LRRK2
Gli inibitori di LRRK2 sono composti che inibiscono l'attività della Leucine-Rich Repeat Kinase 2 (LRRK2), un enzima coinvolto in diversi processi cellulari, tra cui l'autofagia, il traffico vescicolare e l'infiammazione. Le mutazioni nel gene LRRK2 sono associate a un aumento del rischio di sviluppare la malattia di Parkinson, rendendo LRRK2 un bersaglio significativo per la ricerca sulle malattie neurodegenerative. Gli inibitori di LRRK2 sono cruciali per esplorare il ruolo di LRRK2 nel Parkinson e per sviluppare potenziali strategie terapeutiche. Presso CymitQuimica, offriamo una selezione di inibitori di LRRK2 per supportare la tua ricerca in neurodegenerazione, segnalazione chinasi e sviluppo terapeutico.
Trovati 48 prodotti per "LRRK2".
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BIX 02565
CAS:BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).Formula:C26H30N6O2Purezza:97.44% - 99.7%Colore e forma:SolidPeso molecolare:458.5554MLi-2
CAS:MLi-2: Novel, potent CNS-active LRRK2 inhibitor; IC50s: 0.76nM in vitro, 1.4nM cellular, 3.4nM binding.Formula:C21H25N5O2Purezza:98.96% - 99.07%Colore e forma:SolidPeso molecolare:379.4555RN277
RN277 is an inhibitor of LRRK2 type II kinase (LRRK2type II kinase). It serves as a cellular tool targeting the inactive state of LRRK2. In vitro, RN277 inhibits LRRK1 kinase activity and the kinase activity of LRRK2, with an IC50 of 70 nM. Additionally, it reduces Rab8a phosphorylation in a dose-dependent manner. RN277 is useful for Parkinson's disease research.Colore e forma:Odour SolidPROTAC LRRK2 Degrader-3
CAS:PROTACLRRK2 Degrader-3 is a PROTACLRRK2 degrader with a DC50 of 0.17 nM. This compound can be utilized in research related to Parkinson's disease and inflammation.Formula:C44H54N10O5Peso molecolare:802.98PROTAC LRRK2 Degrader-5
CAS:PROTAC LRRK2 Degrader-5 Formula (V) is an LRRK2 PROTAC degrader. It can be utilized in the research of diseases associated with LRRK2, such as Parkinson's disease (PD).Formula:C46H57FN10O4Peso molecolare:833.01XL01126
CAS:XL01126 LRRK2 degrader (DC50 14 nM G2019S, 32 nM WT) BBB-penetrant probe for Parkinson’s disease and LRRK2 signaling and protein degradation studies.Formula:C50H64ClFN10O6S2Purezza:99.98%Colore e forma:SolidPeso molecolare:1019.69CZC-54252 hydrochloride
CAS:CZC-54252 hydrochloride: selective LRRK2 inhibitor; IC50 = 1.85/1.28 nM (wild-type/G2019S); neuroprotective; EC50 = 1 nM for G2019S injury.Formula:C22H26Cl2N6O4SPurezza:99.28%Colore e forma:SolidPeso molecolare:541.45RN341
RN341 is a LRRK2-specific type II kinase inhibitor (IC50 of 296 nM). It prevents the phosphorylation of LRRK2 by stabilizing an open conformation, thereby avoiding S935 dephosphorylation. Additionally, RN341 rescues LRRK2-mediated kinesin motility blockage by preventing microtubule binding. This compound effectively inhibits both wild-type and G2019S LRRK2 at the cellular level, offering a novel avenue for Parkinson's disease research.Colore e forma:Odour SolidEB-42486
CAS:EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.Formula:C22H22N8OPurezza:99.53%Colore e forma:White SolidPeso molecolare:414.4631PROTAC LRRK2 Degrader-4
CAS:PROTACLRRK2 Degrader-4 is a PROTACLRRK2 degrader with a DC50 of 0.79 nM, employed in research related to Parkinson's disease and inflammation.Formula:C45H56N10O5Peso molecolare:817.01FX 2149
CAS:FX 2149 is a GTP-binding inhibitor that potently inhibits LRRK2 GTP binding and kinase activity in vitro and attenuates the toxic effects of LRRK2 in Parkinson’s disease models.Formula:C15H17N3O3SPurezza:99.94%Peso molecolare:319.38Nictide
CAS:Nictide, a peptide substrate for LRRK2 (leucine-rich repeat protein kinase-2), undergoes phosphorylation by the activated form of LRRK2[G2019S], exhibiting a Km value of 10 μM.Formula:C123H193N45O28Colore e forma:SolidPeso molecolare:2750.13JH-XII-03-02
CAS:JH-XII-03-02 is a potent and selective leucine-rich repeat kinase 2 (LRRK2) proteolysis targeting chimera (PROTAC) degrader, utilized in Parkinson's Disease (PDFormula:C43H51N9O10Purezza:98%Colore e forma:SolidPeso molecolare:853.92PROTAC LRRK2 Degrader-2
CAS:PROTAC LRRK2 Degrader-2 is a PROTAC-based degrader targeting LRRK2 with a DC50 of 0.14 nM. It recruits LRRK2 or its mutants to cereblon E3 ubiquitin ligase, facilitating the targeted ubiquitination and subsequent proteasomal degradation of LRRK2. PROTAC LRRK2 Degrader-2 is applicable in Parkinson's disease research.Formula:C43H53N11O5Peso molecolare:803.95PROTAC LRRK2 Degrader-1
CAS:PROTAC LRRK2 Degrader-1 (compound 18) is a PROTAC degrader targeting leucine-rich repeat kinase 2 (LRRK2) with an IC50 of less than 10 nM. It is applicable for research in Parkinson's disease.Formula:C45H54FN9O5Peso molecolare:819.97CC-3240
CAS:CC-3240 (compound 13), a molecular glue degrader of CaMKK2 based on CC-8977, has an IC50 of 9 nM [1].Formula:C52H64N6O7SColore e forma:SolidPeso molecolare:917.17Anti-LRRK2 Antibody (1C773)
Anti-LRRK2 Antibody (1C773) is an antibody targeting LRRK2. Anti-LRRK2 Antibody (1C773) can be used in ELISA, IHC.Colore e forma:Odour LiquidGNE-7915 tosylate
CAS:GNE-7915 tosylate is a potent, selective, and brain-penetrant LRRK2 inhibitor, boasting an IC50 value of 9 nM.Formula:C26H29F4N5O6SColore e forma:SolidPeso molecolare:615.597HG-10-102-01
CAS:HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).Formula:C17H20ClN5O3Purezza:99.59%Colore e forma:SolidPeso molecolare:377.825LRRK2-IN-1
CAS:LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.Formula:C31H38N8O3Purezza:98% - 98.82%Colore e forma:SolidPeso molecolare:570.69
