Aminopeptidasi
Le aminopeptidasi sono un gruppo di enzimi che catalizzano la scissione degli amminoacidi dall'estremità N-terminale di peptidi e proteine, svolgendo un ruolo cruciale nella maturazione e degradazione delle proteine. Questi enzimi sono coinvolti in vari processi fisiologici, tra cui la presentazione degli antigeni, la regolazione degli ormoni peptidici e l'omeostasi cellulare. Gli inibitori delle aminopeptidasi sono di interesse per il trattamento di malattie come il cancro, l'infiammazione e le malattie infettive. Presso CymitQuimica, offriamo una varietà di inibitori delle aminopeptidasi per supportare la tua ricerca in proteomica, sviluppo di farmaci e trattamento delle malattie.
Trovati 76 prodotti di "Aminopeptidasi"
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RB 101
CAS:RB 101 suppresses enkephalinase and aminopeptidases; biologically cleaved at disulfide to produce inhibitors of both aminopeptidase N and neutral endopeptidase.Formula:C31H38N2O3S3Purezza:98%Colore e forma:SolidPeso molecolare:582.84Ketomethylenebestatin
CAS:Ketomethylenebestatin, a weaker carba-analog of aminopeptidase inhibitor bestatin, is 10x less potent.Formula:C17H25NO4Purezza:98%Colore e forma:SolidPeso molecolare:307.38Arphamenine A
CAS:<p>Arphamenine A is an inhibitor of aminopeptidase B (aminopeptidaseB) found in HMG361-CF4 of Actinomadura azurea. It exhibits inhibitory effects against Sarcoma 180 and invasive micropapillary carcinoma (IMC).</p>Formula:C16H24N4O3Colore e forma:SolidPeso molecolare:320.387TNP-470
CAS:<p>TNP-470 is a methionine aminopeptidase-2 inhibitor. TNP-470 is also an angiogenesis inhibitor.</p>Formula:C19H28ClNO6Purezza:98%Colore e forma:SolidPeso molecolare:401.884-MDM
CAS:<p>4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the aminopeptidase activity of leukotriene A4 hydrolase (LTA4H). By promoting the degradation of proline-glycine-proline by LTA4H, 4-MDM reduces neutrophil recruitment in the lungs, alleviating inflammation without affecting the epoxide hydrolase activity of LTA4H. This compound is useful for research in pulmonary diseases.</p>Formula:C14H14OColore e forma:SolidPeso molecolare:198.26ERAP1 modulator-2
CAS:<p>ERAP1 modulator-2 (compound 10) is a potent ERAP1 inhibitor with an IC50 value of less than 100 nM.</p>Formula:C22H25F3N2O4SColore e forma:SolidPeso molecolare:470.505QGC583
CAS:QGC583 is an effective and selective AminopeptidaseA (APA) inhibitor, demonstrating an IC50 of 4 nM. It inhibits APA activity in the brain, kidneys, and heart of rats.Formula:C13H20NO5PColore e forma:SolidPeso molecolare:301.28SDX-7539
CAS:<p>SDX-7539 is a selective MetAP2 inhibitor that inhibits the proliferation of HUVEC, with an IC50 of 120 μM. It has demonstrated antitumor activity in xenografted NSCLC in athymic nude mice.</p>Formula:C23H38N2O5Peso molecolare:422.56DG013A
CAS:DG013A inhibits ERAP1 & ERAP2 (IC50: 33 nM & 11 nM) to research autoimmune diseases & cancer.Formula:C27H37N4O4PColore e forma:SolidPeso molecolare:512.58Bestatin methyl ester
CAS:Bestatin methyl ester (600, 900 µM; 24 h) inhibits spore cell differentiation in Dictyostelium discoideum.Formula:C17H26N2O4Colore e forma:SolidPeso molecolare:322.4LTA4H-IN-2
CAS:LTA4H-IN-2 (compound (S)-2) acts as an orally active inhibitor targeting Leukotriene A4 Hydrolase, exhibiting potent activity with an IC 50 of less than 3 nM [1].Formula:C20H19FN6O2Colore e forma:SolidPeso molecolare:394.4PPI-2458
CAS:PPI-2458, a fumagillin derivative, irreversibly blocks MetAP2, hindering abnormal cell growth and angiogenesis with improved toxicity.Formula:C22H36N2O6Colore e forma:SolidPeso molecolare:424.53Beloranib
CAS:Beloranib is a fumagillin anticancer drug. Beloranib belongs to an angiogenesis inhibitor.Formula:C29H41NO6Purezza:98%Colore e forma:SolidPeso molecolare:499.64LTA4H-IN-3
CAS:LTA4H-IN-3 (compound 9) functions as an inhibitor of LTA4H, demonstrating an IC50 of 28 nM [1].Formula:C17H15ClN4O3Colore e forma:SolidPeso molecolare:358.78A-800141
CAS:A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM, while showing weaker inhibitory activity against MetAP1 (IC50: 36 μM). GAPDH can serve as a biomarker for monitoring the inhibition of MetAP2 by A-800141. This compound exhibits anti-angiogenic and anticancer properties in various xenograft tumor models.Formula:C24H30N2O4SColore e forma:SolidPeso molecolare:442.571EC33
CAS:EC33, a selective aminopeptidase A (APA) inhibitor, blocks the pressor response of exogenous Ang II and does not cross the blood-brain barrier, making it a potential candidate for salt-dependent hypertension research [1].Formula:C4H11NO3S2Colore e forma:SolidPeso molecolare:185.27
