Microbiologia/Virologia

<p>Elvucitabine, a reverse transcriptase inhibitor, is used potentially for the treatment of HBV infection and HIV infection.</p>

<p>3'Ome-m7GpppAmpG is a trinucleotide cap with LNA, boosting translation; useful in mRNA vaccines and gene therapy.</p>

<p>CEF1, M1 (58-66) epitope from influenza A; GILGFVFTL is HLA-A2-restricted.</p>

<p>Furaltadone L-tartrate, a nitrofuran, may help study Salmonella enteritidis in chickens; it's an antibacterial agent against staphylococci.</p>

<p>Lankacyclinone C, a congener of lankacidin C devoid of the δ-lactone moiety, exhibits antitumor activity.</p>

<p>Potassium clavulanate cellulose is a mixture of potassium clavulanate and cellulose, is an inhibitor of beta-lactamase.</p>

<p>A-315675 is a neuramidase inhibitor with anti-infuenza activity.</p>

<p>FtsZ-IN-5: Potent inhibitor blocking bacterial division, low resistance and toxicity, enhances FtsZ polymerization.</p>

<p>Compound A09: potent vs fluconazole-resistant fungi; stronger than miconazole; MIC 0.03-0.25 μg/mL for C. albicans.</p>

<p>Mupirocin calcium, an antibiotic from Pseudomonas fluorescens, halts bacterial protein and RNA synthesis.</p>

<p>DENV-IN-10 is a potent tetravalent inhibitor of the dengue virus, exhibiting half-maximal effective concentrations (EC50s) of 1.36, 0.87, 0.94, and 0.95 μM</p>

<p>(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid (compound 15) serves as an antitubercular agent, displaying a minimum inhibitory concentration (</p>

<p>Tibezonium iodide, an oropharyngeal disinfectant, possesses antibacterial properties that aid in preventing mouth infections [1].</p>

<p>LtaS-IN-2 (compound 13), a derivative of LtaS-IN-1 [1], is an LTA synthesis inhibitor with antibacterial properties against S.</p>

<p>Chitinase, found in bacteria, fungi, animals, plants, is a glycosyl hydrolase that hydrolyzes chito-oligosaccharides.</p>

<p>Triclopyricarb (SYP-7017), a strobilurin fungicide, controls crop diseases, halting mycelial growth (EC50: 0.006-0.047 μg/mL).</p>

<p>Apigravin, a potent antibacterial compound, demonstrates activity against Bacillus subtilis, exhibiting a minimum inhibitory concentration (MIC) value of 61 μM</p>

<p>Palmarumycin C3, a spirobisnaphthalene from Berkleasmium sp. Dzf12, shows potent antimicrobial and antioxidant properties.</p>

<p>Batzelladine D inhibits Pdr5p, with IC50 of 7.1 µM, and exhibits antifungal, antiparasitic, antiviral, antibacterial, and antitumor properties.</p>

<p>Asperfuran is a useful organic compound for research related to life sciences. The catalog number is T125958 and the CAS number is 138331-36-9.</p>

<p>Umifoxolaner is an anti-parasitic agent (veterinary).</p>

<p>Anti gram-positive/negative bacteria agent 1 is an antibiotic linked with a synthetic MECAM-based siderophore, serving as a conjugate aimed at combating gram-</p>

<p>Antibacterial agent 40 is an antibacterial agent.</p>

<p>Antibacterialagent 272 (Compound Z22) is a potential antibacterial agent that targets the DNA and DNA-topoisomerase II (DNA-Topo II) complex. It exhibits strong antibacterial activity, with a minimum inhibitory concentration (MIC) of 1 μg/mL against Staphylococcus aureus 25923 and 29213, 2 μg/mL against Staphylococcus epidermidis 12228, 2-4 μg/mL against Enterococcus faecalis, and 4 μg/mL against Pseudomonas aeruginosa 9027 and 27853. Antibacterialagent 272 binds by intercalating between DNA base pairs, disrupting the normal function of bacterial DNA, and is suitable for research into bacterial infectious diseases.</p>

<p>Xinjiachalcone A, from Glycyrrhiza inflata, kills H. pylori effectively (MIC: 12.5-50 μM, 17 strains).</p>

<p>4-Deoxy-4α-phorbol, a tetracyclic diterpene identified in E.</p>

<p>Curvulamine A, an antibacterial alkaloid, shows potent antibacterial activity [1] .</p>

<p>Antibacterial agent 61 (example 27) is a antibacterial agent.</p>

<p>Zegruvirimat is an antiviral agent. Zegruvirimat has antiviral activity [1] .</p>

<p>Hypoglaunine D, an anti-HIV analogue of Triptonine B, inhibits HIV in H9 cells with an EC50 of 22 μg/ml.</p>

<p>HCoV-229E-IN-1 is a potent inhibitor of HCoV-229E replication, demonstrating efficacy with an EC50 value of 0.65 μM in MTS cells and 0.6 μM in CPE cells[1].</p>

<p>DprE1-IN-13 (Compound 42) is an inhibitor of decaprenyl-phosphoryl-β-d-ribose oxidase (DprE1) with an IC50 value of 12.72 μM. It effectively inhibits Mycobacterium tuberculosis H37Ra, with a MIC50 of 1.071 μM.</p>

<p>Rivabazumab is a recombinant antibody against Pseudomonas aeruginosa pcrV [1] .</p>

<p>Glycobiarsol is used for the control of Trichuris vulpis infection.</p>

<p>PROTAC Hemagglutinin Degrader-1 (V3) degrades influenza HA potently (DC50 1.44 μM) with broad-spectrum antiviral effects.</p>

<p>Lomtegovimab (BI 767551) is a monoclonal antibody that targets and neutralizes SARS-CoV-2 for COVID-19 research.</p>

<p>23-O-Demycinosyltylosin (23-DMT), an acyl derivative of tylosin, exhibits antibacterial activity [1].</p>

<p>Laidlomycin, a polyether, polycyclic, monocarboxylic acid, possesses inhibitory activity against various Mycoplasma species, especially Acholeplasma laidlawii.</p>

<p>RPR103611, a betulinic acid derivative, inhibits HIV-1; IC50s: CCR5 (YU2) 80, CXCR4 (NL4-3) 0.27, dual-tropic (89.6) 0.17.</p>

<p>Protoneogracillin: anti-fungal vs. P.oryzae (MMDC=94.0μM), cytotoxic on K562 cells (IC50=6.6μM).</p>

<p>Antibiotic WB is a useful organic compound for research related to life sciences. The catalog number is T125208 and the CAS number is 247919-66-0.</p>

<p>NDV-IN-1 is an antiviral inhibiting neuraminidase and the Newcastle disease virus, preventing virion release from Vero cells.</p>

<p>Antifungalagent 128 (Compound 3ja) is an antifungal agent that, in combination with Fluconazole, has a MIC range of 0.5-4 μg/mL against C. albicans strains. It is applicable in the study of anti-infective therapies.</p>

<p>pBD-1 TFA: an innate AMP from pigs, prevalent in mucosa, with systemic defensive properties.</p>

<p>Homo-BacPROTAC6, a ClpC1 NTD BacPROTAC degrader, effectively targets ClpC2, while Homo-BacPROTAC7 has been shown to efficiently kill M. tuberculosis [1].</p>

<p>Cephaloridine hydrate, a broad-spectrum antibacterial antibiotic, exhibits dose-related nephrotoxicity [1] [2].</p>

<p>SARS-CoV-2-IN-27 disodium is a diphosphate ester with antiviral properties, IC50s of 1.0 and 1.7 μM, and disrupts membranes at an EC50 of 6.5 μM.</p>

<p>Tinophyllol, a furanoditerpenoid derived from Arcangelisia flava MERR., exhibits effective activity against Botrytis cinerea [1] [2].</p>

<p>Moniliformin sodium salt is water-soluble mycotoxin isolate from Fusarium moniliforme.</p>

<p>dTTP sodium hydrate, a DNA synthesis component, is a nucleoside triphosphate.</p>

<p>IPMCL-28b is an antimicrobial agent targeting bacterial cell membranes, with a minimum inhibitory concentration (MIC) of 1.56 μg/mL for Staphylococcus aureus ATCC 25923 and an MIC of 6.25 μg/mL for methicillin-resistant Staphylococcus aureus (MRSA). IPMCL-28b shows potential for research in the field of infection control.</p>

<p>AVX 13616: potent antibacterial vs. drug-resistant Staph, similar to mupirocin with single-use efficiency. MIC: 2-4 ug/ml. Targets various staph, MRSA.</p>

<p>Antibacterialagent 274 (Compound 18b) is an antibacterial agent that targets bacterial cell membranes, exhibiting a minimum inhibitory concentration (MIC) of 8 μg/mL against Acinetobacter baumannii ATCC 17978. It functions by disrupting membrane integrity, causing intracellular accumulation of ROS, which leads to DNA and protein leakage, thereby exerting its antibacterial effects. Antibacterialagent 274 is applicable in research on infections caused by Gram-negative bacteria.</p>

<p>Nuclease S1 breaks down ssDNA and RNA, trims protruding ends of dsDNA.</p>

<p>Protactin, a new antibiotic metabolite, is a possible precursor of the actinomycins.</p>

<p>RAD51-IN-3 is a Rad51 inhibitor.</p>

<p>(8'α,9'β-Dihydroxy)-3-farnesylindole exhibits significant inhibitory effectiveness (EC 50 9.8 μM) against B. subtilis.</p>

<p>JM 1397 is a bioactive chemical.</p>

<p>Potassium Clavulanate Mixture with Silicon Dioxide (1:1) is a compound consisting of an equal parts ratio, specifically one part Potassium Clavulanate to one</p>

<p>Succinate dehydrogenase-IN-7 (Compound 2f) is a succinate dehydrogenase inhibitor with an IC50 value of 2.51 μM and exhibits bactericidal properties.</p>

<p>Antimalarial agent 17 doubles as a herbicide, inhibiting photosystem II with effectiveness akin to market herbicides.</p>

<p>A 201A is a nucleoside antibiotic, it is isolated from Streptomyces capreolus.</p>

<p>Salviandulin E, a diterpenoid from Salvia leucantha, has antitrypanosomal effects with an IC50 of 0.72 µg/mL against T.b. brucei.</p>

<p>PBP4-IN-1 (Compound 1) is an inhibitor targeting penicillin-binding protein 4 (PBP4) in Staphylococcus aureus. By inhibiting the function of PBP4, PBP4-IN-1 enhances the antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) mediated by PBP2a. This compound is used in studies involving osteomyelitis caused by Staphylococcus aureus and in research aimed at reversing PBP4-mediated resistance to β-lactam antibiotics.</p>

<p>Altromycin A is an anticancer agent.</p>

<p>CTP518, a deuterated Atazanivir derivative, is a HIV protease inhibitor.</p>

<p>7-Methoxy-β-carboline-1-propionic acid (compound 46), known for its cytotoxic and antimalarial properties, is derived from the roots of Eurycoma longifolia [1].</p>

<p>Clindamycin phosphate HCl: prodrug, becomes active clindamycin in vivo; used for acne, bacterial vaginosis research.</p>

<p>Levorin A0 is a Levorin component.</p>

<p>A 83016F, an antibiotic from an actinomycete designated A83016, exhibits weak antimicrobial activity.</p>

<p>Mildiomycin, an antibiotic from Streptoverticillium, targets barley mildew, some Mycobacterium, Rhodotorula, but not most fungi/bacteria.</p>

<p>Ganorbiformin B, a lanostane triterpenoid, is C-3 epimer of ganoderic acid T, active against Mycobacterium tuberculosis.</p>

<p>AV-153, a 1,4-dihydropyridine, reduces DNA damage, stimulates repair, and has anti-cancer properties.</p>

<p>Sitafloxacin (DU6859a) is a potent fluoroquinolone, effective against a wide spectrum of bacteria and used for respiratory and urinary infections.</p>

<p>Nannochelin B is a siderophore isolated from Nannocystis exedens.</p>

<p>Razupenem (SMP-601, PTZ601), a broad-spectrum injectable carbapenem, counters antibiotic-resistant bacteria.</p>

<p>Cepeginterferon alfa-2b: pegylated interferon with 20 kDa PEG for HCV, PV, ET research.</p>

<p>Harzianopyridone is an atpenin-like compound that functions as an inhibitor of mammalian and nematode mitochondrial complex II, also known as succinate:ubiquinone oxidoreductase (SQR), demonstrating IC50 values of 0.017, 0.2, and 2 μM against bovine, rat, and nematode complex II, respectively. Additionally, it inhibits nematode quinol-fumarate reductase (QFR) with an IC50 value of 0.36 μM. Significantly selective for complex II over complexes I and III in rats and cattle, as well as complex I in nematodes, with IC50 values exceeding 100 μM, it exhibits notable antibacterial and antifungal properties, with EC50 values of 35.9, 42.2, 60.4, and 50.2 μg/ml against R. solani, S. rolfsii, M. phaseolina, and F. oxysporum, respectively.</p>

<p>HCVP-IN-1 (compound 1) is a hepatitis C viral polymerase (HCVP) inhibitor.</p>

<p>Agent 37 from patent WO2015063714A1 is a potent antimicrobial for bacterial infection research.</p>

<p>PEX5-PEX14 PPI-IN-1 (Compound 8) is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor that disrupts the interaction between PEX5 and TbPEX14 with an</p>

<p>Butyrolactone V from A. terreus targets P. falciparum (IC50 = 7.9 μg/ml), L. amazonensis, S. mansoni, and combats cancer cells and radicals.</p>

<p>Antibacterial agent 50 targets E. coli strains with MICs: 32 mcg/mL for NCTC 13351, 64 for M 50, and 128 for 7 MP.</p>

<p>Maximin 2, an antimicrobial peptide sourced from the skin secretions of Bombina maxima, exhibits cytotoxicity in tumor cells and possesses spermicidal</p>

<p>Collinin, a coumarin in Z. schinifolium, combats M. tuberculosis and inhibits NO production, platelet aggregation, and tumor growth in mice.</p>

<p>S-6123: Oxazolidinone antimicrobial that blocks ribosomal protein synthesis, sparing DNA/RNA.</p>

<p>Antibacterial agent 140 chloride, a first-of-its-kind Ru-based AIEgen photosensitizer, shows promise in detecting and treating Gram-positive bacteria (G+).</p>

<p>AAA-10 is an orally active inhibitor of bile salt hydrolase (BSH) in B. intestinalis that acts on B. thetarBSH (IC50: 10 nM) and B. longumrBSH (IC50: 80 nM).</p>

<p>Compound 18 (compound 8b), a nitrofuran derivative, exhibits potent in vitro trypanocidal activity, with an IC50 value of 0.03 μM [1].</p>

<p>Drimentine C: a terpene diketopiperazine antibiotic; inhibits NS-1 cell growth by 63% (12.5 μg/ml) and 98% (100 μg/ml).</p>

<p>Antifungal agent 82 (compound G34) demonstrates outstanding in vitro antifungal efficacy against Valsa mali, exhibiting an EC50 value of 0.57 μg/mL, and has</p>

<p>PF 1052: Phoma fungal metabolite, combats S. aureus, S. parvulus, C. perfringens, hinders neutrophil migration.</p>

<p>Iedaborbactam, as a beta-lactamase inhibitor (WO2015191907, Example 62), can be used for the research of bacterial infections.</p>

<p>Mtb-IN-5 (compound (-)17j) is an isoxazole exhibiting anti-Mycobacterium tuberculosis (Mtb) activity.</p>

<p>Deoxyfusapyrone, an antifungal α-pyrone, combats C. neoformans and Aspergillus species; ineffective against yeast and B. megaterium.</p>

<p>Bombinin H1, an antimicrobial peptide originating from the skin of the Bombina variegata moth, exhibits lethal concentrations of 3.8 μM against Escherichia coli</p>

<p>Compound E8 (Antimicrobial agent-24) is a hydrazide with broad-spectrum fungicidal properties, disrupting the plasma membrane's functionality and inducing</p>

<p>Gilvocarcin V, a metabolite from Actinomycete DO-38, exhibits potent antibacterial, antifungal, and antiviral activity.</p>

<p>Tetromycin C1 is a useful organic compound for research related to life sciences. The catalog number is T125395 and the CAS number is 205433-82-5.</p>

[(Cys(Bzl)84, Glu(OBzl)85)]CD4 (81-92) is a selective HIV-1 inhibitor that blocks the interaction between HIV-1 and CD4 molecules, thereby inhibiting viral infection and cell fusion. At a concentration of 25 μM, it can completely prevent fusion formation [1].