) inhibitor.</p>Formula:C13H16O3Purezza:99.533%Colore e forma:SolidPeso molecolare:220.26Enoximone
CAS:Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.Formula:C12H12N2O2SPurezza:98.53%Colore e forma:SolidPeso molecolare:248.3MY-5445
CAS:<p>MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5).</p>Formula:C20H14ClN3Purezza:99.77%Colore e forma:SolidPeso molecolare:331.8Amino Tadalafil
CAS:Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.Formula:C21H18N4O4Purezza:99.85%Colore e forma:White PowderPeso molecolare:390.39Sildenafil Mesylate
CAS:Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.Formula:C22H30N6O4S·xCH4O3SPurezza:99.84%Colore e forma:SolidPeso molecolare:570.68Lodenafil
CAS:Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)Formula:C23H32N6O5SPurezza:99.92%Colore e forma:SolidPeso molecolare:504.6[11C]MP 10
CAS:[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.Formula:C25H20N4OPurezza:99.5%Colore e forma:SolidPeso molecolare:391.45Osoresnontrine
CAS:Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.Formula:C16H17N5O2Purezza:99.93%Colore e forma:SolidPeso molecolare:311.34CP671305
CAS:CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.Formula:C23H19FN2O7Purezza:99.39%Colore e forma:SolidPeso molecolare:454.4Ziritaxestat
CAS:Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.Formula:C30H33FN8O2SPurezza:97% - 99.85%Colore e forma:SolidPeso molecolare:588.7PDE10-IN-1
CAS:PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.Formula:C21H19N7Purezza:99.65%Colore e forma:SolidPeso molecolare:369.42Lotamilast
CAS:<p>Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.</p>Formula:C26H24N4O5Purezza:97.03% - 99.29%Colore e forma:SolidPeso molecolare:472.49Enpp-1-IN-1
CAS:Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)Formula:C17H17N3O3SPurezza:97.52%Colore e forma:SolidPeso molecolare:343.4GSK256066 Trifluoroacetate
CAS:GSK 256066 Trifluoroacetate: selective PDE4 inhibitor, IC50: 3.2 pM for PDE4B, treats COPD.Formula:C29H27F3N4O7SColore e forma:SolidPeso molecolare:632.61Crisaborole-d4
Crisaborole-d4 (AN-2728-d4) is the deuterated form of Crisaborole. Crisaborole is a PDE4 inhibitor and also a cytokine release inhibitor.Formula:C14H6D4BNO3Colore e forma:SolidPeso molecolare:255.07Deltarasin
CAS:<p>Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.</p>Formula:C40H37N5OPurezza:99.4%Colore e forma:SolidPeso molecolare:603.75ent-Tadalafil
CAS:ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS).Formula:C22H19N3O4Purezza:98%Colore e forma:SolidPeso molecolare:389.4Lirimilast
CAS:Lirimilast: oral PDE4 inhibitor (IC50: 49 nM), anti-inflammatory, treats asthma/COPD.Formula:C17H12Cl2N2O6SPurezza:98%Colore e forma:SolidPeso molecolare:443.26PAT-048
CAS:<p>PAT-048 is an effective and selective autotaxin inhibitor.</p>Formula:C22H18ClF2N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:461.91Propentofylline
CAS:<p>Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study of Alzheimer's disease.</p>Formula:C15H22N4O3Purezza:99.76% - 99.86%Colore e forma:Off-White SolidPeso molecolare:306.36PDE9-IN-1
CAS:PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).Formula:C17H23FN6O2Purezza:99.86%Colore e forma:SolidPeso molecolare:362.4Senazodan hydrochloride
CAS:Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.Formula:C15H15ClN4OPurezza:99.93%Colore e forma:SolidPeso molecolare:302.76Deltasonamide 2 (TFA)
CAS:Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Formula:C32H40ClF3N6O6S2Purezza:98%Colore e forma:SolidPeso molecolare:761.28BAY 73-6691
CAS:BAY 73-6691 is an inhibitor of brain penetrant PDE9A.Formula:C15H12ClF3N4OColore e forma:SolidPeso molecolare:356.73K134
CAS:<p>K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.</p>Formula:C22H29N3O4Purezza:98%Colore e forma:SolidPeso molecolare:399.48Tilivapram
CAS:Tilivapram is a PDE4 (phosphodiesterase IV) inhibitor that can be used in the study of mental illness.Formula:C16H15Cl2N3O4Purezza:99.87%Colore e forma:SolidPeso molecolare:384.21(R)-DNMDP
CAS:(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.Formula:C15H20N4O3Colore e forma:SolidPeso molecolare:304.34WAY127093B racemate
CAS:WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.Formula:C23H28N4O4Purezza:99.67%Colore e forma:SolidPeso molecolare:424.49PDE7-IN-2
CAS:PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.Formula:C14H11ClN2O3SPurezza:98%Colore e forma:SolidPeso molecolare:322.77AN3199
CAS:AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.Formula:C17H18BNO5Purezza:99.45%Colore e forma:SolidPeso molecolare:327.14Autotaxin-IN-1
CAS:Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.Formula:C21H23N7O2Purezza:98%Colore e forma:SolidPeso molecolare:405.45PF-04822163
CAS:<p>PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.</p>Formula:C19H17ClN2O2Purezza:99.55%Colore e forma:SolidPeso molecolare:340.8ATX inhibitor 5
CAS:ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.Formula:C22H18ClF3N6OPurezza:99.73%Colore e forma:SolidPeso molecolare:474.87KD-027
CAS:KD-027 is a novel and long-acting PDE5A(phosphodiesterase 5A) inhibitor with potential antihypertensive activity.Formula:C25H35N7O6SPurezza:99.55%Colore e forma:SolidPeso molecolare:561.65Imazodan hydrochloride
CAS:<p>Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.</p>Formula:C13H13ClN4OPurezza:98.97%Colore e forma:SolidPeso molecolare:276.72Imazodan
CAS:Imazodan is a compound with positive inotropic activity and is a type III phosphodiesterase inhibitor that can be used to study heart failure.Formula:C13H12N4OPurezza:98% - 98.31%Colore e forma:SolidPeso molecolare:240.26Deltasonamide 2
CAS:Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Formula:C30H39ClN6O4S2Purezza:98%Colore e forma:SolidPeso molecolare:647.25PF-04447943
CAS:<p>PF-04447943, a selective PDE9A inhibitor (IC50=12nM), may aid sickle cell anemia research with its anti-inflammatory properties.</p>Formula:C20H25N7O2Purezza:99.36% - 99.59%Colore e forma:SolidPeso molecolare:395.46PDE4B-IN-2
CAS:<p>PDE4B-IN-2 (A 33), an oral PDE4B inhibitor, IC50: 15 nM; less potent on PDE4D (IC50: 1.7 µM), has anti-inflammatory properties.</p>Formula:C19H18ClN3O2SPurezza:99.32%Colore e forma:SolidPeso molecolare:387.88Dovramilast
CAS:Dovramilast (CC-11050) is a PDE4 inhibitor that reduces the production of pro-inflammatory mediators in lupus erythematosus.Formula:C24H28N2O6SPurezza:98.75% - 99.62%Colore e forma:SolidPeso molecolare:472.55Nanterinone
CAS:Nanterinone: oral phosphodiesterase inhibitor, improves acute heart failure hemodynamics.Formula:C15H15N3OPurezza:99.96%Colore e forma:SolidPeso molecolare:253.3PDE IV-IN-1
CAS:PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary diseaseFormula:C20H23ClN4O2Purezza:99.79%Colore e forma:SolidPeso molecolare:386.88Verofylline
CAS:Verofylline (Verofyllinum) is an orally available, long-acting, multiacting, methylxanthine-substituted bronchodilator with inhibitory effects on PDE4 for theFormula:C12H18N4O2Purezza:98.4% - 99.8%Colore e forma:SolidPeso molecolare:250.3Tofimilast
CAS:Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease.Formula:C18H21N5SPurezza:99.55%Colore e forma:SolidPeso molecolare:339.46Carbazeran
CAS:<p>Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases.</p>Formula:C18H24N4O4Purezza:99.3%Colore e forma:SolidPeso molecolare:360.41AWD 12-281
CAS:<p>AWD 12-281 is a PDE4 inhibitor with anti-inflammatory activity and bronchodilator activity for the study of chronic obstructive pulmonary disease (COPD).</p>Formula:C22H14Cl2FN3O3Purezza:99.25% - 99.85%Colore e forma:SolidPeso molecolare:458.27Autotaxin-IN-3
CAS:<p>Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma.</p>Formula:C22H21N9O2Purezza:99.54% - 99.79%Colore e forma:SolidPeso molecolare:443.46Filaminast
CAS:Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.Formula:C15H20N2O4Purezza:98.93% - 99.99%Colore e forma:SolidPeso molecolare:292.33MK-0873
CAS:MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.Formula:C25H18N4O3Purezza:99.14%Colore e forma:SolidPeso molecolare:422.44Mopidamol
CAS:Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents retinal vascular defects in experimentalFormula:C19H31N7O4Purezza:99.31% - 99.78%Colore e forma:SolidPeso molecolare:421.49Isomazole
CAS:<p>Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.</p>Formula:C14H13N3O2SPurezza:98.66%Colore e forma:SolidPeso molecolare:287.34Dasantafil
CAS:Dasantafil (SCH446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to treat genitourinary disorders and study erectile dysfunction.Formula:C22H28BrN5O5Purezza:99.4% - 99.50%Colore e forma:SolidPeso molecolare:522.39uk-50001
CAS:UK-50001 is a PDE4 inhibitor for treating inflammation, allergies, respiratory issues, and wounds.Formula:C26H24F3N3O4Purezza:99.90%Colore e forma:SolidPeso molecolare:499.48Autotaxin-IN-4
CAS:Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Formula:C22H21N9O2Purezza:98%Colore e forma:SolidPeso molecolare:443.46GSK356278
CAS:<p>GSK356278: selective PDE4A/B/D inhibitor, pIC50~8.7, anti-inflammatory, anxiolytic, cognition-enhancing.</p>Formula:C21H25N7O2SPurezza:99.90% - 99.97%Colore e forma:SolidPeso molecolare:439.53MK-8189
CAS:MK-8189 is a potent and selective pyrimidine PDE10A inhibitor, with excellent PDE (phosphodiesterase) selectivity for the treatment of schizophrenia.Formula:C19H22N6OSPurezza:99.38% - 99.67%Colore e forma:SolidPeso molecolare:382.48Gisadenafil
CAS:Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.Formula:C23H33N7O5SPurezza:98.82% - 99.50%Colore e forma:SolidPeso molecolare:519.62Autotaxin-IN-5
CAS:Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Formula:C30H29N9O2Purezza:98%Colore e forma:SolidPeso molecolare:547.61BIO-32546
CAS:<p>BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.</p>Formula:C28H31F6NO3Purezza:98.03%Colore e forma:SolidPeso molecolare:543.54Gisadenafil besylate
CAS:Gisadenafil besylate (UK 369003-26) is a potent and orally active PDE5 inhibitor, for lower urinary tract symptoms associated with benign prostatic hyperplasia.Formula:C29H39N7O8S2Colore e forma:SolidPeso molecolare:677.79PDE5-IN-2
CAS:PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)Formula:C25H21N3O6SPurezza:98%Colore e forma:SolidPeso molecolare:491.52CI-1044
CAS:<p>CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).</p>Formula:C23H19N5O2Colore e forma:SolidPeso molecolare:397.43Siguazodan
CAS:Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.Formula:C14H16N6OPurezza:99.62% - 99.87%Colore e forma:SolidPeso molecolare:284.32Difamilast
CAS:<p>Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).</p>Formula:C23H24F2N2O5Purezza:99.64%Colore e forma:SolidPeso molecolare:446.44PF-04957325
CAS:PF-04957325 is an inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A.PF-04957325 can be used for the study of autoimmune encephalomyelitis.Formula:C14H15F3N8OSPurezza:99.02%Colore e forma:SolidPeso molecolare:400.38Adibendan
CAS:<p>Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.</p>Formula:C16H14N4OPurezza:99.52% - >99.99%Colore e forma:SolidPeso molecolare:278.31TP-10
CAS:TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.Formula:C26H19F3N4OPurezza:99.21%Colore e forma:SolidPeso molecolare:460.45TPN171
CAS:<p>TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary</p>Formula:C24H35N5O3Purezza:>99.99%Colore e forma:SolidPeso molecolare:441.57Enpp-1-IN-16
CAS:Enpp-1-IN-16 is an ENPP1 inhibitor, yo anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance and chondrocalcinosis.Formula:C23H32N4O4Purezza:99.87%Colore e forma:SolidPeso molecolare:428.52PDE9-IN-(S)-C33
CAS:<p>PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.</p>Formula:C18H20ClN5OPurezza:98.75%Colore e forma:SolidPeso molecolare:357.84Cudetaxestat
CAS:<p>Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.</p>Formula:C21H15Cl2F2N3O2SPurezza:99.9%Colore e forma:SolidPeso molecolare:482.33AMG 579
CAS:AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).Formula:C25H23N5O3Purezza:99.87%Colore e forma:SolidPeso molecolare:441.48Thioquinapiperifil dihydrochloride
CAS:Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.Formula:C24H29ClN6OSPurezza:99.81%Colore e forma:SolidPeso molecolare:485.05Z21090
CAS:<p>Z21090 (ZL40) is a highly effective inhibitor of PDE 4, exhibiting an IC 50 value of 37.4 nM, and possesses oral bioavailability. It is significant in the study of alcohol-related diseases [1].</p>Formula:C12H14ClN3O3Colore e forma:SolidPeso molecolare:283.71TAK-915
CAS:TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.Formula:C19H18F4N4O5Purezza:98%Colore e forma:SolidPeso molecolare:458.36NHTD
CAS:NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).Formula:C24H26N2O5Colore e forma:SolidPeso molecolare:422.47Deltasonamide 2 hydrochloride
Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.Formula:C30H40Cl2N6O4S2Purezza:98%Colore e forma:SolidPeso molecolare:683.71BMS-341400 mesylate
CAS:BMS-341400 mesylate (Compound 6) is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM and is useful in the study of erectile dysfunction.Formula:C24H26ClN9O5SColore e forma:SolidPeso molecolare:588.039Tovinontrine
CAS:<p>Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.</p>Formula:C21H26N6O2Purezza:98.14%Colore e forma:SolidPeso molecolare:394.47PF-00489791
CAS:PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.Formula:C20H28N8O4SPurezza:99.97%Colore e forma:SolidPeso molecolare:476.55ASP9831
CAS:<p>ASP9831 is an orally active PDE4 inhibitor. It suppresses LPS-induced TNF-α production and exhibits anti-inflammatory properties. ASP9831 is useful in the study of steatohepatitis.</p>Formula:C20H23N3O3Colore e forma:SolidPeso molecolare:353.42
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