
GluR
Gli inibitori dei recettori del glutammato sono composti che bloccano l'attività dei recettori del glutammato, i principali recettori dei neurotrasmettitori eccitatori nel cervello. Questi recettori svolgono un ruolo cruciale nella trasmissione sinaptica, nella plasticità, nell'apprendimento e nella memoria. La disregolazione della segnalazione del glutammato è associata a vari disturbi neurologici, come l'epilessia, l'ictus e le malattie neurodegenerative. Gli inibitori dei recettori del glutammato sono essenziali per studiare i meccanismi dell'eccitotossicità e sviluppare strategie neuroprotettive. Presso CymitQuimica, offriamo una gamma di inibitori dei recettori del glutammato per supportare la vostra ricerca sulla funzione sinaptica, la neuroprotezione e i disturbi cognitivi.
Trovati 261 prodotti di "GluR"
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LY392098
CAS:LY392098 (AMPA receptor modulator-3) is an allosteric modulator of AMPA receptor with EC50 of 4.4 μM and can be used in studies about mammalian nervous system.Formula:C18H22FNO2SPurezza:99.86%Colore e forma:SolidPeso molecolare:335.44NS 1209
CAS:NS 1209 (SPD 502) is a AMPA receptor antagonist.Formula:C24H27N4NaO7SPurezza:98%Colore e forma:SolidPeso molecolare:538.55ML337
CAS:ML337 is a negative allosteric modulator of mGlu3 with an IC50 of 593 nM.Formula:C21H20FNO3Purezza:99.83%Colore e forma:SolidPeso molecolare:353.39LY382884
CAS:LY382884 is a selective and potent GluR5 kainate receptor antagonist with anxiolytic activity.LY382884 blocks blockade of mossy fibre LTP induction.Formula:C18H23NO4Purezza:98.32% - 98.71%Colore e forma:SolidPeso molecolare:317.38Ro 67-4853
CAS:Ro 67-4853 is a positive allosteric modulator of mGluR1, selectively enhancing the response to the agonist (S)-3,5-dihydroxy-phenylglycine (DHPG).Formula:C19H19NO4Purezza:98.57%Colore e forma:SolidPeso molecolare:325.36VU0155041 sodium
CAS:VU0155041 sodium is a positive allosteric modulator of mGluR4 that promotes extinction in male rats.Formula:C14H14Cl2NNaO3Purezza:98%Colore e forma:SolidPeso molecolare:338.16HexylHIBO
CAS:HexylHIBO is a type I mGluR antagonist that inhibits mGlu1a and mGlu5a, with Kb values of 140 and 110 μM, respectively.HexylHIBO decreases sEPSC in rats.Formula:C12H20N2O4Purezza:99.55%Colore e forma:SolidPeso molecolare:256.3(S)-MCPG
CAS:(S)-MCPG is the active isomer of (RS)-MCPG, non-selective group I/group II metabotropic glutamate receptor antagonist.Formula:C10H11NO4Purezza:98.72%Colore e forma:SolidPeso molecolare:209.20MFZ 10-7 hydrochloride
CAS:MFZ 10-7 hydrochloride is a highly potent and selective negative allosteric modulator of mGluR5 NAMFormula:C15H10ClFN2Purezza:98%Colore e forma:SolidPeso molecolare:272.71LYPLAL1-IN-1
CAS:LYPLAL1-IN-1 is a selective covalent small-molecule inhibitor of Lysophospholipase-like 1 (IC50: 0.006 μM). LYPLAL1-IN-1 also enhances glucose production.Formula:C29H29N7O4Purezza:98%Colore e forma:SolidPeso molecolare:539.59Methoxy-PEPy
CAS:Methoxy-PEPy is a potent and selective mGlu5 receptor inhibitor with an IC50 value of 1 nM.Formula:C13H10N2OPurezza:98.66%Colore e forma:SolidPeso molecolare:210.23TC-N 22A
CAS:TC-N 22A is a strong, selective, oral active mGlu4 forward allosteric regulator (PAM) that can cross the blood-brain barrier.Formula:C14H13N5SPurezza:99.95%Colore e forma:SolidPeso molecolare:283.35DMeOB
CAS:DMeOB (3,3'-Dimethoxybenzaldazine) is a negative regulator with mGluR5 agonist activity and is used in the study of neurological disorders.Formula:C16H16N2O2Purezza:98.34%Colore e forma:SolidPeso molecolare:268.31(1R,2S)-VU0155041
CAS:(1R,2S)-VU0155041 is the cis regioisomer of VU0155041 and a partial agonist of mGluR4.Formula:C14H15Cl2NO3Purezza:98.85%Colore e forma:SolidPeso molecolare:316.18CPPHA
CAS:<p>CPPHA, a positive allosteric modulator of glutamate receptors mGluR5 and mGluR1, is commonly used in development for central nervous system diseases.</p>Formula:C22H15ClN2O4Purezza:98.07%Colore e forma:SolidPeso molecolare:406.82ML289
CAS:<p>ML289 is a potent CNS-penetrant mGlu3 modulator with IC50 of 0.66 μM, >15-fold selectivity over mGlu2, and inactive against mGlu5.</p>Formula:C22H23NO3Purezza:99.54%Colore e forma:SolidPeso molecolare:349.42(RS)-PPG
CAS:(RS)-PPG: Potent, selective III mGluRs agonist; EC50s: hmGluR4a 5.2μM, hmGluR6 4.7μM, hmGluR7b 185μM, hmGluR8a 0.2μM; neuroprotective, anticonvulsive.Formula:C8H10NO5PPurezza:98%Colore e forma:SolidPeso molecolare:231.14BMT-145027
CAS:BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM).Formula:C23H14ClF3N4Purezza:99.62%Colore e forma:SolidPeso molecolare:438.83VU0431316
CAS:VU0431316 is a negative mGlu5 allosteric modulator. It has activity in a mouse model of anxiety.Formula:C14H9ClN6O2Purezza:98%Colore e forma:SolidPeso molecolare:328.71DCG-IV
CAS:DCG-IV: Class II mGluR agonist; anticonvulsant; neuroprotective; EC50: mGlu2R-0.35μM, mGlu3R-0.09μM; antagonizes Group I/III mGluRs.Formula:C7H9NO6Purezza:98%Colore e forma:SolidPeso molecolare:203.15VU0410425
CAS:VU0410425 is a metabotropic glutamate receptor subtype 1 negative allosteric modulator.Formula:C19H16ClN3O3Purezza:98%Colore e forma:SolidPeso molecolare:369.8HTL14242
CAS:HTL14242 is a mGlu5 Negative Allosteric Modulator.Formula:C16H8ClFN4Colore e forma:SolidPeso molecolare:310.71(S)-3,5-DHPG
CAS:group I mGlu receptor agonistFormula:C8H9NO4Purezza:98%Colore e forma:SolidPeso molecolare:183.16AZ12216052
CAS:<p>AZ12216052 is a GRP8 antagonist with anxiolytic and anti-inflammatory activity and can be used to study obesity and metabolic disorders.</p>Formula:C19H22BrNOSPurezza:99.29%Colore e forma:SolidPeso molecolare:392.35LY487379 hydrochloride
CAS:Positive allosteric modulator of mGlu2 receptorsFormula:C21H20ClF3N2O4SPurezza:98%Colore e forma:SolidPeso molecolare:488.91VU0361747
CAS:VU0361747 is a positive allosteric modulators (PAM) of metabotropic glutamate receptor subtype 5 (mGlu5).Formula:C19H17FN2O2Colore e forma:SolidPeso molecolare:324.35Auglurant
CAS:Auglurant is a novel and selective mGlu5 antagonist (IC50: 11 nM (rat) and an IC50: 14 nM (human)). Auglurant has an acceptable CNS penetration.Formula:C16H12FN5O2Colore e forma:SolidPeso molecolare:325.3Desmethyl-YM 298198
CAS:mGlu1-selective antagonistFormula:C17H21ClN4OSPurezza:98%Colore e forma:SolidPeso molecolare:364.89Foliglurax monohydrochloride
CAS:Foliglurax monohydrochloride, an antiparkinsonian, is a selective brain-penetrant mGluR4 PAM with an EC50 of 79 nM.Formula:C23H24ClN3O3SColore e forma:SolidPeso molecolare:457.97L-CCG-l
CAS:group II metabotropic glutamate receptor agonistFormula:C6H9NO4Purezza:98%Colore e forma:SolidPeso molecolare:159.14(1S,3R)-ACPD
CAS:(1S,3R)-ACPD is a group I and II mGlu receptor agonist.Formula:C7H11NO4Purezza:98%Colore e forma:SolidPeso molecolare:173.17VU0404251
CAS:<p>VU0404251 is a positive allosteric modulator of mGlu5.</p>Formula:C19H23FN2O2Colore e forma:SolidPeso molecolare:330.4Mavoglurant racemate
CAS:Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist. Mavoglurant (racemate) is the racemate of mavoglurant.Formula:C19H23NO3Purezza:98%Colore e forma:SolidPeso molecolare:313.39ACPT-II
CAS:metabotropic receptor antagonistFormula:C8H11NO6Purezza:98%Colore e forma:SolidPeso molecolare:217.18TASP0433864
CAS:TASP0433864 enhances mGlu2 activity; EC50: 199 nM (human), 206 nM (rat); not an agonist.Formula:C18H23N3O3Purezza:98%Colore e forma:SolidPeso molecolare:329.39JNJ-40068782
CAS:JNJ-40068782 is a potent, selective and systemically active positive allosteric modulator of the mGlu2 receptor.Formula:C21H23N3OPurezza:98%Colore e forma:SolidPeso molecolare:333.43DL-AP4 Sodium salt
CAS:Broad spectrum EAA ligandFormula:C4H10NNaO5PPurezza:98%Colore e forma:SolidPeso molecolare:206.09LY456066
CAS:LY456066 is a mGluR1 receptor-selective, negative allosteric modulator.Formula:C19H23N3OSPurezza:98%Colore e forma:SolidPeso molecolare:341.47mGluR2 modulator 4
CAS:Compound 47 is a potent mGluR2 enhancer with an EC50 of 0.8 μM, potentially useful for antipsychotic research.Formula:C18H18BrN3Colore e forma:SolidPeso molecolare:356.26VU0400195
CAS:VU0400195 is a oral effective, positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)).Formula:C21H16ClN3O3Purezza:98%Colore e forma:SolidPeso molecolare:393.82(RS)-4-Carboxy-3-hydroxyphenylglycine
CAS:broad spectrum EAA agonist/antagonistFormula:C9H9NO5Purezza:98%Colore e forma:SolidPeso molecolare:211.17Ro4491533
CAS:Ro4491533 is a potent and selective negative allosteric modulator for group II of the metabotropic glutamate receptors (mGluR2/3).Formula:C24H20F3N3OColore e forma:SolidPeso molecolare:423.43MMPIP
CAS:allosteric mGlu7-selective receptor antagonistFormula:C19H15N3O3Purezza:98%Colore e forma:SolidPeso molecolare:333.34ADX71743
CAS:ADX71743 is a potent and selective negative allosteric modulator of metabotropic glutamate receptor 7.Formula:C17H19NO2Colore e forma:SolidPeso molecolare:269.34LSP4-2022
CAS:LSP4-2022, a mGlu4 selective agonist, increases behavioral despair in mouse models of antidepressant action.Formula:C13H18NO8PPurezza:100%Colore e forma:SolidPeso molecolare:347.26VU0424465
CAS:VU0424465 is a mGlu5-selective allosteric agonist.Formula:C19H19FN2O2Colore e forma:SolidPeso molecolare:326.36VU0409106
CAS:VU0409106 is a potent, mGlu5-selective inhibitor.Formula:C15H11FN4O2SPurezza:98%Colore e forma:SolidPeso molecolare:330.34Remeglurant
CAS:Remeglurant is used as a selective antagonist of the mGlu5 receptor.Formula:C17H15BrN4OColore e forma:SolidPeso molecolare:371.23IEM 1925 dihydrobromide
CAS:AMPA receptor antagonistFormula:C17H30Br2N2Purezza:98%Colore e forma:SolidPeso molecolare:422.24PHCCC(4Me)
CAS:THCCC, a PHCCC analog, is a dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulator.Formula:C18H16N2O3Colore e forma:SolidPeso molecolare:308.33
