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BACE

BACE

Gli inibitori di BACE sono composti che prendono di mira l'enzima Beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE), cruciale per la produzione di beta-amiloide, una proteina associata alla formazione di placche amiloidi nella malattia di Alzheimer. Inibendo BACE, questi composti mirano a ridurre la produzione di beta-amiloide e la sua accumulazione nel cervello, potenzialmente rallentando la progressione della malattia di Alzheimer. Gli inibitori di BACE sono un focus importante nello sviluppo di strategie terapeutiche per le malattie neurodegenerative. Presso CymitQuimica, offriamo inibitori di BACE per supportare la tua ricerca sulla malattia di Alzheimer, la biologia dell'amiloide e la neurodegenerazione.

Trovati 36 prodotti di "BACE"

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  • Scoulerine
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    Scoulerine

    CAS:
    <p>Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1).</p>
    Formula:C19H21NO4
    Purezza:98.62%
    Colore e forma:Solid
    Peso molecolare:327.37

    Ref: TM-TN2190

  • Eslicarbazepine Acetate
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    Eslicarbazepine Acetate

    CAS:
    Eslicarbazepine Acetate (Zebinix) is an anticonvulsant medication approved for use as an adjunctive therapy for partial-onset seizures.
    Formula:C17H16N2O3
    Purezza:99.58% - >99.99%
    Colore e forma:White To Off-White Solid
    Peso molecolare:296.32

    Ref: TM-T3285

  • Aloeresin D
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    Aloeresin D

    CAS:
    <p>Aloeresin D, a natural chromone glycoside, inhibits β-Secretase (BACE1) activity (IC50: 39 μM).</p>
    Formula:C29H32O11
    Purezza:98.11% - 99.57%
    Colore e forma:Solid
    Peso molecolare:556.56

    Ref: TM-T8179

  • Umibecestat HCl
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    Umibecestat HCl

    CAS:
    <p>Umibecestat HCl (CNP520 HCl) is an efficient β-secretase (BACE1/BACE2) inhibitor that reduces Aβ levels in mice and rats.</p>
    Formula:C19H16Cl2F7N5O2
    Purezza:99.92%
    Colore e forma:Solid
    Peso molecolare:550.26

    Ref: TM-T69664

  • Tenuifolin
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    Tenuifolin

    CAS:
    Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.
    Formula:C36H56O12
    Purezza:97.37% - 99.54%
    Colore e forma:Solid
    Peso molecolare:680.82

    Ref: TM-T3769

  • Epiberberine chloride
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    Epiberberine chloride

    CAS:
    Epiberberine chloride, a natural pro-berberine from Coptis chinensis Franch. is an AChE, BChE, and BACE1 inhibitor.
    Formula:C20H18ClNO4
    Purezza:99.89%
    Colore e forma:Solid
    Peso molecolare:371.81

    Ref: TM-T8306

  • Lanabecestat
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    Lanabecestat

    CAS:
    Lanabecestat (AZD3293) is a BACE1 inhibitor (Ki: 0.4 nM), Lanabecestat is used in the study of neurological diseases like Alzheimer's disease.
    Formula:C26H28N4O
    Purezza:98.55%
    Colore e forma:Solid
    Peso molecolare:412.53

    Ref: TM-TQ0238

  • BACE1-IN-1
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    BACE1-IN-1

    CAS:
    BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
    Formula:C18H14F3N5O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:389.33

    Ref: TM-T10450

  • Atabecestat
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    Atabecestat

    CAS:
    Atabecestat (JNJ-54861911) is an oral BACE1 inhibitor for Alzheimer's treatment with strong brain uptake and lasting PK/PD effects.
    Formula:C18H14FN5OS
    Purezza:99.21% - 99.77%
    Colore e forma:Solid
    Peso molecolare:367.4

    Ref: TM-T14338

  • BACE1-IN-2
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    BACE1-IN-2

    CAS:
    <p>BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).</p>
    Formula:C19H15F4N5O2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:421.35

    Ref: TM-T10451

  • AM-6494
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    AM-6494

    CAS:
    AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).
    Formula:C22H21F2N5O3S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:473.5

    Ref: TM-T10292

  • PF-06751979
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    PF-06751979

    CAS:
    PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
    Formula:C18H19F2N5O3S2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:455.5

    Ref: TM-T12429

  • BACE1-IN-5
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    BACE1-IN-5

    CAS:
    <p>BACE1-IN-5 inhibits BACE1 (IC50: 9.1 nM) &amp; Aβ production (IC50: 0.82 nM), enhances hERG inhibition &amp; P-gp efflux.</p>
    Formula:C18H16F5N5O2S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:461.41

    Ref: TM-T10453

  • BACE1-IN-4
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    BACE1-IN-4

    CAS:
    BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.
    Formula:C21H23F2N5O4S2
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:511.57

    Ref: TM-T10452

  • Umibecestat
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    Umibecestat

    CAS:
    <p>Umibecestat inhibits human and mouse BACE-1 (IC50: 11 nM &amp; 10 nM), potentially for Alzheimer's research.</p>
    Formula:C19H15ClF7N5O2
    Purezza:99.88%
    Colore e forma:Solid
    Peso molecolare:513.8

    Ref: TM-T13253

  • NB-360
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    NB-360

    CAS:
    NB-360: potent, brain-penetrant BACE1/2 inhibitor; IC50s: 5-6 nM; high selectivity vs pepsin, cathepsin E/D.
    Formula:C21H19F4N5O2
    Purezza:99.72%
    Colore e forma:Solid
    Peso molecolare:449.4

    Ref: TM-T12188