CaMK
Gli inibitori della Protein-Chinasi Dipendente dal Calcio/Calmodulina (CaMK) sono composti specializzati che inibiscono l'attività della CaMK, una chinasi critica coinvolta in una varietà di processi cellulari, in particolare nel sistema nervoso. La CaMK è essenziale per tradurre i segnali di calcio in varie risposte cellulari, tra cui la plasticità sinaptica, la formazione della memoria e l'espressione genica. La disregolazione dell'attività della CaMK è associata a numerosi disturbi neurologici, rendendo questi inibitori strumenti preziosi per lo studio della segnalazione sinaptica, dell'apprendimento e della memoria. Presso CymitQuimica, offriamo inibitori della CaMK di alta qualità per supportare la tua ricerca sulla plasticità sinaptica, la funzione cognitiva e la neurofarmacologia.
Trovati 72 prodotti di "CaMK"
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A-3 hydrochloride
CAS:<p>A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.</p>Formula:C12H14Cl2N2O2SPurezza:99.32%Colore e forma:SolidPeso molecolare:321.22Elziverine
CAS:<p>Elziverine: oral calmodulin antagonist, inhibits Ca-induced acanthocyte formation, potential for neurological and cognitive disorder treatment.</p>Formula:C32H37N3O5Purezza:99.79%Colore e forma:SolidPeso molecolare:543.65Dibucaine
CAS:<p>Dibucaine (Cinchocaine), a local anesthetic of the amide type, is now usually used for surface anesthesia.</p>Formula:C20H29N3O2Purezza:99.698% - 99.88%Colore e forma:Colorless Or Almost Colorless Powder SolidPeso molecolare:343.46Y-33075 dihydrochloride
CAS:<p>Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).</p>Formula:C16H18Cl2N4OPurezza:98.88% - 99.89%Colore e forma:SolidPeso molecolare:353.25Trifluoperazine dihydrochloride
CAS:Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.Formula:C21H26Cl2F3N3SPurezza:99.57% - 99.96%Colore e forma:Cream Fine PowderPeso molecolare:480.43Fluphenazine-N-2-chloroethane (hydrochloride)
CAS:Fluphenazine: antipsychotic, binds dopamine D2 (Ki=0.55nM), inhibits calmodulin. Its derivative adds irreversible D2 antagonism and anticancer potential.Formula:C22H27Cl3F3N3SColore e forma:SolidPeso molecolare:528.89CaMKIIα-PHOTAC
<p>CaMKIIα-PHOTAC is a photochemically targeted chimera (PHOTAC) that specifically targets Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα).</p>Formula:C54H58Cl2N10O11Purezza:98%Colore e forma:SolidPeso molecolare:1094TAT-CN21
<p>TatCN21, with an IC 50 of 77 nM, serves as a potent and selective inhibitor peptide of the calcium/calmodulin-dependent protein kinase II (CaMKII), a ubiquitously-expressed multifunctional serine/threonine protein kinase. It is particularly useful in research pertaining to ischemia and neurodegenerative diseases.</p>Formula:C169H303N69O43Colore e forma:SolidPeso molecolare:3989.65Calmodulin Kinase IINtide, Myristoylated
Myristoylated Calmodulin Kinase IINtide (Myr-CaMKIINtide) serves as a selective and noncompetitive inhibitor of CaMKII [1].Formula:C156H275N47O43Purezza:98%Colore e forma:SolidPeso molecolare:3497.14TAT-CN21 (scrambled)
TAT-CN21(scrambled) is a control peptide lacking specific targeting activity and serves as a negative control for TatCN21. TatCN21 is an effective and selective inhibitory peptide for calcium/calmodulin-dependent protein kinase II (CaMKII).Colore e forma:Odour SolidAC3-I, myristoylated
<p>Myristoylated AC3-I is a biologically active peptide and a myristoylated variant of the Autocamtide-3-Derived Inhibitory Peptide (AC3-I).</p>Formula:C78H137N21O20Purezza:98%Colore e forma:SolidPeso molecolare:1689.05Beauverolide Ja
CAS:Beauverolide Ja: cyclotetradepsipeptide, CaM inhibitor; Kd 0.078 μM, Ki 0.39 μM; from Isaria fumosorosea.Formula:C35H46N4O5Colore e forma:SolidPeso molecolare:602.76CALP2
CAS:CALP2 is a CaM antagonist blocking EF-hand/Ca2+ site; inhibits CaM phosphodiesterase, raises Ca2+, and activates alveolar macrophages.Formula:C68H104N14O13SPurezza:98%Colore e forma:SolidPeso molecolare:1357.72Calmodulin-Dependent Protein Kinase II (281-309)
CAS:Calmodulin-Dependent Protein Kinase II (281-309) is a synthetic peptide that can be phosphorylated at Thr286 by PKC and inhibits CaM kinase II (IC50 = 80 nM).Formula:C146H254N46O39S3Purezza:98%Colore e forma:SolidPeso molecolare:3374.06Acremonidin A
CAS:Acremonidin A, from Purpureocillium lilacinum, is a strong CaM inhibitor binding to hCaM M124C-mBBr with a Kd of 19.40 nM.Formula:C33H26O12Colore e forma:SolidPeso molecolare:614.55Fasciculic acid C
CAS:Fasciculic acid C is a calmodulin antagonist isolated from mushroom Naematoloma fasciculare.Formula:C38H63NO11Purezza:98%Colore e forma:SolidPeso molecolare:709.91Fasciculic acid A
CAS:Fasciculic acid A is a calmodulin antagonist isolated from mushroom Naematoloma fasciculare.Formula:C36H60O8Colore e forma:SolidPeso molecolare:620.868RA306
RA306 is an orally active CAMK2 inhibitor that effectively disrupts the PEAK1/CAMK2 signaling pathway. It demonstrates anti-tumor activity by inhibiting proliferation, migration, and invasion of breast cancer cells. Additionally, RA306 shows potential in cardiac disease research, as it improves dilated cardiomyopathy in mice.Colore e forma:Odour SolidCalmodulin Binding Peptide 1
CAS:<p>Calmodulin Binding Peptide 1, a high-affinity MLCK-derived inhibitor, blocks IP3-induced Ca2+ release.</p>Formula:C231H373N69O70S2Purezza:98%Colore e forma:SolidPeso molecolare:5301.1Fasciculic acid B
CAS:Fasciculic acid B: ester of fasciculol B, 3-hydroxy-methylglutaric acid; a calmodulin antagonist from Naematoloma fasciculare.Formula:C36H60O9Purezza:98%Colore e forma:SolidPeso molecolare:636.86Calmodulin-Dependent Protein Kinase II 290-309 acetate
<p>Calmodulin-Dependent Protein Kinase II 290-309 acetate is an effective antagonist of Ca2+/calmodulin-dependent protein kinase II (IC50 = 52 nM).</p>Formula:C105H189N31O26SPurezza:96.7%Colore e forma:SolidPeso molecolare:2333.88Encecalinol
CAS:Encecalinol, a compound isolated from the aerial parts of Ageratina grandifolia, acts as a potent inhibitor of calmodulin [1].Formula:C14H18O3Colore e forma:SolidPeso molecolare:234.29CALP2 TFA
CALP2 TFA, a CaM antagonist with 7.9 µM Kd, blocks CaM-dependent enzymes, boosts Ca2+ levels, and activates macrophages.Formula:C70H105F3N14O15SColore e forma:SolidPeso molecolare:1471.72Cloxacepride
CAS:<p>cloxacepride is a CaM antagonist that is used to treat asthma disease.</p>Formula:C22H27Cl2N3O4Purezza:99.62%Colore e forma:SolidPeso molecolare:468.37Purine riboside-5'-O-triphosphate sodium
CAS:Purine riboside-5'-O-triphosphate sodium is an active metabolite of Nebularine (HY-103694) and acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 µM and 28 µM, respectively. It also inhibits calmodulin-dependent protein kinase II (CaMKII), with a Ki value of 590 µM.Formula:C10H11N4Na4O13P3Peso molecolare:580.09Syntide 2 TFA
Syntide 2 (TFA) is a CaMKII substrate that selectively hinders GA response without affecting other plant processes.Formula:C70H123N20F3O20Colore e forma:SolidPeso molecolare:1621.84CAMKIV Protein, Human, Recombinant (GST)
CAMKIV Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag.Colore e forma:Lyophilized PowderPeso molecolare:79 kDa (predicted); 100 kDa (reducing conditions)NH125
CAS:<p>NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.</p>Formula:C27H45IN2Purezza:98.60%Colore e forma:SolidPeso molecolare:524.56CALP2 acetate(261969-04-4 free base)
<p>CALP2 acetate is an antagonist of calmodulin showing high affinity for binding to the CaM EF-hand/Ca2+-binding site with a Kd of 7.9 µM.</p>Formula:C68H104N14O13SPurezza:97.43%Colore e forma:SolidPeso molecolare:1357.7Syntide 2 acetate(108334-68-5 free base)
Syntide-2 acetate is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII; Km = 12 μM).Formula:C70H126N20O20Purezza:99.74%Colore e forma:SolidPeso molecolare:1567.85Autocamtide-2-related inhibitory peptide
CAS:<p>Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.</p>Formula:C64H116N22O19Purezza:>99.99%Colore e forma:SolidPeso molecolare:1497.74Autocamtide 2 TFA(129198-88-5 free base)
<p>Autocamtide 2 TFA, selective CaMKII peptide substrate, used in its activity assay.</p>Formula:C67H119F3N22O22Purezza:98%Colore e forma:SolidPeso molecolare:1641.79CaMKP Inhibitor
CAS:<p>CaMKP Inhibitor can inhibit CaMKP.</p>Formula:C10H8NNaO7S2Purezza:96.55% - 99.98%Colore e forma:SolidPeso molecolare:341.28GSK3i XIII
CAS:GSK3i XIII (GSK3 inhibitor XIII) is a GSK-3 ATP-binding site inhibitor.Formula:C18H19N5Purezza:98.87%Colore e forma:SolidPeso molecolare:305.38IGS-1.76
CAS:IGS-1.76 binds strongly to hNCS-1, modulates its Ric8a interaction, and inhibits the hNCS-1/Ric8a complex.Formula:C22H18N2OSPurezza:98.18% - 98.56%Colore e forma:SolidPeso molecolare:358.46KN-92
CAS:KN-92 is an inactive analog of the CaM kinase II inhibitor KN 93.Formula:C24H25ClN2O3SColore e forma:SolidPeso molecolare:456.98KN-93
CAS:<p>KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase.</p>Formula:C26H29ClN2O4SPurezza:99.56% - 99.86%Colore e forma:White SolidPeso molecolare:501.04Trifluoperazine
CAS:Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.Formula:C21H24F3N3SPurezza:98.3% - 99.46%Colore e forma:White To Yellowish Crystalline PowderPeso molecolare:407.5CALP1 acetate
<p>CALP1 acetate is a calmodulin (CaM) agonist (Kd of 88 µM) that binds to the CaM EF-hand/Ca2+-binding site.</p>Formula:C42H79N9O12Purezza:99.63%Colore e forma:SolidPeso molecolare:902.13CaMKII-IN-1
CAS:CaMKII-IN-1 is a potent and highly selective inhibitor of CaMKII (IC50 = 63 nM).Formula:C29H30ClN5O2SPurezza:99.69%Colore e forma:SolidPeso molecolare:548.1lavendustin C
CAS:lavendustin C (NSC 666251) is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.Formula:C14H13NO5Purezza:98.06%Colore e forma:Yellow To Tan PowderPeso molecolare:275.26STO-609
CAS:<p>STO-609 inhibits CaM-KKα/KKβ (Ki: 80/15 ng/mL), is specific, cell-permeable, and targets Ca2+/calmodulin-dependent protein kinase kinase.</p>Formula:C19H10N2O3Purezza:97.14% - 98.8%Colore e forma:SolidPeso molecolare:314.29KN-62
CAS:<p>KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.</p>Formula:C38H35N5O6S2Purezza:99.80% - >99.99%Colore e forma:White SolidPeso molecolare:721.84KN-92 hydrochloride
CAS:<p>KN-92 hydrochloride is an inactive derivative of KN-93.</p>Formula:C24H26Cl2N2O3SPurezza:99.68%Colore e forma:SolidPeso molecolare:493.45A-484954
CAS:A-484954 (A 484954) is a highly specific eukaryotic elongation factor-2 (eEF2, IC50: 280 nM) inhibitor.Formula:C13H15N5O3Purezza:97.47% - 99.86%Colore e forma:SolidPeso molecolare:289.29CaM kinase II inhibitor TFA salt
<p>CaM kinase II inhibitor TFA salt (Autocamtide-2-related inhibitory peptide (TFA)) is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.</p>Formula:C66H117F3N22O21Purezza:>99.99%Colore e forma:SolidPeso molecolare:1611.77L-6355
CAS:L-6355 is an agent of bioactive chemicals.Formula:C25H30INO3Colore e forma:SolidPeso molecolare:519.42Zaldaride maleate
CAS:Zaldaride maleate blocks Ca2+, Na+, K+ currents, and nAChR; inhibits CaM cAMP PDE (IC50: 3.3 nM) and estrogen signaling.Formula:C30H32N4O6Purezza:98%Colore e forma:SolidPeso molecolare:544.6TX-1123
CAS:TX-1123: PTK/COX inhibitor, Src/eEF2-K/PKA/EGFR-K/PKC targeted, IC50 of 1.16μM(COX2), 15.7μM(COX1), low mitochondrial toxicity.Formula:C20H24O3Colore e forma:SolidPeso molecolare:312.4Prenylamine lactate
CAS:Prenylamine lactate, an ex-angina drug, depletes heart catecholamines and blocks calcium channels.Formula:C27H33NO3Purezza:98%Colore e forma:SolidPeso molecolare:419.56
