BACE
Gli inibitori di BACE sono composti che prendono di mira l'enzima Beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE), cruciale per la produzione di beta-amiloide, una proteina associata alla formazione di placche amiloidi nella malattia di Alzheimer. Inibendo BACE, questi composti mirano a ridurre la produzione di beta-amiloide e la sua accumulazione nel cervello, potenzialmente rallentando la progressione della malattia di Alzheimer. Gli inibitori di BACE sono un focus importante nello sviluppo di strategie terapeutiche per le malattie neurodegenerative. Presso CymitQuimica, offriamo inibitori di BACE per supportare la tua ricerca sulla malattia di Alzheimer, la biologia dell'amiloide e la neurodegenerazione.
Trovati 37 prodotti per "BACE".
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Epiberberine
CAS:1.Formula:C20H18NO4Purezza:98.52% - 99.59%Colore e forma:SolidPeso molecolare:336.36LY2811376
CAS:LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM).Formula:C15H14F2N4SPurezza:99% - 99.01%Colore e forma:SolidPeso molecolare:320.36Ref: TM-T2639
1mg50,00€2mg70,00€5mg116,00€1mL*10mM (DMSO)116,00€10mg195,00€25mg354,00€50mg530,00€100mg758,00€AZD3839 free base
CAS:AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.Formula:C24H16F3N5Purezza:99.93% - 99.96%Colore e forma:White SolidPeso molecolare:431.41BACE-IN-1 acetate
BACE-IN-1 acetate (350228-37-4), a BACE1 inhibitor with three disulfide bonds and N-linked glycosylation, is used in assays.Formula:C75H122N16O29Purezza:99.71%Colore e forma:SolidPeso molecolare:1711.86Verubecestat
CAS:Verubecestat (MK-8931) (MK-8931) is an effective and specific β-secretase inhibitor and β-site APP-cleaving enzyme 1 inhibitor or BACE1 protein inhibitor.Formula:C17H17F2N5O3SPurezza:94.64% - 99.55%Colore e forma:SolidPeso molecolare:409.41Ref: TM-T7011
2mg38,00€5mg57,00€1mL*10mM (DMSO)63,00€10mg84,00€25mg144,00€50mg205,00€100mg334,00€500mg782,00€Epiberberine chloride
CAS:Epiberberine chloride, a natural pro-berberine from Coptis chinensis Franch. is an AChE, BChE, and BACE1 inhibitor.Formula:C20H18ClNO4Purezza:99.89%Colore e forma:Orange SolidPeso molecolare:371.81DSS30
CAS:DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid secretion to help prevent Alzheimer's.Formula:C16H14ClNO3S2Purezza:99.19% - 99.4%Colore e forma:SolidPeso molecolare:367.87Lanabecestat
CAS:Lanabecestat (AZD3293) is a BACE1 inhibitor (Ki: 0.4 nM), Lanabecestat is used in the study of neurological diseases like Alzheimer's disease.Formula:C26H28N4OPurezza:98.55%Colore e forma:SolidPeso molecolare:412.53BACE1-IN-1
CAS:BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).Formula:C18H14F3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:389.33Atabecestat
CAS:Atabecestat (JNJ-54861911) is an oral BACE1 inhibitor for Alzheimer's treatment with strong brain uptake and lasting PK/PD effects.Formula:C18H14FN5OSPurezza:99.21% - 99.77%Colore e forma:SolidPeso molecolare:367.4Ref: TM-T14338
1mg123,00€5mg295,00€1mL*10mM (DMSO)326,00€10mg477,00€25mg954,00€50mg1.279,00€100mg1.728,00€BACE1-IN-2
CAS:BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).Formula:C19H15F4N5O2Purezza:98%Colore e forma:SolidPeso molecolare:421.35BACE1-IN-5
CAS:BACE1-IN-5 inhibits BACE1 (IC50: 9.1 nM) & Aβ production (IC50: 0.82 nM), enhances hERG inhibition & P-gp efflux.Formula:C18H16F5N5O2SPurezza:98%Colore e forma:SolidPeso molecolare:461.41PF-06751979
CAS:PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).Formula:C18H19F2N5O3S2Purezza:98%Colore e forma:SolidPeso molecolare:455.5AM-6494
CAS:AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).Formula:C22H21F2N5O3SPurezza:98%Colore e forma:SolidPeso molecolare:473.5BACE1-IN-4
CAS:BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.Formula:C21H23F2N5O4S2Purezza:98%Colore e forma:SolidPeso molecolare:511.57Umibecestat
CAS:Umibecestat inhibits human and mouse BACE-1 (IC50: 11 nM & 10 nM), potentially for Alzheimer's research.Formula:C19H15ClF7N5O2Purezza:99.88%Colore e forma:SolidPeso molecolare:513.8Ref: TM-T13253
1mg163,00€5mg334,00€1mL*10mM (DMSO)376,00€10mg485,00€25mg807,00€50mg1.099,00€100mg1.485,00€NB-360
CAS:NB-360: potent, brain-penetrant BACE1/2 inhibitor; IC50s: 5-6 nM; high selectivity vs pepsin, cathepsin E/D.Formula:C21H19F4N5O2Purezza:99.72%Colore e forma:SolidPeso molecolare:449.4Ref: TM-T12188
1mg104,00€5mg215,00€1mL*10mM (DMSO)235,00€10mg318,00€25mg510,00€50mg692,00€100mg888,00€500mg1.783,00€
