Wnt/beta-catenina
Gli inibitori della via Wnt/beta-catenina sono composti che inibiscono la via di segnalazione Wnt/beta-catenina, cruciale per la regolazione dello sviluppo embrionale, della proliferazione cellulare e del mantenimento delle cellule staminali. La disfunzione di questa via è legata a vari tipi di cancro e malattie degenerative. Gli inibitori della segnalazione Wnt/beta-catenina sono preziosi per la ricerca volta a comprendere il ruolo di questa via nelle malattie e a sviluppare terapie mirate. Presso CymitQuimica, offriamo inibitori di Wnt/beta-catenina per supportare la tua ricerca in biologia delle cellule staminali, biologia dello sviluppo e ricerca sul cancro.
Trovati 63 prodotti di "Wnt/beta-catenina"
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KY1220
CAS:<p>KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.</p>Formula:C14H10N4O3SPurezza:99.9%Colore e forma:SolidPeso molecolare:314.32CCT251545
CAS:CCT251545 is an potent and oral-bioavailable WNT signaling inhibitor(IC50 of 5 nM in 7dF3 cells).Formula:C23H24ClN5OPurezza:98.29% - 98.69%Colore e forma:SolidPeso molecolare:421.92Vantictumab
CAS:Vantictumab (OMP-18R5) is a humanized anti-FZD1/2/5/7/8 monoclonal antibody that inhibits Wnt pathway signaling.Purezza:99% (SDS-PAGE); 97.7% (SEC-HPLC) - 99% (SDS-PAGE); 97.7% (SEC-HPLC)Colore e forma:LiquidBML-286
CAS:<p>BML-286 is a WNT pathway modulator with potential anticancer activity and induces β-catenin- and TCF- dependent transcriptional activity.</p>Formula:C22H18N2O4Purezza:98.44%Colore e forma:SolidPeso molecolare:374.39CWP232228
CAS:CWP232228 is a selective Wnt/β-catenin pathway inhibitor targeting β-catenin/TCF binding, halting breast/liver CSC growth and metastasis safely.Formula:C33H34N7Na2O7PPurezza:98.87%Colore e forma:SolidPeso molecolare:717.63TNIK-IN-5
CAS:TNIK-IN-5: strong TNIK inhibitor (IC50=0.05μM), halts Wnt signaling, effective against colorectal cancer in vitro.Formula:C22H17N3O3Purezza:99.58%Colore e forma:SolidPeso molecolare:371.39JW74
CAS:JW74 antagonizes LiCl-induced activation of the canonical Wnt signaling (IC50: 420 nM).Formula:C24H20N6O2SPurezza:95.00%Colore e forma:SolidPeso molecolare:456.52Nefopam hydrochloride
CAS:Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.Formula:C17H20ClNOPurezza:99.32% - 99.85%Colore e forma:SolidPeso molecolare:289.8ABC99
CAS:ABC99 irreversibly inhibits wnt-deacylating enzyme NOTUM (IC50: 13 nM) with high serine hydrolase family selectivity.Formula:C22H21ClN4O5Purezza:99.89%Colore e forma:SoildPeso molecolare:456.88Romosozumab
CAS:Romosozumab (AMG-785) is a humanized monoclonal antibody that binds and inhibits sclerostin, which increases bone formation and decreases bone resorption.Purezza:98.9% (SDS-PAGE); 98.2% (SEC-HPLC) - 98.9% (SDS-PAGE); 98.2% (SEC-HPLC)Colore e forma:LiquidIpafricept
CAS:Ipafricept (OMP-54F28) is a recombinant fusion protein and Wnt inhibitor that blocks Wnt signaling.Purezza:99.2% (SDS-PAGE); 97.4% (SEC-HPLC) - 99.2% (SDS-PAGE); 97.4% (SEC-HPLC)Colore e forma:LiquidWnt pathway inhibitor 3
CAS:Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studiesFormula:C21H17BrN2O5Purezza:99.94%Colore e forma:SoildPeso molecolare:457.27CCT 031374 hydrobromide
CAS:CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.Formula:C23H20BrN3OPurezza:99.50%Colore e forma:SolidPeso molecolare:434.33NLS-StAx-h
Wnt inhibitor; halts cancer cell growth & spread by blocking β-catenin, IC50=1.4μM, cell-permeable.Formula:C161H275N55O29Purezza:98%Colore e forma:SolidPeso molecolare:3445.26Wnt/β-catenin agonist 3
CAS:<p>Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.</p>Formula:C16H15ClN4O2Purezza:99.52%Colore e forma:SolidPeso molecolare:330.77Blosozumab
CAS:Blosozumab (LY2541546) is a monoclonal antibody targeting sclerostin that promotes bone formation, used in the research of osteoporosis.Purezza:98.7% (SEC-HPLC) - 99.53% (SEC-HPLC)Colore e forma:LiquidF7H
CAS:<p>F7H is an FZD7 antagonist, a potent ligand for the FZD7 transmembrane domain (TMD), with potential antitumor and bacteriostatic activities.</p>Formula:C24H18FN3O2S2Purezza:99.85%Colore e forma:SoildPeso molecolare:463.55LP-922056
CAS:<p>LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively.</p>Formula:C11H9ClN2O2S2Purezza:99.84%Colore e forma:SolidPeso molecolare:300.78β-catenin modulator IIa-661
CAS:β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.Formula:C19H23ClN2O3SPurezza:99.58%Colore e forma:SoildPeso molecolare:394.92WIC1
CAS:<p>2H-1-Benzopyran-3-carboxamide, N-[4-(4-ethyl-1-piperazinyl)phenyl]-2-oxo- is a compound that is potential for the treatment of tumours.</p>Formula:C22H23N3O3Purezza:99.82%Colore e forma:SoildPeso molecolare:377.44Foxy-5
CAS:Foxy-5 is a wnt5a peptide mimeticFormula:C26H42N6O12S2Purezza:98%Colore e forma:SolidPeso molecolare:694.771(R),2(S)-epoxy Cannabidiol
CAS:<p>1(R),2(S)-epoxy Cannabidiol (Compound 2a) is a structural analog of phytocannabinoids, exhibiting significant inhibitory activity on the Wnt/β-catenin pathway. It holds potential for research as a neuroprotective agent.</p>Formula:C21H30O3Colore e forma:SolidPeso molecolare:330.46YW2036
CAS:YW2036 is an inhibitor of Wnt signaling pathway.Formula:C20H16N4OPurezza:99.94%Colore e forma:SoildPeso molecolare:328.37Tabituximab
CAS:BMS-986148 is a CHO-expressed humanized antibody-drug coupling targeting mesothelin-expressing cells for cytotoxic load delivery.Purezza:98.7% (SDS-PAGE); 96.4% (SEC-HPLC) - 98.7% (SDS-PAGE); 96.4% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:145.5 kDaIWP-3
CAS:IWP-3 is a potent inhibitor of Wnt production with an IC50 of 40 nM. It inhibits Porcupine (Porcn), blocking the palmitoylation of Wnt proteins, and moderately inhibits CK1γ3 and CK1ε, but does not inhibit CK1α [1] [2].Formula:C22H17FN4O2S3Purezza:98%Colore e forma:SolidPeso molecolare:484.59MSAB
CAS:MSAB inhibits Wnt/β-catenin by binding to β-catenin and inducing its breakdown.Formula:C15H15NO4SPurezza:99.76%Colore e forma:SolidPeso molecolare:305.35Cardiogenol C
CAS:<p>Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.</p>Formula:C13H16N4O2Purezza:98.46%Colore e forma:SolidPeso molecolare:260.29Cardiogenol C hydrochloride
CAS:Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).Formula:C13H17ClN4O2Purezza:99.89% - 99.94%Colore e forma:SolidPeso molecolare:296.75IWR-1
CAS:IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).Formula:C25H19N3O3Purezza:99.19% - 99.82%Colore e forma:SolidPeso molecolare:409.44LF3
CAS:LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)Formula:C20H24N4O2S2Purezza:99.63%Colore e forma:SolidPeso molecolare:416.56SKL2001
CAS:SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.Formula:C14H14N4O3Purezza:97.46% - 99.99%Colore e forma:SolidPeso molecolare:286.29Adavivint
CAS:<p>Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.</p>Formula:C29H24FN7OPurezza:98.27% - 98.6%Colore e forma:SolidPeso molecolare:505.55Wnt-C59
CAS:<p>Wnt-C59 (C59)(C59) is a highly effective and specific Wnt signaling antagonis with PORCN enzymatic activity.</p>Formula:C25H21N3OPurezza:99.56% - 99.95%Colore e forma:SolidPeso molecolare:379.45Teplinovivint
CAS:Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathyFormula:C25H26N6O2Purezza:97.21%Colore e forma:SolidPeso molecolare:442.51iCRT 14
CAS:<p>iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).</p>Formula:C21H17N3O2SPurezza:99.8% - 99.97%Colore e forma:SolidPeso molecolare:375.44BML-284
CAS:BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.Formula:C19H18N4O3Purezza:99.91% - 99.921%Colore e forma:SolidPeso molecolare:350.37KY02111
CAS:<p>KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.</p>Formula:C18H17ClN2O3SPurezza:97.71% - 98.3%Colore e forma:SolidPeso molecolare:376.86β-catenin-IN-2
CAS:β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.Formula:C15H14FN3Purezza:99.93%Colore e forma:SolidPeso molecolare:255.29exo-IWR-1
CAS:<p>exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt/β-catenin</p>Formula:C25H19N3O3Purezza:97.41%Colore e forma:SolidPeso molecolare:409.44Wnt pathway activator 1
CAS:Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM.Formula:C18H16O4Purezza:99.93%Colore e forma:SolidPeso molecolare:296.32WAY 316606
CAS:WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.Formula:C18H19F3N2O4S2Purezza:99.65%Colore e forma:SolidPeso molecolare:448.48IWP-O1
CAS:IWP-O1 is a highly potent Porcupine (Porcn) inhibitor (EC50: 80 pM), effectively suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells.Formula:C26H20N6OPurezza:99.12%Colore e forma:SolidPeso molecolare:432.48Tegatrabetan
CAS:Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.Formula:C28H36N4O6S2Purezza:98.01% - 99.18%Colore e forma:SolidPeso molecolare:588.74KYA1797K
CAS:KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.Formula:C17H11N2O6S2·KPurezza:97.57% - 99.33%Colore e forma:SolidPeso molecolare:442.51Pyrvinium pamoate
CAS:Pyrvinium pamoate (Pyrvinium embonate) is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drugFormula:C26H28N3C23H14O6Purezza:99.76% - >99.99%Colore e forma:SolidPeso molecolare:575.71ETC-159
CAS:ETC-159 (ETC-1922159) is a potent, orally available PORCN inhibitor. It inhibits β-catenin reporter activity with an IC50 of 2.9 nM.Formula:C19H17N7O3Purezza:96.87% - 99.30%Colore e forma:SolidPeso molecolare:391.38BML-284 hydrochloride
CAS:<p>BML-284 hydrochloride (Wnt agonist 1 HCL) is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.</p>Formula:C19H19ClN4O3Purezza:99.80%Colore e forma:SolidPeso molecolare:386.84WAY-262611
CAS:<p>WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay.</p>Formula:C20H22N4Purezza:98.09% - 99.09%Colore e forma:SolidPeso molecolare:318.42IQ 1
CAS:<p>IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions.</p>Formula:C21H22N4O2Purezza:98.57% - ≥95%Colore e forma:SolidPeso molecolare:362.42IWP-4
CAS:IWP-4 (Inhibitor of Wnt Production-4) is a potent Wnt inhibitor.Formula:C23H20N4O3S3Purezza:98% - 99.59%Colore e forma:SolidPeso molecolare:496.62PRI-724
CAS:<p>PRI-724 is a second-generation, selective small molecule inhibitor of the β-catenin/CBP interaction.Cost-effective and quality-assured.</p>Formula:C33H35N6O7PPurezza:98.25% - 99.11%Colore e forma:SoildPeso molecolare:658.64ZW4864 free base
CAS:<p>ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction ( β catenin/BCL9 PPI ) inhibitor.</p>Formula:C33H42N6O3Purezza:99.81%Colore e forma:SolidPeso molecolare:570.72GB1874
CAS:GB1874 is an inhibitor of the Wnt pathway targeting β-catenin-TCF4 protein-protein interaction (PPI), affecting proliferation in Wnt-dependent CRC cells.Formula:C24H27N3O2SColore e forma:SolidPeso molecolare:421.56β-catenin/CBP-IN-1
CAS:β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-cateninFormula:C33H35N6O7PPurezza:98%Colore e forma:SolidPeso molecolare:658.64Wnt pathway activator 2
CAS:Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.Formula:C17H15NO4Purezza:99.41%Colore e forma:SolidPeso molecolare:297.31Wnt/β-catenin agonist 4
CAS:Wnt/β-catenin agonist 4 is an agonist of Wnt that activates Wnt/β-catenin signaling and directs signaling.Formula:C16H15FN4O2Purezza:99.96%Colore e forma:SolidPeso molecolare:314.31FzM1.8
CAS:FzM1.8: allosteric FZD4 agonist, pEC50=6.4; boosts TCF/LEF, activates WNT/β-catenin with no WNT needed.Formula:C18H14N2O4Purezza:99.89%Colore e forma:SolidPeso molecolare:322.31FzM1
CAS:FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2)Formula:C21H16N2O2SPurezza:99.37% - 99.89%Colore e forma:SolidPeso molecolare:360.43JW 67
CAS:<p>JW 67 is an inhibitor of canonical Wnt pathway signaling.</p>Formula:C21H18N2O6Purezza:99.02%Colore e forma:SolidPeso molecolare:394.38β-Catenin modulator-8
CAS:β-Catenin modulator-8 (Compound Ⅸa) is a specific β-catenin modulator for use in cancer research.Formula:C17H20N2O2SPurezza:99.97%Colore e forma:SolidPeso molecolare:316.42Carboxylesterase-IN-3
CAS:<p>Carboxylesterase-IN-3 is a potent inhibitor of Carboxylesterase Notum (IC50 ≤ 10 nM).Carboxylesterase-IN-3 has the potential to study cancer diseases.</p>Formula:C11H6Cl2N4OSPurezza:97.49% - 98.47%Colore e forma:SolidPeso molecolare:313.16CDK8-IN-11
CAS:CDK8-IN-11 is a CDK8 inhibitor that demonstrates anti-proliferative activity against colon cancer cell lines and inhibits the activation of WNT/β-catenin.Formula:C19H15F3N4O2Purezza:99.74%Colore e forma:SolidPeso molecolare:388.34NRX-103095
CAS:<p>NRX-103095 increases β-catenin binding to SCFβ-TrCP E3 ligase; EC50 is 163 nM for pSer33/Ser37 affinity boost.</p>Formula:C22H16Cl2F3N3O3SPurezza:99.58% - 99.95%Colore e forma:SolidPeso molecolare:530.35
