PPAR
I recettori attivati dai proliferatori dei perossisomi (PPARs) sono un gruppo di proteine recettori nucleari che funzionano come fattori di trascrizione regolando l'espressione di geni coinvolti nel metabolismo, in particolare lo stoccaggio degli acidi grassi e il metabolismo del glucosio. Gli inibitori dei PPARs sono strumenti importanti per lo studio dei disturbi metabolici come il diabete, l'obesità e le malattie cardiovascolari. Questi inibitori possono modulare il metabolismo dei lipidi, la sensibilità all'insulina e l'infiammazione, rendendoli preziosi nella ricerca terapeutica. Presso CymitQuimica, offriamo una gamma di inibitori dei PPARs per supportare la tua ricerca in malattie metaboliche, endocrinologia e sviluppo di farmaci.
Trovati 164 prodotti di "PPAR"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
T0070907
CAS:<p>T0070907(IC50=1 nM) , an effective and specific PPARγ inhibitor, with the >800-fold selectivity over PPARα and PPARδ.</p>Formula:C12H8ClN3O3Purezza:98.25% - 99.98%Colore e forma:SolidPeso molecolare:277.66Angeloylgomisin H
CAS:<p>Angeloylgomisin H shows moderate cytotoxic activities with IC50 values ranging from 100 to 200 ug/mL against MCF7, HEK293 and CAL27 cell lines.</p>Formula:C28H36O8Purezza:99.84% - 99.95%Colore e forma:SolidPeso molecolare:500.58Oleuropein
CAS:<p>Oleuropein is an antioxidant polyphenol isolated from olive leaf.</p>Formula:C25H32O13Purezza:98% - 99.95%Colore e forma:Brown PowderPeso molecolare:540.51GSK0660
CAS:<p>GSK0660 is an antagonist and inverse agonist of PPARβ/δ.</p>Formula:C19H18N2O5S2Purezza:99.26% - ≥95%Colore e forma:SolidPeso molecolare:418.49Rosiglitazone hydrochloride
CAS:<p>Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.</p>Formula:C18H19N3O3S·HClPurezza:99.63% - 99.79%Colore e forma:SolidPeso molecolare:393.89EPI-001
CAS:<p>EPI-001 is an androgen receptor N-terminal domain antagonist with IC50 of ～6 μM and a selective PPAR-gamma modulator.</p>Formula:C21H27ClO5Purezza:99% - 99.67%Colore e forma:SolidPeso molecolare:394.89Clofibrate
CAS:<p>Clofibrate (Clofibrato) is an aryloxyisobutyric acid derivate with antihyperlipidemic activity.</p>Formula:C12H15ClO3Purezza:98.77%Colore e forma:Oil LiquidPeso molecolare:242.70DG172 dihydrochloride
CAS:<p>DG172 dihydrochloride (DG-172 dihydrochloride) is an antagonist of PPARβ/δ(IC50 : 27 nM).</p>Formula:C20H22BrCl2N3Purezza:99.87%Colore e forma:SolidPeso molecolare:455.2L-165041
CAS:<p>L-165041 is a potent and selective agonist of the nuclear receptor PPARβ and PPARδ(Ki = 9 nM, EC50 = ~500 nM ,respectively)</p>Formula:C22H26O7Purezza:97.97%Colore e forma:SolidPeso molecolare:402.44GSK3787
CAS:<p>GSK3787 is a specific and irreversible PPARδ inhibitor（pIC50= 6.6）.</p>Formula:C15H12ClF3N2O3SPurezza:98% - 99.56%Colore e forma:SolidPeso molecolare:392.78Oroxin A
CAS:<p>Oroxin A (Baicalein 7-O-glucoside) has antitussive and expectorant effects.</p>Formula:C21H20O10Purezza:98.05% - 99.74%Colore e forma:SolidPeso molecolare:432.38AMG131
CAS:<p>AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for</p>Formula:C21H12Cl4N2O3SPurezza:99.37%Colore e forma:SolidPeso molecolare:514.21Gypenoside XLIX
CAS:<p>Extracted from whole herb of Gynostemsma pentaphyllum(Thunb.)Mak.;Store the product in sealed, cool and dry condition</p>Formula:C52H86O21Purezza:97.05% - 99.78%Colore e forma:SolidPeso molecolare:1047.23Elafibranor
CAS:<p>Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with</p>Formula:C22H24O4SPurezza:98.42% - 98.78%Colore e forma:SolidPeso molecolare:384.49Cinnamyl alcohol
CAS:<p>Cinnamyl alcohol (Styryl Carbinol) readily autoxidizes upon air exposure, and forms strong sensitizers as determined by the local lymph node assay.</p>Formula:C9H10OPurezza:99.00%Colore e forma:Colourless LiquidPeso molecolare:134.18Tesaglitazar
CAS:<p>Tesaglitazar is a potent and selective peroxide PPARα / γ receptor dual agonist with a more potent affinity for PPARγ than PPARα, The EC50 values for rat PPARα</p>Formula:C20H24O7SPurezza:99.95%Colore e forma:SolidPeso molecolare:408.47Pparδ agonist 2
CAS:<p>Pparδ agonist 2 is an agonist of PPARδ.</p>Formula:C20H18F3N3O3SPurezza:98%Colore e forma:SolidPeso molecolare:437.44FTX-6746
CAS:<p>FTX-6746 is an orally active and selective PPARG reverse inhibitor with anticancer activity. It can be used in research on urothelial carcinoma.</p>Formula:C16H7ClF2N2OPurezza:98.68%Colore e forma:SolidPeso molecolare:316.6913-Oxo-9E,11E-octadecadienoic acid
CAS:<p>13-Oxo-9E,11E-octadecadienoic acid from tomato juice, an isomer of 9-oxo-ODA, activates PPARα and lowers triglycerides in diabetic mice.</p>Formula:C18H30O3Purezza:98%Colore e forma:SolidPeso molecolare:294.43Peliglitazar racemate
CAS:<p>Peliglitazar racemate(BMS 426707-01 racemate) is the racemate of Peliglitazar.Peliglitazar racemate may be used as a potential antidiabetic and anti-obesity</p>Formula:C30H30N2O7Purezza:97.75%Colore e forma:SolidPeso molecolare:530.57Daltroban
CAS:<p>Daltroban (SKF 96148) is a specific thromboxane A2 (TXA2) receptor antagonist.</p>Formula:C16H16ClNO4SPurezza:99.74%Colore e forma:SolidPeso molecolare:353.82GW 9578
CAS:<p>GW 9578 is a PPARα agonist with potent lipid-lowering activity for the study of psoriasis, arthritis, alopecia, asthma and type I diabetes.</p>Formula:C26H34F2N2O3SPurezza:98%Colore e forma:SolidPeso molecolare:492.62ARH-049020
CAS:<p>ARH-049020, a peroxisome proliferator-activated receptor (PPAR) agonist, is used potentially for the treatment of insulin resistance and type 2 diabetes.</p>Formula:C24H31NO6Purezza:97.19% - 99.82%Colore e forma:SolidPeso molecolare:429.51Reglitazar
CAS:<p>Reglitazar, a dual PPARα/γ agonist, enhances insulin signaling, reduces insulin resistance, and lowers hypertriglyceridemia in obese rats.</p>Formula:C22H20N2O5Purezza:97.07% - 98.72%Colore e forma:SolidPeso molecolare:392.4THR-0921
CAS:<p>THR-0921 (CLX-0921) is a peroxisome proliferator-activated receptor (PPAR) agonist that can be used to study cardiovascular and metabolic diseases.</p>Formula:C28H25NO7SPurezza:100% - 99.83%Colore e forma:SolidPeso molecolare:519.57AVE-8134
CAS:<p>AVE-8134 is an agonist of PPARα. For human and rodent PPARα receptor, the EC50 values are 100 and 3000 nM, respectively.</p>Formula:C22H23NO5Purezza:98%Colore e forma:SolidPeso molecolare:381.42PPARα-MO-1
CAS:<p>PPARα-MO-1 is a potent modulator of PPARα.</p>Formula:C27H37NO5Purezza:98%Colore e forma:SolidPeso molecolare:455.59LG100754
CAS:LG100754 (UVI 2112) is an insulin sensitizer and RXR modulator, antagonizing RXR homodimers while agonizing RXR:PPARα/γ heterodimers.Formula:C26H36O3Colore e forma:SolidPeso molecolare:396.56Chiglitazar
CAS:<p>Chiglitazar is a PPAR α/γ/δ agonist and insulin sensitizer used in the treatment of type 2 diabetes mellitus , anti-inflammatory and anti-fibrotic.</p>Formula:C36H29FN2O4Colore e forma:SolidPeso molecolare:572.63Inolitazone dihydrochloride
CAS:<p>Inolitazone dihydrochloride is an effective, high-affinity PPARγ agonist; its biological activity is dependent on PPARγ (IC50:0.8 nM) to inhibit cell growth.</p>Formula:C27H28Cl2N4O4SColore e forma:SolidPeso molecolare:575.51Saroglitazar
CAS:<p>Saroglitazar (Lipaglyn) is an agonist of PPAR with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ.</p>Formula:C25H29NO4SPurezza:98.51%Colore e forma:SolidPeso molecolare:439.57GSK376501A
CAS:<p>GSK376501A is a selective and effective modulator of peroxisome proliferator-activated receptor γ (PPARγ) for the study of type 2 diabetes.</p>Formula:C32H37NO6Purezza:>99.99%Colore e forma:SolidPeso molecolare:531.64Indeglitazar
CAS:<p>Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)).</p>Formula:C19H19NO6SPurezza:99.45%Colore e forma:SolidPeso molecolare:389.42K-111
CAS:<p>K-111 is a PPAR alpha agonist. K-111 improves insulin resistance, reducing bodyweight, and ameliorating atherogenic dyslipidemia.</p>Formula:C18H25Cl3O2Purezza:99.64% - 99.88%Colore e forma:SolidPeso molecolare:379.75Farglitazar
CAS:<p>Farglitazar (GI-262570) is a PPAR-γ agonist and insulin sensitizer used in the study of diabetes.</p>Formula:C34H30N2O5Purezza:99.4% - 99.52%Colore e forma:SolidPeso molecolare:546.61Cevoglitazar
CAS:Cevoglitazar (LBM-642) is a PPARɑ agonist and PPARγ agonist. Cevoglitazar potently reduces food intake and body weight in obese mice and cynomolgus monkeys.Formula:C27H21F3N2O6SPurezza:97%Colore e forma:SolidPeso molecolare:558.53Dazmegrel
CAS:<p>Dazmegrel (UK 38,485) is a thromboxane A2 (TXA2) synthase inhibitor for the prevention of increased whole platelet aggregation in normal pregnancy.</p>Formula:C16H17N3O2Purezza:98.81%Colore e forma:SolidPeso molecolare:283.33BAY-0069
CAS:<p>BAY-0069 is a potent and selective PPARγ transactivator that inhibits human PPARγ and murine PPARγ with IC50s of 6.3 nM and 24 nM, respectively.BAY-0069 can be</p>Formula:C22H16BrN3O4Purezza:99.41%Colore e forma:SoildPeso molecolare:466.28Linotroban
CAS:<p>Linotroban（CL-871502） is a potent selective thromboxane (TXA2) receptor antagonist with antithrombotic activity.</p>Formula:C14H15NO5S2Purezza:97.95% - >99.99%Colore e forma:SolidPeso molecolare:341.4BAY-4931
CAS:<p>BAY-4931 is a powerful, covalent, and selective inverse-agonist of PPARγ, exhibiting an IC50 value of 0.17 nM.</p>Formula:C22H16ClN3O4Purezza:99.47%Colore e forma:SoildPeso molecolare:421.83Edaglitazone
CAS:<p>Edaglitazone (R-483) is a PPARγ agonist with antiplatelet activity that can be used in studies of diabetes and obesity.</p>Formula:C24H20N2O4S2Purezza:98%Colore e forma:SolidPeso molecolare:464.56LCB-2853
CAS:<p>LCB-2853 is a potent thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor antagonist with antiplatelet aggregation, antivasospasm, and antithrombotic effects.</p>Formula:C21H24ClNO4SPurezza:97.15%Colore e forma:SolidPeso molecolare:421.94Imiglitazar
CAS:<p>Imiglitazar (TAK559) is a potent PPAR-β/δ receptor agonist with hypoglycemic effects.</p>Formula:C28H26N2O5Purezza:97.33%Colore e forma:SolidPeso molecolare:470.52PPAR agonist 1
CAS:<p>PPAR agonist 1 is an agonist of PPAR α/γ, used for reducing blood glucose, lipid levels, reducing body weight, and lowering cholesterol.</p>Formula:C20H25NO6SPurezza:98%Colore e forma:SolidPeso molecolare:407.48U-46619
CAS:<p>U-46619 is an effective thromboxane A2 (TXA2) agonist and a thromboxane A2 analog (endoperoxide), capable of inducing contraction in the aortic smooth muscle (</p>Formula:C21H34O4Purezza:98%Colore e forma:SolidPeso molecolare:350.49KD-3010
CAS:<p>KD-3010 (Kalypsys) is an orally active potent and selective PPARδ agonist for the study of liver injury.</p>Formula:C30H33F3N2O8S2Purezza:99.61%Colore e forma:SolidPeso molecolare:670.72CRX000227
CAS:<p>CRX000227 is a PPAR modulator suitable for researching metabolic and cell proliferative disorders [1].</p>Formula:C25H24N4O2SPurezza:98%Colore e forma:SolidPeso molecolare:444.55PPARγ agonist 8
CAS:<p>PPARγ agonist 8, a compound that acts on the peroxisome proliferator-activated receptor gamma (PPARγ), has been shown to stimulate peroxisome proliferator</p>Formula:C19H12F4O2SPurezza:98%Colore e forma:SolidPeso molecolare:380.36Darglitazone
CAS:<p>Darglitazone (CP-86325) is a potent, selective agonist of PPAR-γ with antidiabetic actions.</p>Formula:C23H20N2O4SPurezza:99.76%Colore e forma:SolidPeso molecolare:420.48PPARδ agonist 9
CAS:<p>PPARδ agonist 9 (compound 21), with an EC50 of 3.6 nM, is effective in vivo, decreasing serum MCP-1 concentrations in mice and markedly reducing atherosclerotic</p>Formula:C26H28ClF3N4O3SPurezza:98%Colore e forma:SolidPeso molecolare:569.04Ragaglitazar
CAS:<p>Ragaglitazar(NNC-61-0029) is a potent dual activator of PPARγ and PPARα.Cost-effective and quality-assured.</p>Formula:C25H25NO5Purezza:97.46% - 98.56%Colore e forma:SolidPeso molecolare:419.47Inolitazone
CAS:<p>Inolitazone (RS5444) a high-affinity PPARγ agonist. Inolitazone exhibits IC50 for growth inhibition is ~0.8 nM in vitro.</p>Formula:C27H26N4O4SPurezza:99.41% - 99.53%Colore e forma:SolidPeso molecolare:502.58Fonadelpar
CAS:<p>Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.</p>Formula:C25H23F3N2O4SPurezza:98%Colore e forma:SolidPeso molecolare:504.52Anti-NASH agent 2
CAS:<p>Anti-NASH agent 2 (compound 21) is an inhibitor of neolipogenesis activity and α-SMA gene expression. It improves hepatic steatosis, edema, inflammatory infiltration, and liver fibrosis in NASH mouse models.</p>Formula:C32H51N3O2Colore e forma:SolidPeso molecolare:509.766PPARγ agonist 17
CAS:<p>PPARγ agonist17 (Compound C1) is an orally active PPARγ agonist. It enhances PPARγ activity, arrests the cell cycle of HT-29 cells at the G2/M phase, inhibits cell migration, and induces apoptosis. PPARγ agonist17 exhibits broad-spectrum antiproliferative activity against cancer cells with relatively low toxicity to normal cells and does not cross the blood-brain barrier.</p>Formula:C48H63NO7Colore e forma:SolidPeso molecolare:766.016PPARγ modulator-2
CAS:<p>PPARγmodulator-2 (Compound (R)-2n) is a reversible modulator of PPARγ, inhibiting the PPARγ ligand-binding domain (LBD) with an IC50 of 41 nM. It helps lower blood glucose levels, improves glucose tolerance and insulin sensitivity, and demonstrates antidiabetic activity in db/db mouse models.</p>Formula:C26H21NO7S3SeColore e forma:SolidPeso molecolare:634.6Amezalpat
CAS:<p>Amezalpat is a PPARα antagonist with an IC50 of 58 nM [nanomolar]. Amezalpat also exhibits antitumor activity.</p>Formula:C34H41N3O4Colore e forma:SolidPeso molecolare:555.707PPARγ-IN-5
CAS:<p>PPARγ-IN-5 (Compound A3) is an inhibitor of PPARγ. In liver cells, it reduces lipid accumulation and shows no significant cytotoxicity in HepG2 cells at a concentration of 400 µM. PPARγ-IN-5 is applicable for research on non-alcoholic fatty liver disease.</p>Formula:C22H23ClO7Colore e forma:SolidPeso molecolare:434.867PPARα/δ agonist 3
CAS:<p>PPARα/δ agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPARα, PPARδ, and PPARγ, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.</p>Formula:C23H25F3N2O4Colore e forma:SolidPeso molecolare:450.451PPARδ agonist 11
CAS:<p>Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.</p>Formula:C19H15F3N2O3S2Colore e forma:SolidPeso molecolare:440.46Aleglitazar
CAS:<p>Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively.</p>Formula:C24H23NO5SPurezza:99.03%Colore e forma:SolidPeso molecolare:437.51Anti-NASH agent 1
CAS:<p>Anti-NASH Agent 1 (Compound 3d), derived from Elafibranor, serves as a strong PPAR-α/δ agonist aimed at treating nonalcoholic steatohepatitis (NASH).</p>Formula:C26H33NO4Purezza:98%Colore e forma:SolidPeso molecolare:423.54Ref: TM-T79454
Prodotto fuori produzionePPARγ-IN-2
CAS:<p>"PPARγ-IN-2 (Compound 5a), a PPARγ inhibitor, exhibits an EC50 of 0.106 μM in inhibiting TG accumulation in 3T3-L1 preadipocytes.</p>Formula:C19H21N5OPurezza:98%Colore e forma:SolidPeso molecolare:335.4Ref: TM-T79678
Prodotto fuori produzioneMavodelpar free base
CAS:<p>Mavodelpar free acid (REN001 free acid) is an selective agonist of PPARδ.</p>Formula:C31H30FNO5Purezza:98%Colore e forma:SolidPeso molecolare:515.57
