Wnt/beta-catenina

Windorphen is a Wnt inhibitor that selectively abrogates the Wnt signaling.

DK419 is an orally active inhibitor of Wnt/β-catenin signaling (IC50: 0.19 μM). DK419 decreases protein …

1. Isoquercitrin is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. …

1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. …

WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the …

WWL70 is a selective alpha/beta hydrolase domain 6 inhibitors (IC50: 70 nM).

HLY78 targets the DIX domain of Axin, is an activator of the Wnt/β-catenin signaling pathway …

K-756 is a direct and selective inhibitor of tankyrase (TNKS), which inhibits the ADP-ribosylation activity …

Toxoflavin is an antagonist of transcription factor 4 (TCF4)/β-catenin complex. Toxoflavin also acts as an …

KY-05009 pharmacologically inhibits TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells. KY-05009 inhibits the …

Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, …

Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor. It has anti-inflammatory activity and has the …

L-quebrachitol is a natural product.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as …

β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin

EMT inhibitor -1 is an inhibitor of Hippo, Wnt signaling and TGF- macrophages (TGF-) with …

FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for MAT2A binding. FIDAS-3 has anticancer activities. FIDAS-3 is …

iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays …

MSAB is a selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin, promoting its degradation, …

iCRT3 is a Wnt and β-catenin-responsive transcription inhibitor.

KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash …

Salinomycin sodium salt, an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.

Cardiogenol C hydrochloride can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).

exo-IWR-1 is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is …

Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation …

JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).

CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin …

ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 …

1. Kirenol has anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. 2. Kirenol is effective against gram-positive …

Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM. …

LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin …

CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).

Fz7-21 is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 …

Pyrvinium pamoate is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts …

SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.

Methyl vanillate is Hovenia Dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway …

KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of …

G007-LK is a selective inhibitor of TNKS1 and TNKS2, with IC50s of 46 nM and …

Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow …

Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic …

Adavivint (SM04690) is a Wnt pathway inhibitor.

Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells; enables Wnt/β-catenin-driven expansion of mouse ESCs …

BC2059 is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.

NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).

XAV-939 shows the selective inhibition against Wnt/β-catenin-mediated transcription by tankyrase1/2 inhibition (IC50: 11/4 nM in …

PNU 74654 binds to β-catenin (Kd = 450 nM), inhibiting its interaction with the transcription …

N-3-methoxylBenzyllinolenicamide induces osteogenic differentiation and subsequent bone formation of mesenchymal stem cells by activating the …

Wnt agonist 1 (BML-284) is a potent, selective and , cell-permeable Wnt signaling activator.

IWR-1, a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).

IWP-4 is a potent Wnt inhibitor.

ISX9 is necessary to activate neuron-specific genes as neurogenesis inducer.

BML-284 HCL is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.

IWP-2, an inhibitor of Wnt processing and secretion (IC50=27 nM) in a cell-free assay, selectively …

MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and …

WAY-262611 is a wingless β-Catenin agonist.

ETC-159 is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an …

JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active …

TNIK-IN-2 is an inhibitor Traf2- and Nck-interacting protein kinase (TNIK, IC50 = 1.33 μM)) which …

2,5-dimethyl Celecoxib is a celecoxib derivative and a targeted inhibitor of microsomal prostaglandin E synthase-1 …

KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 …