Microbiologia/Virologia

Antibacterial agent 52 (example 18) is a antibacterial agent.

<p>5’-O-DMT-PAC-dA can be used in the synthesis of oligoribonucleotides[1].</p>

<p>RdRP-IN-8 (compound 45) is an antiviral agent targeting influenza viruses. It inhibits the viral RNA-dependent RNA polymerase (RdRP) activity by disrupting the heterodimerization of the PA and PB1 subunits, with an IC50 value of 0.13 μM.</p>

Compound PDK0095, with CAS No. 1777-82-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0095 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

<p>NNRT-IN-6 (Compound 13a) is a non-nucleoside reverse transcriptase inhibitor (NNRT) used to inhibit HIV-1 reverse transcriptase (HIV-1RT), with an IC50 of 0.41 μM. It effectively suppresses both wild-type HIV-1 and mutants L100I, K103N, Y181C, Y188L, E138K, F227L/V106A, and RES056, with an EC50 range of 6.2-250 nM.</p>

<p>PT-129 is a RPOTAC degrader that targets the G3BP1/2NTF2 domain (protein-RNA interaction site), facilitating the breakdown of intracellular stress granules. It prevents the formation of stress granules in stressed cells and deconstructs existing ones, thereby disrupting ATF4 transmission and inhibiting cancer cell proliferation. Stress granules (SGs) are membraneless cytoplasmic compartments formed under stress, which aid in the transfer of ATF4 from fibroblasts to tumor cells, promoting fibroblast-related tumor growth. G3BP1/2 serve as central proteins in the SG network, and inhibiting them may reduce the stress resilience of cancer cells within the tumor microenvironment. PT-129 consists of a target protein ligand (red part) G3BP1/2-Targeting ligand-1, an E3 ligase ligand (blue part) Thalidomide 4-fluoride, and a PROTAC linker (black part) Amino-PEG3-C2-acid; the E3 ligase ligand and linker form the complex Thalidomide-NH-PEG3-propionic acid.</p>

Isouvaretin demonstrates potent antibacterial activity against B. subtilis and S. epidermidis.

<p>LmNADK1-IN-1 (MC1) inhibits L. monocytogenes NADK1, K_i 54 nM, useful in bacterial infection research.</p>

Telithromycin is a macrolide antibiotic and erythromycin derivative,70S bacterial ribosome, antimicrobial, respiratory infections,inhibits protein synthesis.

IBU-DC Phosphoramidite is used for synthesis of oligonucleotides.

<p>Nitroxynil is an anthelmintic for adult/immature parasites, mainly used in Fasciola hepatica studies.</p>

<p>(S)-DI-87 is an isomer of DI-87, a oral dCK inhibitor，reduce dNTP production and cell cycle arrest. significantly inhibits tumor growth with thymidine.</p>

Talaromycesone A, from Talaromyces, fights S. epidermidis & MRSA (IC50: 3.7 & 5.48 μM), inhibits AChE (IC50: 7.49 μM).

LL-37 peptide: acetylated at N-terminus, amidated at C-terminus; crucial in initial infection defense.

<p>Ecubectedin (PM14), a derivative of ecteinascidins family, has antitumor and antimicrobial properties.</p>

<p>Amustaline (S-303) dihydrochloride is a nucleic acid alkylator useful for inactivating pathogens in blood with red cells.</p>

Pacidamycin I is an antimicrobial nucleoside antibiotics. Pacidamycin I inhibits translocase I, a key enzyme in peptidoglycan assembly.

Efrotomycin: an oral antibiotic from Streptomyces Lactamdurans; minimal effect on Salmonella in pigs.

Pyrrole (1H-pyrrole) is a fungicides.

<p>HIV-1 Inhibitor-59 (Compound I-5b) effectively inhibits both wild-type and mutant strains of HIV-1, with EC50 values ranging from 5.62 to 171 nM.</p>