Glucokinasi
La glucocinasi (GK) è un enzima che catalizza la fosforilazione del glucosio a glucosio-6-fosfato, un passaggio critico nella glicolisi. La GK è espressa principalmente nel fegato e nel pancreas, dove svolge un ruolo chiave nella regolazione dei livelli di glucosio nel sangue. Gli inibitori della GK sono di interesse nello studio dei disturbi metabolici come il diabete, poiché possono modulare il metabolismo del glucosio e la secrezione di insulina. Presso CymitQuimica, offriamo inibitori della glucocinasi per supportare la tua ricerca sul diabete, il metabolismo e lo sviluppo terapeutico.
Trovati 56 prodotti di "Glucokinasi"
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MitoPQ
CAS:MitoPQ (MitoParaquat) inhibits insulin-stimulated glucose uptake and plasma membrane translocation in myotubes and can be used to study oxidative stress.Formula:C39H46I3N2PPurezza:99.87% - 99.91%Colore e forma:SolidPeso molecolare:954.48Dorzagliatin
CAS:Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.Formula:C22H27ClN4O5Purezza:98.67% - 99.45%Colore e forma:SolidPeso molecolare:462.93KAN0438757
CAS:<p>KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.</p>Formula:C21H18FNO7SPurezza:99.34%Colore e forma:SolidPeso molecolare:447.43MK-0941 free base
CAS:MK-0941: an oral glucokinase activator for type 2 diabetes with potent glucose-lowering effects.Formula:C21H24N4O6SPurezza:98.75%Colore e forma:SolidPeso molecolare:460.5Oxfendazole
CAS:Oxfendazole (RS-8858), a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.Formula:C15H13N3O3SPurezza:98.99% - 99.17%Colore e forma:White To Yellowish PowderPeso molecolare:315.35WAY-640509
CAS:<p>WAY-640509 is a glucocerebrosidase inhibitor.</p>Formula:C25H23N5O4SPurezza:99.36%Colore e forma:SolidPeso molecolare:489.55Neuron-specific enolase, Human
Neuron-specific enolase, Human (EC 4.2.1.11), is an enolase enzyme that serves as a biomarker for traumatic brain injury (TBI), stroke following cardiac arrest, hypoxic encephalopathy, and acute spinal cord injury (SCI).Colore e forma:Odour SolidWAY-615145
CAS:WAY-615145 is a compound that activates glucokinase.Formula:C16H18N2OSPeso molecolare:286.39AP-III-a4 hydrochloride
CAS:<p>AP-III-a4 hydrochloride (ENOblock hydrochloride) is a direct enolase (enolase) inhibitor that inhibit metastasis and affect glucose homeostasis.</p>Formula:C31H44ClFN8O3Purezza:98%Colore e forma:SolidPeso molecolare:631.18ML266
CAS:<p>ML266: GCase chaperone, non-inhibiting, IC50=2.5 µM, aids mutant protein transport, may help in Gaucher disease study.</p>Formula:C24H22BrN3O4Purezza:99.58%Colore e forma:SolidPeso molecolare:496.35ML251
CAS:ML251, potent inhibitor, targets T. brucei PFK (IC50=0.37μM) & T. cruzi PFK (IC50=0.13μM), aids parasite research.Formula:C17H13Cl2N3O4SPurezza:99.87%Colore e forma:SolidPeso molecolare:426.27ADP-specific glucokinase
CAS:<p>ADP-specific glucokinase, expressed in thermophilic archaea, is an ADP-specific enzyme that catalyzes the conversion of glucose to glucose-6-phosphate, thereby facilitating glycolysis. This enzyme can activate T cells and enhance the phagocytic activity of macrophages. It is used in research related to metabolic disorders, neurological diseases, and tumors.</p>Colore e forma:Solid(1S,2R)-Globalagliatin
CAS:(1S,2R)-Globalagliatin is a highly potent glucokinase (GK) activator for the study of type 2 diabetes.Formula:C28H37N3O3S3Purezza:99.09% - 99.17%Colore e forma:SoildPeso molecolare:559.81Anti-Glucokinase Antibody (5Q209)
Anti-Glucokinase Antibody (5Q209) is a Mouse antibody targeting Glucokinase. Anti-Glucokinase Antibody (5Q209) can be used in ELISA.Colore e forma:Odour Liquid5MPN
CAS:<p>5MPN is a PFKFB4 inhibitor that inhibits the F6P binding site and suppresses the proliferation of myeloma cells.</p>Formula:C15H19N3O4Purezza:98.92% - 99.69%Colore e forma:SolidPeso molecolare:305.33Anti-Glucokinase Antibody (3U461)
Anti-Glucokinase Antibody (3U461) is a Rabbit antibody targeting Glucokinase. Anti-Glucokinase Antibody (3U461) can be used in ELISA.Colore e forma:Odour LiquidHex
CAS:Hex is a potent inhibitor of enolase, exhibiting inhibitory activity with Ki values of 74.4 nM and 269.4 nM against ENO2 and ENO1, respectively.Formula:C5H10NO5PColore e forma:SolidPeso molecolare:195.11Cadisegliatin
CAS:Cadisegliatin (TTP-399) may activate liver GK to lower blood sugar in type 2 diabetes studies.Formula:C21H33N3O4S2Colore e forma:SolidPeso molecolare:455.63PF-04991532
CAS:PF-04991532 is a hepatoselective glucokinase activator that reduces plasma glucose and AMP concentrations in the Goto-Kakizaki rat model.Formula:C18H19F3N4O3Purezza:99.99%Colore e forma:SolidPeso molecolare:396.36Glucokinase Protein, Human, Recombinant
Glucokinase belongs to the bacterial glucokinase family.Colore e forma:Lyophilized PowderPeso molecolare:52.2 kDa (predicted); 52.2 kDa (reducing conditions)AMG-3969
CAS:AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).Formula:C21H20F6N4O3SPurezza:99.65%Colore e forma:SolidPeso molecolare:522.46PFK-015
CAS:<p>PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).</p>Formula:C17H12N2OPurezza:99.7% - 99.85%Colore e forma:SolidPeso molecolare:260.29Genz-123346 free base
CAS:Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.Formula:C24H38N2O4Purezza:99.41%Colore e forma:SolidPeso molecolare:418.57AM-2394
CAS:AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate.Formula:C22H25N5O4Purezza:99.01% - 99.62%Colore e forma:SolidPeso molecolare:423.46Globalagliatin
CAS:Globalagliatin (LY2608204) has been used in trials studying the treatment of Diabetes Mellitus, Type 2.Formula:C28H37N3O3S3Purezza:98% - 99.56%Colore e forma:SolidPeso molecolare:559.81Palmitelaidic Acid
CAS:Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.Formula:C16H30O2Purezza:99.76%Colore e forma:SolidPeso molecolare:254.41ML198
CAS:ML198: Activates & chaperones glucocerebrosidase; a potential Gaucher disease treatment lead.Formula:C17H14N4OPurezza:98.31%Colore e forma:SolidPeso molecolare:290.323PO
CAS:<p>3PO inhibits PFKFB3 (IC50: 22.9 µM) and cancer cell growth (IC50: 1.4-24 µM), reducing glucose uptake and key cellular metabolites.</p>Formula:C13H10N2OPurezza:99.56% - 99.67%Colore e forma:SolidPeso molecolare:210.23(E)-3PO
CAS:(E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.Formula:C13H10N2OPurezza:98.8% - 98.92%Colore e forma:SolidPeso molecolare:210.23YZ9
CAS:Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as a competitive inhibitor against Fru-6-P with a Ki of 0.094 µM[1].Formula:C12H10O5Purezza:99.59%Colore e forma:SolidPeso molecolare:234.2Piragliatin
CAS:<p>Piragliatin (RO4389620) activates glucokinase, boosts insulin, and lowers glucose in type 2 diabetes.</p>Formula:C19H20ClN3O4SColore e forma:SolidPeso molecolare:421.9Glucokinase activator 1
CAS:Glucokinase activator 1 is a liver-directed glucokinase activator (EC50: 34 nM).Formula:C27H20F2N2O7S2Purezza:98%Colore e forma:SolidPeso molecolare:586.58IHVR-11029
CAS:<p>IHVR-11029 inhibits ER α-glucosidase, combats hemorrhagic fever viruses, and hinders enveloped virus morphogenesis.</p>Formula:C18H27F2NO5Colore e forma:SolidPeso molecolare:375.41GKA-71
CAS:GKA-71 is an effective glucokinase activator (GKA).Formula:C21H23N3O6S2Colore e forma:SolidPeso molecolare:477.55Glucokinase activator 3
CAS:Glucokinase activator 3: potent GK activator, AC50=38 nM, potential for type 2 diabetes research.Formula:C26H33N2O9PS2Colore e forma:SolidPeso molecolare:612.65PF-04279405
CAS:PF-04279405 is a potent and selective glucokinase activator.Formula:C25H25FN4O4Colore e forma:SolidPeso molecolare:464.49PSN-GK1
CAS:PSN-GK1 is a potent activator of glucokinase (EC50: 0.13 μM).Formula:C20H23FN2O4S2Purezza:98%Colore e forma:SolidPeso molecolare:438.54Sinogliatin
CAS:Sinogliatin, a glucokinase activator, is used potentially for the treatment of type 2 diabetes.Formula:C22H27ClN4O5Colore e forma:SolidPeso molecolare:462.93Cefetrizole
CAS:Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).Formula:C16H15N5O4S3Purezza:98%Colore e forma:SolidPeso molecolare:437.52RO-28-1675
CAS:RO-28-1675 is a direct and selective glucokinase activator, the GK/GKRP complex,insulin secretion and type 2 diabetes.Formula:C18H22N2O3S2Purezza:98.13%Colore e forma:SolidPeso molecolare:378.51GKA-22
CAS:GKA-22 is a human glucokinase allosteric activator in the absence of glucose.Formula:C22H22N2O5SPurezza:98%Colore e forma:SolidPeso molecolare:426.49AMG-1694
CAS:AMG-1694 disrupts GK-GKRP complex, enhancing GK activity with 7 nM IC50; normalizes glucose in diabetic rodents without affecting normoglycemic animals.Formula:C23H30F3N3O4S2Purezza:98.37%Colore e forma:SolidPeso molecolare:533.63AZD1092
CAS:AZD1092 is the glucokinase enzyme activator.Formula:C24H26N4O5Purezza:98%Colore e forma:SolidPeso molecolare:450.49AR453588
CAS:AR453588 is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.Formula:C25H25N7O2S2Colore e forma:SolidPeso molecolare:519.64PF-04937319
CAS:<p>PF-04937319 activates glucokinase (EC50=154.4μM) with low hypoglycemia risk, researched for type 2 diabetes treatment.</p>Formula:C22H20N6O4Purezza:99.89%Colore e forma:SolidPeso molecolare:432.43AR453588 hydrochloride
CAS:AR453588 hydrochloride is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.Formula:C25H26ClN7O2S2Purezza:98%Colore e forma:SolidPeso molecolare:556.1KDM4-IN-2
CAS:KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.Formula:C25H26N6OPurezza:98%Colore e forma:SolidPeso molecolare:426.51CM-10-18
CAS:CM-10-18: potent ER α-glucosidase inhibitor, strong antiviral against hemorrhagic fever viruses, protects mice from dengue fatality.Formula:C17H35NO5Colore e forma:SolidPeso molecolare:333.46AZD-1656
CAS:AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used in embryofetal development studies and type 2Formula:C24H26N6O5Purezza:97.07% - 99.37%Colore e forma:SolidPeso molecolare:478.5WAY-297848
CAS:<p>WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, obesity, dyslipidemia, and metabolic syndrome.</p>Formula:C13H13ClN2O2SPurezza:98.19%Colore e forma:SolidPeso molecolare:296.77Gcase activator 2
CAS:Gcase activator 2 is a β-glucocerebrosidase activator that induces dimerization of GCase, increases lysosomal substrate metabolism.Formula:C21H24N4O2Purezza:99.51% - 99.76%Colore e forma:SolidPeso molecolare:364.44Glucokinase activator 8
CAS:Glucokinase activator8 is an activator of glucose kinase (glucokinase).Formula:C14H13N3O2SColore e forma:SolidPeso molecolare:287.337Glucokinase activator 7
CAS:Glucokinase activator7 is an activator of glucose kinase (Glucokinase) and can be utilized in research on diabetes and hyperglycemia [refer to compound on page 176].Formula:C14H13N3O2SColore e forma:SolidPeso molecolare:287.337GKA50 quarterhydrate
GKA50 quarterhydrate: glucokinase activator, EC50 of 33 nM, boosts insulin, cuts glucose in rats.Formula:C26H30N2O7Colore e forma:SolidPeso molecolare:469.01MK-0941
CAS:MK-0941 is an orally active and allosteric glucokinase activator, has potential in the treatment of type 2 diabetes.Formula:C22H28N4O9S2Colore e forma:SolidPeso molecolare:556.61GKA50
CAS:GKA50 stimulates insulin release from mouse islets of Langerhans and MIN6 cells. GKA50 shows significant glucose lowering in high fat fed female rats. GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose).Formula:C26H28N2O6Purezza:98%Colore e forma:SolidPeso molecolare:464.51
