NAMPT
La nicotinamide fosforibosiltransferasi (NAMPT) è un enzima coinvolto nella biosintesi del nicotinamide adenina dinucleotide (NAD+), un coenzima critico nel metabolismo cellulare e nella produzione di energia. Gli inibitori della NAMPT sono di grande interesse nella ricerca sul cancro per la loro capacità di interrompere il metabolismo del NAD+ e indurre la morte cellulare nelle cellule tumorali. Questi inibitori vengono anche studiati nel contesto dei disturbi metabolici e dell'invecchiamento. Presso CymitQuimica, offriamo inibitori della NAMPT per supportare la tua ricerca in biologia del cancro, metabolismo e invecchiamento.
Trovati 39 prodotti per "NAMPT".
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SBI-797812
CAS:SBI-797812 is structurally similar to active-site directed inhibitor of NAMPT(NAMPT with EC50 of 0.37 μM).Formula:C19H22N4O4SPurezza:99.31%Colore e forma:White SolidPeso molecolare:402.47Nampt-IN-5
CAS:Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .Formula:C25H25N5O2Purezza:99.30%Colore e forma:SolidPeso molecolare:427.5Ref: TM-T12171
1mg77,00€5mg147,00€1mL*10mM (DMSO)161,00€10mg250,00€25mg398,00€50mg532,00€100mg735,00€200mg973,00€Nampt activator-1
CAS:NAMPT Activator-1, EC50: 3.3-3.7 µM, specific niacinamide phosphotransferase stimulant, shields cells, potential neuroprotectant.Formula:C16H17N3O3Purezza:99.84% - 99.98%Colore e forma:SolidPeso molecolare:299.32ALT-100 (Human IgG1)
ALT-100 (Human IgG1) is a neutralizing mAb targeting eNAMPT used to study the treatment mechanisms of myocardial fibrosis and inflammatory diseases by blocking DAMP signaling.Colore e forma:Odour LiquidNampt-IN-10 trihydrochloride
Nampt-IN-10 trihydrochloride, a NAMPT inhibitor, is effective on A2780 & CORL23 cells (IC50: 5/19 nM); potential ADC payload.Formula:C27H31Cl3FN5O2Colore e forma:SolidPeso molecolare:582.92Nampt degrader-2
Nampt degrader-2: a fluorescent PROTAC that degrades NAMPT at IC50 41.9 nM, reducing NAD+ and having anti-tumor effects.Formula:C59H73N9O7SColore e forma:SolidPeso molecolare:1052.33NAMPT degrader-3
NAMPT Degrader-3 (compound C5) is a NAMPT degrader that functions through a VHL- and proteasome-dependent mechanism.Formula:C56H74N8O7SPurezza:98%Colore e forma:SolidPeso molecolare:1003.3PROTAC NAMPT Degrader-1
PROTACNAMPT Degrader-1 is an effective NAMPT-targeting PROTAC with a DC50 value of 217 nM. It exhibits antiproliferative activity, with an IC50 value of 0.12 μM against A2780 cells.Formula:C57H69N13O8S2Colore e forma:SolidPeso molecolare:1127.48335LYP-8
LYP-8 is a potent NAMPT degrader that achieves a maximum degradation rate of 97% in NAMPT within SKOV-3 cells at a concentration of 0.5 μM. LYP-8 also demonstrates anticancer activity both in vitro and in vivo.Formula:C56H74N8O10SColore e forma:SolidPeso molecolare:1050.52486NAMPT activator-7
NAMPTactivator-7 (Compound 232) is an activator of nicotinamide phosphoribosyltransferase (NAMPT) with an EC50 of less than 0.5 μM. It effectively stimulates NAMPT in U2OS cells, demonstrating a cellular EC50 of less than 0.5 μM.Formula:C21H17ClN4O3Colore e forma:SolidPeso molecolare:408.09892Nampt-IN-13 FA
Nampt-IN-13 FA is a NAMPT inhibitor (patent WO2021013693A1) suitable for synthesising antibody-drug conjugates (ADCs).Formula:C25H32N6O4Purezza:99.06% - 99.30%Colore e forma:Yellow SolidPeso molecolare:480.56CB 300919
CAS:CB 300919, a quinazoline antitumor, inhibits CH1 ovarian tumor growth (IC50: 2 nM) over 96h.Formula:C32H34ClN7O2Colore e forma:SolidPeso molecolare:584.11NAMPT Protein, Human, Recombinant (His)
Pre-B cell colony enhancing factor (PBEF) was originally identified as a cytokine that potentiated the clonal expansion and differentiation of pre-B cells, butPurezza:94% - 94%Colore e forma:Lyophilized PowderPeso molecolare:55 KDa (reducing condition)Ref: TM-TMPJ-00968
5µg74,00€10µg108,00€20µg164,00€50µg279,00€100µg479,00€200µg827,00€500µg1.710,00€1mg2.457,00€NAT
CAS:NAT is a nicotinamide phosphoribosyltransferase (NAMPT) activator that increases intracellular NAD levels.Formula:C18H21NO3Purezza:99.65%Colore e forma:White SolidPeso molecolare:299.36Ref: TM-T60667
1mg38,00€5mg74,00€10mg92,00€1mL*10mM (DMSO)93,00€25mg157,00€50mg222,00€100mg329,00€200mg487,00€(E)-Daporinad
CAS:(E)-Daporinad (FK866) is a highly specific, non-competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT） .Cost-effective and quality-assured.Formula:C24H29N3O2Purezza:98.44% - >99.99%Colore e forma:White SolidPeso molecolare:391.51Ref: TM-T2644
2mg40,00€5mg62,00€1mL*10mM (DMSO)66,00€10mg90,00€25mg178,00€50mg349,00€100mg528,00€500mg1.108,00€Nampt-IN-1
CAS:Nampt-IN-1 (LSN3154567) (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.Formula:C20H25N3O5SPurezza:99.28% - 99.4%Colore e forma:SolidPeso molecolare:419.49Ref: TM-T4376
1mg37,00€2mg49,00€5mg79,00€1mL*10mM (DMSO)87,00€10mg130,00€25mg245,00€50mg409,00€100mg605,00€KPT9274
CAS:KPT9274 (PAK4-IN-1) is a non-competitive dual inhibitor of PAK4 and NAMPT(IC50= ~120 nM). It is an orally bioavailable small molecule.Formula:C35H29F3N4O3Purezza:99.01% - 99.93%Colore e forma:SolidPeso molecolare:610.62LB-60-OF61 hydrochloride
CAS:LB-60-OF61 hydrochloride is a potent NAMPT enzyme inhibitor with cytotoxic effects, targeting MYC-overexpressing cell lines.Formula:C29H31ClN6O2Colore e forma:SolidPeso molecolare:531.06CHS-828
CAS:CHS-828 (GMX1778), a pyridyl cyanoguanidine, is an effective inhibitor of NAD+ biosynthesis enzyme NAMPT (IC50 <25 nM).Formula:C19H22ClN5OPurezza:98% - 99.9%Colore e forma:White SolidPeso molecolare:371.86STF-118804
CAS:STF-118804 is a highly specific NAMPT inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM.Formula:C25H23N3O4SPurezza:99.96%Colore e forma:SolidPeso molecolare:461.53GNE-617 hydrochloride
CAS:GNE-617 hydrochloride is a specific inhibitor of NAMPT and inhibits NAMPT activity (IC50: 5 nM).Formula:C21H16ClF2N3O3SColore e forma:SolidPeso molecolare:463.88GNE-617
CAS:GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.Formula:C21H15F2N3O3SPurezza:99.38% - 99.71%Colore e forma:White SolidPeso molecolare:427.42Ref: TM-T4335
1mg38,00€2mg50,00€5mg80,00€1mL*10mM (DMSO)81,00€10mg117,00€25mg207,00€50mg333,00€100mg495,00€500mg1.071,00€Nampt-IN-12
CAS:Nampt-IN-12 (compound 9), a derivative of N-Pyridinylthiophene carboxamid, exhibits activity against peripheral nerve sheath cancer cells. It is metabolized by the enzymes NAMPT and NMNAT1 within the NAD salvage pathway into an adenine dinucleotide (AD) derivative, an analog of NAD that can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) within the cells. Nampt-IN-12's effective blood-brain barrier permeability makes it suitable for research into cancers of the central and peripheral nervous system.Formula:C10H8N2OSColore e forma:SolidPeso molecolare:204.25Nampt-IN-7
CAS:Nampt-IN-7 (GF8) inhibits NAMPT (IC50: 7.31 μM) and kills HepG2 cells (IC50: 24.28 μM).Formula:C20H21N5O3Colore e forma:SolidPeso molecolare:379.41Teglarinad chloride
CAS:Teglarinad chloride (GMX-1777 chloride) is an inhibitor of NAMPT with antitumor activity that acts by interfering with DNA repair and inhibiting angiogenesis.Formula:C30H43Cl2N5O8Purezza:98.09%Colore e forma:SolidPeso molecolare:672.6Nampt-IN-9
CAS:Nampt-IN-9 (Compound 8) is a potent inhibitor of NAMPT with anticancer properties.Nampt-IN-9 can be used to study ductal adenocarcinoma of the pancreas.Formula:C26H33N3O4Colore e forma:SolidPeso molecolare:451.56Nampt activator-3
CAS:NAMPT activator-3: a NAT derivative, EC50 of 2.6 μM, KD 132 nM, protects cells, prevents FK866 toxicity, and is neuroprotective in CIPN mice.Formula:C19H20N2O3Colore e forma:SolidPeso molecolare:324.37Nampt activator-2
CAS:Nampt activator-2: Potent NAMPT activator (EC50: 0.023 μM), binds CYP2C9 (0.060 μM), 2D6 (0.41 μM), 2C19 (0.59 μM); useful in metabolic disease research.Formula:C17H15ClN4O3SPurezza:98.59% - 98.88%Colore e forma:SolidPeso molecolare:390.84GNE-618
CAS:GNE-618 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (IC50: 6 nM).Formula:C21H15F3N4O3SColore e forma:SolidPeso molecolare:460.43Nampt-IN-10 TFA
CAS:Nampt-IN-10 TFA, a NAMPT inhibitor, shows potency in A2780 (IC50: 5 nM) and CORL23 (IC50: 19 nM), suitable for ADC payloads.Formula:C29H29F4N5O4Colore e forma:SolidPeso molecolare:587.21557JGB-1-155
CAS:JGB-1-155 is a positive allosteric modulator of nicotinamide phosphoribosyltransferase that enhances NAMPT enzymatic activity, elevates intracellular NAD⁺ levels in human monocytes, counteracts oxidative stress, and attenuates TNFα-induced reactive oxygen species production, supporting its application in studies of redox balance and inflammatory signaling.Formula:C26H38N2O3Purezza:99.33%Colore e forma:White SolidPeso molecolare:426.59LB-60-OF61
CAS:LB-60-OF61 is a NAMPT inhibitor, a NAMPT inhibitor that displays antiproliferative activity against MYC oncogene-dependent cancer cell lines.Formula:C29H30N6O2Purezza:99.47%Colore e forma:White SolidPeso molecolare:494.59Ref: TM-T11823
1mg154,00€5mg371,00€1mL*10mM (DMSO)404,00€10mg612,00€25mg1.189,00€50mg2.008,00€100mg3.132,00€NAMPT activator-6
CAS:NAMPT activator-6 regulates NAMPT/NAD⁺ optogenetic systems, used to construct PS-PROTACs for light-dependent reversible regulation and reduced toxicity.Formula:C17H21N5O3SColore e forma:SolidPeso molecolare:375.45Nampt-IN-15
CAS:Nampt-IN-15 (Example 3) is a Nampt inhibitor that exhibits cytotoxic effects on various cell lines, including BxPC-3, HepG2, L540cy, and MOLM-13. The respective IC50 values for these cell lines are 38.5 nM, 8 nM, 8.5 nM, and 7 nM.Formula:C24H30N4O2Colore e forma:SolidPeso molecolare:406.52Nampt activator-4
CAS:Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].Formula:C26H22F3N7OSColore e forma:SolidPeso molecolare:537.56Nampt-IN-14
CAS:Nampt-IN-14 (example 3) is an effective NAMPT inhibitor with an IC50 of 0.2 nM, suited for use in the synthesis of antibody-drug conjugates (ADCs).Formula:C33H35N7O2Colore e forma:SolidPeso molecolare:561.68Nampt-IN-13
CAS:Nampt-IN-13 (example 58m) is an NAMPT inhibitor used in the synthesis of antibody-drug conjugates (ADCs).Formula:C24H30N6O2Colore e forma:SolidPeso molecolare:434.53PD-L1/Nampt-IN-1
CAS:PD-L1/Nampt-IN-1 is an orally active inhibitor that targets both PD-L1 and NAMPT (nicotinamide phosphoribosyltransferase), with IC50 values of 63 nM and 582 nM, respectively. It exhibits cross-species affinity, with KD values of 52.6 nM for hPD-L1 and 49.1 nM for mPD-L1. This compound effectively suppresses tumor growth by activating the tumor immune microenvironment and is applicable in melanoma research.Formula:C28H28N4O2Colore e forma:SolidPeso molecolare:452.55CB30865
CAS:CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.Formula:C26H22BrN5O2Purezza:99.04%Colore e forma:SolidPeso molecolare:516.39
