Proteasoma
Gli inibitori del proteasoma sono composti che inibiscono il proteasoma, un grande complesso proteico responsabile della degradazione delle proteine non desiderate o danneggiate all'interno della cellula. L'inibizione del proteasoma porta all'accumulo di proteine, che può indurre l'arresto del ciclo cellulare e l'apoptosi, in particolare nelle cellule che si dividono rapidamente, come le cellule tumorali. Gli inibitori del proteasoma sono fondamentali nella ricerca e nella terapia del cancro, specialmente nel trattamento del mieloma multiplo e di altre neoplasie ematologiche. Presso CymitQuimica, offriamo inibitori del proteasoma per supportare la tua ricerca in oncologia, biologia cellulare e sviluppo di farmaci.
Trovati 84 prodotti per "Proteasoma".
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Ixazomib
CAS:Ixazomib (MLN2238) is a boron-based peptide proteasome inhibitor targeting β5 site (IC50: 3.4 nM), also affecting β1 and β2 sites.Formula:C14H19BCl2N2O4Purezza:98% - 99.77%Colore e forma:SolidPeso molecolare:361.03VR23
CAS:VR23: Potent proteasome inhibitor; IC50: 1 nM trypsin, 50-100 nM chymotrypsin, 3 μM caspase-like.Formula:C19H16ClN5O6SPurezza:98.99% - 99.22%Colore e forma:White SolidPeso molecolare:477.88Delanzomib
CAS:Delanzomib (CEP-18770) is an oral proteasome inhibitor with an IC50 of 3.8 nM, targeting chymotrypsin-like activity with minimal effect on other activities.Formula:C21H28BN3O5Purezza:95.52% - 99.46%Colore e forma:SolidPeso molecolare:413.28Ref: TM-T6027
1mg43,00€1mL*10mM (DMSO)89,00€5mg92,00€10mg133,00€25mg260,00€50mg416,00€100mg625,00€200mg868,00€PSI
CAS:PSI is a proteasome inhibitor.Formula:C32H50N4O8Purezza:97% - 98.33%Colore e forma:SolidPeso molecolare:618.76KZR-504
CAS:KZR-504 is a selective inhibitor of immunoproteasome low molecular mass polypeptide 2 (LMP2) (IC50s: 51 nM, 4.274 μM for LMP2 and LMP7, respectively).Formula:C21H23N3O6Colore e forma:SolidPeso molecolare:413.42Diprotin B
CAS:Diprotin B is a dipeptidyl peptidase IV inhibitor.Formula:C16H29N3O4Purezza:98%Colore e forma:SolidPeso molecolare:327.42BC-23
CAS:BC-23 (NSC 45382) is a proteasome inhibitor with antitumor and antimicrobial activity for the study of leukemia and small cell lung cancer.Formula:C21H14ClN3O4SPurezza:99.99%Colore e forma:SolidPeso molecolare:439.87Proteasome-IN-1
CAS:Proteasome-IN-1 is an inhibitor of proteasome.Formula:C42H35N5O3Purezza:98%Colore e forma:SolidPeso molecolare:657.76Z-LLF-CHO
CAS:Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) effectively inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex with a Ki value of 460 nM.Formula:C29H39N3O5Purezza:98%Colore e forma:SolidPeso molecolare:509.6420S Proteasome activator 1
CAS:20S Proteasome activator 1: IC50—0.3 μM (trypsin), 0.7 μM (chymotrypsin), 1.8 μM (caspase); reduces alpha-synuclein A53T, aids neurodegenerative studies.Formula:C27H19ClF2N2OSPurezza:99.82%Colore e forma:SolidPeso molecolare:492.97Arimoclomol
CAS:Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (Formula:C14H20ClN3O3Purezza:99.15%Colore e forma:SolidPeso molecolare:313.78Proteasome β2c/i-IN-1
CAS:Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].Formula:C32H48N4O7Purezza:98%Colore e forma:SolidPeso molecolare:600.75Proteasome-IN-5
CAS:Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].Formula:C20H30BN5O7Purezza:98%Colore e forma:SolidPeso molecolare:463.29LU-002i
CAS:LU-002i is a selective inhibitor targeting the human proteasome subunits β2c and β2i, demonstrating an inhibitory concentration (IC50) of 220 nM for β2i [1].Formula:C35H52N4O7Purezza:98%Colore e forma:SolidPeso molecolare:640.81Gemigliptin tartrate hydrate
CAS:Gemigliptin (LC15-0444) tartrate hydrate is a selective, reversible, and competitive inhibitor of dipeptidyl peptidase 4 (DPP-4), with an IC50 value of 10.3 nM for human recombinant DPP-4. It exhibits strong anti-glycation properties and is used in research on advanced glycation end product-related diabetic complications.Formula:C22H27F8N5O9Colore e forma:SolidPeso molecolare:657.47Immunoproteasome activator 1
CAS:Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.Formula:C24H23N3O3Colore e forma:SolidPeso molecolare:401.46TCL1
CAS:TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.Formula:C19H14BrClN4O2SColore e forma:SolidPeso molecolare:477.762PB01
CAS:PB01 is a DPP-4 inhibitor with an IC50 of 15.66 nM. It effectively suppresses high glucose-induced ROS generation and mitochondrial superoxide production while significantly reducing the cellular expression of DPP-4. Additionally, PB01 notably lowers blood glucose levels in diabetic mice. It demonstrates excellent safety, exhibiting almost no cytotoxicity at a concentration of 100 μM. PB01 holds promise for research in the diabetes field.Formula:C18H21N5O3Colore e forma:SolidPeso molecolare:355.391ZINC09518833
CAS:ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).Formula:C24H25N3O5Colore e forma:SolidPeso molecolare:435.47RBx-0597
CAS:RBx-0597 is a selective DPP-IV inhibitor with IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. It is utilized in research focused on type 2 diabetes.Formula:C19H20F2N4O2Colore e forma:SolidPeso molecolare:374.384
