Microbiologia/Virologia

<p>AL-470 demonstrates significant antiviral efficacy, exhibiting EC50 values of 0.27 µM against HIV-1, 0.63 µM against HIV-2, and 0.35 µM against EV-A71, as</p>

<p>6'-Hydroxy-3,4,2',3',4'-pentamethoxychalcone is an alkenylphenol from Piper obliquum with antiinflammatory and antibacterial activities.</p>

<p>Isocryptomerin, from Selaginella tamariscina, is an antifungal that depolarizes membranes and has anticancer, antibacterial effects.</p>

<p>Bulevirtide (Myrcludex B) inhibits HBV/HDV entry into hepatocytes, treating chronic hepatitis D.</p>

<p>Vinclozolin (Ornalin) is a fungicide with anti-androgenic activity, commonly used in agriculture.</p>

<p>Septacidin represents a group of l-eptopyranoses including nucleoside antibiotics with antitumor, antifungal, and pain-relief activities.</p>

<p>Compound PDK0270, with CAS No. 551-16-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0270 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>

<p>BABX inhibits FAS-II, affecting fatty acid production in S. aureus/E. coli, and blocks LXRα agonist binding. IC50: 11.4/35.3 μg/ml. MIC: 0.2-0.4 μg/ml.</p>

<p>KWR137 is a WRN degrader with an IC50 of 8 nM. It exhibits significant antiproliferative activity against MSI-H cells, with a GI50 of 509 nM for SW48 cells and 824 μM for HCT116. Additionally, KWR137 demonstrates antitumor growth effects in xenograft mouse models. This compound is applicable for cancer research.</p>

<p>JH-LPH-28, a sulfonyl piperazine, inhibits LpxH with strong antibiotic activity, MIC of 0.83 μg/mL.</p>

<p>Mutanocyclin, a powerful antifungal agent, inhibits the filamentation of Candida albicans (C.</p>

<p>FLGFVGQALNALLGKL-NH2, an antimicrobial peptide derived from frogs, exhibits activity against Staphylococcus aureus ATCC 29213 with a minimum inhibitory</p>

<p>Bibrocathol is a well-established antiseptic drug used for the treatment of acute eyelid diseases like blepharitis.</p>

<p>10-Isobutyryloxy-8,9-epoxythymol isobutyrate is a major constituent of Inula helenium and Inula royleana root cultures.</p>

<p>FR-295389 is a cephalosporin. FR-295389 shows effective antibacterial activity against metallo-beta-lactamase (MBL)-producers in vitro.</p>

<p>Tur1A, an antimicrobial peptide sourced from the bottlenose dolphin (Tursiops truncates), impedes bacterial protein synthesis.</p>

<p>(2E,4E)-Decadienoic acid, an aliphatic anti-oomycete agent, is present in the coculture of Bacillus subtilis and Trichoderma asperellum [1].</p>

<p>Antofloxacin: Broad-spectrum antibiotic, potent against gyrA mutant H. pylori; mild reversible CYP1A2 inhibitor; used for bacterial infections.</p>

<p>Xanthosine-5'-Triphosphate (5'-XTP), a nucleotide derived from the deamination of purine bases, plays a crucial role in various biological processes.</p>

<p>AA35 boosts Ceftazidime's efficacy by lowering its MIC.</p>

<p>Mycothiol detoxifies, links foreign compounds, and acts as microbes' glutathione.</p>

<p>Antibacterial agent 116 is a benzophenone salicylanilide with potent activity, inhibiting peptidoglycan synthesis and labeling PBP1b to halt bacterial growth.</p>

<p>Compound IA-8, an aryl isoxazoline derivative, exhibits insecticidal efficacy against M. separate [1].</p>

<p>Reveromycin B: a spiroketal from Streptomyces, blocks EGF in Balb/MK (IC50=6 μg/ml), antifungal vs. C. albicans, pH-sensitive, not active on KB, K562 cells.</p>

<p>Endosulfan sulfate, a highly toxic, persistent metabolite of the widely-used insecticide Endosulfan, targets multiple crops.</p>

<p>RO7196472 is a potent macrocyclic peptide antibiotic that selectively inhibits the activity of Acinetobacter strains. It targets the lipopolysaccharide (LPS) binding site on the inner membrane's LptB2FG complex, inhibiting lipopolysaccharide transport and thereby suppressing the activity of Acinetobacter strains.</p>

<p>NOSO-502: Bacterial translation inhibitor, active against Enterobacteriaceae, safe and effective antibacterial.</p>

<p>Dodec-1-ene is toxic to MIAPaCa2 cells, Pseudokirchneriella subcapitata, and Daphnia magna,antibacterial. It can also be used in the synthesis of surfactants.</p>

<p>Monogalactosyl diglyceride is a key lipid in photosynthesis and myelin, also boosting PKCα in oligodendrocytes.</p>

<p>Antibiotic JI 20A is a bioactive chemical.</p>

<p>Influenza HA (518-526) is an immunodominant epitope in H2d mice after flu virus infection.</p>

<p>Neuraminidase-IN-22 (compound 3e) serves as a potent, selective, and orally active inhibitor of neuraminidase, exhibiting a low IC 50 value of 0.03 µM. This compound demonstrates cytotoxic effects and possesses activity against the influenza A virus.</p>

<p>Nafcillin sodium, a penicillin antibiotic, treats Gram-positive, penicillin-resistant staph infections.</p>

<p>5H-Pyrido[3,2-b]indole inhibits Plasmodium falciparum and Trypanosoma cruzi, exhibits cytotoxicity toward L6 cells</p>

<p>2,4-Diacetylphloroglucinol is a useful organic compound for research related to life sciences. The catalog number is T21619 and the CAS number is 2161-86-6.</p>

<p>Voriconazole N-oxide, a key metabolite of voriconazole, results from oxidation by CYP3A4 and CYP2C19.</p>

<p>Triacylglycerol with linoleic acid at sn-1,3 and oleic at sn-2; most in grape seed oil.</p>

<p>SARS-CoV-2-IN-109 (compound 50) is an inhibitor targeting SARS-CoV, demonstrating in vivo anti-infection activity. It interferes with the interaction between the SARS-CoV-2 Spike receptor-binding domain (RBD) and the human receptor angiotensin-converting enzyme 2 (ACE2) with an EC50 of 26.5 μM, effectively blocking SARS-CoV-2 entry into VeroE6 cells (ECS50=17.0 μM). The compound has a CC50 greater than 100 μM in VeroE6 cells.</p>

<p>Isogarcinol, a Garcinia-derived immunosuppressant, inhibits T-cell proliferation and exhibits anti-inflammatory and anticancer properties.</p>

<p>3-O-Methylellagic acid from Myrciaria cauliflora is anti-inflammatory, inhibits glucose transport, and kills Staph. Aureus at 32 μg/mL.</p>

<p>RNA Splicing Modulator 1 (Compound 233) is a modulator of RNA splicing, exhibiting an AC50 value of less than 100 nM [1].</p>

<p>XT-2 peptide, an antimicrobial agent sourced from the skin secretions of Xenopus tropicalis, exhibits potent activity against E.</p>

<p>CKP-25 is an inhibitor that disrupts the interaction between Spike RBD and ACE2, preventing virus entry into host cells, thus reducing viral replication and infection. It inhibits SARS-CoV-2 with an IC50 of 3.5 μM in Vero E6 cells.</p>

<p>VIR-165, a derivative of VIRIP (353-372 of alpha1-antitrypsin), blocks several HIV-1 strains.</p>

<p>Allolactose is a disaccharide used as an inducer of the lac operon in Escherichia coli and many other enteric bacteria.</p>

<p>PT-129 is a RPOTAC degrader that targets the G3BP1/2NTF2 domain (protein-RNA interaction site), facilitating the breakdown of intracellular stress granules. It prevents the formation of stress granules in stressed cells and deconstructs existing ones, thereby disrupting ATF4 transmission and inhibiting cancer cell proliferation. Stress granules (SGs) are membraneless cytoplasmic compartments formed under stress, which aid in the transfer of ATF4 from fibroblasts to tumor cells, promoting fibroblast-related tumor growth. G3BP1/2 serve as central proteins in the SG network, and inhibiting them may reduce the stress resilience of cancer cells within the tumor microenvironment. PT-129 consists of a target protein ligand (red part) G3BP1/2-Targeting ligand-1, an E3 ligase ligand (blue part) Thalidomide 4-fluoride, and a PROTAC linker (black part) Amino-PEG3-C2-acid; the E3 ligase ligand and linker form the complex Thalidomide-NH-PEG3-propionic acid.</p>

<p>Antibacterial agent 59 (example 24) is a antibacterial agent.</p>

<p>5’-O-DMT-N4-Bz-2’-F-dC is a nucleoside with protective and modification effects.</p>

<p>Compound 17k, also known as Antileishmanial agent-30, effectively inhibits Leishmania with an IC50 of 0.2 μM for L. donovani. It exhibits a CC50 of &gt;100 μM and an SI of &gt;500, indicating significant selectivity and potency.</p>

<p>HIV-1 inhibitor-11, a fused pyridine ring derivative, is a HIV-1 inhibitor.</p>

<p>Cis-2-dodecenoic acid, identified in Burkholderia cenocepacia, disrupts bacterial quorum sensing, thereby inhibiting biofilm formation and the production of</p>

<p>Rimocidin is a macrolide antifungal compound isolated from Streptomyces rimosus.</p>

<p>Compound 7a: potent, selective MRSA growth inhibitor; MIC ≤ 0.26 µM; non-cytotoxic, non-hemolytic.</p>

<p>2-Amino-6-bromopyridine has inhibitory effect on HIV-68 protease.</p>

<p>2-ethyl-1,3-thiazole is a 1,3-thiazole derivative with antimicrobial activity (MIC=200 μg/mL) and can be used in organic synthesis and biochemical experiments.</p>

<p>RNA Pol II-IN-2 (20iii) strongly inhibits Pol II (Ki=9.5 nM), is more toxic to CHO/HEK293 than α-amanitin.</p>

<p>HIV-1inhibitor-75 is a human immunodeficiency virus 1 (HIV-1) inhibitor with an EC50 range of 0.0039-0.338 μM. Its target is the reverse transcriptase, exhibiting an IC50 value of 0.055 μM. Additionally, HIV-1inhibitor-75 demonstrates good metabolic stability in vitro, presenting moderate clearance rates and an extended half-life in human plasma and liver microsomes.</p>

<p>K 41 is a polycyclic polyether antibiotic from Streptomyces hygroscopicus.</p>

<p>Thrazarine is a new antitumor antibiotic agent produced by Streptomyces coerulescens MH802-fF5.</p>

<p>Plectasin, a peptide antibiotic derived from saprophytic fungi, can effectively kill Streptococcus pneumoniae in vitro. Additionally, it alleviates experimental peritonitis and pneumonia caused by Streptococcus pneumoniae in mice.</p>

<p>Neoaureothin, a Streptomyces metabolite, is an AR antagonist with anti-androgen and cytotoxic effects, also active against B. xylophilus.</p>

<p>LASV inhibitor 3.3 blocks Lassa virus by targeting LAMP1, a host factor LASV GP binds to during infection.</p>

<p>(+)-Macrosphelide A, from Microsphaeropsis, thwarts HL-60 cell adhesion and SKOV3 cancer growth, fights Gram-positive bacteria, not Gram-negatives or fungi.</p>

<p>Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.</p>

<p>Sarubicin B, an active quinone antibiotic isolated from the culture filtrate of the Streptomyces strain (Streptomyces strain) JA 2861, effectively inhibits Gram-positive bacteria while showing ineffectiveness against Gram-negative organisms.</p>

<p>N-0920 is a potent TMPRSS2 inhibitor with an IC50 value of 0.35 nM. It effectively inhibits the entry of SARS-CoV-2 variants [EG.5.1] and [JN.1] into Calu-3 cells, exhibiting EC50 values of 300 pM and 90 pM, respectively.</p>

<p>M2e, human: a universal vaccine candidate for all human influenza A strains, with 23 conserved extracellular M2 protein residues.</p>

<p>Ac-dA Phosphoramidite is a phosphinamide monomer utilized for oligonucleotide synthesis.</p>

<p>Malolactomycin C (compound 1) is a macrocyclic lactone antifungal antibiotic isolated from the Streptomyces strain KP-3144. It effectively inhibits Botrytis cinerea (gray mold), thereby controlling various plant diseases, including gray mold infections.</p>

<p>Herbicidin A is an adenosine nucleoside antibiotic isolated from Streptomyces scopuliridis M40. Herbicidin A is also a herbicide against dicotyledonous plants.</p>

<p>Chevalone B, a meroterpenoid from E. chevalieri fungus, is cytotoxic with IC50s: KB cells 2.9 μg/ml, NCI-H187 9.8 μg/ml.</p>

<p>Quorum sensing-IN-10 (10p) is an antimicrobial adjuvant that significantly inhibits the virulence, biofilm formation, and motility of Pseudomonas aeruginosa, while exhibiting low toxicity. It is applicable for research related to drug-resistant Pseudomonas aeruginosa infections.</p>

<p>This is the immunodominant epitope gB-8p from herpes simplex virus (HSV) glycoprotein B (gB), amino acids 498 to 505.</p>

<p>SARS-CoV-2 3CLpro-IN-25 (compound 56) effectively inhibits the SARS-CoV-2 3CLpro enzyme, exhibiting an IC50 value of 70 nM, and demonstrates cellular antiviral activity with an EC50 of 3.1 μM.</p>

<p>Trichodecenin II is a peptaibol isolated from Trichoderma viride.</p>

<p>Antibioticadjuvant 2 (compound 5q) is a potent antibiotic adjuvant that enhances the efficacy of polymyxins and exhibits low toxicity in mammals. The minimum resensitization concentration of Antibioticadjuvant 2 for Escherichia coli AR-0493 is 0.125 μg/mL.</p>

<p>Cyclo(Arg-Pro) TFA, also known as Cyclo(Pro-Arg) TFA, serves as an inhibitor of chitinase. This compound impedes the cell separation of Saccharomyces cerevisiae without affecting its growth. Additionally, Cyclo(Arg-Pro) TFA inhibits the morphological transition of Candida albicans from a yeast form to a filamentous form.</p>

<p>Carbazole belongs to the class of carbazole-based organic compounds. Carbazole can form novel DNA small groove complexes, inhibiting the synthesis of new DNA or RNA.</p>

<p>Pleurocidin, an antibacterial peptide, originates from the skin secretions of the Winter Flounder (Pseudopleuronectes americanus) [1].</p>

<p>Ceratotoxin A is a 29-residue peptide extracted from the accessory gland secretion fluid, known for its potent antibacterial properties.</p>

<p>Antibacterial Agent 42 boosts Ceftazidime's efficacy by lowering its MIC.</p>

Ro 41-1879 is a catechol cephalosporin with antimicrobial activity.

<p>PSB-21110 is an irreversible inhibitor of SARS-CoV-2 Mpro, exhibiting antiviral activity with an EC50 value of 2.68 nM.</p>

<p>Avilamycin A: antibiotic, combats C. perfringens and B. hyodysenteriae, lowers mortality in poultry.</p>

<p>(S)-1-(4-Hydroxyphenyl)ethane-1,2-diol, from Angelica sinensis, inhibits Aeromonas hydrophila and acts as an anticoagulant and antibiotic.</p>

<p>Rifasutenizol (TNP-2198) is a powerful, oral dual-target antibacterial effective against microaerophilic and anaerobic bacteria.</p>

<p>Nystatin A1, a polyene macrolide (antibiotic), is isolated from the Streptomyces noursei bacterium. It functions by binding with ergosterol on fungal cell membranes, enhancing membrane permeability, and consequently causing leakage of cellular contents, which inhibits fungal growth and reproduction.</p>

<p>SPD-756, a nucleoside reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection.</p>

<p>Poly(hexamethylenebiguanide) hydrochloride (PHMB HCl) is an antibacterial agent and cationic disinfectant against Gram-negative and Gram-positive bacteria.</p>

<p>SDH-IN-10 is a potent inhibitor of succinate dehydrogenase (SDHI) that exhibits antifungal activity [1].</p>

<p>Nitroxynil is an anthelmintic for adult/immature parasites, mainly used in Fasciola hepatica studies.</p>

<p>Xalnesiran (sodium) is siRNA for the treatment of chronic hepatitis B ( HBV )..</p>

<p>LCMV nucleoprotein (396-404) TFA is a H-2D(b) immunodominant epitope and a viral antigen model.</p>

<p>Choline Iodide has antibacterial activity against Leishmania panamensis and inhibitor of Acetylcholinesterase, degenerative neurological diseases.</p>

<p>FF-10502, a pyrimidine analog of Gemcitabine, inhibits DNA polymerases α/β, targeting dormant cancer cells.</p>

<p>Polyoxin D (Polyoxorim), a polyoxin antibiotic fungicide, effectively inhibits chitin synthetase.</p>

<p>MB-66 (MAPP-66) is a fully human IgG1 antibody targeting HSV and HIV. It is a monoclonal antibody membrane intended for vaginal application. The isotype control for MB-66 can be referred to as HumanIgG1kappa, Isotype Control.</p>

<p>Rolusafine is an antifungal agent [1] .</p>

<p>Lenapenem is a broad-spectrum, carbapenem antibiotic with bactericidal activity by weakens the bacterial cell wall and leads to lytic cell death.</p>

<p>Bismuth Subcitrate is an antibiotic used to treat stomach ulcers associated with Helicobacter pylori, a bacterial infection.</p>

<p>FR901379, an echinocandin-like antifungal, combats various fungi, protects mice from C. albicans, and lessens P. carinii infection symptoms.</p>

<p>Carbomycin B, a precursor in making Carbomycin, is a macrolite antibiotic from Stroptomyces halstedii, akin to Leucomycin and Erythromycin.</p>

<p>Rugulosin (RUG) is a bis-anthraquinoid pigment produced by fungi.</p>

<p>RdRP-IN-8 (compound 45) is an antiviral agent targeting influenza viruses. It inhibits the viral RNA-dependent RNA polymerase (RdRP) activity by disrupting the heterodimerization of the PA and PB1 subunits, with an IC50 value of 0.13 μM.</p>

<p>Lauryl-LF 11 displays antimicrobial activity.</p>