Proteasoma
Gli inibitori del proteasoma sono composti che inibiscono il proteasoma, un grande complesso proteico responsabile della degradazione delle proteine non desiderate o danneggiate all'interno della cellula. L'inibizione del proteasoma porta all'accumulo di proteine, che può indurre l'arresto del ciclo cellulare e l'apoptosi, in particolare nelle cellule che si dividono rapidamente, come le cellule tumorali. Gli inibitori del proteasoma sono fondamentali nella ricerca e nella terapia del cancro, specialmente nel trattamento del mieloma multiplo e di altre neoplasie ematologiche. Presso CymitQuimica, offriamo inibitori del proteasoma per supportare la tua ricerca in oncologia, biologia cellulare e sviluppo di farmaci.
Trovati 84 prodotti per "Proteasoma".
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Calpastatin subdomain B
CAS:Calpastatin subdomain B is a bioactive peptide that inhibits calpain activity.Formula:C140H227N35O44SPurezza:98%Colore e forma:SolidPeso molecolare:3136.57Proteasome-IN-7
Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.Formula:C48H56N6O10SColore e forma:SolidPeso molecolare:909.06Acetyl-Calpastatin(184-210)(human), Negative Control
Acetyl-Calpastatin(184-210)(human), Negative Control is a control scrambled peptide corresponding to Acetyl-Calpastatin(184-210)(human). Acetyl-Calpastatin(184-210)(human) functions as a potent, selective, and reversible calpain inhibitor.Formula:C142H230N36O44SColore e forma:SolidPeso molecolare:3175.65874DPP8/9-IN-1
DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.Colore e forma:Odour SolidDazcapistat
CAS:Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.Formula:C21H18FN3O4Purezza:99.11%Colore e forma:SolidPeso molecolare:395.38Ref: TM-T9710
1mg92,00€5mg192,00€1mL*10mM (DMSO)212,00€10mg289,00€25mg522,00€50mg732,00€100mg1.018,00€Phepropeptin D
CAS:Phepropeptin D is a secondary metabolite produced by microorganisms and acts as a proteasome (proteasome) inhibitor, with an IC50 of 7.8 μg/mL.Formula:C41H58N6O6Colore e forma:SolidPeso molecolare:730.94VAMP
VAMP is a tetrapeptide that acts as a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor, exhibiting an IC50 of 1.00 μM and a Kd of 6.89 μM. It effectively targets the DPP-IV-GLP-1 axis and is utilized in the research of type 2 diabetes.Formula:C18H32N4O5SColore e forma:SolidPeso molecolare:416.535Protease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Colore e forma:Odour SolidRef: TM-L1100
1mgPrezzo su richiesta10μL*10mM (DMSO)Prezzo su richiesta20μL*10mM (DMSO)Prezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaPhepropeptin C
CAS:Phepropeptin C is a microbial secondary metabolite that acts as a proteasome (proteasome) inhibitor, with an IC50 of 12.5 μg/mL.Formula:C38H60N6O6Colore e forma:SolidPeso molecolare:696.92LMP7/LMP2-IN-1
CAS:LMP7/LMP2-IN-1 (Compound 19) is an orally effective inhibitor targeting the immunoproteasome subunits LMP7 and LMP2, with respective IC50 values of 257 and 10 nM. This compound reduces the production of antibodies and downregulates the B cells in the germinal centers of the spleen and plasma cells in NP-OVA immunized mice. It has potential applications in the study of autoimmune diseases.Formula:C16H27BN4O3Colore e forma:SoildPeso molecolare:334.22Alogliptin-13CD3
CAS:Alogliptin (SYR-322) 13CD3 is the deuterium-labeled Alogliptin. Alogliptin is a selective inhibitor of DPP-4.Formula:C18H21N5O2Purezza:98%Colore e forma:SolidPeso molecolare:343.4Teneligliptin-D8
CAS:Teneligliptin D8 a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting inhibitor of DPP-4.Formula:C22H30N6OSPurezza:98%Colore e forma:SolidPeso molecolare:434.635-Amino-8-hydroxyquinoline
CAS:5-Amino-8-hydroxyquinoline(5A8HQ),Proteasome inhibitor. Potential anticancer agent.Formula:C9H8N2OPurezza:99.69%Colore e forma:SolidPeso molecolare:160.17H-Pro-Lys-OH TFA
H-Pro-Lys-OH TFA is a dipeptide composed of proline and lysine, serving as a substrate for imino dipeptidase (prolinase). Additionally, it can be utilized in peptide synthesis.Formula:C13H22F3N3O5Colore e forma:SolidPeso molecolare:357.33ONX-0914
CAS:ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.Formula:C31H40N4O7Purezza:98.24% - 99.31%Colore e forma:SolidPeso molecolare:580.67MDL-28170
CAS:MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.Formula:C22H26N2O4Purezza:95.06%Colore e forma:SolidPeso molecolare:382.45Ref: TM-T2470
1mg34,00€2mg49,00€5mg71,00€1mL*10mM (DMSO)75,00€10mg90,00€25mg128,00€50mg167,00€100mg284,00€Alloxan monohydrate
CAS:Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.Formula:C4H4N2O5Purezza:99.01% - 99.42%Colore e forma:SolidPeso molecolare:160.09ISOGINKGETIN
CAS:ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion.Formula:C32H22O10Purezza:98% - 99.75%Colore e forma:Yellow SolidPeso molecolare:566.514'-Hydroxychalcone
CAS:4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activityFormula:C15H12O2Purezza:99.86% - 99.87%Colore e forma:Yellow-Cream PowderPeso molecolare:224.25PI-1840
CAS:PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.Formula:C22H26N4O3Purezza:98.82%Colore e forma:SolidPeso molecolare:394.47
