NAMPT
La nicotinamide fosforibosiltransferasi (NAMPT) è un enzima coinvolto nella biosintesi del nicotinamide adenina dinucleotide (NAD+), un coenzima critico nel metabolismo cellulare e nella produzione di energia. Gli inibitori della NAMPT sono di grande interesse nella ricerca sul cancro per la loro capacità di interrompere il metabolismo del NAD+ e indurre la morte cellulare nelle cellule tumorali. Questi inibitori vengono anche studiati nel contesto dei disturbi metabolici e dell'invecchiamento. Presso CymitQuimica, offriamo inibitori della NAMPT per supportare la tua ricerca in biologia del cancro, metabolismo e invecchiamento.
Trovati 40 prodotti di "NAMPT"
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CHS-828
CAS:CHS-828 (GMX1778), a pyridyl cyanoguanidine, is an effective inhibitor of NAD+ biosynthesis enzyme NAMPT (IC50 <25 nM).Formula:C19H22ClN5OPurezza:98% - 99.9%Colore e forma:SolidPeso molecolare:371.86GNE-617
CAS:GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.Formula:C21H15F2N3O3SPurezza:99.28% - 99.71%Colore e forma:SolidPeso molecolare:427.42Nampt-IN-12
CAS:Nampt-IN-12 (compound 9), a derivative of N-Pyridinylthiophene carboxamid, exhibits activity against peripheral nerve sheath cancer cells. It is metabolized by the enzymes NAMPT and NMNAT1 within the NAD salvage pathway into an adenine dinucleotide (AD) derivative, an analog of NAD that can inhibit inosine monophosphate dehydrogenase (IMPDH), leading to the accumulation of inosine monophosphate (IMP) within the cells. Nampt-IN-12's effective blood-brain barrier permeability makes it suitable for research into cancers of the central and peripheral nervous system.Formula:C10H8N2OSPeso molecolare:204.25Nampt-IN-9
CAS:Nampt-IN-9 (Compound 8) is a potent inhibitor of NAMPT with anticancer properties.Nampt-IN-9 can be used to study ductal adenocarcinoma of the pancreas.Formula:C26H33N3O4Colore e forma:SolidPeso molecolare:451.56Teglarinad chloride
CAS:<p>Teglarinad chloride (GMX-1777 chloride) is an inhibitor of NAMPT with antitumor activity that acts by interfering with DNA repair and inhibiting angiogenesis.</p>Formula:C30H43Cl2N5O8Purezza:98.09%Colore e forma:SolidPeso molecolare:672.6Nampt-IN-7
CAS:Nampt-IN-7 (GF8) inhibits NAMPT (IC50: 7.31 μM) and kills HepG2 cells (IC50: 24.28 μM).Formula:C20H21N5O3Colore e forma:SolidPeso molecolare:379.41A-1293201
CAS:A-1293201 is a potent and selective NAMPT inhibitor.Formula:C21H23N3O3Colore e forma:SolidPeso molecolare:365.43Nampt activator-3
CAS:NAMPT activator-3: a NAT derivative, EC50 of 2.6 μM, KD 132 nM, protects cells, prevents FK866 toxicity, and is neuroprotective in CIPN mice.Formula:C19H20N2O3Colore e forma:SolidPeso molecolare:324.37Nampt activator-2
CAS:Nampt activator-2: Potent NAMPT activator (EC50: 0.023 μM), binds CYP2C9 (0.060 μM), 2D6 (0.41 μM), 2C19 (0.59 μM); useful in metabolic disease research.Formula:C17H15ClN4O3SPurezza:98.59% - 98.88%Colore e forma:SolidPeso molecolare:390.84GNE-618
CAS:GNE-618 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (IC50: 6 nM).Formula:C21H15F3N4O3SColore e forma:SolidPeso molecolare:460.43Nampt-IN-10 TFA
CAS:Nampt-IN-10 TFA, a NAMPT inhibitor, shows potency in A2780 (IC50: 5 nM) and CORL23 (IC50: 19 nM), suitable for ADC payloads.Formula:C29H29F4N5O4Colore e forma:SolidPeso molecolare:587.21557LB-60-OF61
CAS:<p>LB-60-OF61 is a NAMPT inhibitor, a NAMPT inhibitor that displays antiproliferative activity against MYC oncogene-dependent cancer cell lines.</p>Formula:C29H30N6O2Purezza:99.47%Colore e forma:SolidPeso molecolare:494.59JGB-1-155
CAS:JGB-1-155, serving as a positive allosteric modulator (N-PAMs), effectively enhances the activity of nicotinamide phosphoribosyltransferase (NAMPT) with an EC 50 of 3.29 μM. It mitigates oxidative stress by elevating NAD+ levels in THP-1 human monocytes and reduces TNFα-induced reactive oxygen species (ROS) in HT-22 cells [1].Formula:C26H38N2O3Colore e forma:SolidPeso molecolare:426.59Nampt activator-4
CAS:Nampt activator-4, a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT), has an EC50 of 0.058 μM and can enhance nicotinamide adenine dinucleotide (NAD+) levels in cells [1].Formula:C26H22F3N7OSColore e forma:SolidPeso molecolare:537.56Nampt-IN-15
CAS:Nampt-IN-15 (Example 3) is a Nampt inhibitor that exhibits cytotoxic effects on various cell lines, including BxPC-3, HepG2, L540cy, and MOLM-13. The respective IC50 values for these cell lines are 38.5 nM, 8 nM, 8.5 nM, and 7 nM.Formula:C24H30N4O2Colore e forma:SolidPeso molecolare:406.52PD-L1/Nampt-IN-1
CAS:PD-L1/Nampt-IN-1 is an orally active inhibitor that targets both PD-L1 and NAMPT (nicotinamide phosphoribosyltransferase), with IC50 values of 63 nM and 582 nM, respectively. It exhibits cross-species affinity, with KD values of 52.6 nM for hPD-L1 and 49.1 nM for mPD-L1. This compound effectively suppresses tumor growth by activating the tumor immune microenvironment and is applicable in melanoma research.Formula:C28H28N4O2Colore e forma:SolidPeso molecolare:452.55Nampt-IN-14
CAS:Nampt-IN-14 (example 3) is an effective NAMPT inhibitor with an IC50 of 0.2 nM, suited for use in the synthesis of antibody-drug conjugates (ADCs).Formula:C33H35N7O2Colore e forma:SolidPeso molecolare:561.68Nampt-IN-13
CAS:Nampt-IN-13 (example 58m) is an NAMPT inhibitor used in the synthesis of antibody-drug conjugates (ADCs).Formula:C24H30N6O2Colore e forma:SolidPeso molecolare:434.53CB30865
CAS:CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.Formula:C26H22BrN5O2Purezza:99.04%Colore e forma:SolidPeso molecolare:516.39NAMPT activator-6
CAS:<p>NAMPT activator-6, a regulatory molecule for the optical control system of NAMPT and NAD+, can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) for light-dependent, reversible regulation of NAMPT and NAD+, thereby reducing toxicity associated with inhibitor-based PS-PROTACs. This enables antitumor activity and in vivo modulation of NAMPT and NAD+ through optical manipulation [1].</p>Formula:C17H21N5O3SColore e forma:SolidPeso molecolare:375.45
