GluR
Gli inibitori dei recettori del glutammato sono composti che bloccano l'attività dei recettori del glutammato, i principali recettori dei neurotrasmettitori eccitatori nel cervello. Questi recettori svolgono un ruolo cruciale nella trasmissione sinaptica, nella plasticità, nell'apprendimento e nella memoria. La disregolazione della segnalazione del glutammato è associata a vari disturbi neurologici, come l'epilessia, l'ictus e le malattie neurodegenerative. Gli inibitori dei recettori del glutammato sono essenziali per studiare i meccanismi dell'eccitotossicità e sviluppare strategie neuroprotettive. Presso CymitQuimica, offriamo una gamma di inibitori dei recettori del glutammato per supportare la vostra ricerca sulla funzione sinaptica, la neuroprotezione e i disturbi cognitivi.
Trovati 261 prodotti di "GluR"
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Basimglurant
CAS:<p>Basimglurant (CTEP Derivative) is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).</p>Formula:C18H13ClFN3Purezza:98.35%Colore e forma:SolidPeso molecolare:325.77LY339434 HCl
LY339434 HCl is a low affinity GluR5 erythrocyte receptor agonist.LY339434 HCl causes rapid neuronal death primarily by affecting N-methyl-D-aspartate (NMDA)Formula:C18H20ClNO4Purezza:97.10% - 97.19%Colore e forma:SoildPeso molecolare:349.81Piracetam
CAS:Piracetam (UCB-6215), a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), is used in therapy of the extensive cognitive disorders.Formula:C6H10N2O2Purezza:97.16%Colore e forma:Crystals From Isopropanol SolidPeso molecolare:142.16AZD-8529 mesylate
CAS:AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM).Formula:C25H28F3N5O6SPurezza:99.19%Colore e forma:SolidPeso molecolare:583.58NBQX disodium
CAS:NBQX Disodium (FG9202 disodium) is a highly selective, competitive AMPA receptor antagonist with neuroprotective and anticonvulsant activity.Formula:C12H6N4Na2O6SPurezza:97.32% - 97.6%Colore e forma:SolidPeso molecolare:380.2415DHPG
CAS:DHPG is a potent Group I mGluR agonist; doesn't affect Group II/III; linked to phospholipase D.Formula:C8H9NO4Purezza:99.55%Colore e forma:SolidPeso molecolare:183.16Org-26576
CAS:Org-26576 is a positive allosteric modulator of the AMPA receptor.Formula:C11H12N2O2Purezza:99.67%Colore e forma:SolidPeso molecolare:204.23VU0650786
CAS:VU0650786: selective mGlu3 NAM, CNS-penetrant, IC50 392 nM, shows antidepressant/anxiolytic effects in rodents.Formula:C18H15ClFN5O2Purezza:99.09%Colore e forma:SolidPeso molecolare:387.8KM02894
CAS:KM02894 inhibits glutamate release, potentially reducing cancer-induced bone pain in tumor studies.Formula:C7H9N3OS2Purezza:99.98%Colore e forma:SolidPeso molecolare:215.3Decoglurant
CAS:<p>Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3 and it also is developed as an antidepressant.</p>Formula:C21H11F6N5Purezza:99.77%Colore e forma:SolidPeso molecolare:447.34γ-DGG acetate(6729-55-1 free base)
CAS:gamma-DGG acetate(6729-55-1 free base) (γ-D-Glutamylglycine) is a competitive blocker of AMPA receptor.Formula:C9H16N2O7Purezza:99.81%Colore e forma:SolidPeso molecolare:264.23(R)-3,4-DCPG HCl
<p>(R)-3,4-DCPG HCl is a potent and selective mGlu8a receptor agonist that activates metabotropic glutamate receptors on primary afferent terminals in the neonatal</p>Formula:C10H10ClNO6Purezza:98.80% - 99.89%Colore e forma:SoildPeso molecolare:275.64(R)-ADX-47273
CAS:<p>(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator(EC50 of 168 nM for potentiation ).</p>Formula:C20H17F2N3O2Purezza:99.87%Colore e forma:SolidPeso molecolare:369.36JF-NP-26
Releases pain-blocking raseglurant under 405 nm light. Inhibits Quisqualate. Analgesic in vivo. Quantum yield: 0.18.Colore e forma:SolidMMPIP hydrochloride
CAS:MMPIP hydrochloride is a selective antagonist of allosteric mGluR7.Formula:C19H16ClN3O3Purezza:99.88%Colore e forma:SolidPeso molecolare:369.8ML353
ML353 activates TREK-1/2, binds mGlu5 SAM (Ki=18.2 nM), surpasses 5mpep, may address SAM activity/blocking.Formula:C19H15FN2OPurezza:99.98% - 99.98%Colore e forma:SoildPeso molecolare:306.33LY3027788
CAS:<p>LY3027788, potent oral prodrug of LY3020371, is a strong mGlu2/3 antagonist with notable antidepressant effects.</p>Formula:C25H31F2NO11SColore e forma:SolidPeso molecolare:591.58MGS0028
CAS:MGS0028 is a selective agonist of metabotropic glutamate 2/3 receptor, it could reverse abnormal behaviors in mice induced by isolation rearing.Formula:C8H8FNO5Colore e forma:SolidPeso molecolare:217.15mGluR5 modulator 1
CAS:mGluR5 modulator 1 is a positive modulator for mGluR5, used in schizophrenia and cognitive research.Formula:C18H19ClFN3O2Colore e forma:SolidPeso molecolare:363.82GYKI-47261 dihydrochloride
CAS:<p>GYKI-47261 dihydrochloride is an AMPA receptor antagonist and CYP2E1 inducer, demonstrating broad-spectrum anticonvulsant and neuroprotective activities.</p>Formula:C18H17Cl3N4Purezza:98.32% - 99.14%Colore e forma:SolidPeso molecolare:395.71(S)-AMPA HCl
(S)-AMPA HCl (L-AMPA HCl) is a selective AMPA receptor agonist with potential antidepressant activity. It can be used in research on Parkinson's disease.Formula:C7H11ClN2O4Purezza:99.18%Colore e forma:SolidPeso molecolare:222.63LY3027788 hydrochloride
CAS:LY3027788 HCl, potent oral prodrug of LY3020371, targets mGlu2/3 with antidepressant effects.Formula:C25H32ClF2NO11SColore e forma:SolidPeso molecolare:628.03STX-107
CAS:<p>STX-107 is a potent and selective mGluR5 agonist for the study of Fragile X Syndrome.</p>Formula:C18H10FN3SPurezza:99.17%Colore e forma:SolidPeso molecolare:319.36(S,S)-BMS-984923
CAS:(S,S)-BMS-984923 is a weak mGluR5 modulator with EC50 >1μM; less active than its potent counterpart.Formula:C22H15ClN2O2Colore e forma:SolidPeso molecolare:374.82LY2812223
CAS:LY2812223: selective mGlu2 agonist; binds mGlu2/mGlu3 (Ki=144/156 nM).Formula:C10H12N4O4SPurezza:98%Colore e forma:SolidPeso molecolare:284.29(S)-3,4-DCPG HCl
<p>(S)-3,4-DCPG HCl is a selective mGluR8a agonist, impacting AV12-664 cells with an EC50 of 31 nM.</p>Formula:C10H10ClNO6Purezza:99.53% - 99.9%Colore e forma:SoildPeso molecolare:275.64DD205-291
CAS:DD205-291 is an orally active PROTAC HPK1 degrader with a DC50 of 5.3 nM. It inhibits SLP-76 phosphorylation and induces IL-2 and IFN-γ.Formula:C38H38ClF3N10O3Colore e forma:SolidPeso molecolare:775.22Pomaglumetad methionil anhydrous
CAS:LY2140023, potential schizophrenia treatment, is an oral prodrug of LY404039, a selective mGlu2/3 agonist.Formula:C12H18N2O7S2Purezza:98%Colore e forma:SolidPeso molecolare:366.41KRP-199 sodium
<p>KRP-199 sodium sodium is highly potent and selective for AMPA-R in vitro and exhibits good neuroprotection in vivo.</p>Formula:C22H12F3N5Na2O7Purezza:97.27%Colore e forma:SoildPeso molecolare:561.33MPPG
CAS:MPPG is a selective L-AP4-sensitive receptor antagonist (kD=9.2 μM).Formula:C9H12NO5PColore e forma:SolidPeso molecolare:245.171mGluR3 modulator-1
CAS:1-ethyl-3-morpholin-4-yl tetrahydroisoquinoline: mGluR3 modulator, potential for Parkinson's.Formula:C16H21N3OPurezza:98.99%Colore e forma:SolidPeso molecolare:271.361H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)-
CAS:<p>1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)- is a low activity isomer of S 18986.</p>Formula:C10H12N2O2SPurezza:99.96%Colore e forma:SoildPeso molecolare:224.28MGS0274
CAS:MGS0274, a lipophilic prodrug of mGlu2/3 agonist MGS0008, enhances oral bioavailability, potentially aiding schizophrenia research.Formula:C21H32FNO7Colore e forma:SolidPeso molecolare:429.485(S)-3,4-DCPG
CAS:(S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a selective agonist of human metabotropic glutamate receptor 8a (mGluR8a).Formula:C10H9NO6Purezza:98%Colore e forma:SolidPeso molecolare:239.18(±)-LY367385
CAS:(±)-LY367385 is the racemic form of LY367385, and LY367385 is a highly potent and selective mGluR1a antagonist.Formula:C10H11NO4Colore e forma:SolidPeso molecolare:209.201L-AP3
CAS:L-AP3 blocks mGluR, inhibits D/L-phosphoserine (IC50: 368/2087 μM).Formula:C3H8NO5PColore e forma:White Hygroscopic SolidPeso molecolare:169.073LY3020371
CAS:LY3020371: potent, selective mGlu 2/3 receptor antagonist with Ki of 5.26 nM (hmGluR2) and 2.50 nM (hmGluR3); key in depression studies.Formula:C15H15F2NO5SColore e forma:SolidPeso molecolare:359.34VU0483605
CAS:<p>VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively.</p>Formula:C20H10Cl3N3O3Purezza:99.61%Colore e forma:SolidPeso molecolare:446.67JNJ-46778212
CAS:JNJ-46778212 (VU 0409551) is a selective and potent mGlu5 allosteric modulator (EC50: 260 nM) for the study of neurodissection.Formula:C20H17FN2O3Purezza:99.24%Colore e forma:SolidPeso molecolare:352.36γ-DGG
CAS:gamma-DGG is a competitive blocker of AMPA receptor.Formula:C7H12N2O5Purezza:98%Colore e forma:SolidPeso molecolare:204.18NS-102
CAS:<p>NS-102 is a glutamate receptor and NMDA receptor antagonist that inhibits erythrocyanine (GluK2) and inhibits specific binding to the glur6 receptor.</p>Formula:C12H11N3O4Purezza:98.48% - 98.95%Colore e forma:SolidPeso molecolare:261.23LY341495
CAS:LY341495 is a potent metabotropic glutamate receptor antagonist and can be used to study neurological disorders.Formula:C20H19NO5Purezza:98.53% - 99.37%Colore e forma:SolidPeso molecolare:353.37AMN082
CAS:AMN082 is an mGluR7 agonist with antidepressant effects. Neuroprotective effect of AMN082 on neuronal apoptosis in rats with traumatic brain injury.Formula:C28H30Cl2N2Purezza:97.13% - 98.63%Colore e forma:SolidPeso molecolare:465.46VU0422288
CAS:<p>VU0422288 (ML396) is a type III mGlu receptor (mGlus) orthosteric modulator with inhibitory effects on mGluR4.VU0422288 can be used to study Rett syndrome.</p>Formula:C17H11Cl2N3O2Purezza:95.48%Colore e forma:SolidPeso molecolare:360.19GYKI 53655 hydrochloride
CAS:GYKI 53655 hydrochloride (LY300168 hydrochloride) is an antagonist of AMPA and is used in the study of neurological disorders.Formula:C19H21ClN4O3Purezza:98.02%Colore e forma:SolidPeso molecolare:388.85GYKI 52466 dihydrochloride
CAS:GYKI 52466 dihydrochloride is an AMPA/Kainate receptor antagonist with anticonvulsant activity and can be used to study neurological diseases.Formula:C17H17Cl2N3O2Purezza:99.38%Colore e forma:SolidPeso molecolare:366.24Ro 01-6128
CAS:Positive allosteric modulator of mGlu1 receptorsFormula:C17H17NO3Purezza:98%Colore e forma:SolidPeso molecolare:283.32VU0364770 hydrochloride
CAS:VU0364770 hydrochloride: potent, selective mGlu4 PAM; EC50=290 nM (rat), 1.1 μM (human).Formula:C12H10Cl2N2OPurezza:98%Colore e forma:SolidPeso molecolare:269.13LY487379
CAS:LY487379: human mGluR2 PAM, boosts glutamate binding, aids cognitive flexibility, may treat schizophrenia. EC50: 1.7 μM (mGlu2), >10 μM (mGlu3).Formula:C21H19F3N2O4SColore e forma:SolidPeso molecolare:452.45EGLU
CAS:EGLU, an antidepressant and potent mGluR-2 antagonist, binds with a 66 μM Kd to (lS,3S)-ACPD sites.Formula:C7H13NO4Purezza:99.98%Colore e forma:SolidPeso molecolare:175.18
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