Beta amiloide
Gli inibitori del beta-amiloide sono composti che mirano specificamente a inibire la formazione o l'aggregazione dei peptidi beta-amiloidi, coinvolti in modo critico nella patogenesi della malattia di Alzheimer. L'accumulo di placche di beta-amiloide nel cervello è uno dei tratti patologici distintivi della malattia, contribuendo alla disfunzione neuronale e al declino cognitivo. Inibendo l'aggregazione del beta-amiloide, questi inibitori sono studiati come potenziali agenti terapeutici per rallentare o prevenire la progressione della malattia di Alzheimer. Presso CymitQuimica, offriamo una gamma di inibitori del beta-amiloide di alta qualità per supportare la tua ricerca nella neurodegenerazione, nell'aggregazione proteica e nella terapia dell'Alzheimer.
Trovati 218 prodotti di "Beta amiloide"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Semagacestat
CAS:Semagacestat (LY450139) (LY450139) is a γ-secretase blocker for Aβ42/Aβ40/Aβ38 (IC50: 10.9/12.1/12.0 nM) and also inhibits Notch signaling (IC50: 14.1 nM).Formula:C19H27N3O4Purezza:97.1% - 99.9%Colore e forma:SolidPeso molecolare:361.44FPS-ZM1
CAS:FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE.Formula:C20H22ClNOPurezza:99.32% - 99.52%Colore e forma:SolidPeso molecolare:327.85Miridesap
CAS:<p>Miridesap (GSK2315698) rapidly depletes SAP in blood, cerebrospinal fluid, and amyloid deposits via liver clearance.</p>Formula:C16H24N2O6Purezza:≥95%Colore e forma:SolidPeso molecolare:340.37Aftin-4
CAS:Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor.Formula:C20H28N6OPurezza:98.51%Colore e forma:SolidPeso molecolare:368.48Azeliragon HCl
CAS:Azeliragon: potent oral RAGE inhibitor, blocks Alzheimer's-linked amyloid brain entry.Formula:C32H40Cl3N3O2Colore e forma:SolidPeso molecolare:605.04Edonerpic maleate
CAS:Edonerpic maleate (T-817 maleate) is a neurotrophic agent which can inhibit amyloid-β peptides (Aβ).Formula:C20H25NO6SPurezza:98.24%Colore e forma:SolidPeso molecolare:407.48Pyridoxal 5'-phosphate hydrate
CAS:Pyridoxal 5'-phosphate hydrate (PLP)(1:x), the active form of vitamin B6, is a cofactor for many different enzymes involved in transamination reactions,Formula:C8H10NO6PPurezza:97.52%Colore e forma:SolidPeso molecolare:247.14PiB
CAS:<p>PiB (Pittsburgh Compound-B) is a standard for analysis of 11C-PiB. 11C-PiB is a β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.</p>Formula:C14H12N2OSPurezza:97.02%Colore e forma:SolidPeso molecolare:256.32γ-Secretase modulator 13
CAS:γ-Secretase modulator 13 is a γ-secretase modulator (GSMs) that can be used to study Alzheimer's disease and tumors.Formula:C22H23FN6SPurezza:99.79%Colore e forma:SolidPeso molecolare:422.524-Hydroxyindole
CAS:4-Hydroxyindole: aromatic, antioxidant, used in cancer treatment and preventing neurodegenerative diseases.Formula:C8H7NOPurezza:97.05% - 98.13%Colore e forma:Off-White Cyrstalline SolidPeso molecolare:133.15Solanezumab
CAS:<p>Solanezumab (LY 2062430) is a monoclonal antibody that binds preferentially to soluble amyloid and promotes its clearance from the brain.</p>Purezza:96.3% (SDS-PAGE); 97.5% (SEC-HPLC) - 96.3% (SDS-PAGE); 97.5% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:144.1 (kDa)Dezamizumab
CAS:Dezamizumab is a humanized antibody targeting the serum amyloid P component (SAP) to clear amyloid fibrils via macrophage phagocytosis, for research in systemic amyloid diseases.Purezza:95% - 98.2% (SDS-PAGE); 98.7% (SEC-HPLC)Colore e forma:LiquidBapineuzumab
CAS:Bapineuzumab (AAB-001) is a humanised monoclonal antibody targeting amyloid-beta (Aβ), soluble and oligomeric forms of amyloid β, Alzheimer's disease (AD).Purezza:95%Colore e forma:LiquidRemternetug
CAS:Remternetug (LY3372993) is a humanised monoclonal antibody targeting N3pG-Aβ, recognising pyroglutamated Aβ within amyloid plaques, Alzheimer's disease.Purezza:95% - 97.6% (SDS-PAGE); 98.7% (SEC-HPLC)Colore e forma:LiquidHomotaurine-d6
CAS:<p>Homotaurine-d6 is a deuterated compound of Homotaurine. Homotaurine has a CAS number of 3687-18-1. Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant. Homotaurine has also been investigated as a potential treatment for Alzheimer's disease. It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain. However, clinical trials failed to show improvement compared to placebo.</p>Formula:C3D6H3NO3SColore e forma:SolidPeso molecolare:145.21Eprodisate
CAS:Eprodisate disrupts protein-glycosaminoglycan binding, halting amyloid fibril formation, potentially delaying AA amyloidosis progression.Formula:C3H8O6S2Colore e forma:SolidPeso molecolare:204.224-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
CAS:4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).Formula:C14H11BrN2SPurezza:98%Colore e forma:SolidPeso molecolare:319.22Nicardipine pyridine metabolite II
CAS:<p>Nicardipine pyridine metabolite II is a biaoctive chemical.</p>Formula:C26H27N3O6Colore e forma:SolidPeso molecolare:477.514-(6-Bromo-2-benzothiazolyl)benzenamine
CAS:4-(6-Bromo-2-benzothiazolyl)benzenamine is a β-amyloid PET tracer and can be used in the diagnosis of neurological diseases.Formula:C13H9BrN2SPurezza:98%Colore e forma:SolidPeso molecolare:305.19Aftin-5
CAS:Aftin-5 is an inducer of amyloid beta protein 42 (Aβ42). It functions by modifying the ultrastructure of mitochondria, leading to an upregulation of Aβ42 and a downregulation of Aβ38 through a β-secretase and γ-secretase-dependent mechanism. Aftin-5 exhibits mild cytotoxicity in SH-SY5Y, HT22, N2a, and N2a-AβPP695 cells, with IC50 values of 180, 194, 178, and 150 μM, respectively.Formula:C19H26N6OColore e forma:SolidPeso molecolare:354.45
