Aminopeptidasi
Le aminopeptidasi sono un gruppo di enzimi che catalizzano la scissione degli amminoacidi dall'estremità N-terminale di peptidi e proteine, svolgendo un ruolo cruciale nella maturazione e degradazione delle proteine. Questi enzimi sono coinvolti in vari processi fisiologici, tra cui la presentazione degli antigeni, la regolazione degli ormoni peptidici e l'omeostasi cellulare. Gli inibitori delle aminopeptidasi sono di interesse per il trattamento di malattie come il cancro, l'infiammazione e le malattie infettive. Presso CymitQuimica, offriamo una varietà di inibitori delle aminopeptidasi per supportare la tua ricerca in proteomica, sviluppo di farmaci e trattamento delle malattie.
Trovati 75 prodotti di "Aminopeptidasi"
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Bufexamac
CAS:Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with anti-inflammatory, analgesic, and antipyretic action.Formula:C12H17NO3Purezza:99.73%Colore e forma:Acicular CrystalPeso molecolare:223.27ERAP1-IN-1
CAS:ERAP1-IN-1 inhibits and allosterically activates ERAP1, affecting fluorogenic, chromogenic, and nonamer peptide substrates.Formula:C20H21F3N2O5SPurezza:98.95%Colore e forma:SolidPeso molecolare:458.45JNJ-40929837 succinate
CAS:JNJ-40929837 succinate is a selective, orally active inhibitor of LTA 4 H (leukotriene A 4 hydrolase). This compound effectively inhibits aminopeptidase activity, leading to the accumulation of Pro-Gly-Pro in serum, and can be utilized in asthma research [1].Formula:C22H24N4O2S·xC4H6O4Colore e forma:SolidBDM_92499
BDM_92499 is a nanomolar, selective IRAP inhibitor with an IC50 of 3.4 nM. It also inhibits ERAP1 and ERAP2, with IC50 values of 0.46 μM and 4.2 μM, respectively.Colore e forma:Odour SolidERAP1-IN-3
ERAP1-IN-3 (compound 13) is a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1), with a pIC50 value of 8.6. ERAP1-IN-3 shows potential for research in cancer immunotherapy and autoimmune disease studies.Formula:C22H22N2O4SColore e forma:SolidPeso molecolare:410.49LTA4H-IN-4
<p>LTA4H-IN-4 (compound 3) is an orally active inhibitor of LTA4H. It exhibits an IC50 value of 156 μM against hERG and is applicable for inflammation-related research.</p>Antho-rwamide I
CAS:Antho-rwamide I is an anthozoan neuropeptide.Formula:C31H46N10O7Colore e forma:SolidPeso molecolare:670.76Probestin
CAS:Probestin is an aminopeptidase M inhibitor, isolated from Streptomyces azureus MH663-2F6.Formula:C26H38N4O6Purezza:98%Colore e forma:SolidPeso molecolare:502.60LYS006 hydrochloride
CAS:LYS006 hydrochloride is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) with an IC50 value of 2 nM. It is applicable in the study of inflammatory and autoimmune diseases. For further details, please refer to compound 29 in patent document WO2015092740A1.Formula:C16H15Cl2FN6O3Colore e forma:SolidPeso molecolare:429.23ERAP1 modulator-1
CAS:ERAP1 modulator-1 (Compound 1) is a regulator of endoplasmic reticulum aminopeptidase 1 (ERAP1) with an IC50 of less than 250 nM.Formula:C23H23F3N2O5SColore e forma:SolidPeso molecolare:496.5Matlystatin A
CAS:Matlystatin A is an inhibitor of aminopeptidase. It shows multiple inhibitory activities against both aminopeptidase N and matrix metalloproteinases.Formula:C27H47N5O8SColore e forma:SolidPeso molecolare:601.76SDUY817
<p>SDUY817 is a dual APN/NEP inhibitor with IC50 values of 0.29 μM for APN and 7.4 μM for NEP. It exhibits analgesic effects in a concentration- and time-dependent manner, making it a potential candidate for research in the field of neuropathic pain disorders.</p>Formula:C18H16IN3O3Colore e forma:SolidPeso molecolare:449.24SDUY816
<p>SDUY816 is an orally active dual APN/NEP inhibitor, with IC50 values of 0.68 μM for APN and 6.9 μM for NEP. It exhibits analgesic properties and demonstrates good safety and pharmacokinetic profiles, having an oral bioavailability of 27% and a half-life of 4.02 hours in rats (oral, 10 mg/kg). SDUY816 is applicable for research in the field of neuropathic pain disorders.</p>Formula:C18H16IN3O3Colore e forma:SolidPeso molecolare:449.24Leuhistin
CAS:Leuhistin is an aminopeptidases N inhibitor isolated from Bacillus laterosporus BMI156-14F1.Formula:C11H19N3O3Purezza:98%Colore e forma:White To Off-White SolidPeso molecolare:241.29Aminopeptidase N inhibitor 2
<p>AminopeptidaseN inhibitor 2 is an APN inhibitor (IC50: 4.3 μM) with antitumor properties.</p>Formula:C12H16F2N2O4SColore e forma:SolidPeso molecolare:322.07988NGR peptide Trifluoroacetate
NGR peptide Trifluoroacetate contains an NGR motif recognized by CD13/APN in tumor neovasculature, used for targeted drug delivery in cancer research.Formula:C22H37F3N10O10S2Purezza:99.69%Colore e forma:SolidPeso molecolare:722.72α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid
CAS:α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneacetic acid was identified as possible dual inhibitors for hLTA4H and hLTC4S enzymes by the computer-aidedFormula:C23H23NO3Purezza:97.19% - 99.36%Colore e forma:SoildPeso molecolare:361.43Aclimostat
CAS:Aclimostat (ZGN-1061) is a MetAP2 inhibitor with strong preclinical results, improving obesity-related metrics and gene expression.Formula:C26H42N2O6Colore e forma:SolidPeso molecolare:478.63Relzomostat
CAS:Relzomostat inhibits MetAP2, with research potential for obesity and type 2 diabetes.Formula:C24H36F2N2O5Colore e forma:SolidPeso molecolare:470.558CD13-IN-1
<p>CD13-IN-1 (Compound 5f) is a CD13 inhibitor with an IC50 value of 1.71 μM. It effectively suppresses the proliferation of various tumor cells, demonstrating antitumor activity.</p>Colore e forma:Odour SolidH-Val-βNA
CAS:H-Val-βNA, also known as L-Valine β-naphthylamide, serves as a substrate for aminopeptidase and Valine arylamidase activities.Formula:C15H18N2OColore e forma:SolidPeso molecolare:242.322Amastatin hydrochloride
CAS:Amastatin HCl is an inhibitor of aminopeptidase. It also induces vasoconstriction.Formula:C21H39ClN4O8Colore e forma:White To Off-White PowderPeso molecolare:511.01Lys-psi(CH2NH)-trp(nps)-ome
CAS:Lys-psi(CH2NH)-trp(nps)-ome peptide bond replaced by CH2NH group.Formula:C24H31N5O4SColore e forma:SolidPeso molecolare:485.60BAY-277
<p>BAY-277 is a degrader of METAP2, with IC50 values of 5.8 nM for human METAP2 (hMETAP2) and 5.9 nM for mouse METAP2 (mMETAP2).</p>Formula:C44H52N8O5Colore e forma:SolidPeso molecolare:772.93DG013A formate
DG013A (formate) is a tripeptide-mimicking inhibitor of hypophosphorous acid. It exhibits IC50 values of 33 nM for ERAP1 and 11 nM for ERAP2. This compound can be utilized in research related to autoimmune diseases and cancer.Formula:C27H37N4O4PCH2O2Colore e forma:SolidPeso molecolare:530.99ecMetAP-IN-1
CAS:ecMetAP-IN-1 可用作 QSAR 模型，以使用多元线性回归研究蛋氨酸氨基肽酶抑制剂作为抗癌剂。Formula:C13H11N3Purezza:99.34%Colore e forma:SolidPeso molecolare:209.25NGR peptide
CAS:Cell-penetrating peptideFormula:C20H36N10O8S2Purezza:98%Colore e forma:SolidPeso molecolare:608.69Apstatin TFA
<p>Apstatin TFA is a potent inhibitor of aminopeptidase P (APP), with Ki values of 2.6 µM for rat APP and 0.64 µM for human APP. This compound also exhibits cardioprotective properties.</p>Formula:C25H34F3N5O7Colore e forma:SolidPeso molecolare:573.56HFI-142
CAS:HFI-142 is a inhibitor to aminopeptidase N; inhibit leukotriene A4 biosynthesis in red blood cells; inhibit dditional aminopeptidases.Formula:C17H16N2O4Colore e forma:SolidPeso molecolare:312.32L(+)-Leucinol
CAS:L(+)-Leucinol is a potent inhibitor of leucine aminopeptidase.Formula:C6H15NOPurezza:98%Colore e forma:Clear Colorless To Slightly Yellow LiquidPeso molecolare:117.19Methyl arachidate
CAS:<p>Methyl arachidate (Methyl Icosanoate) is an esterified form of arachidic acid</p>Formula:C21H42O2Purezza:≥95%Colore e forma:White PowderPeso molecolare:326.56DG051
CAS:DG051 is a potent leukotriene A4 hydrolase (LTA4H) inhibitor (IC50: 47 nM).Formula:C21H25Cl2NO4Purezza:98.26%Colore e forma:SolidPeso molecolare:426.33Bestatin trifluoroacetate
CAS:Bestatin trifluoroacetate inhibits CD13/APN and leukotriene A4 hydrolase, used in cancer research.Formula:C18H25F3N2O6Colore e forma:SolidPeso molecolare:422.401N-Acetyl-β-Asp-Glu
CAS:N-Acetyl-β-Asp-Glu is a peptide neurotransmitter, the third most common neurotransmitter in the mammalian nervous system.Formula:C11H16N2O8Purezza:99.94%Colore e forma:SolidPeso molecolare:304.25Bestatin hydrochloride
CAS:<p>Bestatin hydrochloride (Ubenimex hydrochloride) is an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.</p>Formula:C16H25ClN2O4Purezza:98% - 99.93%Colore e forma:SolidPeso molecolare:344.84Tosedostat
CAS:Tosedostat (CHR-2797), an oral M1 aminopeptidase inhibitor, turns into CHR-79888, blocks tumor cell proteins, causing cell death.Formula:C21H30N2O6Purezza:98.14% - 99.4%Colore e forma:SolidPeso molecolare:406.47Acebilustat
CAS:<p>Acebilustat (CTX-4430) (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.</p>Formula:C29H27N3O4Purezza:99.59% - 99.88%Colore e forma:SolidPeso molecolare:481.54Adamantanine
CAS:Adamantanine (NSC-145160) is an amino acid transport inhibitor.Formula:C11H17NO2Purezza:99.79%Colore e forma:SolidPeso molecolare:195.26Puromycin aminonucleoside
CAS:Puromycin aminonucleoside (NSC-3056) increases podocyte permeability by modulating ZO-1 in an oxidative stress-dependent manner.Formula:C12H18N6O3Purezza:99.85% - 99.9%Colore e forma:SolidPeso molecolare:294.31ARM1
CAS:ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.Formula:C16H14N2SPurezza:99.36%Colore e forma:SolidPeso molecolare:266.36Firibastat
CAS:<p>Firibastat (RB150) is a glutamyl aminopeptidase antagonist and an orally active brain penetrating prodrug of EC33.</p>Formula:C8H20N2O6S4Purezza:99.5%Colore e forma:SolidPeso molecolare:368.51DG-051
CAS:DG-051 is a novel leukotriene A4 (LTA4H) hydrolase inhibitor of leukotriene B4 biosynthesis.Formula:C21H24ClNO4Colore e forma:SolidPeso molecolare:389.87SC-57461A
CAS:SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.Formula:C20H26ClNO3Purezza:99.91%Colore e forma:SolidPeso molecolare:363.9Bestatin
CAS:Bestatin (Ubenimex) competitively inhibits many aminopeptidases. Bestatin is a microbial metabolite and dipeptide with immunomodulatory and antitumor effects.Formula:C16H24N2O4Purezza:98% - 99.63%Colore e forma:White Crystalline PowderPeso molecolare:308.37SC-22716
CAS:SC-22716 is a LTA4 hydrolase inhibitor.SC-22716 has anti-inflammatory activity and may be used in the study of inflammatory bowel disease and psoriasis.Formula:C18H21NOPurezza:99.91%Colore e forma:SolidPeso molecolare:267.37Aminopeptidase-IN-1
CAS:Aminopeptidase-IN-1: potent IRAP blocker, Ki 7.7 μM, useful for cognitive/memory disorder research.Formula:C18H16N2O6Purezza:98.34%Colore e forma:SolidPeso molecolare:356.33Acetyltrialanine
CAS:Acetyltrialanine is a dipeptide compound that binds at two sites on the Tb+3-pancreatic elastase complex and can be used as a nitrogen source.Formula:C11H19N3O5Purezza:97.03%Colore e forma:White PowderPeso molecolare:273.29Amastatin
CAS:Amastatin is a non-toxic inhibitor of aminopeptidase A and leucine aminopeptidase, and its Ki for aminopeptidase A is 1 μM .Formula:C21H38N4O8Purezza:98%Colore e forma:SolidPeso molecolare:474.55BDM14471
CAS:BDM14471 is a selective inhibitor of hydroxamate PfAM1.Formula:C17H15FN2O3Purezza:98%Colore e forma:SolidPeso molecolare:314.31TP-004
CAS:TP-004 is a potent and reversible methionine aminopeptidase 2 (MetAP2) inhibitor (IC50: 6 nM).Formula:C17H16F3N5OPurezza:98%Colore e forma:SolidPeso molecolare:363.34M8891
CAS:M8891: Oral, reversible MetAP-2 inhibitor, brain-penetrant (IC50: 54nM; Ki: 4.33nM), hinders endothelial & tumor cell growth, antiangiogenic & antitumor.Formula:C20H17F2N3O3Colore e forma:SolidPeso molecolare:385.36HFI-437
CAS:HFI-437 is a potent, non-peptidic, insulin-regulated aminopeptidase (IRAP) inhibitor with a K i of 20 nM and functions as a cognitive enhancer [1].Formula:C23H20N2O5Colore e forma:SolidPeso molecolare:404.42Leucinal
CAS:Leucinal inhibits the activity of brain aminopeptidase and potentiates analgesia induced by leu-enkephalen.Formula:C6H13NOColore e forma:SolidPeso molecolare:115.17Anticancer agent 51
CAS:Compound 3d (Anticancer agent 51) has a Ki of 731.62 nM, showing promise for prostate cancer research.Formula:C22H20F3N3O2SColore e forma:SolidPeso molecolare:447.47ERAP2-IN-1
CAS:ERAP2-IN-1 is a specific non-competitive ERAP2 inhibitor with IC50s of 27 μM for Arg-AMC and 44 μM for peptides.Formula:C20H21F3N2O5SColore e forma:SolidPeso molecolare:458.45JNJ-26993135
CAS:JNJ-26993135 is a potent and selective leukotriene A4 hydrolase (LTA4H) inhibitor.Formula:C20H20N2O3SColore e forma:SolidPeso molecolare:368.45Aminopeptidase N Inhibitor
CAS:AP-N inhibitor: reversible, selective for AP-N/CD13 (IC50=25 μM), non-toxic to U937 cells at 100 μM.Formula:C17H10N2O8Colore e forma:SolidPeso molecolare:370.27LYS006
CAS:LYS006 is a highly efficient and selective LTA4H (leukotriene A4 hydrolase) inhibitor,for neutrophil-driven inflammatory diseases ulcerative colitis.Formula:C16H14ClFN6O3Purezza:99.33%Colore e forma:SoildPeso molecolare:392.77RB 101
CAS:RB 101 suppresses enkephalinase and aminopeptidases; biologically cleaved at disulfide to produce inhibitors of both aminopeptidase N and neutral endopeptidase.Formula:C31H38N2O3S3Purezza:98%Colore e forma:SolidPeso molecolare:582.84MetAP2-IN-1
CAS:MetAP2-IN-1 is a selective inhibitor of MetAP2, a target involved in angiogenesis-related conditions, suitable for research applications [1].Formula:C8H6BrN3Purezza:98%Colore e forma:SolidPeso molecolare:224.06JNJ-40929837
CAS:JNJ-40929837 is an oral inhibitor of LTA4 hydrolase, which catalyzes LTB4 production.Formula:C22H24N4O2SColore e forma:SolidPeso molecolare:408.52PPI-2458
CAS:PPI-2458, a fumagillin derivative, irreversibly blocks MetAP2, hindering abnormal cell growth and angiogenesis with improved toxicity.Formula:C22H36N2O6Colore e forma:SolidPeso molecolare:424.53Beloranib
CAS:Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor.Formula:C29H41NO6Purezza:98%Colore e forma:SolidPeso molecolare:499.644-MDM
CAS:<p>4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the aminopeptidase activity of leukotriene A4 hydrolase (LTA4H). By promoting the degradation of proline-glycine-proline by LTA4H, 4-MDM reduces neutrophil recruitment in the lungs, alleviating inflammation without affecting the epoxide hydrolase activity of LTA4H. This compound is useful for research in pulmonary diseases.</p>Formula:C14H14OColore e forma:SolidPeso molecolare:198.26ERAP1 modulator-2
CAS:<p>ERAP1 modulator-2 (compound 10) is a potent ERAP1 inhibitor with an IC50 value of less than 100 nM.</p>Formula:C22H25F3N2O4SColore e forma:SolidPeso molecolare:470.505Arphamenine A
CAS:<p>Arphamenine A is an inhibitor of aminopeptidase B (aminopeptidaseB) found in HMG361-CF4 of Actinomadura azurea. It exhibits inhibitory effects against Sarcoma 180 and invasive micropapillary carcinoma (IMC).</p>Formula:C16H24N4O3Colore e forma:SolidPeso molecolare:320.387TNP-470
CAS:<p>TNP-470 is a methionine aminopeptidase-2 inhibitor. TNP-470 is also an angiogenesis inhibitor.</p>Formula:C19H28ClNO6Purezza:98%Colore e forma:SolidPeso molecolare:401.88SDX-7539
CAS:<p>SDX-7539 is a selective MetAP2 inhibitor that inhibits the proliferation of HUVEC, with an IC50 of 120 μM. It has demonstrated antitumor activity in xenografted NSCLC in athymic nude mice.</p>Formula:C23H38N2O5Peso molecolare:422.56Bestatin methyl ester
CAS:Bestatin methyl ester (600, 900 µM; 24 h) inhibits spore cell differentiation in Dictyostelium discoideum.Formula:C17H26N2O4Colore e forma:SolidPeso molecolare:322.4LTA4H-IN-2
CAS:LTA4H-IN-2 (compound (S)-2) acts as an orally active inhibitor targeting Leukotriene A4 Hydrolase, exhibiting potent activity with an IC 50 of less than 3 nM [1].Formula:C20H19FN6O2Colore e forma:SolidPeso molecolare:394.4LTA4H-IN-3
CAS:LTA4H-IN-3 (compound 9) functions as an inhibitor of LTA4H, demonstrating an IC50 of 28 nM [1].Formula:C17H15ClN4O3Colore e forma:SolidPeso molecolare:358.78QGC583
CAS:QGC583 is an effective and selective AminopeptidaseA (APA) inhibitor, demonstrating an IC50 of 4 nM. It inhibits APA activity in the brain, kidneys, and heart of rats.Formula:C13H20NO5PColore e forma:SolidPeso molecolare:301.28EC33
CAS:EC33, a selective aminopeptidase A (APA) inhibitor, blocks the pressor response of exogenous Ang II and does not cross the blood-brain barrier, making it a potential candidate for salt-dependent hypertension research [1].Formula:C4H11NO3S2Colore e forma:SolidPeso molecolare:185.27Ketomethylenebestatin
CAS:Ketomethylenebestatin, a weaker carba-analog of aminopeptidase inhibitor bestatin, is 10x less potent.Formula:C17H25NO4Purezza:98%Colore e forma:SolidPeso molecolare:307.38A-800141
CAS:A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM, while showing weaker inhibitory activity against MetAP1 (IC50: 36 μM). GAPDH can serve as a biomarker for monitoring the inhibition of MetAP2 by A-800141. This compound exhibits anti-angiogenic and anticancer properties in various xenograft tumor models.Formula:C24H30N2O4SColore e forma:SolidPeso molecolare:442.571
