Microbiologia/Virologia
Gli inibitori in microbiologia e virologia sono composti che bersagliano microrganismi, inclusi batteri, virus e funghi, interrompendo la loro crescita, replicazione o sopravvivenza. Questi inibitori sono essenziali per studiare la patogenesi microbica, comprendere i meccanismi di resistenza e sviluppare nuove terapie antimicrobiche e antivirali. Gli inibitori in questa categoria vengono utilizzati per combattere le malattie infettive, esplorare l'ecologia microbica e studiare le interazioni ospite-patogeno. Presso CymitQuimica, offriamo un'ampia selezione di inibitori di alta qualità in microbiologia e virologia per supportare la tua ricerca in malattie infettive, microbiologia e virologia.
Sottocategorie di "Microbiologia/Virologia"
- Antibatterico(2.957 prodotti)
- Antibiotico(920 prodotti)
- Antinfettivo(23 prodotti)
- DHFR(33 prodotti)
- Sintesi del DNA/RNA(708 prodotti)
- HBV(176 prodotti)
- Proteasi HIV(449 prodotti)
- HSV(91 prodotti)
- Integrasi(2 prodotti)
- Ribosoma(13 prodotti)
Mostrare 2 più sottocategorie
Trovati 5842 prodotti di "Microbiologia/Virologia"
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GC373
CAS:<p>GC373, an effective inhibitor of the SARS-CoV-2 M pro, impedes virus replication, exhibiting an inhibition concentration (IC 50) of 0.4 μM. This compound is valuable for use in anti-COVID-19 research.</p>Formula:C21H29N3O5Colore e forma:SolidPeso molecolare:403.47LN002
CAS:<p>LN002 is an orally active inhibitor of Cryptosporidium oxidase, utilized for research in cryptosporidiosis.</p>Formula:C22H15N7Colore e forma:SolidPeso molecolare:377.40Valopicitabine dihydrochloride
CAS:<p>Valopicitabine, a NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>Formula:C15H25ClN4O6Colore e forma:SolidPeso molecolare:392.84Urease-IN-2
<p>Urease-IN-2 is a non-competitive inhibitor of urease (IC50: 0.94 μM, Ki: 1.6 μM) that non-competitively inhibits Jack bean urease (JBU).</p>Formula:C26H25N5O5S3Colore e forma:SolidPeso molecolare:583.7HIV-1 inhibitor-41
<p>HIV-1 inhibitor-41 (B23): Oral non-nucleoside reverse transcriptase blocker, EC50 of 50 nM (E138K), 20.8 nM (WT), low hERG/CYP impact, non-toxic.</p>Formula:C16H15F2N3OSColore e forma:SolidPeso molecolare:335.37Anti-MRSA agent 27
CAS:<p>Anti-MRSA agent 27 (compound 4a) is a potent antimicrobial agent against methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 0.0975 μmol/L. It effectively disrupts MRSA biofilms and inhibits the production of hemolysins.</p>Formula:C15H10F3N3OSColore e forma:SolidPeso molecolare:337.32OPC-167832
CAS:<p>OPC-167832: oral dprE1 inhibitor, IC50 0.258 μM, anti-tuberculosis, for Mycobacterium tuberculosis research.</p>Formula:C21H20ClF3N2O4Colore e forma:SolidPeso molecolare:456.84Artefenomel
CAS:<p>Artefenomel (OZ439) is an orally active anti-malarial ozone analog with antiviral activity for the study of SARS-CoV-2 infections and malaria infections.</p>Formula:C28H39NO5Colore e forma:SolidPeso molecolare:469.61ZK-806450
CAS:<p>ZK-806450 is a compound with antiviral properties. It exhibits high binding potential to the allosteric site of the SARS-CoV-2 3CL protease and is capable of specific and stable interaction with the GAG site of the dengue virus envelope protein.</p>Formula:C31H31N5OColore e forma:SolidPeso molecolare:489.611UNI418
CAS:<p>UNI418 is a dual inhibitor targeting PIKfyve and PIP5K1C, exhibiting antiviral activity against SARS-CoV-2 (EC50=1.4 μM). It inhibits the endocytosis of the virus mediated by ACE2 by suppressing PIP5K1C (IC50=60.1 nM; Kd=61 nM). Additionally, UNI418 impedes the entry of SARS-CoV-2 into host cells by inhibiting the proteolytic activation regulated by PIKfyve (Kd=0.78 nM).</p>Formula:C22H16N6Colore e forma:SolidPeso molecolare:364.40iPAF1C
CAS:<p>iPAF1C is a powerful inhibitor of the polymerase-associated factor 1 complex (PAF1C) and exhibits anti-HIV activity [1].</p>Formula:C27H26BrFN4OColore e forma:SolidPeso molecolare:521.42NDM-1 inhibitor-3
<p>NDM-1 inhibitor-3 is a New Delhi Metallo-β-lactamase-1 (NDM-1) inhibitor (Ki : 4 μM) widely found in nature and is associated with antibiotic resistance.</p>Formula:C16H12O4Purezza:98.66%Colore e forma:SolidPeso molecolare:268.26DNA ligase-IN-2
CAS:<p>DNA ligase-IN-2 (compound 2) acts as a potent LigA inhibitor, effectively hindering the DNA-independent spontaneous adenylation activity of full-length LigA and the truncated enzyme LigA:AD with an IC50 of 29 nM. It also significantly suppresses the in vitro growth of Staphylococcus aureus, showing MIC values of 1 μg/mL for S. aureus ATCC 29213 and S. aureus ATCC 700699, while the MIC for Escherichia coli (E. coli) ATCC 25922 is >64 μg/mL.</p>Formula:C13H8FN3O3Colore e forma:SolidPeso molecolare:273.219Antibacterial agent 76
<p>Antibacterial agent 76 (compound 9) is a potent antibacterial agent.</p>Formula:C23H27N3O2SColore e forma:SolidPeso molecolare:409.54PLpro-IN-5
CAS:<p>PLpro-IN-5 (compound 21), serving as a PLPro protease inhibitor, boasts an IC50 of 91.14 nM. This compound exhibits a broad-spectrum antivirus efficacy, particularly effective against SARS-CoV, MERS-CoV, and SARS-CoV-2.</p>Formula:C26H33N3OColore e forma:SolidPeso molecolare:403.56Neocryptolepine-Cl
CAS:<p>Neocryptolepine-Cl (compound Z24) is an inhibitor of Bcthi4, demonstrating excellent antifungal activity against B. cinerea, with an EC50 value of 0.56 μg/mL.</p>Formula:C16H11ClN2Colore e forma:SolidPeso molecolare:266.725SAG-524
CAS:<p>SAG-524 is a powerful oral small molecule that inhibits HBV viral replication. In HepG2.2.15 cells, SAG-524 reduced HBV-DNA and HbsAg levels in the supernatant with IC₅₀ values of 0.92 nM and 1.4 nM, respectively [1].</p>Formula:C30H32ClN5O4SColore e forma:SolidPeso molecolare:594.12ACHN-975 TFA
CAS:<p>ACHN-975 TFA is a selective LpxC inhibitor with a subnanomolar inhibitory. It is against a wide range of gram-negative bacterias with low MIC values (≤1 μg/mL).</p>Formula:C22H24F3N3O6Purezza:98%Colore e forma:SolidPeso molecolare:483.4377HBV-IN-24
<p>HBV-IN-24 inhibits HBV DNA, HBsAg, HBeAg (EC50: 0.6, 0.6, 4.6 nM), and has antiviral properties with neurotoxicity mitigation.</p>Formula:C23H27NO6Colore e forma:SolidPeso molecolare:413.46Encephalitic alphavirus-IN-1
<p>Alphavirus-IN-1 blocks VEEV (EC50: 0.24 μM) & EEEV (EC50: 0.16 μM), non-toxic, stable in mice plasma.</p>Formula:C27H25FN6O2Colore e forma:SolidPeso molecolare:484.52HldA/E-IN-1
CAS:<p>HldA/E-IN-1 (compound 8) is a dual inhibitor of HldA/E, exhibiting IC50 values of 17.2 μM and 67.8 μM, respectively. This compound is utilized in research on antibacterial infections.</p>Formula:C8H17FO13P2Colore e forma:SolidPeso molecolare:402.16Anti-MRSA agent 2
CAS:<p>Anti-MRSA agent 2 inhibits MRSA at 0.098 μg/ml, with low toxicity and disrupts bacterial membranes and DNA.</p>Formula:C18H10Br2N2OColore e forma:SolidPeso molecolare:430.09Antitrypanosomal agent 5
<p>Antitrypanosal agent 5 is a selective anti-trypanosomal agent that acts on T. brucei (IC50: 1 nM) and HEK293 cells (IC50: 483.3 μM).</p>Formula:C30H30N6O4SColore e forma:SolidPeso molecolare:570.66Cefoxazole
CAS:<p>Cefoxazole is a β-lactam antibiotic featuring an isoxazole structure, known for its antibacterial activity. It can be utilized in the study of infectious diseases.</p>Formula:C21H18ClN3O7SColore e forma:SolidPeso molecolare:491.902MPro N3
CAS:<p>Mpro inhibitor blocks MHV-A29, HCoV-229E, FOPV (IC50: 2.7–8.8 μM), and SARS-CoV-2 (IC50: 16.8 μM) in plaque assays.</p>Formula:C35H48N6O8Colore e forma:SolidPeso molecolare:680.79Antibacterial agent 113
<p>Antibacterial agent 113 targets multiple bacteria including P. aeruginosa and E. coli, showing efficacy at MIC 15625 μM.</p>Formula:C29H18ClN5OColore e forma:SolidPeso molecolare:487.94Thiolactomycin
CAS:<p>Thiolactomycin is a novel reversible dual inhibitor of D-amino acid oxidase (DAO) and D-Aspartate oxidase (DDO).</p>Formula:C11H14O2SPurezza:98%Colore e forma:SolidPeso molecolare:210.29Telinavir
CAS:<p>Telinavir (SC-52151) is a potent and selective inhibitor of HIV protease. It effectively inhibits both HIV-1 and HIV-2, as well as lymphotropic, monocytotropic strains, and wild isolates of simian immunodeficiency viruses, with an EC50 of 26 ng/mL (43 nM). Telinavir shows high protein binding in human plasma and a low distribution rate in red blood cells.</p>Formula:C33H44N6O5Colore e forma:SolidPeso molecolare:604.74Antibacterial agent 279
CAS:<p>Antibacterialagent 279 (compound A12) is an effective antibacterial agent. It inhibits the SOS response of Pseudomonas aeruginosa.</p>Formula:C9H11NO2SColore e forma:SolidPeso molecolare:197.25Bilanafos
CAS:<p>Bilanafos is an agent of Anti-Bacterial.</p>Formula:C11H22N3O6PPurezza:98%Colore e forma:SolidPeso molecolare:323.28Antimicrobial agent-38
CAS:<p>Antimicrobial agent-38 (compound 10) effectively inhibits methicillin-resistant Staphylococcus aureus (S. aureus) strain ATCC 700699 and non-resistant strain ATCC 29213, with minimum inhibitory concentrations (MIC) of 32 mg/L and 64 mg/L, respectively.</p>Formula:C14H11N3O4SColore e forma:SolidPeso molecolare:317.32WRN inhibitor 13
CAS:<p>WRN inhibitor 13 is an inhibitor of the WRN helicase with a pIC50 value ranging from 6 to 7.</p>Formula:C16H20N2O5SColore e forma:SolidPeso molecolare:352.4059-tert-Butyldoxycycline
CAS:<p>9-tert-Butyldoxycycline exhibits immunomodulatory activity by altering the polarization state of polymorphonuclear neutrophils and ameliorating inflammatory responses in ischemia-reperfusion injury models. Additionally, 9-tert-Butyldoxycycline serves as a ligand for the "Tet-On" inducible gene expression system.</p>Formula:C26H32N2O8Colore e forma:SolidPeso molecolare:500.541Carumonam Sodium
CAS:<p>Carumonam Sodium is a monobactam, penicillin-binding protein inhibitor. It is used as antibacterials.</p>Formula:C12H12N6Na2O10S2Purezza:98%Colore e forma:SolidPeso molecolare:510.37SARS-CoV-2 3CLpro-IN-28
CAS:<p>SARS-CoV-2 3CLpro-IN-28 (Compound 19) is an inhibitor of SARS-CoV-2 3CLpro, exhibiting an IC50 value of 0.018 μM.</p>Formula:C27H18Cl2N4O4Colore e forma:SolidPeso molecolare:533.362Glasmacinal
CAS:<p>Glasmacinal is a non-antibacterial macrolide compound with anti-inflammatory activities.</p>Formula:C37H62N2O10Colore e forma:SolidPeso molecolare:694.90Antitrypanosomal agent 6
<p>Compound 18a: potent vs. T. brucei (IC50: 0.47 μM), >2x efficacy compared to Nifurtimox, good ADME, binds AT-rich DNA.</p>Formula:C22H29Cl2N5OColore e forma:SolidPeso molecolare:450.4Antibacterial agent 63
CAS:<p>Aztreonam-siderophore conjugate 63 is an antibacterial agent that exhibits efficacy against Gram-negative bacteria through the linkage of aztreonam to a</p>Formula:C35H43N9O14S2Colore e forma:SolidPeso molecolare:877.9LolCDE-IN-2
CAS:<p>LolCDE-IN-2 is a potent Lol protein (LolCDE) inhibitor. LolCDE-IN-2 shows antibacterial activity with a MIC of 2 μg/ml against E. coli MG1655 [1].</p>Formula:C22H17N5OPurezza:98%Colore e forma:SolidPeso molecolare:367.40LasR-IN-2
<p>LasR-IN-2 blocks LasR via H-bond with TRY-56, useful in bacterial infection and CF research.</p>Formula:C21H16ClN3O2Colore e forma:SolidPeso molecolare:377.82PfPKG-IN-1
<p>PfPKG-IN-1, an imidazole-based inhibitor, targets the Plasmodium falciparum cyclic guanosine monophosphate-dependent protein kinase (PfPKG).</p>Formula:C24H22ClN7OSColore e forma:SolidPeso molecolare:492MI-1851
CAS:<p>MI-1851 is a potent peptidomimetic inhibitor. MI-1851could prevent proteolytic processing of the S protein from SARSCoV-2 by endogenous furin in HEK293 cells.</p>Formula:C34H53N15O6Colore e forma:SolidPeso molecolare:767.88CDA-IN-1
CAS:<p>CDA-IN-1 (Compound vs#2-1) is an inhibitor of chitin deacetylase (CDA) that exhibits antifungal activity. By inhibiting fungal CDA activity, it activates plant immune responses and leads to the accumulation of reactive oxygen species (ROS), hindering fungal growth. At a concentration of 100 μM, CDA-IN-1 achieves inhibition rates of 86.9% on P. xanthii's PxCDA1 and 74.5% on PxCDA2. CDA-IN-1 is applicable in research on fungal plant diseases, such as cucumber powdery mildew and tomato gray mold.</p>Formula:C15H14N2O6Colore e forma:SolidPeso molecolare:318.281RSV-IN-5
CAS:<p>RSV-IN-5: Dual inhibitor for RSV fusion proteins, effective on wild-type A2 and D486N mutant with EC50s of 2.0 nM & 8.1 nM. Potent anti-RSV.</p>Formula:C28H37N7O2Colore e forma:SolidPeso molecolare:503.64BDM91288
CAS:<p>BDM91288, an orally active AcrB efflux pump inhibitor of pyridinium piperazine, enhances the in vivo efficacy of levofloxacin in treating Klebsiella pneumoniae pulmonary infection in mouse models [1].</p>Formula:C17H22ClN5Colore e forma:SolidPeso molecolare:331.84Antifungal agent 28
<p>Antifungal 28 disrupts Candida, hits fluconazole-resistant strains, and inhibits biofilms.</p>Formula:C22H29N5OSColore e forma:SolidPeso molecolare:411.56Metallo-β-lactamase-IN-14
CAS:<p>Metallo-β-lactamase-IN-14 (Compound 17e) serves as an inhibitor of Metallo-β-Lactamase, displaying inhibitory activity against VIM-1 and VIM-2. This compound also exhibits antibacterial effects on Gram-negative (GN) bacteria and P. aeruginosa [1].</p>Formula:C20H22N8O2S2Colore e forma:SolidPeso molecolare:470.57Secutrelvir
CAS:<p>Secutrelvir inhibits the 3CL protease (3CL protease), thereby exhibiting antiviral activity by preventing the replication of SARS-CoV-2.</p>Formula:C23H16Cl2F3N5O2Colore e forma:SolidPeso molecolare:522.307Antitubercular agent-13
<p>Compound 3d: antitubercular, MIC 0.007 μg/mL vs MTB H37Rv, 1.851 μg/mL vs MDR-MTB 16833, metabolically unstable.</p>Formula:C18H18N4O5Colore e forma:SolidPeso molecolare:370.36Cap-dependent endonuclease-IN-25
CAS:<p>Cap-dependent endonuclease-IN-25 is a potent inhibitor of CEN, useful in studying Orthomyxoviridae viruses. (See WO2020075080A1, compound 4.)</p>Formula:C25H25N3O3Colore e forma:SolidPeso molecolare:415.48SARS-CoV-2 3CLpro-IN-32
CAS:<p>SARS-CoV-2 3CLpro-IN-32 (compound B16) is a potent inhibitor of the SARS-CoV-2 3CLpro enzyme, with an IC50 of 0.109 μM. It also demonstrates antiviral activity against the coronavirus HCoV-OC43, with an EC50 of 1.99 μM.</p>Formula:C30H37N3O4S3Colore e forma:SolidPeso molecolare:599.83MCB-3681
CAS:<p>MCB-3681, active against gram-positive bacterium, is the antibacterial Oxaquin's active substance.</p>Formula:C31H32F2N4O8Colore e forma:SolidPeso molecolare:626.6Antibacterial agent 81
CAS:<p>Antibacterial agent 81 blocks DNA transcription, targets S. aureus (MIC 12.5μM) & M. smegmatis (MIC 7.8μM). Used in infection research.</p>Formula:C33H28N2O8Colore e forma:SolidPeso molecolare:580.58MsbA-IN-4
<p>MsbA-IN-4 (Compound 32) is a highly selective and potent inhibitor of MsbA (IC50: 3 nM).MsbA-IN-4 inhibits Escherichia coli (MIC: 12 μM).</p>Formula:C23H18Cl2FN5OColore e forma:SolidPeso molecolare:470.337-Hydroxytropolone
CAS:<p>7-Hydroxytropolone (3-Hydroxytropolone) is an antibiotic that exhibits activity against Gram-positive and Gram-negative bacteria, as well as yeasts and fungi. It also functions as an inhibitor of 2''-O-adenylate transferase.</p>Formula:C7H6O3Colore e forma:SolidPeso molecolare:138.12BMIM-TFSI
CAS:<p>BMIM-TFSI (compound8) is an HIV-1 integrase inhibitor that effectively suppresses both the 3'-processing (3'-P) and strand transfer (ST) steps of the integration process. It is applicable in HIV-1 research.</p>Formula:C10H15F6N3O4S2Colore e forma:SolidPeso molecolare:419.364Antimalarial agent 3
<p>Antimalarial agent 3 has a potent IC50 of 0.035 μM against Plasmodium and high selectivity for mammalian cells.</p>Formula:C15H16BrN3O2Colore e forma:SolidPeso molecolare:350.21Chitin synthase inhibitor 7
<p>Compound 9c, a chitin synthase inhibitor, has an IC50 of 0.37 nM and is useful for studying fungal infections.</p>Formula:C24H25N3O5Colore e forma:SolidPeso molecolare:435.474,5'-Dimethylangelicin-NHS
<p>NHS-modified coumarin, 4,5'-Dimethylangelicin-NHS, shows photochemical activity & photosensitivity.</p>Formula:C21H19NO7SColore e forma:SolidPeso molecolare:429.44GT-055
<p>GT-055 (LCB18-055) is a novel inhibitor of broad-spectrum β-lactamase.</p>Formula:C13H20F3N5O8SColore e forma:SolidPeso molecolare:463.39Chitinase-IN-4
<p>Chitinase-IN-4 (compound 8f) is a potent and selective inhibitor of OfChi-h with an IC50 value of 0.1 μM and good insecticidal activity.</p>Formula:C21H24ClN7Colore e forma:SolidPeso molecolare:409.92Deprodone
CAS:<p>Deprodone is an active compound that inhibits key processes such as bacterial cell wall synthesis by interacting with hydrolase and transferase proteins of methicillin-resistant Staphylococcus aureus (MRSA). It is applied in the research of MRSA infections, inflammatory skin diseases, intestinal disorders, and fatty acid metabolism disorders.</p>Formula:C21H28O4Colore e forma:SolidPeso molecolare:344.44NDM-1 inhibitor-5
CAS:<p>NDM-1 Inhibitor-5 (compound 57) exhibits strong inhibition of NDM-1, characterized by a K i of 2.5 μM. Additionally, it demonstrates synergistic antibacterial effects when combined with meropenem [1].</p>Formula:C24H23NO4Colore e forma:SolidPeso molecolare:389.44Cap-dependent endonuclease-IN-10
CAS:<p>Cap-dependent endonuclease-IN-10, with low toxicity & good stability, effectively inhibits flu viruses and shows promise against A, B, C types.</p>Formula:C25H18F2N4O5SColore e forma:SolidPeso molecolare:524.50Antibacterial agent 88
<p>Antibacterial agent 88 is an effective antibacterial agent against B. subtilis (MIC: 4 μg/ml) with MIC values of ≤0.0156 μg/mL for MRSA, MRSE and S. aureus.</p>Formula:C31H44N2O6SColore e forma:SolidPeso molecolare:572.76BPR3P0128
CAS:<p>BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase (RdRp) inhibitor, is effective orally and can inhibit various SARS-CoV-2 variants. It exhibits EC 50 values of 0.62 µM for SARS-CoV-2 and 0.14 µM for HCoV-229E, demonstrating potent anti-pancoronavirus activity at submicromolar concentrations. Additionally, BPR3P0128 displays synergistic antiviral effects when used in combination with Remdesivir [1].</p>Formula:C22H18BrN3O2Colore e forma:SolidPeso molecolare:436.30PF 03709270
CAS:<p>PF 03709270 is an oral prodrug of sulopenem with broad-spectrum antibacterial effects on gram-positive and gram-negative bacteria.</p>Formula:C19H27NO7S3Purezza:98%Colore e forma:SolidPeso molecolare:477.61Pibrozelesin
CAS:<p>Pibrozelesin, a water-soluble duocarmycin B2 derivative, binds AT-rich DNA, blocking replication and inducing cell death.</p>Formula:C32H36BrN5O8Colore e forma:SolidPeso molecolare:698.56Cap-dependent endonuclease-IN-7
CAS:<p>Cap-dependent endonuclease-IN-7, a potent CEN inhibitor, blocks viral mRNA synthesis and virus spread, with research use for influenza A, B, C.</p>Formula:C36H28FN3O7SColore e forma:SolidPeso molecolare:665.69Antifungal agent 16
<p>Antifungal agent 16 has antimicrobial activity comparable to that of ciprofloxacin and has higher antifungal activity than fluconazole.</p>Formula:C27H21N5O2SColore e forma:SolidPeso molecolare:479.55Quorum sensing-IN-9
CAS:<p>Quorum sensing-IN-9 (Compound 7d) inhibits quorum sensing in Pseudomonas aeruginosa by binding to the PqsR protein. It suppresses the expression of quorum sensing system-related genes lasB, rhlA, and pqsA, thereby preventing the production of virulence factors elastase, pyocyanin, and rhamnolipid. Quorum sensing-IN-9 disrupts the motility of P. aeruginosa, inhibits biofilm formation, and reduces the bacterium's virulence and pathogenicity. Additionally, it exhibits anti-infective activity in the Galleria mellonella larval model.</p>Formula:C9H10OS2Colore e forma:SolidPeso molecolare:198.305TCMDC-125431
<p>TCMDC-125431 is a novel inhibitor of Plasmodium calcium kinetics with minimal inhibition of haemoglobin crystals.</p>Formula:C25H27N3O2SColore e forma:SolidPeso molecolare:433.57(4-Aminobenzoyl)-D-glutamic acid
CAS:<p>(4-Aminobenzoyl)-D-glutamic acid (Compound 17) exhibits competitive inhibitory activity against the H2-pterin synthesis system, affecting folic acid synthesis and subsequently inhibiting bacterial growth.</p>Formula:C12H14N2O5Colore e forma:SolidPeso molecolare:266.25Antileishmanial agent-5
<p>Antileishmanial agent-4, a ribonucleoside analogue, targets L.infantum and T.cruzi with EC50s of 0.68 μM and 0.83 μM.</p>Formula:C17H17ClN4O4Colore e forma:SolidPeso molecolare:376.79Cap-dependent endonuclease-IN-14
CAS:<p>Cap-dependent endonuclease-IN-14 hinders CEN and could treat influenza virus infections. (Patent CN113620948A, compound 1-c).</p>Formula:C30H23FN2O6SColore e forma:SolidPeso molecolare:558.58Anti-Trypanosoma cruzi agent-2
<p>Compd 3b: anti-trypanosomal, IC50 0.51 μM (NINOA), 3.06 μM (INC-5), also combats T. gondii.</p>Formula:C17H10ClNO5Colore e forma:SolidPeso molecolare:343.72Antileishmanial agent-4
<p>Antileishmanial agent-4, a ribonucleoside analogue, functions as an antileishmanial agent [1].</p>Formula:C17H18N4O4Colore e forma:SolidPeso molecolare:342.35(E)-Antiviral agent 67
CAS:<p>(E)-Antiviral agent 67 (compound PC6) is a pyrazolone-based antiviral compound that exhibits inhibitory activity against RNA-dependent RNA polymerase.</p>Formula:C19H19N3OColore e forma:SolidPeso molecolare:305.374Succinate dehydrogenase-IN-8
CAS:<p>Succinate dehydrogenase-IN-8 (compound i19) is a potent inhibitor of succinate dehydrogenase (SDH). This indanoyl amino acid derivative demonstrates strong antifungal activity in vitro against Rhizoctonia solani (EC50 = 0.1843 mg/L), Botrytis cinerea (EC50 = 0.4829 mg/L), and Sclerotinia sclerotiorum (EC50 = 0.1349 mg/L).</p>Formula:C22H19Cl2F2N5O2Colore e forma:SolidPeso molecolare:494.32FNC-TP trisodium
<p>FNC-TP trisodium, active intracellular FNC form, inhibits NRTI, fights HIV, HBV, and HCV.</p>Formula:C9H11FN6Na3O13P3Colore e forma:SolidPeso molecolare:592.11RAD51-IN-8
<p>RAD51-IN-8 inhibits RAD51-BRCA2 interaction and H4A4 with EC50 of 19 μM; a micromolar PPI inhibitor.</p>Formula:C16H14Cl2FN3O2Colore e forma:SolidPeso molecolare:370.21Elongation factor P-IN-1
<p>EFP-IN-1: potent β-lysine derivative, inhibits EFP, slows E. coli growth.</p>Formula:C14H31N3O2Colore e forma:SolidPeso molecolare:273.41DC-159a
CAS:<p>DC-159a, an 8-methoxy fluoroquinolone, possesses broad-spectrum antibacterial activity, with a particular efficacy against Gram-positive pathogens. The MIC90 values for DC-159a are 0.5 μg/mL against Streptococcus anginosus group, 4 μg/mL against Clostridium difficile, and 2 μg/mL against Bacteroides fragilis.</p>Formula:C21H23F2N3O40·5H2OColore e forma:SolidPeso molecolare:428.4295Teslexivir
CAS:<p>Teslexivir is a topical antiviral agent that is an effective and selective inhibitor of the interaction between two essential viral proteins, E1 and E2.</p>Formula:C35H36BrN3O4Purezza:98%Colore e forma:SolidPeso molecolare:642.58Anticaries agent-1
CAS:<p>Anticaries agent-1 (Compound 21b) is utilized as an anticaries agent. It effectively inhibits biofilm formation with an IC50 of 77 μM and restricts the growth of S. mutans.</p>Formula:C15H12O4Colore e forma:SolidPeso molecolare:256.253Anti-Influenza agent 3
<p>Compound 11h: Potent, low-toxicity anti-influenza, inhibits M2 ion channels. EC50: 3.29μM (H3N2), 2.45μM (H1N1).</p>Formula:C16H22ClNOSColore e forma:SolidPeso molecolare:311.87Polθ-IN-6
CAS:<p>Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.</p>Formula:C25H23N3O3SColore e forma:SolidPeso molecolare:445.533-Deazaguanosine
CAS:<p>3-Deazaguanosine (C3Guo) exhibits potent antiviral activity against SARS-CoV-2 with an EC50 of 1.14 μM and a CC50 greater than 200 μM in Vero E6 cells. It has the potential to prevent COVID-19.</p>Formula:C11H14N4O5Colore e forma:SolidPeso molecolare:282.25HBV-IN-19 TFA
CAS:<p>HBV-IN19 TFA suppresses HBsAg, hampers HBV infection, and aids in HBV research.</p>Formula:C26H31F3N2O8Colore e forma:SolidPeso molecolare:556.53Enzyme-IN-3 disodium
CAS:<p>Enzyme-IN-3 disodium (compound 7) is a selective inhibitor of Mycobacterium tuberculosis shikimate kinase with an IC50 of 1.6 μM. Additionally, Enzyme-IN-3 disodium exhibits antibacterial properties.</p>Formula:C20H13N3Na2O8S2Colore e forma:SolidPeso molecolare:533.442DXR-IN-3
CAS:<p>DXR-IN-3 is an anti-Toxoplasma DXR inhibitor. It exhibits in vitro activity against the TgDXR enzyme, with an IC50 value of 0.62 μM and a Ki value of 0.19 μM. Furthermore, DXR-IN-3 can inhibit the proliferation of Toxoplasma, displaying an IC50 value of 5.46 μM.</p>Formula:C10H12Cl2NO5PSColore e forma:SolidPeso molecolare:360.15PqsR-IN-2
<p>PqsR-IN-2, potent PqsR inhibitor, curbs Pseudomonas aeruginosa communication, reduces pyocyanin, with low toxicity.</p>Formula:C18H20ClN3OSColore e forma:SolidPeso molecolare:361.89WM382
CAS:<p>WM382, a potent dual PMIX/X inhibitor, has IC50s of 1.4 nM/0.03 nM and effective against various malaria stages.</p>Formula:C29H36N4O4Colore e forma:SolidPeso molecolare:504.62Antifungal agent 125
CAS:<p>Antifungalagent 125 (compound 4H) is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 3.59 μg/mL and exhibits fungicidal activity against Alternaria alternata.</p>Formula:C13H10BrNO4SColore e forma:SolidPeso molecolare:356.192Meclocycline
CAS:<p>Meclocycline: a tetracycline antibiotic, inhibits LDH, reduces cell toxicity from mutant huntingtin, doesn't change protein levels in PC12 cells.</p>Formula:C22H21ClN2O8Colore e forma:SolidPeso molecolare:476.86WRN inhibitor 12
CAS:WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.Formula:C33H33ClF3N9O5Colore e forma:SolidPeso molecolare:728.12CDA-IN-2
CAS:<p>CDA-IN-2 (Compound VS#2-3) is an inhibitor of chitin deacetylase (CDA) that exhibits antifungal properties. At a concentration of 100 μM, it inhibits P. xanthii's CDAPxCDA1 by 83.7% and PxCDA2 by 74.5%. CDA-IN-2 is applicable in research on agricultural fungal diseases, including resistance to powdery mildew and gray mold.</p>Formula:C17H16N2O7Colore e forma:SolidPeso molecolare:360.318PIQ-2
CAS:PIQ-2 (compound 54) serves as an antiprotozoal agent, displaying potent activity against IP. falciparum 3D7 and B. divergens Rouen, with IC50 values of 9.4 nM and 1.6 nM, respectively.Formula:C23H21F3N4O3Colore e forma:SolidPeso molecolare:458.43GSK3739936
CAS:<p>GSK3739936 inhibits HIV-1 integrase (IC50: 11.1 nM, EC50: 1.7 nM), weak on CYP (IC50 >24.3 μM), rapid absorption, moderate clearance, high oral availability.</p>Formula:C34H43FN2O4Colore e forma:SolidPeso molecolare:562.71Avibactam sodium dihydrate
<p>Avibactam sodium dihydrate (NXL-104) is a reversible covalent inhibitor for CTX-M-15 and TEM-1 β-lactamases with IC50s of 5 nM and 8 nM.</p>Formula:C7H14N3NaO8SColore e forma:SolidPeso molecolare:323.26
