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BACE

BACE

Gli inibitori di BACE sono composti che prendono di mira l'enzima Beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE), cruciale per la produzione di beta-amiloide, una proteina associata alla formazione di placche amiloidi nella malattia di Alzheimer. Inibendo BACE, questi composti mirano a ridurre la produzione di beta-amiloide e la sua accumulazione nel cervello, potenzialmente rallentando la progressione della malattia di Alzheimer. Gli inibitori di BACE sono un focus importante nello sviluppo di strategie terapeutiche per le malattie neurodegenerative. Presso CymitQuimica, offriamo inibitori di BACE per supportare la tua ricerca sulla malattia di Alzheimer, la biologia dell'amiloide e la neurodegenerazione.

Trovati 35 prodotti per "BACE".

prodotti per pagina.
  • Sophoflavescenol
    Targetmol
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    Sophoflavescenol

    CAS:
    Sophoflavescenol: PDE5 inhibitor (K(i) 0.005 µM), antioxidant, anti-inflammatory, pro-apoptotic, potential antitumor, mild side effects.
    Formula:C21H20O6
    Purezza:99.65%
    Colore e forma:Solid
    Peso molecolare:368.3799

    Ref: TM-TN2217

  • LX2343
    Targetmol
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    LX2343

    CAS:
    LX2343 inhibits BACE1 (IC50: 11.43 μM) and PI3K non-competitively (IC50: 15.99 μM), and enhances autophagy for Aβ removal.
    Formula:C22H19ClN2O6S
    Purezza:99.45%
    Colore e forma:Solid
    Peso molecolare:474.914

    Ref: TM-T4398

  • Umibecestat HCl
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    Umibecestat HCl

    CAS:
    Umibecestat HCl (CNP520 HCl) is an efficient β-secretase (BACE1/BACE2) inhibitor that reduces Aβ levels in mice and rats.
    Formula:C19H16Cl2F7N5O2
    Purezza:99.92%
    Colore e forma:White Solid
    Peso molecolare:550.26

    Ref: TM-T69664

  • Epiberberine chloride
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    Epiberberine chloride

    CAS:
    Epiberberine chloride, a natural pro-berberine from Coptis chinensis Franch. is an AChE, BChE, and BACE1 inhibitor.
    Formula:C20H18ClNO4
    Purezza:99.97%
    Colore e forma:Orange Solid
    Peso molecolare:371.814

    Ref: TM-T8306

  • DSS30
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    DSS30

    CAS:
    DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid secretion to help prevent Alzheimer's.
    Formula:C16H14ClNO3S2
    Purezza:99.19% - 99.4%
    Colore e forma:Solid
    Peso molecolare:367.87

    Ref: TM-T61439

  • BACE1-IN-1
    Targetmol
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    BACE1-IN-1

    CAS:
    BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
    Formula:C18H14F3N5O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:389.3313

    Ref: TM-T10450

  • Lanabecestat
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    Lanabecestat

    CAS:
    Lanabecestat (AZD3293) is a BACE1 inhibitor (Ki: 0.4 nM), Lanabecestat is used in the study of neurological diseases like Alzheimer's disease.
    Formula:C26H28N4O
    Purezza:98.55%
    Colore e forma:Solid
    Peso molecolare:412.5267

    Ref: TM-TQ0238

  • Atabecestat
    Targetmol
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    Atabecestat

    CAS:
    Atabecestat (JNJ-54861911) is an oral BACE1 inhibitor for Alzheimer's treatment with strong brain uptake and lasting PK/PD effects.
    Formula:C18H14FN5OS
    Purezza:99.27% - 99.87%
    Colore e forma:Solid
    Peso molecolare:367.4

    Ref: TM-T14338

  • BACE1-IN-5
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    BACE1-IN-5

    CAS:
    BACE1-IN-5 inhibits BACE1 (IC50: 9.1 nM) & Aβ production (IC50: 0.82 nM), enhances hERG inhibition & P-gp efflux.
    Formula:C18H16F5N5O2S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:461.41

    Ref: TM-T10453

  • AM-6494
    Targetmol
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    AM-6494

    CAS:
    AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).
    Formula:C22H21F2N5O3S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:473.5

    Ref: TM-T10292

  • PF-06751979
    Targetmol
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    PF-06751979

    CAS:
    PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
    Formula:C18H19F2N5O3S2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:455.502

    Ref: TM-T12429

  • BACE1-IN-2
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    BACE1-IN-2

    CAS:
    BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).
    Formula:C19H15F4N5O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:421.35

    Ref: TM-T10451

  • Umibecestat
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    Umibecestat

    CAS:
    Umibecestat inhibits human and mouse BACE-1 (IC50: 11 nM & 10 nM), potentially for Alzheimer's research.
    Formula:C19H15ClF7N5O2
    Purezza:99.88%
    Colore e forma:Solid
    Peso molecolare:513.797

    Ref: TM-T13253

  • NB-360
    Targetmol
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    NB-360

    CAS:
    NB-360: potent, brain-penetrant BACE1/2 inhibitor; IC50s: 5-6 nM; high selectivity vs pepsin, cathepsin E/D.
    Formula:C21H19F4N5O2
    Purezza:99.72%
    Colore e forma:Solid
    Peso molecolare:449.4015

    Ref: TM-T12188

  • AZD3839 free base
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    AZD3839 free base

    CAS:
    AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
    Formula:C24H16F3N5
    Purezza:99.93% - 99.96%
    Colore e forma:White Solid
    Peso molecolare:431.4125

    Ref: TM-T6772