PDE
Le fosfodiesterasi (PDEs) sono enzimi che idrolizzano i nucleotidi ciclici, come cAMP e cGMP, nelle loro forme inattive, svolgendo un ruolo chiave nella regolazione delle vie di segnalazione intracellulare. Gli inibitori delle PDE sono utilizzati nel trattamento di varie condizioni, tra cui malattie cardiovascolari, disfunzione erettile e disturbi respiratori, grazie alla loro capacità di modulare i livelli di nucleotidi ciclici. Presso CymitQuimica, offriamo una gamma di inibitori delle PDE per supportare la tua ricerca nella segnalazione cellulare, farmacologia e sviluppo terapeutico.
Trovati 165 prodotti di "PDE"
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ent-Tadalafil
CAS:ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS).Formula:C22H19N3O4Purezza:98%Colore e forma:SolidPeso molecolare:389.4Lirimilast
CAS:Lirimilast: oral PDE4 inhibitor (IC50: 49 nM), anti-inflammatory, treats asthma/COPD.Formula:C17H12Cl2N2O6SPurezza:98%Colore e forma:SolidPeso molecolare:443.26PAT-048
CAS:<p>PAT-048 is an effective and selective autotaxin inhibitor.</p>Formula:C22H18ClF2N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:461.91Propentofylline
CAS:<p>Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study of Alzheimer's disease.</p>Formula:C15H22N4O3Purezza:99.76% - 99.86%Colore e forma:Off-White SolidPeso molecolare:306.36PDE9-IN-1
CAS:PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).Formula:C17H23FN6O2Purezza:99.86%Colore e forma:SolidPeso molecolare:362.4Senazodan hydrochloride
CAS:Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.Formula:C15H15ClN4OPurezza:99.93%Colore e forma:SolidPeso molecolare:302.76Deltasonamide 2 (TFA)
CAS:Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Formula:C32H40ClF3N6O6S2Purezza:98%Colore e forma:SolidPeso molecolare:761.28BAY 73-6691
CAS:BAY 73-6691 is an inhibitor of brain penetrant PDE9A.Formula:C15H12ClF3N4OColore e forma:SolidPeso molecolare:356.73K134
CAS:<p>K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.</p>Formula:C22H29N3O4Purezza:98%Colore e forma:SolidPeso molecolare:399.48Tilivapram
CAS:Tilivapram is a PDE4 (phosphodiesterase IV) inhibitor that can be used in the study of mental illness.Formula:C16H15Cl2N3O4Purezza:99.87%Colore e forma:SolidPeso molecolare:384.21(R)-DNMDP
CAS:(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.Formula:C15H20N4O3Colore e forma:SolidPeso molecolare:304.34WAY127093B racemate
CAS:WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.Formula:C23H28N4O4Purezza:99.67%Colore e forma:SolidPeso molecolare:424.49PDE7-IN-2
CAS:PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.Formula:C14H11ClN2O3SPurezza:98%Colore e forma:SolidPeso molecolare:322.77AN3199
CAS:AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.Formula:C17H18BNO5Purezza:99.45%Colore e forma:SolidPeso molecolare:327.14Autotaxin-IN-1
CAS:Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.Formula:C21H23N7O2Purezza:98%Colore e forma:SolidPeso molecolare:405.45PF-04822163
CAS:<p>PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.</p>Formula:C19H17ClN2O2Purezza:99.55%Colore e forma:SolidPeso molecolare:340.8ATX inhibitor 5
CAS:ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.Formula:C22H18ClF3N6OPurezza:99.73%Colore e forma:SolidPeso molecolare:474.87KD-027
CAS:KD-027 is a novel and long-acting PDE5A(phosphodiesterase 5A) inhibitor with potential antihypertensive activity.Formula:C25H35N7O6SPurezza:99.55%Colore e forma:SolidPeso molecolare:561.65Imazodan hydrochloride
CAS:<p>Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.</p>Formula:C13H13ClN4OPurezza:98.97%Colore e forma:SolidPeso molecolare:276.72Imazodan
CAS:Imazodan is a compound with positive inotropic activity and is a type III phosphodiesterase inhibitor that can be used to study heart failure.Formula:C13H12N4OPurezza:98% - 98.31%Colore e forma:SolidPeso molecolare:240.26
