BACE
Gli inibitori di BACE sono composti che prendono di mira l'enzima Beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE), cruciale per la produzione di beta-amiloide, una proteina associata alla formazione di placche amiloidi nella malattia di Alzheimer. Inibendo BACE, questi composti mirano a ridurre la produzione di beta-amiloide e la sua accumulazione nel cervello, potenzialmente rallentando la progressione della malattia di Alzheimer. Gli inibitori di BACE sono un focus importante nello sviluppo di strategie terapeutiche per le malattie neurodegenerative. Presso CymitQuimica, offriamo inibitori di BACE per supportare la tua ricerca sulla malattia di Alzheimer, la biologia dell'amiloide e la neurodegenerazione.
Trovati 36 prodotti di "BACE"
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Elenbecestat
CAS:Elenbecestat (E2609) is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of Alzheimer's disease.Formula:C19H18F3N5O2SPurezza:99.95%Colore e forma:SolidPeso molecolare:437.44BACE1 Protein, Human, Recombinant (hFc)
BACE1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Colore e forma:Lyophilized PowderPeso molecolare:75.2 kDa (predicted, pro-form); 72.6 kDa (predicted, mature-form); 85-100 kDa (reducing condition, due to glycosylation)Anti-BACE1 Antibody-FITC (8D358)
Anti-BACE1 Antibody-FITC (8D358) is a FITC-conjugated Rabbit antibody targeting BACE1. Anti-BACE1 Antibody-FITC (8D358) can be used in FCM.Colore e forma:Odour LiquidAnti-BACE1 Antibody-PE (8D358)
<p>Anti-BACE1 Antibody-PE (8D358) is a PE-conjugated Rabbit antibody targeting BACE1. Anti-BACE1 Antibody-PE (8D358) can be used in FCM.</p>Colore e forma:Odour LiquidAnti-BACE1 Antibody (2Z488)
Anti-BACE1 Antibody (2Z488) is a Mouse antibody targeting BACE1. Anti-BACE1 Antibody (2Z488) can be used in ELISA.Colore e forma:Odour LiquidAnti-BACE1 Antibody (2J206)
Anti-BACE1 Antibody (2J206) is an antibody targeting BACE1. Anti-BACE1 Antibody (2J206) can be used in ELISA, WB.Colore e forma:Odour LiquidAnti-BACE1 Antibody (8A762)
<p>Anti-BACE1 Antibody (8A762) is a Rabbit antibody targeting BACE1. Anti-BACE1 Antibody (8A762) can be used in ELISA.</p>Colore e forma:Odour LiquidAnti-BACE1 Antibody (3R945)
Anti-BACE1 Antibody (3R945) is a Mouse antibody targeting BACE1. Anti-BACE1 Antibody (3R945) can be used in ELISA.Colore e forma:Odour LiquidAnti-BACE1 Antibody (8D358)
<p>Anti-BACE1 Antibody (8D358) is a Rabbit antibody targeting BACE1. Anti-BACE1 Antibody (8D358) can be used in FCM,ICC/IF.</p>Colore e forma:Odour LiquidBACE1 Protein, Human, Recombinant
BACE1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 49 kDa and the accession number is A0A024R3D7.Colore e forma:Lyophilized PowderPeso molecolare:49 kDa (predicted); 65 kDa (reducing condition, due to glycosylation)BACE1 Protein, Human, Recombinant (His)
BACE1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Colore e forma:Lyophilized PowderPeso molecolare:49.5 kDa (predicted); 55-70 kDa (reducing condition, due to glycosylation)Verubecestat
CAS:Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.Formula:C17H17F2N5O3SPurezza:94.64% - 99.55%Colore e forma:SolidPeso molecolare:409.41LY2811376
CAS:LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM).Formula:C15H14F2N4SPurezza:99% - 99.01%Colore e forma:SolidPeso molecolare:320.36BACE-IN-1 acetate
BACE-IN-1 acetate (350228-37-4), a BACE1 inhibitor with three disulfide bonds and N-linked glycosylation, is used in assays.Formula:C75H122N16O29Purezza:96.98%Colore e forma:SolidPeso molecolare:1711.86Sophoflavescenol
CAS:Sophoflavescenol: PDE5 inhibitor (K(i) 0.005 µM), antioxidant, anti-inflammatory, pro-apoptotic, potential antitumor, mild side effects.Formula:C21H20O6Purezza:99.65%Colore e forma:SolidPeso molecolare:368.38LX2343
CAS:LX2343 inhibits BACE1 (IC50: 11.43 μM) and PI3K non-competitively (IC50: 15.99 μM), and enhances autophagy for Aβ removal.Formula:C22H19ClN2O6SPurezza:99.45%Colore e forma:SolidPeso molecolare:474.91AZD3839 free base
CAS:AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.Formula:C24H16F3N5Purezza:99.93% - 99.96%Colore e forma:SolidPeso molecolare:431.41Epiberberine
CAS:1.Formula:C20H18NO4Purezza:98.52% - 99.59%Colore e forma:SolidPeso molecolare:336.36LY2886721
CAS:<p>LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.</p>Formula:C18H16F2N4O2SPurezza:99% - 99.75%Colore e forma:SolidPeso molecolare:390.41Aloenin
CAS:<p>1. Aloenin (Aloenin A) and aloe-emodin are active principles for inhibition of c-ADH and c-ALDH activities in vitro.</p>Formula:C19H22O10Purezza:99.42% - 99.69%Colore e forma:SolidPeso molecolare:410.37Scoulerine
CAS:<p>Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1).</p>Formula:C19H21NO4Purezza:98.62%Colore e forma:SolidPeso molecolare:327.37Eslicarbazepine Acetate
CAS:Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use as an adjunctive therapy for partial-onset seizures.Formula:C17H16N2O3Purezza:99.58% - >99.99%Colore e forma:White To Off-White SolidPeso molecolare:296.32Aloeresin D
CAS:<p>Aloeresin D, a natural chromone glycoside, inhibits β-Secretase (BACE1) activity (IC50: 39 μM).</p>Formula:C29H32O11Purezza:98.11% - 99.57%Colore e forma:SolidPeso molecolare:556.56Umibecestat HCl
CAS:<p>Umibecestat HCl (CNP520 HCl) is an efficient β-secretase (BACE1/BACE2) inhibitor that reduces Aβ levels in mice and rats.</p>Formula:C19H16Cl2F7N5O2Purezza:99.92%Colore e forma:SolidPeso molecolare:550.26Tenuifolin
CAS:Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.Formula:C36H56O12Purezza:97.37% - 99.54%Colore e forma:SolidPeso molecolare:680.82Epiberberine chloride
CAS:Epiberberine chloride, a natural pro-berberine from Coptis chinensis Franch. is an AChE, BChE, and BACE1 inhibitor.Formula:C20H18ClNO4Purezza:99.89%Colore e forma:SolidPeso molecolare:371.81Lanabecestat
CAS:Lanabecestat (AZD3293) is a BACE1 inhibitor (Ki: 0.4 nM), Lanabecestat is used in the study of neurological diseases like Alzheimer's disease.Formula:C26H28N4OPurezza:98.55%Colore e forma:SolidPeso molecolare:412.53BACE1-IN-1
CAS:BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).Formula:C18H14F3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:389.33Atabecestat
CAS:Atabecestat (JNJ-54861911) is an oral BACE1 inhibitor for Alzheimer's treatment with strong brain uptake and lasting PK/PD effects.Formula:C18H14FN5OSPurezza:99.21% - 99.77%Colore e forma:SolidPeso molecolare:367.4BACE1-IN-2
CAS:<p>BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).</p>Formula:C19H15F4N5O2Purezza:98%Colore e forma:SolidPeso molecolare:421.35AM-6494
CAS:AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).Formula:C22H21F2N5O3SPurezza:98%Colore e forma:SolidPeso molecolare:473.5PF-06751979
CAS:PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).Formula:C18H19F2N5O3S2Purezza:98%Colore e forma:SolidPeso molecolare:455.5BACE1-IN-5
CAS:<p>BACE1-IN-5 inhibits BACE1 (IC50: 9.1 nM) & Aβ production (IC50: 0.82 nM), enhances hERG inhibition & P-gp efflux.</p>Formula:C18H16F5N5O2SPurezza:98%Colore e forma:SolidPeso molecolare:461.41BACE1-IN-4
CAS:BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.Formula:C21H23F2N5O4S2Purezza:98%Colore e forma:SolidPeso molecolare:511.57Umibecestat
CAS:<p>Umibecestat inhibits human and mouse BACE-1 (IC50: 11 nM & 10 nM), potentially for Alzheimer's research.</p>Formula:C19H15ClF7N5O2Purezza:99.88%Colore e forma:SolidPeso molecolare:513.8NB-360
CAS:NB-360: potent, brain-penetrant BACE1/2 inhibitor; IC50s: 5-6 nM; high selectivity vs pepsin, cathepsin E/D.Formula:C21H19F4N5O2Purezza:99.72%Colore e forma:SolidPeso molecolare:449.4
