LRRK2
Gli inibitori di LRRK2 sono composti che inibiscono l'attività della Leucine-Rich Repeat Kinase 2 (LRRK2), un enzima coinvolto in diversi processi cellulari, tra cui l'autofagia, il traffico vescicolare e l'infiammazione. Le mutazioni nel gene LRRK2 sono associate a un aumento del rischio di sviluppare la malattia di Parkinson, rendendo LRRK2 un bersaglio significativo per la ricerca sulle malattie neurodegenerative. Gli inibitori di LRRK2 sono cruciali per esplorare il ruolo di LRRK2 nel Parkinson e per sviluppare potenziali strategie terapeutiche. Presso CymitQuimica, offriamo una selezione di inibitori di LRRK2 per supportare la tua ricerca in neurodegenerazione, segnalazione chinasi e sviluppo terapeutico.
Trovati 41 prodotti di "LRRK2"
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MLi-2
CAS:<p>MLi-2: Novel, potent CNS-active LRRK2 inhibitor; IC50s: 0.76nM in vitro, 1.4nM cellular, 3.4nM binding.</p>Formula:C21H25N5O2Purezza:98.96%Colore e forma:SolidPeso molecolare:379.46BIX 02565
CAS:BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).Formula:C26H30N6O2Purezza:97.44% - 99.7%Colore e forma:SolidPeso molecolare:458.56JH-XII-03-02
CAS:JH-XII-03-02 is a potent and selective leucine-rich repeat kinase 2 (LRRK2) proteolysis targeting chimera (PROTAC) degrader, utilized in Parkinson's Disease (PDFormula:C43H51N9O10Purezza:98%Colore e forma:SolidPeso molecolare:853.92RN341
RN341 is a LRRK2-specific type II kinase inhibitor (IC50 of 296 nM). It prevents the phosphorylation of LRRK2 by stabilizing an open conformation, thereby avoiding S935 dephosphorylation. Additionally, RN341 rescues LRRK2-mediated kinesin motility blockage by preventing microtubule binding. This compound effectively inhibits both wild-type and G2019S LRRK2 at the cellular level, offering a novel avenue for Parkinson's disease research.Colore e forma:Odour SolidEB-42486
CAS:EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.Formula:C22H22N8OPurezza:99.53%Colore e forma:SolidPeso molecolare:414.46CZC-54252 hydrochloride
CAS:CZC-54252 hydrochloride: selective LRRK2 inhibitor; IC50 = 1.85/1.28 nM (wild-type/G2019S); neuroprotective; EC50 = 1 nM for G2019S injury.Formula:C22H26Cl2N6O4SPurezza:98.21%Colore e forma:SolidPeso molecolare:541.45XL01126
XL01126 degrades LRRK2 (DC50: 14 nM G2019S, 32 nM WT), crosses the blood-brain barrier, aiding Parkinson's studies.Formula:C50H64ClFN10O6S2Colore e forma:SolidPeso molecolare:1019.69LRRK2 inhibitor 1
CAS:<p>LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM.</p>Formula:C20H23N5O4Purezza:99.94%Colore e forma:SolidPeso molecolare:397.43RN277
RN277 is an inhibitor of LRRK2 type II kinase (LRRK2type II kinase). It serves as a cellular tool targeting the inactive state of LRRK2. In vitro, RN277 inhibits LRRK1 kinase activity and the kinase activity of LRRK2, with an IC50 of 70 nM. Additionally, it reduces Rab8a phosphorylation in a dose-dependent manner. RN277 is useful for Parkinson's disease research.Colore e forma:Odour SolidAnti-LRRK2 Antibody (1C773)
Anti-LRRK2 Antibody (1C773) is an antibody targeting LRRK2. Anti-LRRK2 Antibody (1C773) can be used in ELISA, IHC.Colore e forma:Odour LiquidGNE-7915 tosylate
CAS:GNE-7915 tosylate is a potent, selective, and brain-penetrant LRRK2 inhibitor, boasting an IC50 value of 9 nM.Formula:C26H29F4N5O6SColore e forma:SolidPeso molecolare:615.6LRRK2-IN-1
CAS:LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.Formula:C31H38N8O3Purezza:98% - 98.82%Colore e forma:SolidPeso molecolare:570.69JH-II-127
CAS:JH-II-127 is an oral LRRK2 inhibitor with IC50s: 6.6 nM (WT), 2.2 nM (G2019S), 47.7 nM (A2016T).Formula:C19H21ClN6O3Purezza:98.32%Colore e forma:SolidPeso molecolare:416.86PFE-360
CAS:<p>PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).</p>Formula:C16H16N6OPurezza:98.14% - 99.73%Colore e forma:SolidPeso molecolare:308.34GNE0877
CAS:GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).Formula:C14H16F3N7Purezza:98.01% - 99.97%Colore e forma:SolidPeso molecolare:339.32PF-06454589
CAS:PF-06454589 is a potent inhibitor of LRRK2.Formula:C14H16N6OPurezza:99.06%Colore e forma:SolidPeso molecolare:284.32HG-10-102-01
CAS:HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).Formula:C17H20ClN5O3Purezza:99.59%Colore e forma:SolidPeso molecolare:377.83PF-06447475
CAS:PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.Formula:C17H15N5OPurezza:98.61% - 99.62%Colore e forma:SolidPeso molecolare:305.33GSK2578215A
CAS:GSK2578215A is a potent and selective LRRK2 kinase inhibitor.Formula:C24H18FN3O2Purezza:99.57% - 99.94%Colore e forma:SolidPeso molecolare:399.42CZC-25146 hydrochloride
CAS:<p>CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.</p>Formula:C22H26ClFN6O4SPurezza:98.76%Colore e forma:SolidPeso molecolare:525
