Lipossigenasi
Le lipossigenasi sono una famiglia di enzimi che catalizzano l'ossigenazione degli acidi grassi polinsaturi, portando alla produzione di mediatori lipidici bioattivi come i leucotrieni e le lipossine. Questi mediatori svolgono ruoli critici nell'infiammazione, nelle risposte immunitarie e nel cancro. Gli inibitori della lipossigenasi sono utilizzati per studiare il loro ruolo nelle malattie infiammatorie, nell'asma e nel cancro. Presso CymitQuimica, offriamo una varietà di inibitori della lipossigenasi per supportare la tua ricerca in infiammazione, oncologia e metabolismo lipidico.
Trovati 134 prodotti di "Lipossigenasi"
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Leukotriene A3 methyl ester
CAS:LTA3, made from 5,8,11-eicosatrienoic acid via 5-LO, is unstable; its stable methyl ester form turns into free acid when needed.Formula:C21H34O3Colore e forma:SolidPeso molecolare:334.49Setileuton tosylate
CAS:Setileuton (MK0633): a potent 5-lipoxygenase inhibitor, researched for asthma and atherosclerosis treatment.Formula:C29H25F4N3O7SColore e forma:SolidPeso molecolare:635.58PF-4191834
CAS:PF-4191834: Non-iron, non-redox 5-LOX inhibitor, IC50 = 229 nM, 300x selective over 12/15-LOX, inactive on COX enzymes.Formula:C22H23N3O2SPurezza:99.83% - 99.98%Colore e forma:SolidPeso molecolare:393.5Ref: TM-T16503
5mg50,00€1mL*10mM (DMSO)55,00€10mg79,00€25mg146,00€50mg245,00€100mg355,00€500mg772,00€A-69412
CAS:A-69412 is a reversible 5-lipoxygenase inhibitor, potentially treating ulcerative colitis and asthma.Formula:C7H10N2O3Purezza:99.54%Colore e forma:SolidPeso molecolare:170.17Butibufen
CAS:Butibufen (FF-106) is a non-steroidal anti-inflammatory compound and LOX inhibitor with analgesic and antipyretic activity for the study of rheumatic diseases.Formula:C14H20O2Purezza:98.11% - 98.91%Colore e forma:SolidPeso molecolare:220.315-LOX-IN-1
CAS:5-LOX-IN-1 is a 5-Lipoxygenase (5-LOX) inhibitor (IC50: 2.3 μM).5-LOX-IN-1 can be used for cancer research.
Formula:C20H18N2O2SPurezza:97.45%Colore e forma:SolidPeso molecolare:350.43Lonapalene
CAS:Lonapalene is a topically effective inhibitor of 5-lipoxygenase.Formula:C16H15ClO6Purezza:98.67% - 99.33%Colore e forma:SolidPeso molecolare:338.74Ref: TM-T16802
1mg100,00€2mg160,00€5mg290,00€1mL*10mM (DMSO)318,00€10mg424,00€25mg642,00€50mg858,00€100mg1.153,00€200mg1.558,00€Benoxaprofen
CAS:Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.Formula:C16H12ClNO3Purezza:98.87%Colore e forma:SolidPeso molecolare:301.72Ref: TM-T19679
1mg202,00€1mL*10mM (DMSO)469,00€5mg472,00€10mg707,00€25mg1.035,00€50mg1.311,00€100mg1.663,00€L 670630
CAS:L 670630 is a potent and orally active 5-lipoxygenase inhibitor.Formula:C25H26O3Purezza:98%Colore e forma:SolidPeso molecolare:374.47AA 863
CAS:AA 863 is a 5-lipoxygenase inhibitor, it inhibits the proliferation of human glioma cell lines in dose-dependent.Formula:C21H26O5Purezza:98%Colore e forma:SolidPeso molecolare:358.43A 79175
CAS:A 79175 is a 5-lipoxygenase inhibitor that increases bone formation.Formula:C15H13FN2O4Purezza:98%Colore e forma:SolidPeso molecolare:304.2715(S)-HEDE
CAS:15(S)-HEDE is produced from 11Z,14Z-eicosadienoic acid by 15-LO. 15(S)-HEDE is an inhibitor of RBL-1 cell 5-LO with an IC50 value of 26 μM.Formula:C20H36O3Colore e forma:SolidPeso molecolare:324.51-Stearoyl-2-Oleoyl-3-Linoleoyl-rac-glycerol
CAS:1-Stearoyl-2-oleoyl-3-linoleoyl-rac-glycerol is a triacylglycerol consisting of stearic acid, oleic acid, and linoleic acid esterified at the sn-1, sn-2, and sn-3 positions, respectively. This compound is present in peanut and soybean oils as well as in ostrich and emu oils. Additionally, it serves as a substrate for soybean lipoxygenase in cell-free assays.Formula:C57H104O6Colore e forma:SolidPeso molecolare:885.43TA-270
CAS:TA-720, a 5-lipoxygenase inhibitor, is used potentially for the treatment of asthma.Formula:C29H36N2O7Colore e forma:SolidPeso molecolare:524.61(2E,9Z)-Octadeca-2,9-dienoic acid
CAS:(2E,9Z)-Octadeca-2,9-dienoic acid, a polyunsaturated fatty acid, is utilized in the study of lipoxygenase-dependent metabolism [1].Formula:C18H32O2Colore e forma:SolidPeso molecolare:280.45A 78773
CAS:A 78773: potent reversible 5-lipoxygenase inhibitor; active in cells/tissues; targets inflammation, asthma, IBD.Formula:C15H13FN2O4Colore e forma:SolidPeso molecolare:304.275,6-dehydro Arachidonic Acid
CAS:5,6-dehydro Arachidonic acid, an arachidonic acid analog with a 5,6 acetylene, inhibits 5-LO; Ki=15 μM in RBL cells, IC50=10 μM in guinea pig leukocytes.Formula:C20H30O2Colore e forma:SolidPeso molecolare:302.45CMI-392
CAS:CMI-392 is a dual 5-lipoxygenase inhibitor and platelet-activating factor (PAF) receptor antagonist (IC50s: 100 and 10 nM).Formula:C31H37ClN2O8SPurezza:98%Colore e forma:SolidPeso molecolare:633.15MLS000545091
CAS:MLS000545091 is a potent and selective human epithelial 15-lipoxygenase-2 mixed-type inhibitor.Formula:C14H15ClN2OPurezza:99.84%Colore e forma:SolidPeso molecolare:262.735-Lipoxygenase-In-1
CAS:5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor.Formula:C23H28N4O2SColore e forma:SolidPeso molecolare:424.5617(S)-HpDHA
CAS:17(S)-HpDHA, primarily produced by the 15-Lipoxygenase (LOX) isoenzymes h15-LOX-1 and h15-LOX-2 from docosahexaenoic acid (DHA), is a key regulator in epoxide synthesis through allosteric modulation. Additionally, it effectively inhibits platelet aggregation, demonstrating an EC50 of approximately 1 μM [1].Formula:C22H32O4Colore e forma:SolidPeso molecolare:360.49h15-LOX-2 inhibitor 1
CAS:Compound 105 (h15-LOX-2 inhibitor 1) is a potent inhibitor of human epithelial 15-lipoxygenase-2 (h15-LOX-2), exhibiting an IC50 of 0.34 μM [1].Formula:C17H13F3N2SPurezza:98%Colore e forma:SolidPeso molecolare:334.36CCT365623
CAS:CCT365623: oral Lysyl Oxidase inhibitor, potent, selective, good pharmacokinetics, anti-metastatic.Formula:C18H17NO4S3Purezza:97.299% - 97.63%Colore e forma:SolidPeso molecolare:407.53Ref: TM-T26969
1mg86,00€5mg180,00€1mL*10mM (DMSO)225,00€10mg245,00€25mg374,00€50mg504,00€100mg662,00€200mg875,00€Setileuton
CAS:Setileuton (MK0633) is a specific 5-LOX inhibitor and can be used in research on asthma and atherosclerosis.
Formula:C22H17F4N3O4Purezza:98.85% - 99.35%Colore e forma:SolidPeso molecolare:463.38PXS-6302 hydrochloride
CAS:PXS-6302 hydrochloride is a potent irreversible lysine oxidase (LOX) inhibitor, inhibiting Bovine LOX, rh LOXL1, rh LOXL2, rh LOXL3, and rh LOXL4 with IC50 of 3Formula:C10H11ClF3NO2SPurezza:99.98%Colore e forma:SoildPeso molecolare:301.71h15-LOX-2 inhibitor 3
CAS:Compound 13, identified as h15-LOX-2 inhibitor 3, exhibits inhibitory activity against h15-LOX, with IC50 and Ki values of 25 μM and 15.1 μM, respectively.Formula:C22H13N5O3Colore e forma:SolidPeso molecolare:395.375-LOX/MAOs-IN-1
CAS:Compound 3, known as 5-LOX/MAOs-IN-1, acts as an inhibitor of 5-LOX/MAOs and is an effective free radical scavenger, displaying antioxidant characteristics. It has demonstrated neuroprotective effects in cell models damaged by oxidative stress and is capable of activating the neurogenesis microenvironment in adult mouse neural stem cells. This compound is utilized in research focused on neurodegenerative diseases.Formula:C18H18N2O2Colore e forma:SolidPeso molecolare:294.35AZD 4407
CAS:AZD 4407 is a potent inhibitor of 5-lipoxygenase.Formula:C19H21NO3S2Purezza:98%Colore e forma:SolidPeso molecolare:375.5L 691816
CAS:L 691816 is an effective inhibitor of the 5-LO reaction.Formula:C36H35ClN6OSPurezza:98%Colore e forma:SolidPeso molecolare:635.22Resolvin E2
CAS:RvE2, a bioactive lipid from the SPM family, is made from EPA and reduces inflammatory neutrophil infiltration and helps treat NAFLD and other diseases.Formula:C20H30O4Colore e forma:SolidPeso molecolare:334.45Lobaric acid
CAS:Lobaric acid, from Stereocaulon lichen, has antioxidant and anticancer properties, inhibits PTP1B and 12(S)-LOX, and reduces TMV lesions in plants.Formula:C25H28O8Colore e forma:SolidPeso molecolare:456.48ALOX15-IN-1
ALOX15-IN-1 (8b) inhibits rabbit/human ALOX15; IC50: 0.04 μM for LA, 2.06 μM for AA.Formula:C24H31N3O5SColore e forma:SolidPeso molecolare:473.59ALOX15-IN-2
CAS:ALOX15-IN-2: Potent ALOX15 inhibitor. IC50: 1.55 μM for LA; 2.79 μM for AA. Stops linoleic/arachidonic acid oxidation.Formula:C23H29N3O4SPurezza:99.98%Colore e forma:SolidPeso molecolare:443.56Ref: TM-T62606
1mg46,00€5mg90,00€1mL*10mM (DMSO)100,00€10mg160,00€25mg313,00€50mg537,00€100mg767,00€500mg1.558,00€CJ-13,610
CAS:CJ-13,610 is an orally active and nonredox-type inhibitor of 5-lipoxygenase (5-LOX). CJ-13,610 inhibits the biosynthesis of leukotriene B4 and regulates the expression of IL-6 mRNA in macrophages.Formula:C22H23N3O2SPurezza:99.64%Colore e forma:SolidPeso molecolare:393.5
