Microbiologia/Virologia

The AH-D peptide is an antiviral peptide that selectively disrupts membrane-encased structures within the size range of exosomes, inducing T-EXO depletion and enhancing cancer immunotherapy.

<p>Sofosbuvir impurity A is an diastereoisomer of Sofosbuvir. Sofosbuvir is anHCV RNA replication inhibitor ,with potent anti-hepatitis C virus activity.</p>

Gly6 is a linear peptide with six amino acids.

CMVpp65 (415-429) is a CEF control peptide derived from cytomegalovirus (CMV).

Josamycin HCl is a macrolide antibiotic.

<p>SARS-CoV-2 Mpro-IN-37 (compound 8r) is an inhibitor of the SARS-CoV-2 main protease (Mpro), with an IC50 value of 0.0199 μM. It exhibits IC50 values of 0.00945 μM against SARS-CoV-1 Mpro and 0.111 μM against MERS-CoV Mpro. SARS-CoV-2 Mpro-IN-37 demonstrates potent antiviral activity in the nanomolar range without showing cytotoxicity.</p>

<p>Aibellin is a peptide antibiotic and serves as an effective and beneficial modulator of rumen fermentation.</p>

Alternapyrone is an α-pyrone compound isolated from fungi, exhibiting phytotoxicity that affects the germination of wheat seeds. Its biosynthesis requires only three enzymes.

<p>Adustin is an antifungal antibiotic characterized as a polypeptide that inhibits translation. It effectively suppresses translation in a cell-free rabbit reticulocyte lysate system, exhibiting an IC50 of 0.34 μM.</p>

Setoxaximab is a chimeric humanized antibody of the IgG1-κ isotype that specifically targets Shiga toxin type 1 (Stx1).

Antifungalagent 117 is a bipyrrole carboxamide derivative with antifungal activity, exhibiting an EC50 value of 11.58 mg/L against Sclerotinia sclerotiorum. This compound induces cell death by increasing cell membrane permeability, causing an imbalance in osmotic pressure between the interior and exterior of the cell. It also promotes oxidative damage to the cell membrane by inducing the accumulation of reactive oxygen species (ROS), leading to the leakage of cellular contents. RNA sequencing analysis has demonstrated that Antifungalagent 117 disrupts cell membrane structure by downregulating catalase genes and upregulating neutral ceramidase genes, accelerating ceramide metabolism and hastening cell death. The compound holds significant potential for application in plant protection and the control of fungal infections.

(–)-Voacangarine, an indole alkaloid isolated from V. africana, exhibits cytotoxicity towards various cell lines including HepG2, A375, MDA-MB-231, SH-SY5Y, and CT26 with IC50 values of 20 µg/ml. Additionally, it demonstrates cytostatic effects on wild-type S. cerevisiae and is cytotoxic to Δrad3-e5 and Δrad6-1 mutant strains of S. cerevisiae, which have defects in DNA strand break repair and the mutagenic repair pathway, respectively.

His-Cys-Lys-Phe-Trp-Trp functions as an inhibitor of the human immunodeficiency virus (HIV) integrase, exhibiting an IC50 value of 2 μM.

Carbendazim mixture with flusilazole is a bioactive chemical.

Tetrachloroveratrole forms from chloroguaiacols' degradation, byproducts of wood pulp bleaching in paper production.

VK13 (Compound 6) is a potent inhibitor of human cathepsin L (hCatL) and SARS-CoV-2 3CLpro (3CL-PR), with Ki values of 2.6 nM and 0.55 nM, respectively. It also exhibits activity against CoV-2, with an EC50 value of 1.25 μM.

Piperitenone oxide is a major chemical constituent of the carvone pathway MS essential oil.

AF-615 is an innovative inhibitor of the CDT1/Geminin protein complex, capable of inducing DNA damage and cell death in cancer cells.

Emoquine-1 is a potent orally active antimalarial agent effective against various drug-resistant Plasmodium strains, including artemisinin-resistant dormant parasites. It demonstrates efficacy against proliferative malignant Plasmodium with an IC50 value ranging from 20 to 55 nM. Emoquine-1 holds potential for treating Plasmodium strains resistant to artemisinin combination therapy (ACT), with the capability to eradicate persistent parasites.

Compound 20, also known as LANA-DNA-IN-2, is an inhibitor of the interaction between latency-associated nuclear antigen (LANA) and DNA.

Carbavance treats adult complex UTIs and pyelonephritis; it's a mix of Meropenem and Vaborbactam.

Pyruvic acid semicarbazone is a biochemical.

HIVgp120 (318-327) is a short sequence (rgpgrafvti) from the envelope peptide of the HIV-1 IIIB strain, corresponding to the conserved C-terminal region of the glycoprotein. It is part of the HIV vaccine V3 peptide epitope, also known as the I10 peptide. However, HIVgp120 (318-327) lacks the A2 anchor residues needed for epitope-specific CTL recognition but possesses structural features that allow mixed A2 binding.

Tetranactin: a macrotetrolide ionophore with antibacterial and insecticidal effects; inhibits Gram-positive bacteria and certain fungi.

MK-5204 is an orally active β-1,3-glucan synthesis inhibitor.

1-Acridinamine is a biochemical.

L 693989 is a pneumocandin.

AAP4 is a potent inhibitor of OfChi-h and OfHex1, exhibiting Ki values of 29.3 nM and 4.9 μM, respectively. It also demonstrates insecticidal activity against the lepidopteran pest Ostrinia furnacalis.

Lupinine, (+)- is a bioactive chemical.

VIRIP (human α1-AT(353-372)) serves as an inhibitor of HIV-1. It impedes HIV-1 entry by binding to the gp41 fusion peptide, making it useful in virus research.

ddATP (lithium) (2',3'-Dideoxyadenosine 5'-triphosphate (lithium)) is an active metabolite of 2',3'-dideoxyinosine and acts as a chain extension inhibitor of DNA polymerase. It is employed in DNA sequencing using the Sanger method and is also used in studies related to viral infections.

Clenoliximab (IDEC-151), a macaque-human chimeric monoclonal antibody (immunoglobulin G4), targets the CD4 molecule on T lymphocytes' surface and is utilized in

Mpro/Cathepsin L-IN-2 (Compound 1) is an irreversible dual inhibitor targeting the main protease of SARS-CoV-2 (Mpro, pIC50=8.61) and human cathepsin L (hCTSL, pIC50=7.64). Mpro/Cathepsin L-IN-2 shows potential for use in research related to COVID-19 and other coronavirus infections.

5-Azacytidine 5'-triphosphate sodium, a cytidine analog, selectively inhibits the incorporation of [3 H]CTP into RNA by DNA-dependent RNA polymerase, without

SCH 725674, a macrolide, halts fungi like S. cerevisiae and C. albicans growth; MICs are 8 and 32 μg/ml.

Pezulepistat is a macrolide broad-spectrum antibiotic. It can be utilized in research to study its effects on infections caused by Gram-negative bacteria and other microbial infections.

Targeting thebacterialsliding clamp peptide 46 TFA is a short peptide that specifically targets the bacterial sliding clamp (SC) and inhibits SC-dependent DNA synthesis.

Isoleucylcysteine is the first intermediate peptide in bacitracin biosynthesis.

Bacillosporin C, an oxaphenalenone dimer with antibiotic properties, inhibits acetylcholinesterase; derived from mangrove fungus T. bacillosporus.

Nanangenine F, a drimane sesquiterpene from A. nanangensis, inhibits B. subtilis (IC50=78μg/ml) and is cytotoxic to various cells (IC50=49-95μg/ml).

DIACC-1010 is a humanized monoclonal antibody (mAb) targeting PLA2G1B. It is applicable in research related to HIV infection.

Cinerubine A is an anthracycline.

GT-1 (LCB10-0200), a siderophore cephalosporin, fights P. aeruginosa, K. oxytoca, Proteus, S. marcescens, E. aerogenes.

Polyketide synthase 13-IN-1 (compound 32) is a polyketide synthase 13 inhibitor.

Neomycin C hexaacetate is a tetracyclic antibacterial agent and the primary active isomer in the neomycin complex. Neomycin, an aminoglycoside containing 2-DOS, is composed of Neomycin A, Neomycin B, and Neomycin C.

Carbendazim HCl is a widely used, broad-spectrum benzimidazole fungicide and a metabolite of benomyl.

Unguinol, from A. unguis, inhibits PPDK (IC50=42.3μM), C4 plant growth, S. aureus/V. harveyi (GI50=8.7/69.5μM), and certain cancer cells.

RNA MTase-IN-1 (Compound 47) is an inhibitor of RNA methyltransferase (RNA MTase), exhibiting an IC50 of 68 μM against 16S rRNA (m1A1408) methyltransferase (NpmA). It demonstrates significant inhibitory activity against aminoglycoside resistance linked to pathogens and is applicable in research on antibiotic-resistant bacterial infections.

Bis-Br-ANT-ATP(tetrasodium) is a fluorescent derivative of adenosine-5'-triphosphate (ATP). It selectively inhibits the adenylyl cyclase toxin CyaA of Bordetella pertussis with a Ki of 12.6 nM. This compound is utilized in research related to whooping cough.

SEB Domain (152-161) TFA represents amino acid positions 152-161 within the structural domain of staphylococcal enterotoxin B, produced by Staphylococcus aureus. This segment is highly conserved and inhibits the transcytosis of multiple staphylococcal enterotoxins, including SEA, SEE, and TSST-1.