NAMPT
La nicotinamide fosforibosiltransferasi (NAMPT) è un enzima coinvolto nella biosintesi del nicotinamide adenina dinucleotide (NAD+), un coenzima critico nel metabolismo cellulare e nella produzione di energia. Gli inibitori della NAMPT sono di grande interesse nella ricerca sul cancro per la loro capacità di interrompere il metabolismo del NAD+ e indurre la morte cellulare nelle cellule tumorali. Questi inibitori vengono anche studiati nel contesto dei disturbi metabolici e dell'invecchiamento. Presso CymitQuimica, offriamo inibitori della NAMPT per supportare la tua ricerca in biologia del cancro, metabolismo e invecchiamento.
Trovati 39 prodotti per "NAMPT".
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GNE-617 hydrochloride
CAS:GNE-617 hydrochloride is a specific inhibitor of NAMPT and inhibits NAMPT activity (IC50: 5 nM).Formula:C21H16ClF2N3O3SColore e forma:SolidPeso molecolare:463.88GNE-617
CAS:GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.Formula:C21H15F2N3O3SPurezza:99.38% - 99.71%Colore e forma:White SolidPeso molecolare:427.42Ref: TM-T4335
1mg38,00€2mg50,00€5mg80,00€1mL*10mM (DMSO)81,00€10mg117,00€25mg207,00€50mg333,00€100mg495,00€500mg1.071,00€Nampt-IN-12
CAS:Nampt-IN-12 (compound 9), a derivative of N-Pyridinylthiophene carboxamid, exhibits activity against peripheral nerve sheath cancer cells. It is metabolized by the enzymes NAMPT and NMNAT1 within the NAD salvage pathway into an adenine dinucleotide (AD) derivative, an analog of NAD that can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) within the cells. Nampt-IN-12's effective blood-brain barrier permeability makes it suitable for research into cancers of the central and peripheral nervous system.Formula:C10H8N2OSColore e forma:SolidPeso molecolare:204.25Nampt-IN-7
CAS:Nampt-IN-7 (GF8) inhibits NAMPT (IC50: 7.31 μM) and kills HepG2 cells (IC50: 24.28 μM).Formula:C20H21N5O3Colore e forma:SolidPeso molecolare:379.41Teglarinad chloride
CAS:Teglarinad chloride (GMX-1777 chloride) is an inhibitor of NAMPT with antitumor activity that acts by interfering with DNA repair and inhibiting angiogenesis.Formula:C30H43Cl2N5O8Purezza:98.09%Colore e forma:SolidPeso molecolare:672.6Nampt-IN-9
CAS:Nampt-IN-9 (Compound 8) is a potent inhibitor of NAMPT with anticancer properties.Nampt-IN-9 can be used to study ductal adenocarcinoma of the pancreas.Formula:C26H33N3O4Colore e forma:SolidPeso molecolare:451.56Nampt activator-3
CAS:NAMPT activator-3: a NAT derivative, EC50 of 2.6 μM, KD 132 nM, protects cells, prevents FK866 toxicity, and is neuroprotective in CIPN mice.Formula:C19H20N2O3Colore e forma:SolidPeso molecolare:324.37Nampt activator-2
CAS:Nampt activator-2: Potent NAMPT activator (EC50: 0.023 μM), binds CYP2C9 (0.060 μM), 2D6 (0.41 μM), 2C19 (0.59 μM); useful in metabolic disease research.Formula:C17H15ClN4O3SPurezza:98.59% - 98.88%Colore e forma:SolidPeso molecolare:390.84GNE-618
CAS:GNE-618 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (IC50: 6 nM).Formula:C21H15F3N4O3SColore e forma:SolidPeso molecolare:460.43Nampt-IN-10 TFA
CAS:Nampt-IN-10 TFA, a NAMPT inhibitor, shows potency in A2780 (IC50: 5 nM) and CORL23 (IC50: 19 nM), suitable for ADC payloads.Formula:C29H29F4N5O4Colore e forma:SolidPeso molecolare:587.21557JGB-1-155
CAS:JGB-1-155 is a positive allosteric modulator of nicotinamide phosphoribosyltransferase that enhances NAMPT enzymatic activity, elevates intracellular NAD⁺ levels in human monocytes, counteracts oxidative stress, and attenuates TNFα-induced reactive oxygen species production, supporting its application in studies of redox balance and inflammatory signaling.Formula:C26H38N2O3Purezza:99.33%Colore e forma:White SolidPeso molecolare:426.59LB-60-OF61
CAS:LB-60-OF61 is a NAMPT inhibitor, a NAMPT inhibitor that displays antiproliferative activity against MYC oncogene-dependent cancer cell lines.Formula:C29H30N6O2Purezza:99.47%Colore e forma:White SolidPeso molecolare:494.59Ref: TM-T11823
1mg154,00€5mg371,00€1mL*10mM (DMSO)404,00€10mg612,00€25mg1.189,00€50mg2.008,00€100mg3.132,00€NAMPT activator-6
CAS:NAMPT activator-6 is a NAMPT activator that can regulate the NAMPT and NAD⁺-related optogenetic systems. NAMPT activator-6 can be used to construct high-efficiency photoswitchable PROTACs (PS-PROTACs), bidirectionally and reversibly regulate NAMPT and NAD⁺ levels in a light-dependent manner, and reduce the related toxicity caused by inhibitor-based PS-PROTACs.Formula:C17H21N5O3SColore e forma:SolidPeso molecolare:375.45Nampt-IN-15
CAS:Nampt-IN-15 (Example 3) is a Nampt inhibitor that exhibits cytotoxic effects on various cell lines, including BxPC-3, HepG2, L540cy, and MOLM-13. The respective IC50 values for these cell lines are 38.5 nM, 8 nM, 8.5 nM, and 7 nM.Formula:C24H30N4O2Colore e forma:SolidPeso molecolare:406.52Nampt activator-4
CAS:Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].Formula:C26H22F3N7OSColore e forma:SolidPeso molecolare:537.56Nampt-IN-14
CAS:Nampt-IN-14 (example 3) is an effective NAMPT inhibitor with an IC50 of 0.2 nM, suited for use in the synthesis of antibody-drug conjugates (ADCs).Formula:C33H35N7O2Colore e forma:SolidPeso molecolare:561.68Nampt-IN-13
CAS:Nampt-IN-13 (example 58m) is an NAMPT inhibitor used in the synthesis of antibody-drug conjugates (ADCs).Formula:C24H30N6O2Colore e forma:SolidPeso molecolare:434.53PD-L1/Nampt-IN-1
CAS:PD-L1/Nampt-IN-1 is an orally active inhibitor that targets both PD-L1 and NAMPT (nicotinamide phosphoribosyltransferase), with IC50 values of 63 nM and 582 nM, respectively. It exhibits cross-species affinity, with KD values of 52.6 nM for hPD-L1 and 49.1 nM for mPD-L1. This compound effectively suppresses tumor growth by activating the tumor immune microenvironment and is applicable in melanoma research.Formula:C28H28N4O2Colore e forma:SolidPeso molecolare:452.55CB30865
CAS:CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.Formula:C26H22BrN5O2Purezza:99.04%Colore e forma:SolidPeso molecolare:516.39
